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Biological Cybernetics
Biological Cybernetics

... • Relate basic neural activities on the cellular level to: • The various observed electroencephalograms (EEG) • Potential differences in the cortex ...
Diverse Origins of Network Rhythms in Local Cortical Circuits
Diverse Origins of Network Rhythms in Local Cortical Circuits

... magnitude larger than local circuit connections using gap junctions (above). It should be noted that some synaptic inhibition can originate from principal, projection neurons over much greater spatial scales (e.g., cerebellar Purkinje cells), but they will not be dealt with here. Synaptic inhibition ...
Bio 211 Lecture 18
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... • absolute - time when threshold stimulus does not start another action potential (Na+ channels inactivated) • relative – time when stronger threshold stimulus can start another action potential (Na+ channels restored, K+ channels begin ...
Electroencephalography
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... Reference montage: Each waveform in the EEG represents the difference in voltage between a specific active electrode and a designated reference electrode. There is no standard position for the reference, but usually a midline electrode is chosen so as not to bias the signal in any one hemisphere. Ot ...
Synapses - UBC Zoology
Synapses - UBC Zoology

... - increase in Ca 2+ induces fusion of synaptic vesicles to membrane - vesicles contain neurotransmitters 4. Vesicle fusion to membrane releases stored neurotransmitter 5. Transmitter diffuses across cleft to postsynaptic side 6. Neurotransmitters bind to receptor either: i) ligand-gated ion channel ...
Synaptic Responses of Cortical Pyramidal Neurons to Light
Synaptic Responses of Cortical Pyramidal Neurons to Light

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A. What is a neuron? 1. A neuron is a type of cell that receives and
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The role of nicotinic acetylcholine receptors and GABAergic
The role of nicotinic acetylcholine receptors and GABAergic

... low neuronal activity and lower EEG frequency. Body temperature and metabolism decrease to their lowest levels. However, some muscle tone is retained. Non-REM sleep is divided into four stages. The first stage is the initial transition into the sleeping state, with a duration of only a few minutes. ...
MS Word Version
MS Word Version

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Walter J. Freeman Journal Article e-Reprint
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Abstract
Abstract

... development is essential not only to gain insight into its normal functioning, but also to progress in the compre­ hension of neurological and psychiatric disease. Indeed, there is increasing evidence that defects occur­ring during embryonic development lead to impaired functioning of the cerebral c ...
BioCapture™ : Acquiring EEG data Quick Notes
BioCapture™ : Acquiring EEG data Quick Notes

... These patterns have particular frequency ranges and are associated with different states of brain function (e.g., waking and various levels of sleep). These patterns represent synchronized activity over a network of neurons. Delta waves are the slowest of the known EEG frequencies—no faster than 4 H ...
Mathematical neuroscience: from neurons to circuits to systems
Mathematical neuroscience: from neurons to circuits to systems

... and time sensitivity of the various neuronal conductances. Once each of the currents had been properly characterized, it was found that the same non-linear gating mechanisms were sufficient to explain the generation of action potentials, i.e. explosive all or none voltage spikes that initiate synaptic ...
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Spike-and-Wave Oscillations Based on the Properties of GABAB
Spike-and-Wave Oscillations Based on the Properties of GABAB

... recordings also indicate that spindle oscillations, which are generated by thalamic circuits (Steriade et al., 1990, 1993), can be transformed gradually into SW discharges, and all manipulations that promote or antagonize spindles have the same effect on SW (Kostopoulos et al., 1981a,b; McLachlan et ...
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... oxidative stress resulted to be the hippocampus, cerebellum and amygdala/piriform cortex, which is very similar to the pattern of neuronal loss assessed histopathologically.3,5 Taking into account our findings, it seems that hypothalamus, striatum and cerebral cortex are resistant to KA-induced oxid ...
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A5: Neuropharamcology (student) - Ms De Souza`s Super Awesome

... Affects cerebellum (involved in coordination) which causes motor impairment ...
Cholinergic Basal Forebrain Neurons Burst with Theta during
Cholinergic Basal Forebrain Neurons Burst with Theta during

... instantaneous firing frequency using the first modal peak of the interspike interval histogram (ISIH), rhythmicity of discharge and its frequency using the autocorrelation histogram (ACH), and crosscorrelated EEG activity using the spike-triggered average (STA). Gamma (30 –58 Hz) power, delta (1– 4. ...
Action Potential
Action Potential

... Components of an Action Potential 1. Threshold: Minimum strength of current required 2. All or none phenomena: - Either a complete action potential that propagates along the axon or no response at all - once generated, moves along the axon without a drop or gain in amplitude 3. Always followed by a ...
A4a - Viktor`s Notes for the Neurosurgery Resident
A4a - Viktor`s Notes for the Neurosurgery Resident

...  each neuron divides to form > 2000 synaptic endings.  single spinal motor neuron has ≈ 10,000 synapses (2000 on cell body, 8000 on dendrites) – synapses cover ≈ 40% of soma membrane and ≈ 75% of dendritic membrane.  in cortical neurons, 98% synapses are on dendrites and only 2% are on cell bodie ...
The role of synchronous gamma-band activity in schizophrenia
The role of synchronous gamma-band activity in schizophrenia

... Neural synchrony: synchronous oscillations of membrane potentials in a network of neurons Gamma-band: Oscillation in high-frequencies band ...
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LO #1

... LO #2: Compare ionotropic and metabotropic receptors. Fast synaptic potentials: the transmitter binds to and activates receptors that also function as ion channels – these are referred to as ionotropic receptors (1–20 ms in duration, e.g., nicotinic AChR in skeletal muscle).  Recovery of the poten ...
Physiology Lecture 6
Physiology Lecture 6

... The neuron at the resting membrane potential is much more permeable to K+ than to Na+, but some Na+ does enter the cell. Because of the slight inward movement of Na+, the resting membrane potential is a little less negative than the equilibrium potential for K+ . Depolarization of a small region of ...
Abstract
Abstract

... features including symptoms of disrupted colonic motility and visceral pain. To better understand and treat these conditions, it is necessary to elucidate the neural mechanisms responsible for altered gut functions and to develop targeted therapeutic strategies. The objectives of my dissertation stu ...
4-CPG1
4-CPG1

... can generate a stereotyped rhythmic movement without sensory afference or somatic feedback. • It can be activated/sustained by a triggering stimulus (either tonic or phasic), but requires no modulation of the input to generate the basic pattern. • Lundberg and Grillner had a nasty argument on whethe ...
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Spike-and-wave



Spike-and-wave is the term that describes a particular pattern of the electroencephalogram (EEG) typically observed during epileptic seizures. A spike-and-wave discharge is a regular, symmetrical, generalized EEG pattern seen particularly during absence epilepsy, also known as ‘petit mal’ epilepsy. The basic mechanisms underlying these patterns are complex and involve part of the cerebral cortex, the thalamocortical network, and intrinsic neuronal mechanisms. The first spike-and-wave pattern was recorded in the early twentieth century by Hans Berger. Many aspects of the pattern are still being researched and discovered, and still many aspects are uncertain. The spike-and-wave pattern is most commonly researched in absence epilepsy, but is common in several epilepsies such as Lennox-Gastaut syndrome (LGS) and Ohtahara syndrome. Anti-epileptic drugs (AEDs) are commonly prescribed to treat epileptic seizures, and new ones are being discovered with less adverse effects. Today, most of the research is focused on the origin of the generalized bilateral spike-and-wave discharge. One proposal suggests that a thalamocortical (TC) loop is involved in the initiation spike-and-wave oscillations. Although there are several theories, the use of animal models has provided new insight on spike-and-wave discharge in humans.
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