Inhibitory postsynaptic potential
... Gross Electrical Activity of the Human Brain • An electroencephalogram (EEG) is a recording of brain potentials, or brain waves. – patterns of activity from large areas of the brain • measure electrical activity from more than 100,000 neurons ...
... Gross Electrical Activity of the Human Brain • An electroencephalogram (EEG) is a recording of brain potentials, or brain waves. – patterns of activity from large areas of the brain • measure electrical activity from more than 100,000 neurons ...
Seizures
... Generalized – uncontolled discharge of neurons on BOTH sides of brain. Seizure starts in one area and spreads across the brain. Partial – abnormal electrical activity involving only a small part of the brain - although sometimes a partial seizure can spread to the whole brain ...
... Generalized – uncontolled discharge of neurons on BOTH sides of brain. Seizure starts in one area and spreads across the brain. Partial – abnormal electrical activity involving only a small part of the brain - although sometimes a partial seizure can spread to the whole brain ...
Lecture 6C
... • Epilepsy (from the Ancient Greek meaning "to seize") is a group of neurological disorders characterized by epileptic seizures. Prevalence: 1 in 100 • Epileptic seizures are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking. • Often brought on by factors ...
... • Epilepsy (from the Ancient Greek meaning "to seize") is a group of neurological disorders characterized by epileptic seizures. Prevalence: 1 in 100 • Epileptic seizures are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking. • Often brought on by factors ...
Epilepsy and Seizure Disorders
... one of the most excitable parts of the brain Limbic system One of the very few brain regions that is capable of constant generation of new neurons ...
... one of the most excitable parts of the brain Limbic system One of the very few brain regions that is capable of constant generation of new neurons ...
Implications in absence epileptic seizures
... Paz, J., Chavez, M., Saillet,S., Deniau, J-M., & Charpier, S. (2007). Activity of Ventral Medial Thalamic Neurons during Absence Seizures and Modulation of Cortical Paroxysms by the Nigrothalamic Pathway. Journal of Neuroscience, 27(4), 929-941. Pellegrini, A., Musgrave, J., & Gloor, P. (1979) Role ...
... Paz, J., Chavez, M., Saillet,S., Deniau, J-M., & Charpier, S. (2007). Activity of Ventral Medial Thalamic Neurons during Absence Seizures and Modulation of Cortical Paroxysms by the Nigrothalamic Pathway. Journal of Neuroscience, 27(4), 929-941. Pellegrini, A., Musgrave, J., & Gloor, P. (1979) Role ...
Predicting and Preventing Epileptic Seizures
... Currently, the technology is still in clinical trials but human testing should be underway within the next 2-3 years. Research on epilepsy and specifically how it affects the nervous system is still underway Help people with epileptic episodes to live normal, ...
... Currently, the technology is still in clinical trials but human testing should be underway within the next 2-3 years. Research on epilepsy and specifically how it affects the nervous system is still underway Help people with epileptic episodes to live normal, ...
Levetiracetam in the Treatment of Epilepsy
... Astrogliosis – abnormal shape and increased numbers of astrocytes – is a prominent feature of Ammon’s horn sclerosis. Glu released from neurons can activate mGluR on astrocytes. Glu released from an astrocyte is sufficient to trigger a PDS (paroxysmal depolarizing shift) in neighboring neuron. A no ...
... Astrogliosis – abnormal shape and increased numbers of astrocytes – is a prominent feature of Ammon’s horn sclerosis. Glu released from neurons can activate mGluR on astrocytes. Glu released from an astrocyte is sufficient to trigger a PDS (paroxysmal depolarizing shift) in neighboring neuron. A no ...
Pathophysiology of Epilepsy
... EEG reflect phase locked oscillations between excitation and inhibition in thalamocortical networks – aberrations of oscillatory rhythms that are normally generated during sleep by circuits connecting the cortex and thalamus ...
... EEG reflect phase locked oscillations between excitation and inhibition in thalamocortical networks – aberrations of oscillatory rhythms that are normally generated during sleep by circuits connecting the cortex and thalamus ...
Spike-and-wave
Spike-and-wave is the term that describes a particular pattern of the electroencephalogram (EEG) typically observed during epileptic seizures. A spike-and-wave discharge is a regular, symmetrical, generalized EEG pattern seen particularly during absence epilepsy, also known as ‘petit mal’ epilepsy. The basic mechanisms underlying these patterns are complex and involve part of the cerebral cortex, the thalamocortical network, and intrinsic neuronal mechanisms. The first spike-and-wave pattern was recorded in the early twentieth century by Hans Berger. Many aspects of the pattern are still being researched and discovered, and still many aspects are uncertain. The spike-and-wave pattern is most commonly researched in absence epilepsy, but is common in several epilepsies such as Lennox-Gastaut syndrome (LGS) and Ohtahara syndrome. Anti-epileptic drugs (AEDs) are commonly prescribed to treat epileptic seizures, and new ones are being discovered with less adverse effects. Today, most of the research is focused on the origin of the generalized bilateral spike-and-wave discharge. One proposal suggests that a thalamocortical (TC) loop is involved in the initiation spike-and-wave oscillations. Although there are several theories, the use of animal models has provided new insight on spike-and-wave discharge in humans.