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... facilitates glutamate actions at NMDA receptors [26,27,69,70]. D2 receptor activity attenuates glutamate actions at non-NMDA receptors [26,70]. Since the nonNMDA glutamate activity is necessary before the NMDA receptor can become activated, this selective amplification of the NMDA response should se ...
PDF
PDF

... Abnormalities induced by tissue trauma in brain slices are exacerbated by several additional factors. The lack of blood flow in slices dramatically changes the way energy substrates and oxygen are delivered to cells. Energy substrates and O2 are instead supplied exogenously by artificial extracellular ...
Deep Tendon Reflex
Deep Tendon Reflex

... Mechanism of the myotatic reflex Tapping of a muscle tendon leads to elongation (stretching) of the fibers of that muscle.  This leads to stimulation of muscle spindles within the muscle.  The muscle spindles are sensory receptors present within the skeletal muscles. ...
Auditory Nerve Stochasticity Impedes Category Learning: the Role
Auditory Nerve Stochasticity Impedes Category Learning: the Role

... excitatory (E) and red circles represent inhibitory (I) neurons. The connectivity within each stage of the models is demonstrated using one excitatory cell as an example: E→I connection is shown in black, I→E connections are shown in red. feedforward connections between the last two stages of each m ...
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... (from -1,000 to -100 ms) before stimulus onset. A unit was considered responsive if all of the following were fulfilled: 1) the median number of spikes exceeded 5 SD of the baseline distribution across stimuli per session; 2) the median number of spikes was ⱖ2; and 3) a paired t-test between the bas ...
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Full Text PDF - J

... mouse brain. GCP-WD and CDK5RAP2 are well known γtubulin-recruiting proteins that are localized at the centrosome in general interphase cells and bind to γ-tubulin ring complex (γTuRC) [5, 9, 18]. GCP-WD and CDK5RAP2, together with many kinds of kinases, make γTuRC change conformation so that the co ...
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... low-threshold afferent input.19 These PKC␥ + positive (PKC␥ + ) neurons are a key element for activated circuits after disinhibition by intrathecal application of glycine receptor antagonist, unmasking normally blocked local excitatory circuits onto nociceptive output neurons.2,3 However, this circu ...
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Untitled
Untitled

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PDF file
PDF file

... mechanisms, Hebbian learning and lateral inhibition, but we further its optimality. The inter-layer developmental mechanisms specify how information between layers are passed and used, which enables both unsupervised and supervised learning to occur in the same network. Of course there are many othe ...
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Variance and invariance of neuronal long

... Downloaded from http://rstb.royalsocietypublishing.org/ on May 6, 2017 ...
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Stimulus (physiology)



In physiology, a stimulus (plural stimuli) is a detectable change in the internal or external environment. The ability of an organism or organ to respond to external stimuli is called sensitivity. When a stimulus is applied to a sensory receptor, it normally elicits or influences a reflex via stimulus transduction. These sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanorceptors. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.
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