Are there differences between the secretion characteristics of NGF
... discordant results have been reported for high potassium-mediated secretion of BDNF from virus-transduced primary cultures of hippocampal neurons and AtT-20 and PC12 cells (Goodman et al., 1996). These authors observed that the high potassium-mediated secretion of BDNF was dependent on extracellular ...
... discordant results have been reported for high potassium-mediated secretion of BDNF from virus-transduced primary cultures of hippocampal neurons and AtT-20 and PC12 cells (Goodman et al., 1996). These authors observed that the high potassium-mediated secretion of BDNF was dependent on extracellular ...
Distinct Neuropathologic Phenotypes After Disrupting the
... been characterized in detail. gl and Clcn7-deficient mice display disease phenotypes that are very similar to each other and death occurs by 7 weeks (4, 8). Both of these mice share neuropathologic phenotypes with the NCLs including severe retinal and CNS degeneration (4, 8). Clcn7j/j mice show optic ...
... been characterized in detail. gl and Clcn7-deficient mice display disease phenotypes that are very similar to each other and death occurs by 7 weeks (4, 8). Both of these mice share neuropathologic phenotypes with the NCLs including severe retinal and CNS degeneration (4, 8). Clcn7j/j mice show optic ...
Background - Harvard University
... and microeconomic utility theory, on the understanding of these brain mechanisms. Given the space limits and the only just beginning neurophysiological studies based on game theory (Barraclough et al. 2004, Dorris & Glimcher 2004), the description of the neurophysiology of this promising field will ...
... and microeconomic utility theory, on the understanding of these brain mechanisms. Given the space limits and the only just beginning neurophysiological studies based on game theory (Barraclough et al. 2004, Dorris & Glimcher 2004), the description of the neurophysiology of this promising field will ...
Hox Genes: Choreographers in Neural Development, Architects of
... identity, displaying migration patterns and molecular signatures of trigeminal MNs, and fail to migrate caudally, leading to the subsequent loss of the facial nerve (Gavalas et al., 2003; Goddard et al., 1996; Studer et al., 1996). Hoxb2/ and Hoxa1/ mice also show a severe reduction of the facia ...
... identity, displaying migration patterns and molecular signatures of trigeminal MNs, and fail to migrate caudally, leading to the subsequent loss of the facial nerve (Gavalas et al., 2003; Goddard et al., 1996; Studer et al., 1996). Hoxb2/ and Hoxa1/ mice also show a severe reduction of the facia ...
Role of the bed nucleus of the stria terminalis in the control
... neuronal activity. We refer also to an excellent review for studies on the role of BST in the pathophysiology of stress-related psychiatric disorders (Forray and Gysling, 2004). The anterior part of the BST receives excitatory inputs primarily from the ventral subiculum of the hippocampus (vSUB) and ...
... neuronal activity. We refer also to an excellent review for studies on the role of BST in the pathophysiology of stress-related psychiatric disorders (Forray and Gysling, 2004). The anterior part of the BST receives excitatory inputs primarily from the ventral subiculum of the hippocampus (vSUB) and ...
Review Article Type 3 adenylyl cyclase: a key enzyme mediating the
... Abstract: Cilia are rigid, centriole-derived, microtubule-based organelles present in a majority of vertebrate cells including neurons. They are considered the cellular “antennae” attuned for detecting a range of extracellular signals including photons, odorants, morphogens, hormones and mechanical ...
... Abstract: Cilia are rigid, centriole-derived, microtubule-based organelles present in a majority of vertebrate cells including neurons. They are considered the cellular “antennae” attuned for detecting a range of extracellular signals including photons, odorants, morphogens, hormones and mechanical ...
Calcium Regulation of Dendritic Growth via CaM Kinase IV and
... few days (Wu et al., 1999). During this period of rapid dendritic growth, synaptic currents are principally mediated by NMDA receptors, and pharmacological blockade of NMDA receptors markedly reduces dendritic growth rates (Rajan and Cline, 1998). While these observations indicate that afferent acti ...
... few days (Wu et al., 1999). During this period of rapid dendritic growth, synaptic currents are principally mediated by NMDA receptors, and pharmacological blockade of NMDA receptors markedly reduces dendritic growth rates (Rajan and Cline, 1998). While these observations indicate that afferent acti ...
Neocortical Very Fast Oscillations (Ripples, 80–200 Hz) During
... in Fig. 11) had this pattern, which was revealed in filtered traces. Sometimes, recordings with macroelectrodes did not show this pattern, while local field potential recorded with a micropipette or cellular recordings did (see for example Fig. 11, DC field and glial cell recordings vs. EEG). Ripple ...
... in Fig. 11) had this pattern, which was revealed in filtered traces. Sometimes, recordings with macroelectrodes did not show this pattern, while local field potential recorded with a micropipette or cellular recordings did (see for example Fig. 11, DC field and glial cell recordings vs. EEG). Ripple ...
Axon Initial Segment Cytoskeleton: Architecture, Development, and
... C-terminal tail into the inner AIS shaft where it is predicted to interact with microtubule fascicles. (b) Domain organization of isoforms of ankyrin G (AnkG). AnkG population contains two large neuron-specific isoforms, 270 kDa and 480 kDa, that localize specifically to AIS and nodes of Ranvier. Th ...
... C-terminal tail into the inner AIS shaft where it is predicted to interact with microtubule fascicles. (b) Domain organization of isoforms of ankyrin G (AnkG). AnkG population contains two large neuron-specific isoforms, 270 kDa and 480 kDa, that localize specifically to AIS and nodes of Ranvier. Th ...
MODELING THE MIRROR: GRASP LEARNING AND ACTION
... Keysers and Evelyne (Kohler) for not only actively involving me in their recording sessions but also offering their sincere friendship. I am very thankful to Hideo Sakata for giving me the opportunity to visit his lab in Tokyo and interact with many researchers including Murata-san with whom I had v ...
... Keysers and Evelyne (Kohler) for not only actively involving me in their recording sessions but also offering their sincere friendship. I am very thankful to Hideo Sakata for giving me the opportunity to visit his lab in Tokyo and interact with many researchers including Murata-san with whom I had v ...
Shape Selectivity in Primate Frontal Eye Field
... have shown that although the initial activity of visually responsive neurons in FEF does not discriminate whether a target or distractor stimulus appears in their receptive fields, over time (⬎100 ms), the activity of FEF neurons evolves to signal the location of the task-defined target (Schall 2002 ...
... have shown that although the initial activity of visually responsive neurons in FEF does not discriminate whether a target or distractor stimulus appears in their receptive fields, over time (⬎100 ms), the activity of FEF neurons evolves to signal the location of the task-defined target (Schall 2002 ...
Sensors for impossible stimuli may solve the stereo correspondence
... Figure 1 Different types of disparity. (a) Disparity stimulus that optimally stimulates a neuron with phase disparity (example receptive fields shown below, odd-symmetric receptive field in left eye and even-symmetric in the right eye). This is a set of luminance gratings (shown as opaque, but actua ...
... Figure 1 Different types of disparity. (a) Disparity stimulus that optimally stimulates a neuron with phase disparity (example receptive fields shown below, odd-symmetric receptive field in left eye and even-symmetric in the right eye). This is a set of luminance gratings (shown as opaque, but actua ...
Selective attention through selective neuronal synchronization
... with two other groups (B and C) can be predicted by their pattern of precise synchronization (Figure 1c). This has recently been demonstrated for interactions of triplets of neuronal groups from within and between areas in awake cat and monkey visual cortex (Womelsdorf et al., 2007). This study meas ...
... with two other groups (B and C) can be predicted by their pattern of precise synchronization (Figure 1c). This has recently been demonstrated for interactions of triplets of neuronal groups from within and between areas in awake cat and monkey visual cortex (Womelsdorf et al., 2007). This study meas ...
Filamentous contacts: the ultrastructure and three
... &p.1:Abstract. Filamentous contacts are non-synaptic interneuronal junctions characteristic of thalamic relay nuclei. Symmetrical filamentous contacts occur between two dendrites, two somata or a dendrite and a soma; asymmetrical filamentous contacts occur between axon terminals and dendrites, or oc ...
... &p.1:Abstract. Filamentous contacts are non-synaptic interneuronal junctions characteristic of thalamic relay nuclei. Symmetrical filamentous contacts occur between two dendrites, two somata or a dendrite and a soma; asymmetrical filamentous contacts occur between axon terminals and dendrites, or oc ...
Module 10 - Neuronal Signalling
... complexity. To function in such circuits, each neuron must receive and process information entering from one set of neurons and then relay signals to other neurons in the circuit. The neuronal processes of signal reception and transmission are key elements of neuronal function and are located at opp ...
... complexity. To function in such circuits, each neuron must receive and process information entering from one set of neurons and then relay signals to other neurons in the circuit. The neuronal processes of signal reception and transmission are key elements of neuronal function and are located at opp ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... that are characteristic for each form of NCL (Santavuori, 1988; Goebel, 1995, 1997). Biochemical studies of these deposits in CLN2, CLN3, and CLN4 have shown that the major protein component is subunit c of the mitochondrial ATPase (Hall et al., 1991; Kominami et al., 1992; Palmer et al., 1992). In ...
... that are characteristic for each form of NCL (Santavuori, 1988; Goebel, 1995, 1997). Biochemical studies of these deposits in CLN2, CLN3, and CLN4 have shown that the major protein component is subunit c of the mitochondrial ATPase (Hall et al., 1991; Kominami et al., 1992; Palmer et al., 1992). In ...
Input-specific control of reward and aversion in the ventral tegmental
... respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (c-aminobutyric-acid-co ...
... respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (c-aminobutyric-acid-co ...
Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice
... mouse whisker sensory thalamus (V2 VPM). In the present study, using transgenic mice whose lemniscal fibers originate from the whisker sensory principle trigeminal nucleus (PrV2) are specifically labeled, we identified that the transection induced retraction of PrV2-originating lemniscal fibers and ...
... mouse whisker sensory thalamus (V2 VPM). In the present study, using transgenic mice whose lemniscal fibers originate from the whisker sensory principle trigeminal nucleus (PrV2) are specifically labeled, we identified that the transection induced retraction of PrV2-originating lemniscal fibers and ...
Propagation of Epileptiform Events across the Corpus Callosum in a
... to identify cell populations with calcium transients by the fluorescence change of each cell over the course of the movie (movie analysis macros written by Dmitriy Aronov, and David Sussillo with modifications by Gloster Aaron). Fluorescence change was calculated through subtraction of background fl ...
... to identify cell populations with calcium transients by the fluorescence change of each cell over the course of the movie (movie analysis macros written by Dmitriy Aronov, and David Sussillo with modifications by Gloster Aaron). Fluorescence change was calculated through subtraction of background fl ...
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... The SAD serine-threonine kinases have been implicated in regulating neuronal polarization and synapse formation. Here, we show that the C. elegans SAD-1 kinase regulates axonal identity and synapse formation through distinct mechanisms. We identified a scaffolding protein, Neurabin (NAB-1), as a phy ...
... The SAD serine-threonine kinases have been implicated in regulating neuronal polarization and synapse formation. Here, we show that the C. elegans SAD-1 kinase regulates axonal identity and synapse formation through distinct mechanisms. We identified a scaffolding protein, Neurabin (NAB-1), as a phy ...
Number, Density, and Surface/Cytoplasmic
... gel were 6900, 5500, 4120, 2750, and 1375 GFP per cubic micrometer. The gels were sectioned at 60 m slices using a vibratome and mounted for imaging. The sectioning and imaging were done within 30 min to prevent GFP diff usion. The sensitivities were proportional to photopower and equaled 0.02343, ...
... gel were 6900, 5500, 4120, 2750, and 1375 GFP per cubic micrometer. The gels were sectioned at 60 m slices using a vibratome and mounted for imaging. The sectioning and imaging were done within 30 min to prevent GFP diff usion. The sensitivities were proportional to photopower and equaled 0.02343, ...
Dopaminergic control of the globus pallidus and its impact
... The work of my thesis is a part of integrative neurobiology and focuses on studying the control exerted by dopamine on basal ganglia (BG), especially the "external part of globus pallidus or GPe". GPe being a nucleus, which plays a key role in the control of movement by exerting an inhibitory influe ...
... The work of my thesis is a part of integrative neurobiology and focuses on studying the control exerted by dopamine on basal ganglia (BG), especially the "external part of globus pallidus or GPe". GPe being a nucleus, which plays a key role in the control of movement by exerting an inhibitory influe ...