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Motor Unit and All or None principle
Motor Unit and All or None principle

... Without the Nervous System – Muscles will not contract. ...
Effect of Outer Hair Cells on Tuning Curves
Effect of Outer Hair Cells on Tuning Curves

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We are investigating the use of novel stimulus
We are investigating the use of novel stimulus

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nervous system - Doctor Jade Main
nervous system - Doctor Jade Main

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Slide ()
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The vertebrate nervous system is regionally specialized

... An increase in the magnitude of the membrane potential is called a hyperpolarization; a decrease in magnitude is called a depolarization. Changes in membrane potential that vary with the strength of a stimulus are known as graded potentials Production of action potentials An action potential is a br ...
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Information Processing in Motor Learning

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Rheobase



Rheobase is a measure of membrane excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ""rhe"" translates to current or flow, and ""basi"" means bottom or foundation: thus the rheobase is the minimum current that will produce an action potential or muscle contraction.Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied. These variables are inversely related: as the strength of the applied current increases, the time required to stimulate the membrane decreases (and vice versa) to maintain a constant effect. Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.The strength-duration curve was first discovered by G. Weiss in 1901, but it was not until 1909 that Louis Lapicque coined the term ""rheobase"". Many studies are being conducted in relation to rheobase values and the dynamic changes throughout maturation and between different nerve fibers. In the past strength-duration curves and rheobase determinations were used to assess nerve injury; today, they play a role in clinical identification of many neurological pathologies, including as Diabetic neuropathy, CIDP, Machado-Joseph Disease, and ALS.
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