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Altered Patterns of Dynorphin lmmunoreactivity Suggest
Altered Patterns of Dynorphin lmmunoreactivity Suggest

... in the polymorph (PM), CA3i and CA1 regions. Varying degrees of cell loss are found in CA30. Scale bars, 1 mm. ...
Electroencephalogram based Brain
Electroencephalogram based Brain

... hence a low pass filter is normally used to filter VEP prior to analysis. It is evoked in a variety of decision-making tasks and in particular, when a target stimulus is identified, for example when a picture is recognised. A popular paradigm is the Donchin’s speller matrix paradigm [15] shown in Fi ...
The Olfactory Sensory Map in Drosophila
The Olfactory Sensory Map in Drosophila

... is bilaterally symmetric in the two appendages and highly stereotyped between individual flies. Early reports discussed the existence of “zones” of OR gene expression, reminiscent of the zones of OR gene expression on the olfactory turbinates of the rodent.50,51 Careful examination of the relationsh ...
An Animal Model of Early-treated PKU
An Animal Model of Early-treated PKU

... children are not usually placed on a restricted diet. Since Phe and tyrosine compete for the same transporter proteins to cross the blood-brain barrier, increases in the ratio of Phe to tyrosine in plasma result in less tyrosine crossing into the brain (Chirigos et al., 1960; Pardridge and Olendorf, ...
Neurophysiological evidence of spared upper motor neurons after
Neurophysiological evidence of spared upper motor neurons after

... (SSEPs) for both clinical and experimental use has been an important factor in assessing spinal cord injury (SCI) for the last two decades.1-3 SSEPs are based on the principle that when a sensory nerve in the periphery is stimulated, evoked electrical activity can be recorded from the somatosensory ...
Somatic motor pathways
Somatic motor pathways

... Integrative Functions of the Cerebrum  Wakefulness and sleep: relies on the reticular activating system (RAS).  Learning and memory: includes immediate, short-term and long-term memory. ...
Hedonic Hotspots Regulate Cingulate-driven
Hedonic Hotspots Regulate Cingulate-driven

... presented. Each trial in the block showed the imperative flanker stimulus (a row of 5 black arrows pointing either left or right; 100 × 7 pix) for 1 s, followed by a fixation cross ( jittered, 3–5 s). The fixation cross following the final flanker stimulus of each mini-block was presented one second long ...
Germinal center B cells recognize antigen through a
Germinal center B cells recognize antigen through a

... signaling in GC B cells exists, which together with the requirement for the T cell help, suggests that BCR signaling is not sufficient for GC B cell selection. However, despite the importance of GC B cell antigen acquisition from synapses with FDCs, GC B cell synapse formation and its contribution t ...
Modulation of premotor circuits controlling locomotor activity by
Modulation of premotor circuits controlling locomotor activity by

... project to someone who barely knew what the brain was about (as of November 2011) was a risky choice, but we made it work. I am super proud of what we have accomplished as a team. Thank your for your constant enthusiasm, trust, support, and passion. You are an example to follow on many different lev ...
Print this article - University of Toronto Journal of Undergraduate Life
Print this article - University of Toronto Journal of Undergraduate Life

... to generate adverse effects such as dyskinesias and motor fluctuations in a vast majority of responding patients [9]. The most prominent hyperkinetic features of dyskinesia are exhibited usually as a mixture of choreiform and dystonic movements. In addition, involuntary writhing movements along the ...
The Basal Ganglia - The Brain from Top to Bottom
The Basal Ganglia - The Brain from Top to Bottom

... This resembles in many respects a displaced portion of the globus pallidus. It receives inputs from the striatum and the subthalamic nucleus. It projects to the VL/VA and DM nuclei of the thalamus. In fact, it is a more important route for information from the caudate nucleus to reach the thalamus t ...
Optogenetic Brain Interfaces
Optogenetic Brain Interfaces

... Optogenetics applies light-sensitive proteins which have been isolated from various microorganisms and plants, to manipulate excitable cells in heterologous systems. Initial work in the field used naturally occurring photosensitive proteins such as channelrhodopsin (ChR) [6] and halorhodopsin (HR) [ ...
Pierre Berthet Computational Modeling of the Basal Ganglia – Functional Pathways
Pierre Berthet Computational Modeling of the Basal Ganglia – Functional Pathways

... We perceive the environment via sensor arrays and interact with it through motor outputs. The work of this thesis concerns how the brain selects actions given the information about the perceived state of the world and how it learns and adapts these selections to changes in this environment. This lea ...
Computing with Spiking Neuron Networks
Computing with Spiking Neuron Networks

... Consider some different ways to decode the temporal information that can be transmitted by the n spiking neurons. If the code is to count the overall number of spikes fired by the set of neurons (population rate coding), the maximum amount of available information is log2 (n + 1), since only n + 1 d ...
The neuroepithelial basement membrane serves as a boundary and
The neuroepithelial basement membrane serves as a boundary and

... the fast, posterior phase of migration, suggesting that they may have contacted the basement membrane before we began recording. In many migratory cell types, such as wound-edge astrocytes and fibroblasts [12,21] or migrating cortical neurons [22], the centrosome localizes between the nucleus and th ...
The central nervous system.
The central nervous system.

... teleostean optic tectum is not exclusively a visual structure, it is unquestionably the major Visual center in the teleostean brain where information concerning movement, shape, and color of objects are analyzed.52»81147 Distinct large retinal terminalfieldsare also present in the thalamus, lateral ...
Review Article Regeneration of Zebrafish CNS
Review Article Regeneration of Zebrafish CNS

... genetic tools and the commonality of its CNS architecture with that of other higher vertebrates, would be of major biomedical significance in inducing the regenerative potential in mammals including human. Thus, zebrafish could serve as an invaluable model to target functional regeneration of spinal ...
Limitations in anti-obesity drug development: the critical role of
Limitations in anti-obesity drug development: the critical role of

... periods of time in combination with intense behavioural interventions. In addition, we discuss how targeting hunger, or the molecular pathways involved in hunger (such as during calorie restriction), may be a successful alternative approach to improving health in patients with chronic metabolic diso ...
PDF file
PDF file

... vector) states and learns the skills conditioned on each state, so that one skill learned from a particular context sequence can be correctly transfer to infinitely many equivalent context sequences in the future without a need for explicit learning. TCM Properties: The new work here proves a series ...
Localization of Ca2+ Channel Subtypes on Rat Spinal Motor
Localization of Ca2+ Channel Subtypes on Rat Spinal Motor

... TBS containing 10% normal goat serum for 1 hr. The spinal cord sections were then incubated in anti-C N B1 (made in goat; diluted 1:15) for 36 hr at 4°C. The tissue was then rinsed in TBS for 1 hr, incubated in biotinylated anti-goat IgG (diluted 1:300) for 1 hr at 37°C, rinsed for 1 hr in TBS, and ...
University of Birmingham Drosophila neurotrophins reveal a
University of Birmingham Drosophila neurotrophins reveal a

... the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival, targeting, synaptic plasticity, memory and cognition. We have identified a neurotrophic factor in flies, Drosophila Neurotrophin (DNT1), structurally related to all kno ...
Membrane-shaping disorders: a common pathway in axon
Membrane-shaping disorders: a common pathway in axon

... Membrane-shaping proteins closely cooperate and directly interact with each other, but their structural features and localization to distinct subdomains of organelles suggests mutually exclusive roles. In some individuals a mutation in a shaping protein can result in upper motor neuron dysfunction, ...
Distribution of Agrin mRNAs in the Chick Embryo Nervous System
Distribution of Agrin mRNAs in the Chick Embryo Nervous System

... that lack one or both inserts (A,B, and A,B,) encoded proteins with little or no AChR-aggregating activity in this assay, and were detected in both neural and non-neural tissues. The A,B,, variant, which encodes an isoform that may have greater AChRaggregating activity than those lacking the inserts ...
Action Potential Riddle Quiz
Action Potential Riddle Quiz

... Please take out 1 piece of notebook paper & label it “Action Potential Riddle Quiz”. Write your NAME, DATE & PERIOD in the top right! For the 10 questions of the quiz, you will see screens for 30 secs. with “riddles” about Action Potentials. Write JUST THE ANSWER to the riddle next to the number (do ...
Transfer Effects and Conditional Learning in Rats With Selective
Transfer Effects and Conditional Learning in Rats With Selective

... Rats were divided into two groups: those receiving cholinergic medial septal lesions (MS/VDB, n ⫽ 12) and surgical controls (CONT, n ⫽ 12). Prior to surgery, each rat was deeply anaesthetized by an intramuscular injection of a ketamine–xylazine mixture (80 mg/kg ketamine and 5 mg/kg xylazine; Phoeni ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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