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Clonal heterogeneity in the germinal zone of the
Clonal heterogeneity in the germinal zone of the

... diameters to micrometers, we multiplied by a factor 5 (the average germinal cell diameter is 5 µm at this time). The exact delineations of double-labeled somata (and thus accurate counts of the numbers of [3H]thymidine grains over each cell body) were assessed by focussing through each stained cell, ...
Distribution, classification, and development of Drosophila glial cells
Distribution, classification, and development of Drosophila glial cells

... Most of our strains also showed GAL4 expression in structures other than the CNS, such as salivary glands, oenocytes, epidermis and gut. Since we dissected out the larval CNS by cutting the peripheral nerves, glia in the peripheral nervous system (PNS) were not investigated (exit glia and peripheral ...
Acetylcholine Facilitates Recovery of Episodic Memory after Brain
Acetylcholine Facilitates Recovery of Episodic Memory after Brain

... that were involved in separate, but methodologically similar, experiments. Water was available ad libitum in the home enclosure, and each monkey’s daily food ration was provided during the course of behavioral testing, or in the home enclosure on days on which testing did not take place. Data from t ...
Introduction to Psychology
Introduction to Psychology

... The next time you are in a market that sells beef brains, stop and have a look. What you will see is similar to your own brain, only smaller. How could such a squishy little blob of tissue allow us to become neuroscientists? To make music of exquisite beauty? To seek a cure for cancer? To fall in lo ...
Neural Mechanisms of Subclinical Depressive
Neural Mechanisms of Subclinical Depressive

... hyperactivity during reward selection that predicted depressive symptom severity and caudate nucleus hypoactivation during reward anticipation. Pizzagalli and colleagues [23] found that individuals with MDD showed decreased putamen responses during reward anticipation and decreased nucleus accumbens ...
Impairment of a parabolic bursting rhythm by the ectopic expression
Impairment of a parabolic bursting rhythm by the ectopic expression

... It is widely held that slowly activating, voltagedependent currents play a key role in producing the bursting rhythm of R15. Previous studies on this topic have focused on two transient currents, designated ID (depolarizing) and IH (hyperpolarizing), both of which increment by a fixed amount after e ...
How Do Neurons Convey Information?
How Do Neurons Convey Information?

... Because we do not feel waves traveling around our bodies, the waves that carry the nervous system’s messages must be very small and restricted to the surface of neurons. Still, we can measure such waves and determine how they are produced by using electrical-stimulation and -recording techniques. If ...
How We Know It Hurts: Item Analysis of Written - Saxelab
How We Know It Hurts: Item Analysis of Written - Saxelab

... suffering: bilateral secondary sensory cortex (l and r SII), bilateral insula, anterior middle cingulate cortex (AMCC), bilateral thalamus, and dorsal medial prefrontal cortex (DMPFC) (for details, see Methods S1 and [25]). Then, the average response (i.e. beta value) within each ROI for the current ...
Full Text - Harvard University
Full Text - Harvard University

... current research and models of decision making have largely focused on the former problem, or action selection, less is known about the latter problem of the selection of motivational drive. Thus, I designed a self-paced decision-making paradigm that aimed to dissociate both facets of selection in r ...
The Face as a Sensory Organ
The Face as a Sensory Organ

... The ascending pathways transmit the somatosensory information collected by the facial receptors, and conveyed by the peripheral axons of the trigeminal sensory neurons (along the peripheral pathways), to higher cortical centers for processing and integration.26 These primary sensory neurons reside i ...
The role of the basal ganglia in reinforcement learning
The role of the basal ganglia in reinforcement learning

... of rate modulations. A simulation suggests that the changes in dopaminergic synchronization could provide an additional mechanism for controlling their concentrations in the striatum, beyond firing rate and pattern. Thus, the difference between the response properties of the basal ganglia subsystems ...
Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine
Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine

... buffer wash. Sections were then incubated with DAB (Sigma), 0.0002% H2O2, and 0.6% nickel ammonium sulfate in Tris buffer solution to produce a black Fos nuclear stain. Tissue was transferred to Tris buffer to stop the reaction, washed, and transferred to PBS with 1% sodium azide for 45 min. For sub ...
Basal Ganglia objectives - NBio401
Basal Ganglia objectives - NBio401

... -Be able to describe the effect of the substantia pars compacta on the direct and indirect pathways. -Be able to explain how, in addition to the pathways affecting limb movements, there are other loops between the basal ganglia and cerebral cortex that perform analogous functions for oculomotor, exe ...
Topographic cues of nanoscale height direct neuronal growth pattern
Topographic cues of nanoscale height direct neuronal growth pattern

... few hundreds of nanometers. Vertical nanopillars protruding from a flat surface serve as focal adhesion points and non-invasively inhibit migration of neurons on the substrate (Xie et al., 2010). Nanowires and lithography-based patterns have been used for both positioning neurons and for directing ax ...
.... _ ACKNOWLEDGMENT !_ This monograph is based on the
.... _ ACKNOWLEDGMENT !_ This monograph is based on the

... system in a variety of ways. In addition, knowledge of the structure and function of the nervous system is not sufficient to entrust a single endpoint with predicting the neurotoxic potential of a substance. The purpose of structural assessments is to provide a convincing picture of the location and ...
central effects of centripetal impulses in axons of spinal ventral roots
central effects of centripetal impulses in axons of spinal ventral roots

... sections. However, the assertion that the responding units in question are located in the ventral horn is not based merely on the fact that their action potentials may be recorded only when an electrode is advanced an appropriate distance ventrad of the dorsal surface of the cord. The simultaneous r ...
Analysis and Classification of EEG signals using Mixture of
Analysis and Classification of EEG signals using Mixture of

... Electroencephalography (EEG) signal is the recording of spontaneous electrical activity of the brain over a small period of time [1]. The term EEG refers that the brain activity emits the signal from head and being drawn. It is produced by bombardment of neurons within the brain. It is measured for ...
neuro 2009 - addiction education home
neuro 2009 - addiction education home

... significantly worse than the comparison group on all measures Also, there were significant differences among the subgroups as the alcoholic group was much worse followed by the amphetamine then the opioids groups. Patients with longer duration of dependence and multiple hospital readmissions were mu ...
Mechanisms of developmental neurite pruning
Mechanisms of developmental neurite pruning

... Stanfield and colleagues [17] using anterograde and retrograde labeling, first in rats and then in mice and other rodents [18, 19], have beautifully demonstrated that L5 cortical neurons from the motor and visual regions initially send identical projections to various targets including the spinal co ...
ABSTRACT  Title of dissertation: MOLECULAR MECHANISMS OF NEURONAL
ABSTRACT Title of dissertation: MOLECULAR MECHANISMS OF NEURONAL

... hippocampal neurons. First, I showed that the SALMs, a newly discovered family of CAMs, regulate changes in neurite outgrowth with distinct morphological characteristics. Through transfections of primary hippocampal neurons, I investigated the roles of each SALM in neurite outgrowth. In addition to ...
Potts Networks – Latching – Correlated patterns
Potts Networks – Latching – Correlated patterns

... Thesis presentation. September 19th, 2007 ...
The subfornical organ: A central nervous system site for actions of
The subfornical organ: A central nervous system site for actions of

... obvious question as to how this peripheral peptide gains access to the central sites. While peptide transporter systems (2) and transendothelial signaling (35) represent mechanisms through which peripheral signals may reach hypothalamic neurons behind the BBB, an alternative explanation also deserve ...
Invulnerability of retinal ganglion cells to NMDA excitotoxicity
Invulnerability of retinal ganglion cells to NMDA excitotoxicity

... functional NMDA and non-NMDA glutamate currents, purified RGCs in culture are invulnerable to glutamate and NMDA-mediated excitotoxicity. In contrast to these results, it has been reported that even a 5-min exposure to NMDA (200 AM) or glutamate (500 AM) produces widespread excitotoxic death in cult ...
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... • how  individual  neurons  work   • how  neurons  communicate  with  each  other   • how  the  nervous  system  receives  information  from  the  environment     • how  the  nervous  system  can  store  this  information   • how  neural  i ...
Symmetrical hemispheric priming in spatial neglect: A
Symmetrical hemispheric priming in spatial neglect: A

... participants without neurological signs or symptoms (Experiment 1; eight females; age range 24e42 years) to verify the hemispheric effects on masked syllabic priming in normal people. In Experiment 2, we examined 12 spatial neglect patients with right-hemisphere damage (three females; mean age ¼ 63. ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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