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Intersegmental synchronization of spontaneous activity of dorsal
Intersegmental synchronization of spontaneous activity of dorsal

... discharges showed the highest incidence of overlapping receptive fields. However, in these studies, very little information was presented on mechanisms and/or pathways contributing to the intersegmental synchronization of the spontaneous activity of these neurons. One question that emerged from the ...
The Use of Cross-Correlation Mapping in Identifying Backwards Projecting Connections between Visual Cortical Areas
The Use of Cross-Correlation Mapping in Identifying Backwards Projecting Connections between Visual Cortical Areas

... The technique pioneered by Sugihara et al [5]–Cross-Correlation Mapping (CCM)–uses the dynamical systems definition of causality. More specifically, CCM constructs shadow manifold for two variables in the proposed system using time-lagged coordinate embedding. That is, CCM creates a shadow manifold ...
An implantable neural probe with monolithically integrated dielectric
An implantable neural probe with monolithically integrated dielectric

... regions such as the hippocampus. In the current application, we have designed, fabricated and tested a monolithically integrated optical waveguide in a multi-electrode array silicon probe. This novel approach provides spatially-confined stimulation (activation and silencing) of simultaneously monito ...
Looking for the roots of cortical sensory computation in three
Looking for the roots of cortical sensory computation in three

... of remarkable technical advances in the past few decades, we are still far from understanding mammalian cerebral cortex. With its six layers, modular architecture, canonical circuits [1], innumerable cell types [2], and computational complexity [3], isocortex remains a challenging mystery. Isocortex ...
36_LectureSlidesAdde..
36_LectureSlidesAdde..

... • Leptin inhibits NPY/AgRP neurons. This decreases inhibition to the catabolic pathway and decreases excitation to the anabolic pathway. The net result is an increase in catabolic pathway activity relative to the anabolic pathway. • Leptin stimulates POMC otherwise known as aMSH/CART neurons. This i ...
Control and Coordination
Control and Coordination

... What do you think? Before you read, decide if you agree or disagree with each of these statements. As you read this chapter, see if you change your mind about any of the statements. 1 The nervous system contains two parts—the central nervous system and the peripheral nervous system. 2 The autonomic ...
world-of-psychology-7th-edition-wood-test-bank
world-of-psychology-7th-edition-wood-test-bank

... 4. Which part of the neuron is responsible for maintaining the life of the cell? a) axon b) soma Correct. The soma is responsible for maintaining the life of the cell. c) dendrite d) cell membrane Incorrect. The soma is responsible for maintaining the life of the cell. ANS: b, p. 38, F, LO=2.1, (2) ...
uncorrected page page page proofs
uncorrected page page page proofs

... If you cupped a human brain in your hands it would feel soft and squishy, like firm jelly. After a couple of minutes, if you turned the brain upside down, you would see a flattened bit left in the tissue from the weight of the brain resting in your hands. This would give you an idea of how delicate ...
A thalamic reticular networking model of consciousness
A thalamic reticular networking model of consciousness

A Weighted and Directed Interareal Connectivity
A Weighted and Directed Interareal Connectivity

... Aflalo and Graziano 2011). Because the patterns of connections between cortical areas are so complex, graph theoretic approaches offer a valuable way to explore their network properties (Watts and Strogatz 1998; Barabasi and Albert 1999; Watts 1999; Newman 2003; Boccaletti et al. 2006). Just as with ...
Full Text
Full Text

... Considering the structural and functional similarity between Rapgef2 and Rapgef6, we first examined the effects of Rapgef6 knockout on the brain malformations of Rapgef2-cKO mice by generating Rapgef2/6-dKO mice. At postnatal day 90 (P90), Rapgef2/6-dKO mice, compared with Rapgef2-cKO mice, showed m ...
Peripheral and Central Mechanisms of Pain Generation
Peripheral and Central Mechanisms of Pain Generation

... nociceptive pain. It protects tissue from being (further) damaged because withdrawal reflexes are usually elicited. Pathophysiological nociceptive pain occurs when the tissue is inflamed or injured. It may appear as spontaneous pain (pain in the absence of any intentional stimulation) or as hyperalges ...
Muscular System
Muscular System

... • It serves to pump (propel) the blood. • Cardiac muscle contractions are inherent (originate in the heart not nervous system) and includes a pacemaker that causes the heart to beat. Autorhythmic. • The heart rate may be modulated by ANS nerves (neurotransmitters) and other chemicals (hormones: epin ...
Responses of the human motor system to observing actions across
Responses of the human motor system to observing actions across

... goal of actions regardless of the effector used to complete the action, similar modulations in activity should be elicited during observation of actions with the same goal across species, even when the action is performed by a non-human-like effector, such as an elephant’s trunk. It is also possible ...
Frequency-Dependent Recruitment of Fast Amino Acid and Slow
Frequency-Dependent Recruitment of Fast Amino Acid and Slow

... control GnRH-GFP-Gpr54 ⫹/⫹ mice. All exand location of the two slices used. B, Schematic three-dimensional view of the relevant structures and cell types contained within perimentation was approved by the University the two slices. The oval dots represent GnRH neurons. C, Photograph of a brain slice ...
Spatial tuning of reaching activity in the medial parieto
Spatial tuning of reaching activity in the medial parieto

... (iv) M2. Inward reach movement, i.e. movement towards the memorized target outside the field of view. M1 and M2 periods of neural modulation related to arm movements towards the LED and towards the home button, respectively; both epochs could start before the onset of arm movement in case the neural ...
Severely dystrophic axons at amyloid plaques
Severely dystrophic axons at amyloid plaques

Central nervous system control of food intake and body
Central nervous system control of food intake and body

... has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any ...
Mapping synaptic pathology within cerebral cortical circuits in
Mapping synaptic pathology within cerebral cortical circuits in

... identification of the synaptic structures specifically affected. Some findings that have identified alterations in specific structures, such as reduced bouton densities, have used a general marker such as synaptophysin, which labels nearly all boutons in cortex (Jahn et al., 1985; Navone et al., 198 ...
Title: Gene expression analysis of human induced pluripotent stem
Title: Gene expression analysis of human induced pluripotent stem

... region. We found that while the overall gene expression levels of the chromosome 15q genes largely reflect the copy number in AS and idic(15) iPSCs and neurons, the gene expression levels did not correlate as well with copy number in the paternal or maternal int dup(15) neurons, suggesting that the ...
Is Cell Death Primary or Secondary in the Pathophysiology of
Is Cell Death Primary or Secondary in the Pathophysiology of

... impact on postsynaptic dendritic spines. By analyzing pre- and postsynaptic markers, we found a 50% reduction of the presynaptic markers synuclein and synaxin compared to controls [44]. This was previously shown by others in DLB and Parkinson’s disease [41,50]. Looking at postsynaptic markers, an al ...
Novel visual stimuli activate a population of neurons
Novel visual stimuli activate a population of neurons

... latencies at t100 ms to eVective stimuli as illustrated in Fig. 1B. While searching for visual cells, the task was run with 12 images in a standard familiar set used every day that were rewarded, and one (the S¡) that was associated with saline. To test a cell for responsiveness to novel stimuli, on ...
Technologies émergentes de mémoire résistive pour les systèmes
Technologies émergentes de mémoire résistive pour les systèmes

here - University of California San Diego
here - University of California San Diego

... Studies show that limited functional recovery can be achieved by plasticity and adaptation of the remaining circuitry in partial injuries in the central nervous system, although the new circuits that arise in these contexts have not been clearly identified or characterized. We show here that synaptic ...
neurophysics.ucsd.edu
neurophysics.ucsd.edu

... Mammals perform a multitude of well-coordinated orofacial behaviors such as breathing, sniffing, chewing, licking, swallowing, vocalizing, and in rodents, whisking. The coordination of these actions must occur without fault to prevent fatal blockages of the airway. Deciphering the neuronal circuitry ...
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Nervous system network models

Network of human nervous system comprises nodes (for example, neurons) that are connected by links (for example, synapses). The connectivity may be viewed anatomically, functionally, or electrophysiologically. These are presented in several Wikipedia articles that include Connectionism (a.k.a. Parallel Distributed Processing (PDP)), Biological neural network, Artificial neural network (a.k.a. Neural network), Computational neuroscience, as well as in several books by Ascoli, G. A. (2002), Sterratt, D., Graham, B., Gillies, A., & Willshaw, D. (2011), Gerstner, W., & Kistler, W. (2002), and Rumelhart, J. L., McClelland, J. L., and PDP Research Group (1986) among others. The focus of this article is a comprehensive view of modeling a neural network (technically neuronal network based on neuron model). Once an approach based on the perspective and connectivity is chosen, the models are developed at microscopic (ion and neuron), mesoscopic (functional or population), or macroscopic (system) levels. Computational modeling refers to models that are developed using computing tools.
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