Minireviews Cracking the Egg: Potential of the Developing Chicken
... cardiovascular system, and respiratory system. Traditionally, these studies have been performed on selected drug candidates late in the nonclinical phase and continued during firstin-human trials. In an attempt to reduce costs and accelerate development, there has been a shift toward performing safe ...
... cardiovascular system, and respiratory system. Traditionally, these studies have been performed on selected drug candidates late in the nonclinical phase and continued during firstin-human trials. In an attempt to reduce costs and accelerate development, there has been a shift toward performing safe ...
comparative study of the effect of sucralose and sugar on some
... and unreactive material. This sweetener sold in pharmacies in commercial varieties. The sweetening effect of a small tablet of commercial package Mardin (sucralose) is equal to 2.7 g sugar. It readily dissolves in water and due to better stability can be used in cooking. This sweetener has been conf ...
... and unreactive material. This sweetener sold in pharmacies in commercial varieties. The sweetening effect of a small tablet of commercial package Mardin (sucralose) is equal to 2.7 g sugar. It readily dissolves in water and due to better stability can be used in cooking. This sweetener has been conf ...
metronidazole
... removed during an eight hour period of dialysis, so that the plasma concentration quickly falls below the therapeutic range. Hence a further dose of metronidazole would be needed after dialysis to restore an adequate plasma concentration. In patients with renal failure, the half-life of metronidazol ...
... removed during an eight hour period of dialysis, so that the plasma concentration quickly falls below the therapeutic range. Hence a further dose of metronidazole would be needed after dialysis to restore an adequate plasma concentration. In patients with renal failure, the half-life of metronidazol ...
Drug-Induced Weight Gain: A Review for Pharmacy
... have been proposed to induce weight gain by causing carbohydrate craving and increased appetite.5 The monoaminoxidase inhibitors (MAO-I) have also been shown to have an effect on body weight. Balon et al., reported that phenelzine induced a weight gain at an extent comparable to that of imipramine.1 ...
... have been proposed to induce weight gain by causing carbohydrate craving and increased appetite.5 The monoaminoxidase inhibitors (MAO-I) have also been shown to have an effect on body weight. Balon et al., reported that phenelzine induced a weight gain at an extent comparable to that of imipramine.1 ...
- EBioMedicine
... N-acetyltransferase 2 (NAT2) catalyzes the acetylation of isoniazid to N-acetylisoniazid. NAT2 polymorphism explains 88% of isoniazid clearance variability in adults. We examined the effects of clinical and genetic factors on Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and ...
... N-acetyltransferase 2 (NAT2) catalyzes the acetylation of isoniazid to N-acetylisoniazid. NAT2 polymorphism explains 88% of isoniazid clearance variability in adults. We examined the effects of clinical and genetic factors on Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and ...
View Full Article in PDF - Knowledgebase publishers
... be different in simple stomach animal like pigs and rabbits. In these species fodder feeding is also a common practice and the effect of the agent would be the constriction of blood vessels so as to enable blood supply to other very important tissues like the brain, inhibition of both the gastric an ...
... be different in simple stomach animal like pigs and rabbits. In these species fodder feeding is also a common practice and the effect of the agent would be the constriction of blood vessels so as to enable blood supply to other very important tissues like the brain, inhibition of both the gastric an ...
MORPHINE Juno
... When morphine is administered by continuous intravenous or subcutaneous infusion for relief of severe, chronic pain associated with cancer, the dosage of morphine must be individualised according to the response and tolerance of the patient. In some patients with exceptionally severe, chronic pain i ...
... When morphine is administered by continuous intravenous or subcutaneous infusion for relief of severe, chronic pain associated with cancer, the dosage of morphine must be individualised according to the response and tolerance of the patient. In some patients with exceptionally severe, chronic pain i ...
What Does This Course Contain - Addiction Technology Transfer
... clinical settings. This will decrease the time it takes for research to be incorporated into treatment settings and will thereby to improve the quality of drug abuse treatment throughout the country. Focus on Buprenorphine In 2002, tablet formulations of buprenorphine were approved by the Food and D ...
... clinical settings. This will decrease the time it takes for research to be incorporated into treatment settings and will thereby to improve the quality of drug abuse treatment throughout the country. Focus on Buprenorphine In 2002, tablet formulations of buprenorphine were approved by the Food and D ...
Best Practice Guide for the treatment of ReM Sleep Behavior
... The apparent efficacy of multiple families of medications for RBD may be related to the complexity of its pathogenesis. The neuropharmacology underlying RBD is inferred from animal studies, case reports of lesions, and physiologic neuroimaging data, which implicate serotonin, norepinephrine, hypocre ...
... The apparent efficacy of multiple families of medications for RBD may be related to the complexity of its pathogenesis. The neuropharmacology underlying RBD is inferred from animal studies, case reports of lesions, and physiologic neuroimaging data, which implicate serotonin, norepinephrine, hypocre ...
Intra-Ventral Tegmental Area Injection of Rat Cocaine and
... comparatively less effective (data not shown), whereas the highest dose (5.0 g/side) gradually induced prolonged seizure activity (see below). The behavioral data of these three rats was not included in subsequent data analysis. Injections were bilateral in all cases, and doses given refer to the d ...
... comparatively less effective (data not shown), whereas the highest dose (5.0 g/side) gradually induced prolonged seizure activity (see below). The behavioral data of these three rats was not included in subsequent data analysis. Injections were bilateral in all cases, and doses given refer to the d ...
... 70 mmHg and an increase or decrease in heart rate of more than 50 beats·min-1 were noted as side-effects during adenosine infusion. Comparison between adenosine and prostacyclin. The overall effect of the two drugs on PVR is similar, as well as a substantial increase in cardiac output. Both compound ...
First clinical data of the neuroprotective effects of nasal insulin
... 3. Clinical trials of nasally applied insulin in patients with mild cognitive impairment/AD Based on the encouraging findings of these first trials in healthy human subjects that demonstrated that the method of application was safe and effective even in nondemented subjects, first clinical studies h ...
... 3. Clinical trials of nasally applied insulin in patients with mild cognitive impairment/AD Based on the encouraging findings of these first trials in healthy human subjects that demonstrated that the method of application was safe and effective even in nondemented subjects, first clinical studies h ...
Featured Article
... particular merits mention. The incidence of subacute stent thrombosis following the recent clinical release of drug-eluting stents has been of much interest. The FDA recently reported several hundred cases of sub-acute stent thrombosis following use of drug-eluting stents. Because re-endothelializat ...
... particular merits mention. The incidence of subacute stent thrombosis following the recent clinical release of drug-eluting stents has been of much interest. The FDA recently reported several hundred cases of sub-acute stent thrombosis following use of drug-eluting stents. Because re-endothelializat ...
panadol osteo data sheet
... taken three times daily) and standard immediate release paracetamol (2 caplets taken 4 times daily) were clinically equivalent at a total daily dose of 4 g based on patient global assessment after treatment for 7 days. PANADOL OSTEO and standard immediate release paracetamol were not significantly d ...
... taken three times daily) and standard immediate release paracetamol (2 caplets taken 4 times daily) were clinically equivalent at a total daily dose of 4 g based on patient global assessment after treatment for 7 days. PANADOL OSTEO and standard immediate release paracetamol were not significantly d ...
WHO Technical Consultation on a comprehensive National Hepatitis
... progression to cirrhosis and liver cancer. Out of 7 million people infected with the hepatitis C virus (HCV), 2.5 million need treatment. China has the highest burden of hepatocellular carcinoma (HCC) and HCC-related deaths in the world, largely caused by viral hepatitis. Of all HCC cases in China, ...
... progression to cirrhosis and liver cancer. Out of 7 million people infected with the hepatitis C virus (HCV), 2.5 million need treatment. China has the highest burden of hepatocellular carcinoma (HCC) and HCC-related deaths in the world, largely caused by viral hepatitis. Of all HCC cases in China, ...
Sodium Chloride and Glucose Intravenous
... prolonged seizures, coma and brain damage. Hyperglycaemia has been associated with cerebral injury, including intraventricular haemorrhage, late onset bacterial and fungal infection, retinopathy of prematurity, necrotising enterocolitis, increased oxygen requirements, bronchopulmonary dysplasia, pro ...
... prolonged seizures, coma and brain damage. Hyperglycaemia has been associated with cerebral injury, including intraventricular haemorrhage, late onset bacterial and fungal infection, retinopathy of prematurity, necrotising enterocolitis, increased oxygen requirements, bronchopulmonary dysplasia, pro ...
Rare Adverse Effects of Human Immunoglobulin Therapy
... is not uncommon, particularly in older individuals receiving high IVIG doses. Barton et al. in 1987 first reported renal failure after IVIG in a 39-year-old woman with lymphoma and cryoglobulinemia. 21 They postulated that immune complexes caused glomerular necrosis. Jordan in 1989 observed hematuri ...
... is not uncommon, particularly in older individuals receiving high IVIG doses. Barton et al. in 1987 first reported renal failure after IVIG in a 39-year-old woman with lymphoma and cryoglobulinemia. 21 They postulated that immune complexes caused glomerular necrosis. Jordan in 1989 observed hematuri ...
European Federation of Neurological Societies
... cabergoline (class I: Ref. [68]). The results of these individual studies are confirmed by systematic reviews showing that levodopa monotherapy lead to better UPDRS scores than cabergoline, pramipexole and ropinirole [25,63], and bromocriptine, lisuride and pergolide [63]. Adjunctive therapy of parki ...
... cabergoline (class I: Ref. [68]). The results of these individual studies are confirmed by systematic reviews showing that levodopa monotherapy lead to better UPDRS scores than cabergoline, pramipexole and ropinirole [25,63], and bromocriptine, lisuride and pergolide [63]. Adjunctive therapy of parki ...
Pravin R - Pivot Pharmaceuticals
... Established the bi-continental business strategy for IndUS leveraging the chemistry and natural product research from India and biology and drug discovery expertise from the US Developed a novel drug development strategy for IndUS by combining ‘translational medicine’ from the US with ‘traditional m ...
... Established the bi-continental business strategy for IndUS leveraging the chemistry and natural product research from India and biology and drug discovery expertise from the US Developed a novel drug development strategy for IndUS by combining ‘translational medicine’ from the US with ‘traditional m ...
Pharmacological Management of Persistent Pain in Older Persons
... of life are candidates for pharmacological therapy, with intervention decisions based on careful weighing of risks and benefits. Positive outcomes are maximized when clinicians are knowledgeable about the drugs they prescribe and regularly monitor patients for adverse effects, although it is unreali ...
... of life are candidates for pharmacological therapy, with intervention decisions based on careful weighing of risks and benefits. Positive outcomes are maximized when clinicians are knowledgeable about the drugs they prescribe and regularly monitor patients for adverse effects, although it is unreali ...
CDASH Serious Adverse Event Supplement Version 1
... The demographic and subject identification data elements listed in this document are based on global guidelines for the collection of safety data. However, some of these data elements might be considered personal data and therefore should not be collected in cases where prohibited by local data priv ...
... The demographic and subject identification data elements listed in this document are based on global guidelines for the collection of safety data. However, some of these data elements might be considered personal data and therefore should not be collected in cases where prohibited by local data priv ...
Antifungal management in the haematology patient
... therapy? Absolute contraindications • Drug interactions (ie rifampicin, carbamazepine, phenytoin etc) • Voriconazole used as prophylaxis (but not itraconazole or posaconazole) • Resistance to voriconazole (esp zygomycosis, A. lentulus or azole resistance) Relative contraindications • Renal failure ( ...
... therapy? Absolute contraindications • Drug interactions (ie rifampicin, carbamazepine, phenytoin etc) • Voriconazole used as prophylaxis (but not itraconazole or posaconazole) • Resistance to voriconazole (esp zygomycosis, A. lentulus or azole resistance) Relative contraindications • Renal failure ( ...
nitropress
... decreased 11 to 20 mmHg from baseline across the four doses (Table 1). There were 63 pediatric patients in a long-term infusion trial (Study 2). During an open-label phase (12 to 24 hours), sodium nitroprusside was started at ≤0.3 μg/kg/min and titrated according to the BP response. Patients were th ...
... decreased 11 to 20 mmHg from baseline across the four doses (Table 1). There were 63 pediatric patients in a long-term infusion trial (Study 2). During an open-label phase (12 to 24 hours), sodium nitroprusside was started at ≤0.3 μg/kg/min and titrated according to the BP response. Patients were th ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.