Experience of the use of Ketamine to manage opioid withdrawal in
... In such cases, it might be worth investigating whether ketamine, widely used by anaesthetists to limit opioid tolerance, reduce use of painkillers, and increase the time preceding the first request for painkillers during the postoperative period [9], may be efficient for managing opioid withdrawal. ...
... In such cases, it might be worth investigating whether ketamine, widely used by anaesthetists to limit opioid tolerance, reduce use of painkillers, and increase the time preceding the first request for painkillers during the postoperative period [9], may be efficient for managing opioid withdrawal. ...
Journal of the American Academy of Dermatology
... may bind to nerve terminals at autonomic cholinergic ganglia with autonomic effects, but only in very large doses. It is unlikely that therapeutic doses are associated with any significant autonomic adverse reactions.[33] There are three steps involved in neurotoxicity[35] (Fig 1). Binding The first ...
... may bind to nerve terminals at autonomic cholinergic ganglia with autonomic effects, but only in very large doses. It is unlikely that therapeutic doses are associated with any significant autonomic adverse reactions.[33] There are three steps involved in neurotoxicity[35] (Fig 1). Binding The first ...
A Probable Case of Clarithromycin-Digoxin
... History of large ingestion of digoxin accompanied by elevated digoxin levels Early use in patients older than 55 years or who have cardiovascular disease Shock Hyperkalemia (serum level > 5 mEql/L) Cardiac arrhythmias: heart block or ventricular arrhythmia Adapted with permission from Flanagan RJ, J ...
... History of large ingestion of digoxin accompanied by elevated digoxin levels Early use in patients older than 55 years or who have cardiovascular disease Shock Hyperkalemia (serum level > 5 mEql/L) Cardiac arrhythmias: heart block or ventricular arrhythmia Adapted with permission from Flanagan RJ, J ...
Bactericidal Activity and Resistance
... of secondary resistance in patients undergoing therapy with dalbavancin would seem unlikely. Also, it is thought that VISA strains may be selected as a result of the twice-daily occurrence of subtherapeutic trough levels of vancomycin in some patients; the effects of low but prolonged posttherapy le ...
... of secondary resistance in patients undergoing therapy with dalbavancin would seem unlikely. Also, it is thought that VISA strains may be selected as a result of the twice-daily occurrence of subtherapeutic trough levels of vancomycin in some patients; the effects of low but prolonged posttherapy le ...
Document
... of acute gouty arthritis.[1] The drug recently became more widely used for the treatment of many rheumatological and nonrheumatological conditions including pseudogout, familial Mediterranean fever amyloidosis [1], scleroderma, sarcoidosis[2], Bechet's disease [3] Paget's disease, [4] psoriasis.[5] ...
... of acute gouty arthritis.[1] The drug recently became more widely used for the treatment of many rheumatological and nonrheumatological conditions including pseudogout, familial Mediterranean fever amyloidosis [1], scleroderma, sarcoidosis[2], Bechet's disease [3] Paget's disease, [4] psoriasis.[5] ...
CLSI 2014 AST Update - Log into your Online Media Solutions portal
... – higher dose may be effective if MIC in “SDD” – (lower dose may be effective if MIC in “S” range) ...
... – higher dose may be effective if MIC in “SDD” – (lower dose may be effective if MIC in “S” range) ...
Abnormally persistent latent inhibition induced by
... 1996a, 1997, 2003a,b), it does not differentiate between typical and atypical APDs, limiting considerably the utility of the LI model as a tool for the detection of novel atypical APDs with potentially superior clinical efficacy. We have recently shown that typical and atypical APDs exert a differential ...
... 1996a, 1997, 2003a,b), it does not differentiate between typical and atypical APDs, limiting considerably the utility of the LI model as a tool for the detection of novel atypical APDs with potentially superior clinical efficacy. We have recently shown that typical and atypical APDs exert a differential ...
The treatment of cyanide poisoning
... 4. It is in France that the newest drug (hydroxocobalamin) is gaining ground. It is the precursor of vitamin B12 and has very little toxicity. It is a very large molecule and only binds cyanide in equimolar fashion. Early preparations were much too dilute to be effective, but a freeze-dried preparat ...
... 4. It is in France that the newest drug (hydroxocobalamin) is gaining ground. It is the precursor of vitamin B12 and has very little toxicity. It is a very large molecule and only binds cyanide in equimolar fashion. Early preparations were much too dilute to be effective, but a freeze-dried preparat ...
Nicotine Decreases Blood Alcohol
... are administered simultaneously. However, it is unclear whether such a phenomenon can be observed in adult subjects, given the fact that there is an ontogenetic difference in alcohol metabolism. Methods: A range of nicotine doses (0, 0.25, 0.5, 1, 2, 4, and 6 mg/kg) were administered individually wi ...
... are administered simultaneously. However, it is unclear whether such a phenomenon can be observed in adult subjects, given the fact that there is an ontogenetic difference in alcohol metabolism. Methods: A range of nicotine doses (0, 0.25, 0.5, 1, 2, 4, and 6 mg/kg) were administered individually wi ...
Product Monograph
... Skin Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease or other factors, such as drugs used ...
... Skin Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease or other factors, such as drugs used ...
Final Protocol - Medical Services Advisory Committee
... up of 120 months and found that fractures within the active treatment period were more frequent in patients receiving AIs than tamoxifen (odds ratio 1.33, 95% Confidence interval 1.15-1.55; p<0.001). A randomised controlled trial (Coleman et al 2007) involving 206 postmenopausal women (with 2-3 year ...
... up of 120 months and found that fractures within the active treatment period were more frequent in patients receiving AIs than tamoxifen (odds ratio 1.33, 95% Confidence interval 1.15-1.55; p<0.001). A randomised controlled trial (Coleman et al 2007) involving 206 postmenopausal women (with 2-3 year ...
LITHIUM CARBONATE Extended-Release
... The distribution space of lithium approximates that of total body water. Lithium is primarily excreted in urine with insignificant excretion in feces. Renal excretion of lithium is proportional to its plasma concentration. The half-life of elimination of lithium is approximately 24 hours. Lithium de ...
... The distribution space of lithium approximates that of total body water. Lithium is primarily excreted in urine with insignificant excretion in feces. Renal excretion of lithium is proportional to its plasma concentration. The half-life of elimination of lithium is approximately 24 hours. Lithium de ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... substituted for cocaine. WIN 35,428 produced dose-related leftward shifts in the cocaine dose-effect curve, whereas selected BZT analogs produced minimal changes in the effects of cocaine. The results suggest that reducing M1 affinity of 4⬘,4⬘⬘diF-BZT with N-substitutions reduces effectiveness in po ...
... substituted for cocaine. WIN 35,428 produced dose-related leftward shifts in the cocaine dose-effect curve, whereas selected BZT analogs produced minimal changes in the effects of cocaine. The results suggest that reducing M1 affinity of 4⬘,4⬘⬘diF-BZT with N-substitutions reduces effectiveness in po ...
Inhaled loop diuretics as potential ... asthmatic drugs - *
... asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to be involved in the pathogenesis of bronchial hyperreactivity in asthma are potential targets for the action ...
... asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to be involved in the pathogenesis of bronchial hyperreactivity in asthma are potential targets for the action ...
ESRD Complications Management
... with stage 5 CKD With meals It reduces LDL and total cholesterol as well Cap 403mg, tab 400, 800mg Serum P<7.5mg/dL: 800mg TID; Serum P≥7.5mg/dL: 1600mg TID Adjust dose at 2 weeks interval based on [P] ...
... with stage 5 CKD With meals It reduces LDL and total cholesterol as well Cap 403mg, tab 400, 800mg Serum P<7.5mg/dL: 800mg TID; Serum P≥7.5mg/dL: 1600mg TID Adjust dose at 2 weeks interval based on [P] ...
Evaluation of rat ultrasonic vocalizations as predictors of the
... Specifically, animals conditioned with the high [0.36±0.23; t(17)=2.61, P<0.05] but not the low dose of NAL (3.87±1.23) emitted fewer 50 kHz USVs in the drug-paired compartment, relative to VEH-conditioned animals (3.25±1.26). Analysis of percentage 50 kHz USVs emitted in the drug-paired chamber, co ...
... Specifically, animals conditioned with the high [0.36±0.23; t(17)=2.61, P<0.05] but not the low dose of NAL (3.87±1.23) emitted fewer 50 kHz USVs in the drug-paired compartment, relative to VEH-conditioned animals (3.25±1.26). Analysis of percentage 50 kHz USVs emitted in the drug-paired chamber, co ...
Analgesic and Anti-inflammatory Activities of Ethanolic Root Extract
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
Clindamycin in 0.9% Sodium Chloride Injection
... aerobic gram-positive cocci and the more susceptible anaerobes (NOT generally including Bacteroides fragilis, Peptococcus species and Clostridium species other than Clostridium perfringens). For more severe infections, particularly those due to proven or suspected Bacteroides fragilis, Peptococcus s ...
... aerobic gram-positive cocci and the more susceptible anaerobes (NOT generally including Bacteroides fragilis, Peptococcus species and Clostridium species other than Clostridium perfringens). For more severe infections, particularly those due to proven or suspected Bacteroides fragilis, Peptococcus s ...
Biopsies - University Hospitals
... (Insert standard of care treatment options for disease.) What are my other choices if I do not take part in this study? If you decide not to take part in this study, you have other choices. For example: you may choose to have the usual approach described above you may choose to take part in a di ...
... (Insert standard of care treatment options for disease.) What are my other choices if I do not take part in this study? If you decide not to take part in this study, you have other choices. For example: you may choose to have the usual approach described above you may choose to take part in a di ...
Public Summary Document (PSD) March 2016 PBAC Meeting
... on the number of occasions required. The perceived advantage of using the dexamethasone implant was the reduced requirement for injections. This would benefit patients who were unlikely to be compliant with frequent injections or who may benefit from alternative treatments with longer duration of ac ...
... on the number of occasions required. The perceived advantage of using the dexamethasone implant was the reduced requirement for injections. This would benefit patients who were unlikely to be compliant with frequent injections or who may benefit from alternative treatments with longer duration of ac ...
Effect of novel adenosine A3 receptor antagonist
... Allergen challenge increases the bronchial level of adenosine [5], which can affect mast cell function [6]. Exogenous adenosine induces and/or enhances antigen-induced mast cell degranulation through the activation of A2b and/or A3 adenosine receptors [7-9]. Inhaled adenosine causes bronchoconstrict ...
... Allergen challenge increases the bronchial level of adenosine [5], which can affect mast cell function [6]. Exogenous adenosine induces and/or enhances antigen-induced mast cell degranulation through the activation of A2b and/or A3 adenosine receptors [7-9]. Inhaled adenosine causes bronchoconstrict ...
Review Article Amla (Emblica officinalis) – Medicinal Food and
... (200‐900 mg per 100 g of edible portion). Numerous studies conducted on Emblica officinalis fruit suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-fungal agent. The gelatinous plum-sized Amla fruit contains naturally occurring vitamin, heat stable vitamin C. ...
... (200‐900 mg per 100 g of edible portion). Numerous studies conducted on Emblica officinalis fruit suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-fungal agent. The gelatinous plum-sized Amla fruit contains naturally occurring vitamin, heat stable vitamin C. ...
LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A
... liposomes have received attention not only for their utility as model membrane systems, but also for use in drug delivery. Typically, liposomes are used as drug carriers, with the solubilized drug encapsulated in the internal aqueous space formed by the liposomal lamellae. Liposomal drug formulation ...
... liposomes have received attention not only for their utility as model membrane systems, but also for use in drug delivery. Typically, liposomes are used as drug carriers, with the solubilized drug encapsulated in the internal aqueous space formed by the liposomal lamellae. Liposomal drug formulation ...
Myrin-P Forte - The Filipino Doctor
... The pyrazinamide in Ethambutol HCl / Rifampicin / Isoniazid / Pyrazinamide (Myrin-P Forte ) inhibits renal excretion of urates, frequently resulting in hyperuricemia that is usually asymptomatic. Blood uric acid determination should be made at baseline and periodically during treatment. If hyperuric ...
... The pyrazinamide in Ethambutol HCl / Rifampicin / Isoniazid / Pyrazinamide (Myrin-P Forte ) inhibits renal excretion of urates, frequently resulting in hyperuricemia that is usually asymptomatic. Blood uric acid determination should be made at baseline and periodically during treatment. If hyperuric ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.