annexure ii
... The occurrence of gastrointestinal damage (bleeding, ulceration) is probably among the most prevalent and serious of the side-effects associated with the use of non-steroid antiinflammatory (NSAI) drugs. Ketoprofen is a potent anti-inflammatory drug. Chemically, it is propionic acid derivative provi ...
... The occurrence of gastrointestinal damage (bleeding, ulceration) is probably among the most prevalent and serious of the side-effects associated with the use of non-steroid antiinflammatory (NSAI) drugs. Ketoprofen is a potent anti-inflammatory drug. Chemically, it is propionic acid derivative provi ...
In the scientific literature, which countries first appeared term
... A. To triturate it with alcohol or ether B. To triturate it with glycerine or chloroform C. To triturate it with purified water D. To triturate it with other components of the formulation E. To triturate it thoroughly with sugar ANSWER: A Stability of suspensions can be enhanced by substances which ...
... A. To triturate it with alcohol or ether B. To triturate it with glycerine or chloroform C. To triturate it with purified water D. To triturate it with other components of the formulation E. To triturate it thoroughly with sugar ANSWER: A Stability of suspensions can be enhanced by substances which ...
off-label use - Moodle Lille 2
... Two Randomized, Double Masked, Active Controlled, multicenter phase 3 studies. View1: n= 1217, in USA and Canada View2: n= 1240, in Europe, Asia Pacific, Japan and Latin ...
... Two Randomized, Double Masked, Active Controlled, multicenter phase 3 studies. View1: n= 1217, in USA and Canada View2: n= 1240, in Europe, Asia Pacific, Japan and Latin ...
taste masking methods and agents in pharmaceutical formulations
... most widely used complexing agent for inclusion complex formation having lipophilic inner cavities and hydrophilic inner surfaces and are capable of interacting with a large cavity of guest molecules to form inclusion complexes. They are available in three different forms like alpha, beta and gamma ...
... most widely used complexing agent for inclusion complex formation having lipophilic inner cavities and hydrophilic inner surfaces and are capable of interacting with a large cavity of guest molecules to form inclusion complexes. They are available in three different forms like alpha, beta and gamma ...
Clinical pharmacology of anti-infectives and nonsteroidal_англ
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
Compliance, Validation, and Related Processes
... • Prohibited interstate transport of unlawful food and drugs under penalty of seizure of the questionable products and/or prosecution of the responsible parties • Basis on regulation of product labeling rather than premarket approval • Drugs, defined in accordance with the standards of strength, qua ...
... • Prohibited interstate transport of unlawful food and drugs under penalty of seizure of the questionable products and/or prosecution of the responsible parties • Basis on regulation of product labeling rather than premarket approval • Drugs, defined in accordance with the standards of strength, qua ...
The proportion of patient reports of suspected ADRs to
... from other reporters, meaning healthcare professionals or pharmaceutical companies, that were considered a ‘trigger report’ was also determined per year and for the total study period. In addition the eight signals of drug–ADR associations with the highest percentage of patient reports were determin ...
... from other reporters, meaning healthcare professionals or pharmaceutical companies, that were considered a ‘trigger report’ was also determined per year and for the total study period. In addition the eight signals of drug–ADR associations with the highest percentage of patient reports were determin ...
english, pdf
... which could have been due to the supersaturation generated by the amorphous form of the drug (10). Corveleyn and Remon (33) studied the influence of various formulation and process parameters on the characteristics of ODT made by lyophilization using hydrochlorthiazide as a model drug. Maltodextrin, ...
... which could have been due to the supersaturation generated by the amorphous form of the drug (10). Corveleyn and Remon (33) studied the influence of various formulation and process parameters on the characteristics of ODT made by lyophilization using hydrochlorthiazide as a model drug. Maltodextrin, ...
September 2006 - Highmark Blue Shield
... This policy pertains to the products categorized as direct renin inhibitors. Aliskeren (Tekturna®) is currently the only product available within this therapeutic category. Aliskeren is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive ag ...
... This policy pertains to the products categorized as direct renin inhibitors. Aliskeren (Tekturna®) is currently the only product available within this therapeutic category. Aliskeren is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive ag ...
Formulation and Evaluation of Bioadhesive Gels Containing Miconazole Nitrate
... were 25.31%, 14.70% and 11.33% for HPMC, carbopol 934 and sodium alginate respectively. Tested enhancers were shown to increase the amount of miconazole released at an optimum concentration specific for each vehicle, as shown by 1% tween 80 which proved to be superior when incorporated with sodium a ...
... were 25.31%, 14.70% and 11.33% for HPMC, carbopol 934 and sodium alginate respectively. Tested enhancers were shown to increase the amount of miconazole released at an optimum concentration specific for each vehicle, as shown by 1% tween 80 which proved to be superior when incorporated with sodium a ...
Bromday_CDER_letter_Nov_30
... members. The information presented at the DODAC meeting and the DODAC’s advice may facilitate resolution of this matter without the need for a hearing. Postponement of action on ISTA’s hearing request is also appropriate because CDER has become aware that ISTA recently began marketing a "twin pack" ...
... members. The information presented at the DODAC meeting and the DODAC’s advice may facilitate resolution of this matter without the need for a hearing. Postponement of action on ISTA’s hearing request is also appropriate because CDER has become aware that ISTA recently began marketing a "twin pack" ...
SENATE BILL 15-053 BY SENATOR(S) Aguilar, Crowder, Guzman
... the administration of an opiate antagonist - limited immunity legislative declaration - definitions. (2) Definitions. As used in this section, unless the context otherwise requires: (b) (I) "Health care provider" means: (A) A licensed or certified physician, nurse practitioner ADVANCED PRACTICE NURS ...
... the administration of an opiate antagonist - limited immunity legislative declaration - definitions. (2) Definitions. As used in this section, unless the context otherwise requires: (b) (I) "Health care provider" means: (A) A licensed or certified physician, nurse practitioner ADVANCED PRACTICE NURS ...
Factors that affect mass transport from drug eluting stents into the
... procedures available to the clinician but the successful emergence of drug eluting stents (DES) has seen them become the preferred choice, so much so that by the beginning of 2006 more than 8 out of 10 coronary stents were DES [4] at a cost of between $4 and $5 billion annually [5]. When used in con ...
... procedures available to the clinician but the successful emergence of drug eluting stents (DES) has seen them become the preferred choice, so much so that by the beginning of 2006 more than 8 out of 10 coronary stents were DES [4] at a cost of between $4 and $5 billion annually [5]. When used in con ...
FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLETS OF SILDENAFIL CITRARTE Research Article
... concentration of drug in plasma (or at the site of action) and maintains it constant for the entire duration of treatment. This is possible through administration of conventional dosage form in a particular dose and at a particular frequency1. Thus drug may ...
... concentration of drug in plasma (or at the site of action) and maintains it constant for the entire duration of treatment. This is possible through administration of conventional dosage form in a particular dose and at a particular frequency1. Thus drug may ...
Quantum of Effectiveness Evidence in FDA’s Approval of Orphan Drugs
... purports or claims to have in the sponsor’s proposed labeling for that therapy. FD&C Act § 505(d). FDA has interpreted “adequate and well-controlled studies” to mean generally a minimum of two such studies. FDA has promulgated regulations defining the types of trial designs that are “adequate and we ...
... purports or claims to have in the sponsor’s proposed labeling for that therapy. FD&C Act § 505(d). FDA has interpreted “adequate and well-controlled studies” to mean generally a minimum of two such studies. FDA has promulgated regulations defining the types of trial designs that are “adequate and we ...
Frog intestinal perfusion to evaluate drug permeability: application to
... in situ, from steady state values of Cout corr /Cin , for losartan, and midazolam. Steady state was attained in about 30–40 min, after beginning of the perfusion. Compounds were perfused alone and in presence of inhibitors to elucidate the role of P-gp and CYP3A4. Equilibrium was reached within 30–4 ...
... in situ, from steady state values of Cout corr /Cin , for losartan, and midazolam. Steady state was attained in about 30–40 min, after beginning of the perfusion. Compounds were perfused alone and in presence of inhibitors to elucidate the role of P-gp and CYP3A4. Equilibrium was reached within 30–4 ...
literature review ii
... following literature have been extensively reviewed and complied as follows. 2.1. Review of literature on sustained release dosage form: Mohsen A. et al, 2012; formulated sustained release matrix tablets of aceclofenac with Eudragit® RSPO and Eudragit® RLPO were prepared using three techniques; dire ...
... following literature have been extensively reviewed and complied as follows. 2.1. Review of literature on sustained release dosage form: Mohsen A. et al, 2012; formulated sustained release matrix tablets of aceclofenac with Eudragit® RSPO and Eudragit® RLPO were prepared using three techniques; dire ...
Current Drugs for Antimalarial Chemoprophylaxis: A Review of
... tance to commonly used antimalarial drugs has also emerged and is spreading rapidly.6 Resistance of Plasmodium falciparum to chloroquine, the most widely used antimalarial, is common in most endemic countries,7 and multidrug resistance has evolved in certain areas.6 To prevent malaria, travelers to ...
... tance to commonly used antimalarial drugs has also emerged and is spreading rapidly.6 Resistance of Plasmodium falciparum to chloroquine, the most widely used antimalarial, is common in most endemic countries,7 and multidrug resistance has evolved in certain areas.6 To prevent malaria, travelers to ...
The Rational Use of Drugs - Part 4
... When the assumption of linearity does not hold, the EC50 no longer approximates the KD. For example, the EC50 will be much smaller than the KD when “spare receptors” are present. A tissue is said to express “spare receptors” when only a small fraction of the receptor population must be occupied by d ...
... When the assumption of linearity does not hold, the EC50 no longer approximates the KD. For example, the EC50 will be much smaller than the KD when “spare receptors” are present. A tissue is said to express “spare receptors” when only a small fraction of the receptor population must be occupied by d ...
D I NEW DRUGS - Ontario Pharmacists Association
... In the study by Smith et al.,12 it is of note that the primary efficacy variable—difference in mean ambulatory blood pressure during the 10 to 16 hour post-dose period—was selected based on previous pharmacokinetic studies that demonstrated significant differences in diltiazem concentrations between ...
... In the study by Smith et al.,12 it is of note that the primary efficacy variable—difference in mean ambulatory blood pressure during the 10 to 16 hour post-dose period—was selected based on previous pharmacokinetic studies that demonstrated significant differences in diltiazem concentrations between ...
INTERACTION BETWEEN GRAPEFRUIT JUICE AND DRUGS*
... include some dihydroxypyridine-type Ca blockers, terfenadine, and saquinavir; (2) those drugs that are associated with sharply curved concentration (dosage)response relationship; and (3) those with narrow therapeutic ranges and possible potentiation of the drug effects, resulting in excessive drug a ...
... include some dihydroxypyridine-type Ca blockers, terfenadine, and saquinavir; (2) those drugs that are associated with sharply curved concentration (dosage)response relationship; and (3) those with narrow therapeutic ranges and possible potentiation of the drug effects, resulting in excessive drug a ...
Formulation Development of Chlorpheniramine Maleate Tablet by
... administering the drug, attention must be paid to their design, development and manufacturing technique in order to get the correct medicinal benefits. This directly compressible formulation was compared with three leading marketed brands for efficiency and competence. These marketed brands are manu ...
... administering the drug, attention must be paid to their design, development and manufacturing technique in order to get the correct medicinal benefits. This directly compressible formulation was compared with three leading marketed brands for efficiency and competence. These marketed brands are manu ...