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Molecular imaging with SPECT as a tool for drug
Molecular imaging with SPECT as a tool for drug

... that yields a pharmacological effect established from animal studies, with a maximum a 100 μg. Nuclear imaging modalities such as PET and SPECT have an important and evolving role in this aspect. The very low doses of drugs that are recommended for microdosing studies (in the low microgram range) ar ...
pharmaceuticals: restrictions in use and availability
pharmaceuticals: restrictions in use and availability

... requested from governments; products which clearly do not meet the criteria have been omitted after consultation with governments. Information received from non-governmental organizations has, in each case, been verified with governments. The information provided also includes references to relevant ...
EpilEpsy BoARD REviEw MAnuAl Antiepilepsy Drugs: Mechanisms
EpilEpsy BoARD REviEw MAnuAl Antiepilepsy Drugs: Mechanisms

Prevalence and predictors of potential drug
Prevalence and predictors of potential drug

... and 1637 (64%) as 2, corresponding to 136 drug combinations. The mean number of DDIs per exposed patient was 1.72 (ranged 1–10), and 852 patients (57.26%) were exposed to 1 potential DDIs, 393 (26.41%) to 2 potential DDIs, 133 (8.94%) to 3 potential DDIs and 110 (7.39%) to ≥ 4 potential DDIs. The me ...
Follow the Script_ Spring 2015
Follow the Script_ Spring 2015

... Chris: Yes, prescription drug addiction is common. In my estimation, many of these methadone patients were just looking for a high – they started from zero in their system – taking nothing – and at that point it was easy to get high. But, as they get used to the drug, it takes more and more narcotic ...
Adverse drug reactions in patients with gastroenterological diseases
Adverse drug reactions in patients with gastroenterological diseases

... developed computer monitoring system generated a daily list of alerts (automatically generated laboratory signals), including patients' data and date of event. The alerts were assessed by the pharmacoepidemiological team, regardless of whether or not they were associated with an adverse drug reactio ...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING AMLODIPINE  Research Article
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING AMLODIPINE Research Article

... The purpose of the present investigation was to increase the solubility and dissolution rate of amlodipine besylate by the preparation of its solid dispersion with PEG 4000, PVP K-30 using kneading process. Drug polymer interactions were investigated using differential scanning calorimetry (DSC) and ...
Pharmacy Shortages – February 27, 2015 (Updated monthly, if not
Pharmacy Shortages – February 27, 2015 (Updated monthly, if not

... use continues this may impact other IV medications that need to be in NS or D5W 250mL solutions (i.e. amiodarone IV, pressors, antibiotics, etc.). Currently all three manufactures, Baxter, BBraun, and Hospira have all presentation on allocations. It is unknown at this time when the companies can pro ...
Conscious_Sedation - ARIN Golden Gate Chapter
Conscious_Sedation - ARIN Golden Gate Chapter

... delivery”, according to Ethicon’s press release, with propofol sedation “personalized to the needs of each patient, by precisely integrating drug delivery and comprehensive patient monitoring.” The Sedasys device is designed for “healthy” adult patients who undergo colonoscopy and esophagogastroduod ...
physicochemical properties and the discovery of - Beilstein
physicochemical properties and the discovery of - Beilstein

... up to their promise”. These statements are partly true but misleading because they fail to differentiate between the early and later stage of combinatorial chemistry and whether the problem is in the HTS process or the combinatorial chemistry screening file. In my opinion there is not a problem with ...
Ultrasonic nebulization platforms for pulmonary drug
Ultrasonic nebulization platforms for pulmonary drug

Temperature and pH stimuli-responsive polymers
Temperature and pH stimuli-responsive polymers

... (LCST) are the most used on drug delivery systems. The therapeutic agents, as drugs, cells or proteins can be mixed with the polymer when this is on its liquid state (temperature below the transition temperature) being able to be injected in the human body on the subcutaneous layer or in the damaged ...
srija
srija

3. ACHIEVEment of policy goals
3. ACHIEVEment of policy goals

... with the objective of protecting consumers against excessive prices. Regulation has very likely been responsible for bringing Canada’s prices for patented medicines roughly in line with European comparators. Prices of generic products, which are not regulated, are relatively high although high penet ...
Situation Report National Drug Intelligence Center Synthetic Cathinones (Bath Salts):
Situation Report National Drug Intelligence Center Synthetic Cathinones (Bath Salts):

... Synthetic cathinones, typically marketed as “bath salts” and “plant food,” are sold legally under various names (Ivory Wave, Blizzard, etc.) in most areas of the United States. The products are generally sold in retail establishments such as adult stores, independently owned convenience stores, gas ...
EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM  SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT 
EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM  SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT 

... hydrophilic polymers (e.g. HPMC) have been reported. However, low cost, ease of availability and non toxic property makes use of natural gums (e.g.  gum damar), an alternative approach for development of sustained release matrix tablets. Compatibility between aceclofenac and GD was studied  using  F ...
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT)
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT)

... maintenance of general anesthesia, usually in combination with a sedative. Other uses include sedation in intensive care, analgesia (particularly in emergency medicine), and treatment of bronchospasm. Ketamine has a wide range of effects in humans, including analgesia, anesthesia,hallucinations, ele ...
a review on technologies, recent trends and regulatory aspects
a review on technologies, recent trends and regulatory aspects

... (orthonasal route) or mouth (retronasal route) and information is then sent to glomeruli in the olfactory bulb to mitral cells traveling to higher centers in the brain. Person-to-person differences in the taste response to bitter chemicals are largely determined by genetic variation in a bitter rece ...
simultaneous estimation of salbutamol and ketotifen in tablet dosage
simultaneous estimation of salbutamol and ketotifen in tablet dosage

... is still commonly delivered as a racemic mixture (+,-). Salbutamol, even though S-Salbutamol is known to have a detrimental effect on asthma sufferers (in fact the exact opposite effect of the R Isomer [4]. Salbutamol also has certain anti-inflammatory properties whose clinical significance is not d ...
Medications in the Breast-Feeding Mother
Medications in the Breast-Feeding Mother

... Quinolones have not been well studied in breast milk and are not rated by the AAP. They should be used in the breast-feeding mother only when other, better-studied options cannot be used and after the risks and benefits have been assessed.3 Metronidazole (Flagyl) is rated by the AAP as a drug whose ...
PATENTED TECHNOLOGY IN SOFT GELATIN CAPSULE
PATENTED TECHNOLOGY IN SOFT GELATIN CAPSULE

... rate of up to 60 billion pills/year (i.e. more than 3600 kinds of drugs) in the world3. Up to now, there are more than 30 manufacturers producing morethan 40 kinds of soft capsules by using over 60 sets of advanced machines. Softgels’ ability to enhance bioavailability not only makes them the prefer ...
This PDF is a selection from a published volume from... Research Volume Title: Regulation vs. Litigation: Perspectives from Economics and Law
This PDF is a selection from a published volume from... Research Volume Title: Regulation vs. Litigation: Perspectives from Economics and Law

... is in effect equivalent to submitting a new PMA. More modest changes require a 180-day Supplement, and minor modifications require a Real-time Supplement. In addition, changes in the manufacturing process must be approved via a 30-day Supplement. While the FDA is the primary and most visible player i ...
APRI 7149$
APRI 7149$

... to the public health risk associated with these In recent years, at least 26 U.S. states have placed substances. additional controls on ephedrine, and additional states have proposed legislation. The DEA data regarding ephedrine primarily represents its diversion for use in illicit laboratories. Fed ...
10:30am - 12:30pm
10:30am - 12:30pm

... that the maximum percentage error must be equal to or less than 5%  MWQ: Minimum weighable quantity (limited by this ...
B. Pharmacy 2009-10
B. Pharmacy 2009-10

... Introduction to Dosage Forms 4 hrs/ week 1. Pharmacy Profession : History of Pharmacy, Pharmacy as a career, Pharmaceutical education in India and abroad, Pharmacopoeia of India and other Pharmacopoeias, Other official books. ...
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Compounding

Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient, it is known as ""traditional"" compounding.Due to the rising cost of compounding and the shortage of drugs, many hospitals have shown a tendency to rely more upon large-scale compounding pharmacies to meet their regular requirement, particularly of sterile-injectable medications. When compounding is done on bulk production of a given formulation rather than patient-specific production, it is known as ""non-traditional"" compounding (which, as discussed below, is arguably not ""compounding"" but rather ""manufacturing""). This development raises concerns about patient safety and makes a case for proper regulatory control and monitoring.
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