Download In the scientific literature, which countries first appeared term

In the scientific literature, which countries first appeared term
"biopharmacy"?
A. USSR
B. Russia
C. USA
D. Ukraine
E. England
ANSWER: C
Which of the twentieth century appeared in the scientific literature the
term "biopharmacy"?
A. 50-s
B. 60's
C. 80th
D. 90th
E. 40-s
ANSWER: B
In what year were discovered polymorphs of carbon?
A. 1756 p
B. 1801,
C. 1809
D. 1811
E. 1821
ANSWER: C
The sample from which drugs should be done to determine bioequivalence?
A. Preparations different manufacturing plants
B. Preparations made by manufacturers of different countries
C. Preparations are making one plant, but in different series
D. Preparations are making one plant, but one series
E. Preparations different manufacturing plants, Preparations are making
one plant, but in different series
ANSWER: E
Add a known fact that underlies the emergence of Biopharmaceutics?
A. installation pharmacological incompatibility of drugs;
B. identify technological incompatibility of drugs
C. identify therapeutic drugs Nonequivalence
D. identify synergies of
E. detection of antagonism
ANSWER: C
Indicate which term corresponds to the following statement: "The
description of the changes over time of concentrations injected drug and
its metabolites in the body, covering such transport processes active
substance and its metabolites in the body, as absorption, distribution,
and elimination biotrasformatsiya."
A. bioavailability
B. equivalence
C. systemic availability
D. pharmacokinetics
E. occlusion
ANSWER: D
This term to describes the relationship between the dose and the
pharmacological effect at the site of action
A. bioavailability
B. equivalence
C. systemic availability
D. pharmacodynamics
E. occlusion
ANSWER: D
This term to describes the relationship between the dose and the
pharmacological effect at the site of action
A. Distribution
B. Pharmacokinetics
C. Biopharmaceutics
D. Pharmacodynamics
E. Elimination
ANSWER: D
General term characterizing the separate areas of co-operation of
medicine with an organism (Liberation, Absorption, Distribution,
Metabolism, Elimination, Response), i.e. includes biopharmaceutics,
pharmaсokinetics and pharmaсodynamiсs
A. Distribution
B. Pharmacokinetics
C. Biopharmaceutics
D. LADMER
E. Elimination
ANSWER: D
Indicate which term corresponds to the following statement: "The state
that allows medicinal substances when introduced into the body to reach
the place of influence."
A. relative bioavailability
B. bioavailability
C. absolute bioavailability
D. therapeutic non-equivalence
E. bioequivalence
ANSWER: B
What scientists were founders of Biopharmaceutics?
A. Chernykh VP
B. Levy
C. Wagner
D. Tichonov AI
E. Levy, Wagner
ANSWER: E
What concentration of alcohol should be taken to grind streptotsida?
A. 40%
B. 60%
C. 70%
D. 90%
E. 95%
ANSWER: E
What titrant used to quantify streptotsida that evolved from the
ointment?
A. sodium nitrate
B. sodium nitrite
C. potassium bromide
D. sodium bicarbonate
E. potassium iodide
ANSWER: B
What method is used to quantify streptotsida in the dialysate?
A. Alkalimetry
B. gravimetry
C. kompleksonometriya
D. nitrytometriya
E. fotokolorymetriya
ANSWER: D
Which processes will be negative with increasing degree of grinding
pharmaceutical substances?
A. inactivation of the active substance
B. increase stupennya release
C. better distribution in the ointment basis
D. slower dissolution of active substances
E. prolongation of drug action
ANSWER: A
Which of these factors does not apply to pharmaceuticals?
A. auxiliary substances
B. pregnancy
C. dosage form and how its introduction into the body
D. physical state of the drug
E. Technological process
ANSWER: B
Which of these factors does not apply to pharmaceuticals?
A. auxiliary substances
B. technological process
C. dosage form and how its introduction into the body
D. physical state of the drug
E. while taking the drug
ANSWER: E
Which of these factors does not apply to pharmaceuticals?
A. auxiliary substances
B. technological process
C. dosage form and how its introduction into the body
D. physical state of the drug
E. has no right answer
ANSWER: E
Which of these factors does not apply to pharmaceuticals?
A. auxiliary substances
B. concomitant diseases
C. dosage form and how its introduction into the body
D. physical state of the drug
E. Technological process
ANSWER: B
Which of these factors does not apply to pharmaceuticals?
A. auxiliary substances
B. simple chemical modification
C. dosage form and how its introduction into the body
D. sex of patient
E. Technological process
ANSWER: D
How much time is left Agrarian gel swelling?
A. 10 minutes.
B. 20 min
C. 30 min
D. 40 min
E. 60 min
ANSWER: C
At what stage of the research method of agar plates using Ehrlich
reagent?
A. added to the agar at cooking
B. put into agar after solidification
C. put into ointment before using
D. ointment applied to the agar after filling holes
E. add simultaneously in ointment and agar
ANSWER: A
How long to grind streptotsid. to prepare 50.0 10% streptotsydovoyi
ointment?
A. 1 min
B. 5 min
C. 2-3 min
D. 20 min
E. 15 min
ANSWER: C
Among which drugs widespread phenomenon of polymorphism?
A. salicylates
B. barbiturates
C. hormones
D. sulfonamides
E. all answers are correct
ANSWER: E
Among which drugs widespread phenomenon of polymorphism?
A. opiates
B. vitamins
C. hormones
D. antibiotics
E. antihistamines
ANSWER: C
How much agar should take to prepare 50.0 2% agar gel?
A. 0.5
B. 1.0
C. 2.0
D. 5.0
E. 10.0
ANSWER: B
How much vaseline should take to prepare 100.0 10% streptotsydovoyi
ointment?
A. 50.0
B. 80.0
C. 95.0
D. 100.0
E. 90.0
ANSWER: E
What does the term "in vitro"?
A. experiments conducted on living tissues and whole organisms or within
them
B. this technique of in vitro experiments or, more generally, in a
controlled environment outside a living organism
C. done by a computer or by using computer simulations
D. learning process at the same place where it occurs (no moving object
tracking to any special conditions in a special environment)
E. means that events occurring outside the living organism
ANSWER: B
What does the term "in vivo"?
A. Experiments conducted on living tissues and whole organisms or within
them
B. This technique of in vitro experiments or, more generally, in a
controlled environment outside a living organism
C. done by a computer or by using computer simulations
D. learning process at the same place where it occurs (no moving object
tracking to any special conditions in a special environment)
E. means that events occurring outside the living organism
ANSWER: A
What is meant when using the term physical state of drugs?
A. amorphous
B. form crystals
C. nature of the crystals
D. dispersion
E. amorphous, form crystals, nature of the crystals
ANSWER: E
What is meant when using the term physical state of drugs?
A. conductivity
B. solubility
C. amorphous
D. polymorphism
E. pH
ANSWER: C
What is meant when using the term physical state of drugs?
A. conductivity
B. solubility
C. crystallinity
D. polymorphism
E. pH
ANSWER: C
What is meant when using the term physico-chemical properties of drugs?
A. pH
B. polymorphism
C. Physical and chemical properties
D. degree of purity
E. all answers are correct
ANSWER: A
What is meant when using the term physico-chemical properties of drugs?
A. optical activity
B. melting point
C. solubility
D. pH
E. all answers are correct
ANSWER: E
What is meant when using the term physical condition drugs?
A. dispersion
B. polymorphism
C. Physical and chemical properties
D. degree of purity
E. All answers are correct
ANSWER: E
How literally translated term «biofarmaceutics»?
A. biological pharmacy
B. pharmacy
C. biopharmacy
D. biohalenika
E. homeopathy
ANSWER: D
Which of the following disciplines is not is at the heart of
Biopharmaceutics?
A. pharmaceutical Chemistry
B. technology drugs
C. anatomy
D. pharmacokinetics
E. pharmacodynamics
ANSWER: C
Which of the following disciplines underlies the development of
Biopharmaceutics?
A. pharmaceutical Chemistry
B. technology drugs
C. all answers are correct
D. pharmacokinetics
E. pharmacodynamics
ANSWER: C
What is the main task of Biopharmaceutics as a science?
A. theoretical and experimental study on developing new drugs
B. improvement of existing drugs
C. quality control of drugs
D. synthesis of new substances
E. theoretical and experimental study on developing new drugs,
improvement of existing drugs
ANSWER: E
Which of the following parameters determined in the analysis of stained
areas in the method of agar plates?
A. color colored zone
B. color intensity
C. diameter of the colored zone
D. depth colored zone
E. discoloration zone
ANSWER: C
Which of the following parameters affect the size of the colored area in
the course of the study ointment streptotsida by agar plates?
A. Physical state streptotsida
B. The degree of comminution streptotsida
C. phenomenon of polymorphism in the ointment
D. quantitative content streptotsida
E. purity substances
ANSWER: B
A pharmaceutist made a tincture of althaea root. What is the proportion
of herbal crude drug and extractant?
A. 1:20
B. 1:10
C. 1:30
D. 1:100
E. 1:400
ANSWER: A
A pharmaceutist revealed incompatibility in the formulation.
Rp.:Sol. Collargoli 1% - 10 ml
Sol. Adrenalini hydrochloridi 0,1% - 1 ml
M.D.S. Nasal drops.
What chemical process underlies this incompatibility?
A. Oxidization
B. Neutralization
C. Precipitation
D. Hydrolysis
E. Adsorption
ANSWER: A
A pharmaceutist prepared solution of ethacrydine lactate. What is the
peculiarity of this substance dissolving?
A. Dissolving in hot water
B. Dissolving in freshly distilled water
C. Dissolving in cold water
D. Grinding in a mortar with water
E. Dissolving in potassium iodide solution
ANSWER: A
A pharmaceutist made a tincture of Adonis herb. A peculiarity of its
preparation is that the active substances are derived in:
A. In the neutral medium
B. In the alkalescent medium
C. In the alkaline medium
D. In the subacid medium
E. In the acid medium
ANSWER: A
A pharmaceutist prepared some powders whose composition includes camphor.
What capsules are required for their packaging?
A. Parchment
B. Paper
C. Waxed
D. Paraffin
E. Cellophane
ANSWER: A
Ophthalmic drops are produced on the base of concentrated riboflavin
solution (1:5000). How much solution should be taken if the formulation
says "0,001 of riboflavin"?
A. 5 ml
B. 2 ml
C. 3 ml
D. 4 ml
E. 1 ml
ANSWER: A
A doctor prescribed a patient 100 ml of tincture made out of 0,25 of
Herba Thermopsidis. How much dried concentrated extract of Herba
Thermopsidis should be weighed by a pharmaceutist?
A. 0,25 g
B. 0,5 g
C. 0,3 g
D. 0,2 g
E. 0,1 g
ANSWER: A
A patient has been administered powders containing menthol. What is the
best way to achieve the required extent of menthol comminution?
A. To triturate it with alcohol or ether
B. To triturate it with glycerine or chloroform
C. To triturate it with purified water
D. To triturate it with other components of the formulation
E. To triturate it thoroughly with sugar
ANSWER: A
Stability of suspensions can be enhanced by substances which increase the
viscosity of the dispersion medium. Specify the substance that exhibits
such properties:
A. Glycerol
B. Purified water
C. Ethanol
D. Dimexid
E. Ether
ANSWER: A
A doctor prescribed an olive oil emulsion whose composition includes
anesthesin. In order that anesthesin can be incorpotated into the
emulsion it should be dissolved:
A. In the oil before emulsifying
B. In the mature emulsion
C. In the treated water
D. In the primary emulsion
E. In the alcohol and add to the primary emulsion
ANSWER: A
A pharmaceutist-technologist has to prepare a medication with the
following formulation:
Rp.:Mentholi 0,1
Glycerini 10,0
M.D.S. Nasal drops.
What is the reason for their incompatibility?
A. Insolubility of ingredients
B. Separation of the mixture
C. Adsorption of the medicinal agent
D. Eutectic alloy formation
E. Coagulation of colloidal system
ANSWER: A
A pharmacy got an order for a mixture containing manzanita decoction and
belladonna extract. What is the reason for their incompatibility?
A. Sedimentation
B. Hydrolysis
C. Redox (oxidation-reduction) processes
D. Liberation of gaseous substances
E. Coagulation of colloidal systems
ANSWER: A
A pharmaceutist refused preparation of nasal drops to a patient because
of incompatibility between collargol and dimedrol written in the
prescription. What is the reason for incompatibility between these
ingredients?
A. Coagulation
B. Immiscibility
C. Adsorption
D. Dissection
E. Eutectic formation
ANSWER: A
Preparation of multicomponent powders with phenyl salicylate and camphor
is accompanied by generation of some fluid. What is the reason for their
incompatibility?
A. Eutectic alloy formation
B. Adsorption
C. Crystallization water exudation
D. Hygroscopic components
E. Gases separation
ANSWER: A
A doctor wrote a prescription for the tincture of digitalis with
hydrochloric acid. What is the
reason for their incompatibility?
A. Hydrolysis (with no visible change)
B. Precipitation
C. Gassing
D. Change in colour
E. Change in odour
ANSWER: A
A pharmaceutist revealed incompatibility in a prescription for powders
with ascorbic acid and hexamethylenetetramine. What process takes place
when these components are combined?
A. Mixture dampening
B. Eutectic formation
C. Immiscibility
D. Substances adsorption
E. Crystallization water exudation
ANSWER: A
A pharmacy received the following prescription: 0,0002 g of scopolamine
hydrobromide per 1 powder. How much of 1:100 trituration is required for
the preparation of 10 powders?
A. 0,2
B. 0,04
C. 4,0
D. 0,4
E. 2,0
ANSWER: A
A pharmacy received a prescription for 3% alcohol solution of boric acid.
What concentration of ethyl alcohol is required for preparing the drug
form?
A. 70%
B. 60%
C. 40%
D. 90%
E. 96%
ANSWER: A
During production of powders in a pharmacy physiochemical properties of
certain ingredients should be taken into consideration. What
pharmaceutical substance can be incorporated into the powder mass without
additional grinding?
A. Starch
B. Camphor
C. Menthol
D. Salicylic acid
E. Streptocid
ANSWER: A
Suspensions as heterogenous systems can be characterized by kinetic and
sedimentary instability. What substance is used for increasing suspension
stability with hydrophobic substances?
A. Gelatose
B. Sodium chloride
C. Boric acid
D. Sodium sulphate
E. Glucose
ANSWER: A
Liquid dosage forms are prepared with concentrated solutions of
pharmacetical substances or under consideration of volume increase factor
during substance dissolution when the following substance is used as a
solvent:
A. Treated water
B. Aromatic water
C. Glycerol
D. Ethanol (ethyl alcohol)
E. Polyethylene glycol-400
ANSWER: A
While preparing decoctions in volume from 1000 to 3000 ml time of
processing in boiling water bath should be:
A. 40 minutes
B. 25 minutes
C. 30 minutes
D. 45 minutes
E. 15 minutes
ANSWER: A
How much water should be taken in order to prepare 200 ml of aqueous
extract of motherwort (water absorption coefficient = 2 ml/g)?
A. 240 ml
B. 220 ml
C. 200 ml
D. 160 ml
E. 210 ml
ANSWER: A
Powders make up an important group among the extemporal medicinal
preparations. Which of the following components can be incorporated into
a powder without being preliminarily ground?
A. Basic Bismuth nitrate
B. Ascorbic acid
C. Camphor
D. Xeroform
E. Calcium gluconate
ANSWER: A
A pharmaceutist is preparing powders according to the following
formulation:
Rp.:Scopolamini hydrobromidi 0,0003
Ephedrini hydrochlorodi 0,05
Sachari 0,15
M.f. pulvis
D.t.d. № 10
S. 1 powder thrice a day.
Calculate the mass of 1 powder providing that the trituration (1:100) is
used:
A. 0,20
B. 0,15
C. 0,23
D. 0,17
E. 0,203
ANSWER: A
A pharmaceutist is preparing powders by the way of triturating one of the
components with ethyl alcohol. Such technology of preparation is typical
for the following substance:
A. Streptocid
B. Starch
C. Talc
D. Zinc oxide
E. Bolus alba
ANSWER: A
A pharmaceutist prepared a suspension. It must contain the following
amount of fluid in order to comply with Deriagin's rule:
A. 0,4-0,6 millilitre for 1,0 substance
B. 1-0,8 millilitre of 1,0 substance
C. 1,5-0,7 millilitre for 1,0 substance
D. 0,9-2 millilitres for 1,0 substance
E. 0,1-1,0 millilitre for 1,0 substance
ANSWER: A
A pharmacy got an order for powders containing ascorbic acid and sodium
hydrocarbonate. What process takes place between the ingredients?
A. Dampening
B. Oxidization
C. Absorption
D. Sedimentation
E. Stratification
ANSWER: A
A pharmacy got the following recipe:
Rp.:Mucilaginis Amyli 50,0
Da. Signa. For the enema purposes.
How much starch and distilled water did the pharmaceutist use in order to
make this preparation?
A. 1,0 g of starch; 49 ml of distilled water
B. 1,0 g of starch; 50 ml of distilled water
C. 2,0 g of starch; 48 ml of distilled water
D. 5,0 g of starch; 45 ml of distilled water
E. 10,0 g of starch; 40 ml of distilled water
ANSWER: A
A pharmacy received a prescription for a topical powder including a
substance that is hard to disperse. Which of the listed fluids may be
used for dispersing the substance?
A. Diethyl ether
B. Purified water
C. Water for injections
D. Dimexid
E. Spring water
ANSWER: A
Powders that quickly enter into a reaction in presence of water and emit
carbon dioxide relate to the following group:
A. Effervescent powder
B. Soluble powder
C. Powders for oral use
D. Nasal powders
E. Powders for external use
ANSWER: A
Calculate the quantity of dried belladonna extract (1:2) required for
preparing the following drug formulation:
Rp.: Extraсti Belladоnnae 0,015
Magnesii oxydi 0,5
Natrii hydrocarbonatis 0,2
Misce ut fiat pulvis Da tales doses №10
Signa. 1 powder thrice a day
A. 0,3
B. 0,15
C. 0,4
D. 0,6
E. 0,015
ANSWER: A
This substance is of blue colour but unlike the colouring substances it
doesn’t leave any stain. The powders prepared out of it are made
according to the general rules. What substance is it?
A. Copper sulfate
B. Ethacridine lactate
C. Riboflavin
D. Acrichine
E. Furacilin
ANSWER: A
A pharmaceutist brews an aqueous extract out of medicinal raw material in
the tightly closed infusion vessel for 15 minutes and stirs it without
opening the lid. Such technology of infusion preparation is typical for
the following medicinal raw material:
A. Mint leaves
B. Bilberry leaves
C. Senna leaves
D. Manzanita leaves
E. Cowberry leaves
ANSWER: A
A pharmaceutist made 10 powders containing atropine sulfate at a rate of
0,00005 pro dose. What trituration did he use?
A. 1:100
B. 1:10
C. 1:1000
D. 1:50
E. 1:20
ANSWER: A
A pharmaceutist prepares internal drops with the following formulation: 5
ml of adoniside, 10 ml of valerian and lily-of-the-valley tincture each,
0,1 g of menthol, 2,0 g of potassium bromide. It will be efficient to
dissolve potassium bromide in the following substance:
A. In the adoniside
B. In the lily-of-the-valley tincture
C. In the valerian tincture
D. In the mixture of tinctures
E. Potassium bromide should be added into the selling vial last of all
ANSWER: A
Therapeutic non-equivalence of drugs is a clinical mismatch drugs to each
other, made in the form
A. various dosage forms containing different doses of the drug
B. single dosage form containing an equal dose of the drug, but
manufactured in different ways
C. various dosage forms containing an equal dose of the drug
D. single dosage form containing an equal dose of the drug, but made by
different chemical and pharmaceutical plants (firms)
E. single dosage form containing an equal dose of the drug, made by the
same chemical-pharmaceutical factory
ANSWER: D
Possible causes of therapeutic inequivalence of drugs produced by
different factories are:
A. Technology
B. dose of the drug
C. gender and age of the patient
D. route of administration
E. dosage form
ANSWER: A
Biopharmacy - the science that studies the biological effects of drugs,
depending on factors:
A. Intraspecific
B. Clinical
C. Physiological
D. |Pharmaceutical
E. Veterinary
ANSWER: D
In the manufacture of ointments streptotsida 10% pharmacist mixed with
medicated ointment base without pre-grinding, which led to a decrease in
the rate of release streptocide. To improve the quality of ointment to
disperse streptocid, pulverized it with:
A. |with ethanol or diethyl ether;
B. with half of the mass of the drug liquid paraffin
C. with a half or part of the molten Vaseline;
D. with all the Vaseline
E. with dichloroethane
ANSWER: A
Mixing of the dissolution medium provides:
A. uniform concentration of the drug;
B. reproducibility of experimental results;
C. increasing diffusion;
D. |the ability to change the rate of dissolution and the type of
kinetics;
E. pharmacological activity
ANSWER: D
The doctor prescribed the patient a simple sulfuric ointment for the
treatment of scabies. Select a platform to the desired therapeutic
effect:
A. Vaseline;
B. grease emulsion basis E. Kutumova ;
C. lanolin;
D. pork fat;
E. bentonite base.
ANSWER: D
Increase the availability of pharmaceutical tablets containing
difficultly soluble in water, drug, perhaps by :
A. reduce the degree of dispersion of the substance;
B. introducing an optimum amount of surfactant;
C. introducing an optimum number of sub-agents;
D. using granulation;
E. changing the shape of the crystals.
ANSWER: A
From the point of view indifferent biopharmaceutical substances are:
A. Sugar,
B. Flavoring;
C. Detergents;
D. Preservatives;
E. none of the above;
ANSWER: A
Dissolution medium for tablets and capsules is chosen with the account of
the fact:
A. nature of the drug;
B. ionization of drug;
C. portion of the gastrointestinal tract, where there is a suction;
D. reception time of the dosage form;
E. seasonality;
ANSWER: C
The main ways of excretion of drugs are the highlight:
A. the urine;
B. the secret of breasts;
C. faeces;
D. bile;
E. saliva
ANSWER: A
Select the most frequently used methods of analysis of drugs in
biological samples:
A. microbiology;
B. chromatography;
C. GC-spectroscopy;
D. spectroscopy and photocolorimetric;
E. chronopharmacological.
ANSWER: A
Factors affecting the bioavailability and biological object defined:
A. All answers are correct
B. age,
C. sex,
D. weight,
E. the kind of food.
ANSWER: A
Specify the method for the preparation of tablets provides the most rapid
release of the drug:
A. through the formation of solid dispersions;
B. by wet granulation;
C. direct compression;
D. molding;
E. through structural granulation.
ANSWER: C
On
A.
B.
C.
D.
the absorption of drugs in the gastrointestinal tract influence:
food intake and its composition;
the volume of fluid that is used in conjunction with the drug
rate of gastric emptying;
enzymes of the gastrointestinal tract;
E. mucin, bile.
ANSWER: A
To determine the dissolution of the drug from tablets USP recommends that
devices such as:
A. "Swing basket";
B. "Rezomat";
C. "Sartorius";
D. "Revolving basket";
E. stirrer above the disk
ANSWER: D
In the USP to determine the kinetics of drug release from the dosage form
of prolonged use of the medium:
A. acid,
B. alkaline;
C. Buffer;
D. purified water;
E. chloroform
ANSWER: A
Identifying the factors that influence the release of the drug in the
solution:
A. temperature;
B. composition and quantity of the dissolution medium;
C. the rate and nature of mixing;
D. time spent for the experience;
E. equipment.
ANSWER: A
Which of the following areas is not used in scientific research
Biopharmaceutics?
A. Search main modulators bioavailability
B. bioequivalence study drugs
C. Pre-clinical studies
D. study the influence of pharmaceutical and other variable factors
E. determine the biological synergism
ANSWER: C
What method are the methods in vivo?
A. On guinea pigs
B. direct diffusion through the membrane
C. chromatographic
D. test "solubility"
E. plates of agar
ANSWER: A
What method are the methods in vivo?
A. direct diffusion through the membrane
B. On isolated organs
C. chromatographic
D. test "solubility"
E. agar plates
ANSWER: B
What method do not apply to methods in vitro?
A. direct diffusion through the membrane
B. On healthy people, volunteers
C. agar plates
D. chromatographic
E. test "solubility"
ANSWER: B
What method do not apply to methods in vitro?
A. agar plates
B. In rats
C. test "solubility"
D. direct diffusion through the membrane
E. chromatographic
ANSWER: B
What method do not apply to methods in vitro?
A. Chromatographic
B. direct diffusion through the membrane
C. test "solubility"
D. agar plates
E. On laboratory animals
ANSWER: E