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FIGURE LEGENDS FIGURE 37.1 Starling forces governing
FIGURE LEGENDS FIGURE 37.1 Starling forces governing

... is especially sensitive to hyperosmolality. Hyperosmolality also activates other neurons in the anterior hypothalamus, such as those in the subfornical organ (SFO) and median preoptic nucleus (MnPO), and magnocellular neurons, which are intrinsically osmosensitive. Circulating angiotensin II (AII) a ...
Effect of deep brain stimulation on substantia nigra neurons in a
Effect of deep brain stimulation on substantia nigra neurons in a

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text - Systems Neuroscience Course, MEDS 371, Univ. Conn. Health

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... - I can describe the generalized functions of the system as a whole - I can describe how the nervous tissue is organized - I can Identify the major types of cells in the nervous system and discuss the function of each - I can Identify types of neurons - I can briefly describe the mechanisms of trans ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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