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Genetic Epidemiology of High Blood Pressure in Chinese
Genetic Epidemiology of High Blood Pressure in Chinese

... • a two-point LOD score defined by Morton (1955) •L(pedigree|=x): the likelihood of observing a particular configuration of a disease and a marker locus in a family assuming a selected range of  (0  0.5) ...
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Chapter 17 - Madeira City Schools
Chapter 17 - Madeira City Schools

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... This is the transfer of genes from one species to another. Organisms which contain DNA from a different species are said to be transgenic. Transgenesis can be used to move desirable traits from one species to another. It may one day be used to cure genetic defects in humans (= gene therapy). Ways of ...
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Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
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