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Restriction Enzyme Digestion
Restriction Enzyme Digestion

... A restriction enzyme works by identifying a specific DNA sequence and cleaving: A. The sugar-phosphate backbone of one strand B. The sugar-phosphate backbone of both strands C. The nitrogenous bases from one strand D. The nitrogenous bases from both strands ...
Exchange of genetic material between harmless bacteria could be
Exchange of genetic material between harmless bacteria could be

... Exchange of genetic material between harmless bacteria could be reservoir of antibiotic resistance 21 February 2014 Streptococcus pneumoniae is a bacterium that is a major global health problem. Although there are vaccines currently available against this bacterium, S. pneumoniae can evade the vacci ...
press alert - the Gregor Mendel Institute
press alert - the Gregor Mendel Institute

... Transposons are parasitic mobile DNA elements, contained in large quantities in plant and animal DNA, which normally move from place to place within the genome, unless inactivated by defense mechanisms such as DNA methylation. But besides acting as harmful mutators, transposons contribute to importa ...
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gen-305-lect-14-2016

... - Viruses can infect living cells and propagate themselves by taking control of the host’s metabolic machinery. When a gene is inserted into a viral genome, the gene is replicated every time the viral DNA is replicated. Table 20.2 provides a general description of several vectors used to clone small ...
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Molecular Genetics

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... more resistant to insect or viral pests, such as herbicide- and insecticide-resistant soybeans, corn, cotton, and canola. Researchers also are developing peanuts and soybeans that do not cause allergic reactions. Other crops are being field-tested: sweet-potato plants that are resistant to a virus t ...
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... form, the unequal chromosome number could suppress fertilization. Mario R. Capecchi recognized that deleting transgenic information from the gametes would make such technologies reversible. The Cre/ loxP system allows recombination events. A gene of interest, for example in a mouse, can be flanked by ...
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DNA cloning by homologous recombination in Escherichia coli

... tion of a selectable gene, such as of mAf4 an antibiotic resistance gene. Hence the PCR product contains Figure 1. Subcloning by ET recombination. (A). Diagram of the strategy showing the linear cloning vector the selectable gene flanked by carrying an E. coli plasmid origin and an antibiotic select ...
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Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
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