Pharmacovigilance of drug allergy and hypersensitivity using
... parameters). These aspects of the history and the examinations represent a common denominator within the different European centres using this protocol. Skin tests represent an essential tool for the diagnosis of drug allergy, although many drugs cannot be tested (21–23). The standardized procedure f ...
... parameters). These aspects of the history and the examinations represent a common denominator within the different European centres using this protocol. Skin tests represent an essential tool for the diagnosis of drug allergy, although many drugs cannot be tested (21–23). The standardized procedure f ...
Cholinergic agonists
... Cholinergic agonists can be divided into two major groups: 1. Direct-acting agonists chemically bind with and activate muscarinic and nicotinic receptors in the ...
... Cholinergic agonists can be divided into two major groups: 1. Direct-acting agonists chemically bind with and activate muscarinic and nicotinic receptors in the ...
Antiatherosclerotic drugs
... • “Statins” – Indications – Atorvastatin is most efficacious agent for use in severe hypercholesterolemia – High potency (>40-50% LDL lowering) – atorvastatin, simvastatin, cerivastatin – Low potency (20-40% LDL lowering) – lovastatin, fluvastatin, pravastatin – ↓ LDL within 2 weeks; max reduction ...
... • “Statins” – Indications – Atorvastatin is most efficacious agent for use in severe hypercholesterolemia – High potency (>40-50% LDL lowering) – atorvastatin, simvastatin, cerivastatin – Low potency (20-40% LDL lowering) – lovastatin, fluvastatin, pravastatin – ↓ LDL within 2 weeks; max reduction ...
LEVODOPA
... becomes more brittle with abrupt swings between hyper- and hypomobility (the on-off phenomenon). In this case a more effective approach is to use a COMT inhibitor, e.g. entacapone, which can sometimes allay early end-of-dose deterioration without causing dyskinesia. Some 20% of patients with Parkins ...
... becomes more brittle with abrupt swings between hyper- and hypomobility (the on-off phenomenon). In this case a more effective approach is to use a COMT inhibitor, e.g. entacapone, which can sometimes allay early end-of-dose deterioration without causing dyskinesia. Some 20% of patients with Parkins ...
REGULATION (EC) No 1394/2007 OF THE EUROPEAN
... well as of the product and its starting materials is essential to monitor the safety of advanced therapy medicinal products. The establishment and maintenance of that system should be done in such a way as to ensure coherence and compatibility with traceability requirements laid down in Directive 20 ...
... well as of the product and its starting materials is essential to monitor the safety of advanced therapy medicinal products. The establishment and maintenance of that system should be done in such a way as to ensure coherence and compatibility with traceability requirements laid down in Directive 20 ...
Detection times for equine medications
... This information is based on a series of studies in which each drug was administered to a limited number of horses. The data should not be regarded as absolute for every horse to which these substances are administered, nor does it apply to routes of administration or dosages other than those specif ...
... This information is based on a series of studies in which each drug was administered to a limited number of horses. The data should not be regarded as absolute for every horse to which these substances are administered, nor does it apply to routes of administration or dosages other than those specif ...
Warfarin-herb interactions: a review and study based on assessment
... medications, and hence, interactions between the two needs to be addressed and reviewed properly (Gohil and Patel, 2007). Concurrent use of herbs may mimic, magnify or oppose the effect of drugs and thus may raise the potential of herb-drug interactions, contrary to the popular belief, that nature i ...
... medications, and hence, interactions between the two needs to be addressed and reviewed properly (Gohil and Patel, 2007). Concurrent use of herbs may mimic, magnify or oppose the effect of drugs and thus may raise the potential of herb-drug interactions, contrary to the popular belief, that nature i ...
Anti-Inflammatory Activity of Aqueous Extract of Ipomoea Carnea
... extracts of Ipomoea carnea leaves. Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. Therefore, the search for a better tolerated anti-inflammatory agent appears to be a necessity. Ipomoea carnea is used for the treatment of skin disease in I ...
... extracts of Ipomoea carnea leaves. Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. Therefore, the search for a better tolerated anti-inflammatory agent appears to be a necessity. Ipomoea carnea is used for the treatment of skin disease in I ...
Developing Analytical Toxicology Services
... writing must be in place. Proper interpretation of results, especially for less common analytes, remains the responsibility of the laboratory producing the result, at least in the first instance. National requirements may vary, but typically full records of the analysis should be kept for a minimum ...
... writing must be in place. Proper interpretation of results, especially for less common analytes, remains the responsibility of the laboratory producing the result, at least in the first instance. National requirements may vary, but typically full records of the analysis should be kept for a minimum ...
The Role of Ligand Efficiency Measures in Drug Discovery
... Negative LLE values are clearly unfavourable. Based on the properties of an average oral drug, with cLogP ~2.5-3.0 and potency in the range ~1–10 nM, an ideal LLE value for an optimised candidate drug is ~5–7 or greater.7 Fragments or lead-like molecules used as chemical starting points generally ca ...
... Negative LLE values are clearly unfavourable. Based on the properties of an average oral drug, with cLogP ~2.5-3.0 and potency in the range ~1–10 nM, an ideal LLE value for an optimised candidate drug is ~5–7 or greater.7 Fragments or lead-like molecules used as chemical starting points generally ca ...
ppt - Chair of Computational Biology
... Methods that intrinsically handle correlated variables • neural networks ...
... Methods that intrinsically handle correlated variables • neural networks ...
The extemporaneous compounding of paediatric medicines at Mater
... solution. It can be noted that most medications are marketed without adequate studies and availability of appropriate dosages for infants and children.9 Even medications such as phenobarbital and spironolactone, which have been approved for use in paediatric patients, are not available in an appropr ...
... solution. It can be noted that most medications are marketed without adequate studies and availability of appropriate dosages for infants and children.9 Even medications such as phenobarbital and spironolactone, which have been approved for use in paediatric patients, are not available in an appropr ...
11521/16 JV/tt 1 DGD 2C Following the Council`s request to conduct
... available information on MDMB-CHMICA, and in accordance with Article 5 of the Council Decision, on 14 April 2016 the EMCDDA and Europol submitted a Joint Report on MDMBCHMICA 6 to the Council of the European Union, the European Commission, and the European Medicines Agency (EMA). Taking into account ...
... available information on MDMB-CHMICA, and in accordance with Article 5 of the Council Decision, on 14 April 2016 the EMCDDA and Europol submitted a Joint Report on MDMBCHMICA 6 to the Council of the European Union, the European Commission, and the European Medicines Agency (EMA). Taking into account ...
STATISTICAL OPTIMIZATION OF FIXED DOSE COMBINATION OF GLIMEPIRIDE AND ATORVASTATIN CALCIUM IN IMMEDIATE RELEASE TABLET FORMULATION
... combination product (FDCs) should be formulated in such a way that it should have an advantage over single formulation product in therapeutic effect, safety or compliance. With combination therapy, it is important to model how the drugs act in combination (synergistically, ...
... combination product (FDCs) should be formulated in such a way that it should have an advantage over single formulation product in therapeutic effect, safety or compliance. With combination therapy, it is important to model how the drugs act in combination (synergistically, ...
Building a Smart Infusion System Drug Library
... workflow between the EHR system and infusion system programming and ensures that all clinical scenarios related to drug orders and other related interaction with the EHR system are considered. This individual provides detailed understanding of required clinical documentation in the EHR for infusions ...
... workflow between the EHR system and infusion system programming and ensures that all clinical scenarios related to drug orders and other related interaction with the EHR system are considered. This individual provides detailed understanding of required clinical documentation in the EHR for infusions ...
Antimicrobial Agents
... • Mode of action - The aminoglycosides irreversibly bind to the 16S ribosomal RNA and freeze the 30S initiation complex (30S-mRNAtRNA) so that no further initiation can occur. They also slow down protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r ...
... • Mode of action - The aminoglycosides irreversibly bind to the 16S ribosomal RNA and freeze the 30S initiation complex (30S-mRNAtRNA) so that no further initiation can occur. They also slow down protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r ...
Enzyme Kinetics for Clinically Relevant CYP Inhibition
... Abstract: In vitro cytochrome P450 (CYP)-associated metabolic studies have been considered cost-effective for predicting the potential clinical drug-drug interactions (DDIs), one of the major attritions in drug development. The breakthroughs during the past decade in understanding the biochemistry o ...
... Abstract: In vitro cytochrome P450 (CYP)-associated metabolic studies have been considered cost-effective for predicting the potential clinical drug-drug interactions (DDIs), one of the major attritions in drug development. The breakthroughs during the past decade in understanding the biochemistry o ...
Antiparkinsonian drugs_E
... becomes more brittle with abrupt swings between hyper- and hypomobility (the on-off phenomenon). In this case a more effective approach is to use a COMT inhibitor, e.g. entacapone, which can sometimes allay early end-of-dose deterioration without causing dyskinesia. Some 20% of the patients with Par ...
... becomes more brittle with abrupt swings between hyper- and hypomobility (the on-off phenomenon). In this case a more effective approach is to use a COMT inhibitor, e.g. entacapone, which can sometimes allay early end-of-dose deterioration without causing dyskinesia. Some 20% of the patients with Par ...
5 - NewsletterVol4_1 - Phospholipid Forschungszentrum Heidelberg
... polar modifier. Depending on the polarity of the compounds to separate, typical mobile phases are hexane/ethyl acetate, hexane/2-propanol, chloroform/methanol etc. The retention time of a specific analyte is now dependent form the partition of the analyte between the stationary and the mobile phase. ...
... polar modifier. Depending on the polarity of the compounds to separate, typical mobile phases are hexane/ethyl acetate, hexane/2-propanol, chloroform/methanol etc. The retention time of a specific analyte is now dependent form the partition of the analyte between the stationary and the mobile phase. ...
$doc.title
... "One reported case of "convulsions" was reported in a multicenter, double-blind, placebo-controlled study of238 subjects with dizziness after stroke (Shinohara and Nakashima, 2002)" but seizures are not listed as an adverse event associated with ibudilast in the investigator's brochure. Therefore, t ...
... "One reported case of "convulsions" was reported in a multicenter, double-blind, placebo-controlled study of238 subjects with dizziness after stroke (Shinohara and Nakashima, 2002)" but seizures are not listed as an adverse event associated with ibudilast in the investigator's brochure. Therefore, t ...
2009
... developed signs of intoxication with this preparation. The patient was prescribed unithiol. What is the mechanism of unithiol action in case of intoxication with cardiac glycosides? * A. Reduction of K+-Na+-adenosinetriphosphatase B. Binding of calcium ions С. Increased potassium permeability in the ...
... developed signs of intoxication with this preparation. The patient was prescribed unithiol. What is the mechanism of unithiol action in case of intoxication with cardiac glycosides? * A. Reduction of K+-Na+-adenosinetriphosphatase B. Binding of calcium ions С. Increased potassium permeability in the ...
SEMINAR ON - Pharmawiki.in
... In a nut shell, the advantages of IN delivery are numerous and very importantly it is rapid and non-invasive. An alternative to parenteral and oral route. IN delivery suitable for both topical or systemic delivery and to treat both acute and chronic diseases. ...
... In a nut shell, the advantages of IN delivery are numerous and very importantly it is rapid and non-invasive. An alternative to parenteral and oral route. IN delivery suitable for both topical or systemic delivery and to treat both acute and chronic diseases. ...
443 - The AIDS InfoNet
... Saquinavir, also called Invirase, is a drug used as part of antiretroviral therapy (ART). There used to be a version called Fortovase that is no longer made. Saquinavir is manufactured by Roche Laboratories. Saquinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HI ...
... Saquinavir, also called Invirase, is a drug used as part of antiretroviral therapy (ART). There used to be a version called Fortovase that is no longer made. Saquinavir is manufactured by Roche Laboratories. Saquinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HI ...
Effects of Δ9-tetrahydrocannabinol on reward and anxiety in rats
... responses in humans leading to drug-seeking behaviour, the reinforcing attributes of these subjective effects are difficult to define in experimental animals. The aim of this study was to examine how exposure to chronic unpredictable stress (CUS) will affect reward function and anxiety after acute a ...
... responses in humans leading to drug-seeking behaviour, the reinforcing attributes of these subjective effects are difficult to define in experimental animals. The aim of this study was to examine how exposure to chronic unpredictable stress (CUS) will affect reward function and anxiety after acute a ...
Biomarker as Essential Part of Clinical Development
... The idea of using biomarker to detect disease and improve treatment has started from the beginning of medical treatment. Uroscopy, the examination of urine for color and sediment is practiced even before 14th century for observing the signs of disease. Biomarkers have been used in pre-clinical resea ...
... The idea of using biomarker to detect disease and improve treatment has started from the beginning of medical treatment. Uroscopy, the examination of urine for color and sediment is practiced even before 14th century for observing the signs of disease. Biomarkers have been used in pre-clinical resea ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.