Discriminative Stimulus Effects of Zolpidem in Pentobarbital
... Discrimination training. The monkeys had been trained previously to discriminate pentobarbital from saline in a two-lever, discrete-trials shock avoidance procedure (FR 1). Each monkey was placed in the chair, given an intragastric infusion (via nasogastric tube) of saline or 10 mg/kg pentobarbital, ...
... Discrimination training. The monkeys had been trained previously to discriminate pentobarbital from saline in a two-lever, discrete-trials shock avoidance procedure (FR 1). Each monkey was placed in the chair, given an intragastric infusion (via nasogastric tube) of saline or 10 mg/kg pentobarbital, ...
Soothing Properties of Glycerol in Cough Syrups for Acute Cough
... of £104 million to the healthcare system along with the purchase of non-prescription medicines [21]. Estimating the global prevalence of cough is difficult considering its benign and self-limiting nature. An estimated 48 million cases of acute cough occur every year in the United Kingdom [21]. In ge ...
... of £104 million to the healthcare system along with the purchase of non-prescription medicines [21]. Estimating the global prevalence of cough is difficult considering its benign and self-limiting nature. An estimated 48 million cases of acute cough occur every year in the United Kingdom [21]. In ge ...
AusPAR: Rifaximin - Therapeutic Goods Administration
... The proposed new chemical entity, rifaximin, is a semisynthetic antibiotic derived from the fermentation product, Rifamycin B. It has very poor oral absorption and achieves high concentrations in the gut lumen following oral administration. There is a European Pharmacopeia (Ph.Eur.)/British Pharmaco ...
... The proposed new chemical entity, rifaximin, is a semisynthetic antibiotic derived from the fermentation product, Rifamycin B. It has very poor oral absorption and achieves high concentrations in the gut lumen following oral administration. There is a European Pharmacopeia (Ph.Eur.)/British Pharmaco ...
Buprenorphine and Naloxone: Clinical Pharmacology Abuse Liability
... (liquid) to 15 to 25 % (tablets) Poor oral bioavailability ...
... (liquid) to 15 to 25 % (tablets) Poor oral bioavailability ...
Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir
... NOTE: This submission was considered at the same time as the submission to register Viekira Pak RBV which contains applications for the Viekira Pak product presented as combination packs with different strengths of ribavirin (Submission number PM-201401438-1-2). The data in these submissions overlap ...
... NOTE: This submission was considered at the same time as the submission to register Viekira Pak RBV which contains applications for the Viekira Pak product presented as combination packs with different strengths of ribavirin (Submission number PM-201401438-1-2). The data in these submissions overlap ...
1. Clinical Pharmacology
... methadone, morphine or heroin. Consequently, buprenorphine displaces agonists from opioid receptors and, in the short term, may not produce sufficient agonist effects to compensate for the displaced methadone or heroin, producing opioid withdrawal as the buprenorphine reaches its peak effects (appro ...
... methadone, morphine or heroin. Consequently, buprenorphine displaces agonists from opioid receptors and, in the short term, may not produce sufficient agonist effects to compensate for the displaced methadone or heroin, producing opioid withdrawal as the buprenorphine reaches its peak effects (appro ...
KEY and EXPLANATION for SET-A
... Answer: B Explanation: The large intestine is heavily colonized by certain types of bacteria, which synthesize vitamin K and folic acid. They include Escherichia coli, Enterobacter aerogenes, Streptococcus faecalis and Clostridium perfringens. These microbes are commensals, i.e. normally harmless, i ...
... Answer: B Explanation: The large intestine is heavily colonized by certain types of bacteria, which synthesize vitamin K and folic acid. They include Escherichia coli, Enterobacter aerogenes, Streptococcus faecalis and Clostridium perfringens. These microbes are commensals, i.e. normally harmless, i ...
Annex 1 - Emcdda
... (25H-NBOMe), ethyl (25E-NBOMe), nitro (25N-NBOMe), methyl (25D-NBOMe) or isopropyl (25iP-NBOMe), respectively, whereas the 2,5-dimethoxy-3,4-dimethylphenyl analogue was represented as 25G-NBOMe. The phenethylamine nucleus may also be replaced by their corresponding amphetamine (methyl group present ...
... (25H-NBOMe), ethyl (25E-NBOMe), nitro (25N-NBOMe), methyl (25D-NBOMe) or isopropyl (25iP-NBOMe), respectively, whereas the 2,5-dimethoxy-3,4-dimethylphenyl analogue was represented as 25G-NBOMe. The phenethylamine nucleus may also be replaced by their corresponding amphetamine (methyl group present ...
Sootheze Six Plus Paracetamol 250mg/5ml Oral Suspension
... Other ingredients Other ingredients consist of pharmaceutical excipients, namely glycerol, xantham gum, avicel, maltitol syrup, polysorbate 80, sodium saccharin, citric acid monohydrate, methyl hydroxybenzoate sodium (E219), propyl hydroxybenzoate sodium (E217), strawberry flavour, and purified wate ...
... Other ingredients Other ingredients consist of pharmaceutical excipients, namely glycerol, xantham gum, avicel, maltitol syrup, polysorbate 80, sodium saccharin, citric acid monohydrate, methyl hydroxybenzoate sodium (E219), propyl hydroxybenzoate sodium (E217), strawberry flavour, and purified wate ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... Ondansetron does not itself appear to induce or inhibit the cytochrome P450 drugmetabolizing enzyme system of the liver. Because ondansetron is metabolised by hepatic cytochrome P450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life ...
... Ondansetron does not itself appear to induce or inhibit the cytochrome P450 drugmetabolizing enzyme system of the liver. Because ondansetron is metabolised by hepatic cytochrome P450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
TCCC Change Prop 1403 Ondansetron 150403 JSOM
... Vella’s well-designed and executed study compared promethazine, metoclopramide, and placebo when given with pethidine (meperidine) in laboring mothers. He demonstrated that promethazine and metoclopramide were equally effective and better than placebo in reducing nausea, but patients receiving metoc ...
... Vella’s well-designed and executed study compared promethazine, metoclopramide, and placebo when given with pethidine (meperidine) in laboring mothers. He demonstrated that promethazine and metoclopramide were equally effective and better than placebo in reducing nausea, but patients receiving metoc ...
INHIBITION OF OAT3-MEDIATED RENAL UPTAKE AS A
... biliary excretion. Interactions of fexofenadine with drugs and food have been reported. The interactions with rifampicin (Hamman et al., 2001), St John’s wort (Wang et al., 2002), and fruit juice (Dresser et al., 2002) caused a reduction in the AUC of fexofenadine after oral administration, and thes ...
... biliary excretion. Interactions of fexofenadine with drugs and food have been reported. The interactions with rifampicin (Hamman et al., 2001), St John’s wort (Wang et al., 2002), and fruit juice (Dresser et al., 2002) caused a reduction in the AUC of fexofenadine after oral administration, and thes ...
The Role of Intrathecal Drugs in the Treatment of Acute Pain
... total knee arthroplasty exceeded the analgesia afforded by even the largest dose of intrathecal morphine (300 g), yet patients who received this dose nearly universally reported nausea, vomiting, and pruritus. Intrathecal morphine has been studied as an analgesic for pain after cesarean delivery (1 ...
... total knee arthroplasty exceeded the analgesia afforded by even the largest dose of intrathecal morphine (300 g), yet patients who received this dose nearly universally reported nausea, vomiting, and pruritus. Intrathecal morphine has been studied as an analgesic for pain after cesarean delivery (1 ...
Actavis v ICOS
... There is a debate about claim construction concerning the reference to a maximum total dose per day. There are also issues on infringement which relates only to Actavis and Mylan. One is about whether a threat to infringe has been established and this applies to 181 and 092. The other is about the t ...
... There is a debate about claim construction concerning the reference to a maximum total dose per day. There are also issues on infringement which relates only to Actavis and Mylan. One is about whether a threat to infringe has been established and this applies to 181 and 092. The other is about the t ...
Nail Forum One Day Meeting
... Attempts to increase the penetration of drugs into the nail plate have included physical techniques such as iontophoresis, sonophoresis and abrasion, all with some degree of experimental success but unlikely product potential. The concept of sandpaper abrasion followed by lacquer application is attr ...
... Attempts to increase the penetration of drugs into the nail plate have included physical techniques such as iontophoresis, sonophoresis and abrasion, all with some degree of experimental success but unlikely product potential. The concept of sandpaper abrasion followed by lacquer application is attr ...
Winter 2013 - Ontario College of Pharmacists
... workflow, appreciating that this can have a major impact in freeing up pharmacists’ time so they can focus on the delivery of more clinical services. It is a time of change, to new ways of providing enhanced patient care, and like all transition it will require some effort and patience as we each le ...
... workflow, appreciating that this can have a major impact in freeing up pharmacists’ time so they can focus on the delivery of more clinical services. It is a time of change, to new ways of providing enhanced patient care, and like all transition it will require some effort and patience as we each le ...
Full-Text PDF
... For many decades, serial analyses of routine LTs (liver tests) like ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), and total bilirubin (TBIL) have traditionally been used for detection of DILI with marketed products and during clinical trials [1–3]. In ...
... For many decades, serial analyses of routine LTs (liver tests) like ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), and total bilirubin (TBIL) have traditionally been used for detection of DILI with marketed products and during clinical trials [1–3]. In ...
CEFOPERAZONE SODIUM + SULBACTAM
... risks involved should be considered before instituting therapy (see section 5.3 Preclinical Safety Data “Use in Pediatrics”). Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including sulbactam sodium/cefoperazone sodium, and may range ...
... risks involved should be considered before instituting therapy (see section 5.3 Preclinical Safety Data “Use in Pediatrics”). Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including sulbactam sodium/cefoperazone sodium, and may range ...
Paracetamol - IARC Monographs on the Evaluation of Carcinogenic
... Paracetamol is used as an analgesic and antipyretic drug. It is the preferred alternative analgesic-antipyretic to aspirin (acetylsalicylic acid), particularly in patients with coagulation disorders, individuals with a history of peptIc ulcer or who ...
... Paracetamol is used as an analgesic and antipyretic drug. It is the preferred alternative analgesic-antipyretic to aspirin (acetylsalicylic acid), particularly in patients with coagulation disorders, individuals with a history of peptIc ulcer or who ...
Chinese Herbs Botanical Extracts
... parallel may be drawn here with the use of plants as sources of fragrance materials, where the fragrance compounds of the plant alter almost as soon as the plant is harvested due, for example, to enzymatically catalysed reactions, oxidation, etc. In recognition of this, head-space analysis is becomi ...
... parallel may be drawn here with the use of plants as sources of fragrance materials, where the fragrance compounds of the plant alter almost as soon as the plant is harvested due, for example, to enzymatically catalysed reactions, oxidation, etc. In recognition of this, head-space analysis is becomi ...
Gamma-butyrolactone (GBL) - World Health Organization
... studies of GBL. In one study in which GBL was intentionally administered to human subjects under experimental conditions, Schrock and colleagues 28 administered a single dose of 1.5 ml of GBL spiked to a soft drink to each of two volunteers. The dose of GBL was estimated to be equivalent to 2.1 g of ...
... studies of GBL. In one study in which GBL was intentionally administered to human subjects under experimental conditions, Schrock and colleagues 28 administered a single dose of 1.5 ml of GBL spiked to a soft drink to each of two volunteers. The dose of GBL was estimated to be equivalent to 2.1 g of ...
Timolol Metabolism in Human Liver Microsomes Is Mediated
... to about 160 ions/count. A cone voltage of 26 V was used. In hydrogendeuterium exchange experiments the D2O was delivered into the HPLC eluent flow postcolumn by a syringe pump (Harvard Apparatus, Holliston, MA) via a T-mode flow splitter with a flow rate of 100 l/ml. The number of labile protons i ...
... to about 160 ions/count. A cone voltage of 26 V was used. In hydrogendeuterium exchange experiments the D2O was delivered into the HPLC eluent flow postcolumn by a syringe pump (Harvard Apparatus, Holliston, MA) via a T-mode flow splitter with a flow rate of 100 l/ml. The number of labile protons i ...
PHARMACEUTICAL IMPURITY ANALYSIS SOLUTIONS
... impurities, followed by their isolation and characterization. For all three types of impurities, it is critical to develop a robust method during process development that can eventually be validated and transferred to QA/QC. Developing reliable methods for impurities regulated at very low levels, su ...
... impurities, followed by their isolation and characterization. For all three types of impurities, it is critical to develop a robust method during process development that can eventually be validated and transferred to QA/QC. Developing reliable methods for impurities regulated at very low levels, su ...
67Dihydroxybergamottin Contributes to the Grapefruit
... research has been devoted to the identification of the active ingredients responsible for the grapefruit juice effect. Such knowledge not only would allow the prediction of other foods that might produce this type of food-drug interaction but may also have commercial applications. For example, by us ...
... research has been devoted to the identification of the active ingredients responsible for the grapefruit juice effect. Such knowledge not only would allow the prediction of other foods that might produce this type of food-drug interaction but may also have commercial applications. For example, by us ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.