P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants,
... hand, hydrophilic and charged compounds often require specific transport mechanisms to facilitate cellular uptake and/or trans-cellular transport. The efflux mechanisms play a critical role in limiting the absorption and accumulation of potentially toxic substances and can effectively confer resista ...
... hand, hydrophilic and charged compounds often require specific transport mechanisms to facilitate cellular uptake and/or trans-cellular transport. The efflux mechanisms play a critical role in limiting the absorption and accumulation of potentially toxic substances and can effectively confer resista ...
Characteristics and Consequences of Use of Anabolic Androgenic
... The history of testosterone Substances with anabolic properties were not discovered until the 19th century, when John Hunter, a Scottish physician developed methods to transplant testicular tissue into foreign tissue. His work inspired another physician, Berthold of Göttingen, to experiment with ca ...
... The history of testosterone Substances with anabolic properties were not discovered until the 19th century, when John Hunter, a Scottish physician developed methods to transplant testicular tissue into foreign tissue. His work inspired another physician, Berthold of Göttingen, to experiment with ca ...
- the University of Huddersfield Repository
... systemic availability of inhaled drugs but have not been extended to corticosteroids. The main aims were to validate the urinary pharmacokinetic methodology when applied to inhaled beclometasone dipropionate (BDP), demonstrate the usefulness of the method and compare its indices to the in-vitro char ...
... systemic availability of inhaled drugs but have not been extended to corticosteroids. The main aims were to validate the urinary pharmacokinetic methodology when applied to inhaled beclometasone dipropionate (BDP), demonstrate the usefulness of the method and compare its indices to the in-vitro char ...
Chlorhexidine: The Gold Standard Antiplaque Agent
... Chlorhexidine is an antimicrobial agent. It acts on the inner cytoplasmic membrane hence it is a membrane active type of substance. It is dicationic at pH levels above 3.5. It prevents plaque accumulation, hence it is a antiplaque and antigingivitis agent[6] and reduces the adherence of Porphyromona ...
... Chlorhexidine is an antimicrobial agent. It acts on the inner cytoplasmic membrane hence it is a membrane active type of substance. It is dicationic at pH levels above 3.5. It prevents plaque accumulation, hence it is a antiplaque and antigingivitis agent[6] and reduces the adherence of Porphyromona ...
The Gateway Drug: Marijuana
... AIDS, or nausea caused by cancer chemotherapy. There is, however, no solid evidence that smoking marijuana creates any greater benefits than approved medications (including oral THC) now used to treat these patients, relieve their suffering, or mitigate the side effects of their treatment. Anecdotal ...
... AIDS, or nausea caused by cancer chemotherapy. There is, however, no solid evidence that smoking marijuana creates any greater benefits than approved medications (including oral THC) now used to treat these patients, relieve their suffering, or mitigate the side effects of their treatment. Anecdotal ...
EFNS guideline on the drug treatment of migraine
... trials of which metaanalyses have been published [42,43]. For sumatriptan [9,44] and zolmitriptan [45] comparative studies with ASA and metoclopramide exist. In these comparative studies, the triptans were not or only a little more effective than ASA. In about 60% of nonresponders to NSAID, triptans ...
... trials of which metaanalyses have been published [42,43]. For sumatriptan [9,44] and zolmitriptan [45] comparative studies with ASA and metoclopramide exist. In these comparative studies, the triptans were not or only a little more effective than ASA. In about 60% of nonresponders to NSAID, triptans ...
Study on off-label use of medicinal products in the European
... part of this authorisation, the terms under which a product can be used safely and effectively are described in the product information. However, medicinal products might be prescribed and used outside these terms; this is what is called ‘off-label use’. This report describes a study on the complex ...
... part of this authorisation, the terms under which a product can be used safely and effectively are described in the product information. However, medicinal products might be prescribed and used outside these terms; this is what is called ‘off-label use’. This report describes a study on the complex ...
PrDALACIN* C FLAVOURED GRANULES
... determine whether they respond differently from younger patients. Pediatrics (over one month of age): It is not known if use of clindamycin in the pediatric population is associated with differences in safety or effectiveness compared with adult patients. To reduce the development of drug-resistant ...
... determine whether they respond differently from younger patients. Pediatrics (over one month of age): It is not known if use of clindamycin in the pediatric population is associated with differences in safety or effectiveness compared with adult patients. To reduce the development of drug-resistant ...
Discriminative Stimulus Properties of MDMA
... evidence that training dose can markedly impact the results of drug discrimination studies, the impact of training dose on the discriminative stimulus properties of MDMA has been largely overlooked. The broad aims of these experiments were 1) to test the ability of two different doses of MDMA to sup ...
... evidence that training dose can markedly impact the results of drug discrimination studies, the impact of training dose on the discriminative stimulus properties of MDMA has been largely overlooked. The broad aims of these experiments were 1) to test the ability of two different doses of MDMA to sup ...
Study on off-label use of medicinal products in the European Union
... part of this authorisation, the terms under which a product can be used safely and effectively are described in the product information. However, medicinal products might be prescribed and used outside these terms; this is what is called ‘off-label use’. This report describes a study on the complex ...
... part of this authorisation, the terms under which a product can be used safely and effectively are described in the product information. However, medicinal products might be prescribed and used outside these terms; this is what is called ‘off-label use’. This report describes a study on the complex ...
The Eclectic Materia Medica, Pharmacology and Therapeutics by
... Locally, aconite and its alkaloid, aconitine, act as irritants, producing a tingling, pricking sensation and numbness, followed by peripheral sensory impairment, resulting in anaesthesia of the part. The latter is due to paralysis of the sensory nerve terminals. Usually no redness nor inflammation f ...
... Locally, aconite and its alkaloid, aconitine, act as irritants, producing a tingling, pricking sensation and numbness, followed by peripheral sensory impairment, resulting in anaesthesia of the part. The latter is due to paralysis of the sensory nerve terminals. Usually no redness nor inflammation f ...
Malaysian Statistics on Medicines 2008
... Routinely compiled statistics on medicines utilization have many uses, such as: 1. Estimate the consumption of medicines and describe pattern of medicines use through assessing which alternative drugs are being used for particular conditions and to what extent. 2. Estimate the number of medicine u ...
... Routinely compiled statistics on medicines utilization have many uses, such as: 1. Estimate the consumption of medicines and describe pattern of medicines use through assessing which alternative drugs are being used for particular conditions and to what extent. 2. Estimate the number of medicine u ...
BIAXIN® Filmtab® (clarithromycin tablets, USP) BIAXIN
... Concomitant administration of fluconazole 200 mg daily and clarithromycin 500 mg twice daily to 21 healthy volunteers led to increases in the mean steady-state clarithromycin Cmin and AUC of 33% and 18%, respectively. Steady-state concentrations of 14-OH clarithromycin were not significantly affect ...
... Concomitant administration of fluconazole 200 mg daily and clarithromycin 500 mg twice daily to 21 healthy volunteers led to increases in the mean steady-state clarithromycin Cmin and AUC of 33% and 18%, respectively. Steady-state concentrations of 14-OH clarithromycin were not significantly affect ...
Supramolecularly engineered phospholipids
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
Europol–EMCDDA Joint Report on a new psychoactive substance: 4
... Mass spectral data for mephedrone (m/z): 58 (base peak, 100 %). This technique does not distinguish between methylmethcathinone isomers (i.e. 4methylmethcathinone from 3-methylmethcathinone). Analysis using gas chromatography coupled with mass spectrometry (GC/MS) and infrared spectroscopy (IR) is s ...
... Mass spectral data for mephedrone (m/z): 58 (base peak, 100 %). This technique does not distinguish between methylmethcathinone isomers (i.e. 4methylmethcathinone from 3-methylmethcathinone). Analysis using gas chromatography coupled with mass spectrometry (GC/MS) and infrared spectroscopy (IR) is s ...
LSD (Lysergic acid diethylamide), death? and distraction
... mechanisms of LSD ? • LSD is thought to preferentially inhibit serotonergic (5HT) cell firing in the CNS (Passie et al, 2008) • So called “partial agonist activity” at 5HT2A receptors mediates the psychedelic effects of LSD. LSD also has full agonist activity at 5HT1A and 5HT1C receptors • Since ser ...
... mechanisms of LSD ? • LSD is thought to preferentially inhibit serotonergic (5HT) cell firing in the CNS (Passie et al, 2008) • So called “partial agonist activity” at 5HT2A receptors mediates the psychedelic effects of LSD. LSD also has full agonist activity at 5HT1A and 5HT1C receptors • Since ser ...
MDMA in humans: factors which affect the neuropsychobiological
... depressed mood, persistent elevation of anxiety, impulsivity and hostility, and selective impairment of episodic memory, working memory and attention.’ Subsequent neurocognitive/psychobiological findings have been broadly consistent with this conclusion (see above studies). The importance of cumulat ...
... depressed mood, persistent elevation of anxiety, impulsivity and hostility, and selective impairment of episodic memory, working memory and attention.’ Subsequent neurocognitive/psychobiological findings have been broadly consistent with this conclusion (see above studies). The importance of cumulat ...
Methamphetamine - Department of Electrical Engineering
... Following oral administration, methamphetamine is readily absorbed with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. The amphetamine metabolite peaks at 10 to 24 hours.[11] Methamphetamine is also well absorbed following inhalation and following intranasal admin ...
... Following oral administration, methamphetamine is readily absorbed with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. The amphetamine metabolite peaks at 10 to 24 hours.[11] Methamphetamine is also well absorbed following inhalation and following intranasal admin ...
Antibody–Drug Conjugates (ADCs) Derived from
... linker stability, which correlates with improved efficacy.14 The combined results indicate that ADC activity is highly dependent upon the conjugation sites and suggest that optimal conjugation sites are likely to be different for each antibody. Recombinant methods using non-natural amino acids to enabl ...
... linker stability, which correlates with improved efficacy.14 The combined results indicate that ADC activity is highly dependent upon the conjugation sites and suggest that optimal conjugation sites are likely to be different for each antibody. Recombinant methods using non-natural amino acids to enabl ...
A Closer Look at the Risks vs. Benefits of Kava (Piper methysticum)
... complementary and herbal treatments for anxiety disorders. The complementary treatment was distinguished by using any self-help treatment not generally upheld in the health system. Each treatment was evaluated for its effectiveness in reducing anxiety symptoms in generalized and specific anxiety dis ...
... complementary and herbal treatments for anxiety disorders. The complementary treatment was distinguished by using any self-help treatment not generally upheld in the health system. Each treatment was evaluated for its effectiveness in reducing anxiety symptoms in generalized and specific anxiety dis ...
Acute and Chronic Effects of Inhalants in Intracranial Self
... Inhalants Defined Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. ...
... Inhalants Defined Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. ...
Product Monograph - Paladin Labs Inc.
... quickly cleared from the bloodstream by the liver (T½= 3-6 min); thus the amount excreted in the milk of nursing mothers following treatment of severe hypoglycemic reactions will be extremely small. As glucagon is degraded in the digestive tract and cannot be absorbed in its intact form, it will not ...
... quickly cleared from the bloodstream by the liver (T½= 3-6 min); thus the amount excreted in the milk of nursing mothers following treatment of severe hypoglycemic reactions will be extremely small. As glucagon is degraded in the digestive tract and cannot be absorbed in its intact form, it will not ...
Milk and Dairy Beef Drug Residue Prevention 2012
... specific disease challenge. As dairy producers, we strategically and judiciously use our antibiotic therapy to help an individual animal that has been threatened with a disease. We take this responsibility of judicious antibiotic use seriously and take many precautions with our antibiotic-treated an ...
... specific disease challenge. As dairy producers, we strategically and judiciously use our antibiotic therapy to help an individual animal that has been threatened with a disease. We take this responsibility of judicious antibiotic use seriously and take many precautions with our antibiotic-treated an ...
Antiatherogenic Properties of Naringenin, a Citrus Flavonoid
... INTRODUCTION An inverse association between flavonoid intake and coronary heart disease (CHD) has been suggested by a number of epidemiological studies (42,44,54,78). As a consequence, there is considerable interest in investigating the antiatherogenic nature of these compounds. Flavonoids are natur ...
... INTRODUCTION An inverse association between flavonoid intake and coronary heart disease (CHD) has been suggested by a number of epidemiological studies (42,44,54,78). As a consequence, there is considerable interest in investigating the antiatherogenic nature of these compounds. Flavonoids are natur ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.