- Wiley Online Library
... require low loadings of iridium. The methodology is operationally very simple and can be scaled up. On-going mechanistic investigations should also contribute to the future development of Ir-catalyzed reactions for the formation of carbon–heteroatom bonds, and will be reported in due course. ...
... require low loadings of iridium. The methodology is operationally very simple and can be scaled up. On-going mechanistic investigations should also contribute to the future development of Ir-catalyzed reactions for the formation of carbon–heteroatom bonds, and will be reported in due course. ...
Mapping Post-Transcriptional Modifications onto Transfer
... RNA. Not only are tRNAs heavily decorated, the types of chemical covalent modifications are rich and varied in both structure and biosynthesis routes. To date, more than 100 different chemical modifications have been characterized on tRNAs from all three domains of life, and two data ...
... RNA. Not only are tRNAs heavily decorated, the types of chemical covalent modifications are rich and varied in both structure and biosynthesis routes. To date, more than 100 different chemical modifications have been characterized on tRNAs from all three domains of life, and two data ...
Retrosynthetic Analysis of Nabumetone
... Nabumetone has the ability to slow prostaglandin synthesis, a chemical used in the peripheral nervous system to signal pain. Nabumetone works by inhibiting the activity of cyclooxygenase, an enzyme that is critical in the biosynthesis of prostaglandin. Its action is much like other NSAIDs in its cla ...
... Nabumetone has the ability to slow prostaglandin synthesis, a chemical used in the peripheral nervous system to signal pain. Nabumetone works by inhibiting the activity of cyclooxygenase, an enzyme that is critical in the biosynthesis of prostaglandin. Its action is much like other NSAIDs in its cla ...
SCHEMA Recombination of a
... Notably, one characterized chimera fits this pattern (13333232) and is more stable than the parents (67 °C), in accord with the regression model fit (68 °C). Another mechanism by which coupling could arise, block structural divergence, does not depend on the presence of novel residue pairs at block ...
... Notably, one characterized chimera fits this pattern (13333232) and is more stable than the parents (67 °C), in accord with the regression model fit (68 °C). Another mechanism by which coupling could arise, block structural divergence, does not depend on the presence of novel residue pairs at block ...
Ester - Net Texts
... • using the alcohol in large excess (i.e., as a solvent) • using a dehydrating agent: Sulfuric acid not only catalyzes the reaction but sequesters water (a reaction product). Other drying agents like molecular sieves can also be used. • removal of water by physical means such as distillation as a lo ...
... • using the alcohol in large excess (i.e., as a solvent) • using a dehydrating agent: Sulfuric acid not only catalyzes the reaction but sequesters water (a reaction product). Other drying agents like molecular sieves can also be used. • removal of water by physical means such as distillation as a lo ...
Rhenium Nanochemistry for Catalyst Preparation
... Unfortunately, a major part of the rhenium content in the thermal decomposition processes is reduced into an inactive form and then re-oxidized and removed in volatiles at higher temperatures (over 500 °C). Further steps in the synthesis of rhenium oxides nanocomposites derived from metal alkoxides ...
... Unfortunately, a major part of the rhenium content in the thermal decomposition processes is reduced into an inactive form and then re-oxidized and removed in volatiles at higher temperatures (over 500 °C). Further steps in the synthesis of rhenium oxides nanocomposites derived from metal alkoxides ...
Chem E2b - Organic Chemistry II What is Organic Chemistry?
... half-filled p-orbital is a SOMO (Singly Occupied Molecular Orbital) ...
... half-filled p-orbital is a SOMO (Singly Occupied Molecular Orbital) ...
Full-Text PDF
... science-oriented research. In particular, commercial pharmaceuticals and agrochemicals frequently contain single fluorine atoms or trifluoromethyl groups [1–4]. Nevertheless, growing interest in emergent fluorinated substituents, like α-fluorinated ethers, has been observed within recent years [5–8] ...
... science-oriented research. In particular, commercial pharmaceuticals and agrochemicals frequently contain single fluorine atoms or trifluoromethyl groups [1–4]. Nevertheless, growing interest in emergent fluorinated substituents, like α-fluorinated ethers, has been observed within recent years [5–8] ...
Developments in Synthetic Application of Selenium(IV) Oxide and
... Selenium(IV) oxide mediates the unique allylic oxidation of alkenes 9 with usual retention of the double bond position. The mechanism of this reaction remained unclear until Sharpless and Lauer in 1972 [33] explained the selective oxidation as the result of a two-step process: an ene reaction follow ...
... Selenium(IV) oxide mediates the unique allylic oxidation of alkenes 9 with usual retention of the double bond position. The mechanism of this reaction remained unclear until Sharpless and Lauer in 1972 [33] explained the selective oxidation as the result of a two-step process: an ene reaction follow ...
Processes for making sugar and/or sugar alcohol dehydration
... been evaluated as a treatment for sickle cell anemia. In short, HMF is an important chemical compound and a method of ...
... been evaluated as a treatment for sickle cell anemia. In short, HMF is an important chemical compound and a method of ...
Chapter 15 Lipids Lipids Types of Lipids Classes of Lipids Fatty
... • have cis double bonds that cause “kinks” in the fatty acid chains. • with “kinks” in the chains do not allow the triacylglycerol molecules to pack closely. • have lower melting points than saturated fatty acids. • are liquids at room temperature. ...
... • have cis double bonds that cause “kinks” in the fatty acid chains. • with “kinks” in the chains do not allow the triacylglycerol molecules to pack closely. • have lower melting points than saturated fatty acids. • are liquids at room temperature. ...
Surveillance of microbial resistance in European Intensive Care Units: a first
... laboratory. Repeat isolates were excluded and only initial isolates were considered. It was not determined if the isolates represented ICU-acquired infections, community acquired infections or only colonisation of the patients. Data on distribution of species were entered for all isolates including ...
... laboratory. Repeat isolates were excluded and only initial isolates were considered. It was not determined if the isolates represented ICU-acquired infections, community acquired infections or only colonisation of the patients. Data on distribution of species were entered for all isolates including ...
niculescu m - Revista de Chimie
... the combined action of structural elements at nanometric and micrometric level [1, 2] and offers a unique opportunity for modulation and adaptation of properties for certain functions [3, 4]. Development of concepts for collagen-based biomaterials began many years ago and new elements are constantly ...
... the combined action of structural elements at nanometric and micrometric level [1, 2] and offers a unique opportunity for modulation and adaptation of properties for certain functions [3, 4]. Development of concepts for collagen-based biomaterials began many years ago and new elements are constantly ...
Comparative analyses of Saccharomyces cerevisiae RNAs using
... The total yeast nucleic acid material containing doublestranded (ds) RNAs was extracted from stationary-phase cells of S. cerevisiae T158C (a, his3 ) (Collection of the Department of Genetics and Microbiology, Charles University, Prague, Czech Republic) using the ‘frost method’ [6]. Brie£y, stationa ...
... The total yeast nucleic acid material containing doublestranded (ds) RNAs was extracted from stationary-phase cells of S. cerevisiae T158C (a, his3 ) (Collection of the Department of Genetics and Microbiology, Charles University, Prague, Czech Republic) using the ‘frost method’ [6]. Brie£y, stationa ...
Stereoselective Construction of a β
... did not proceed in Et2O14 (entry 5). The rearrangement of (Z)-8 proceeded with relatively high diastereoselectivity (84-92%de) compared with that of (E)-8 (entries 8-10). Assignment of the relative stereochemistry of both anti- and syn-9 was based on 2D-NOE experiments15 and comparison of the 1H NMR ...
... did not proceed in Et2O14 (entry 5). The rearrangement of (Z)-8 proceeded with relatively high diastereoselectivity (84-92%de) compared with that of (E)-8 (entries 8-10). Assignment of the relative stereochemistry of both anti- and syn-9 was based on 2D-NOE experiments15 and comparison of the 1H NMR ...
Metal-catalysed approaches to amide bond formation
... 3. Amides from esters As the preparation of amides from carboxylic acids is difficult to achieve in a catalytic manner, their derivatives, particularly esters, have been explored as an alternative in catalytic amide forming reactions. In 2003, a simple procedure was published by Ranu and Dutta, using ...
... 3. Amides from esters As the preparation of amides from carboxylic acids is difficult to achieve in a catalytic manner, their derivatives, particularly esters, have been explored as an alternative in catalytic amide forming reactions. In 2003, a simple procedure was published by Ranu and Dutta, using ...
3.1 Life`s molecular diversity is based on the properties of carbon
... – Proteins are made from amino acids linked by peptide bonds ...
... – Proteins are made from amino acids linked by peptide bonds ...
ref. #27 of the TIBS article
... Medicine, Divsion of Clinical Immunology, Karolinska Hospital, S-171 76 Stockholm Sweden ...
... Medicine, Divsion of Clinical Immunology, Karolinska Hospital, S-171 76 Stockholm Sweden ...
Sensitive Detection of Botulinum Neurotoxin Type A
... can be captured and detected using SNAPtide® in an overnight digestion at room temperature. Optimization of this assay is currently in progress. Conclusions: This highly sensitive assay captures and detects as low as 1 pg of BoNT/A which is significantly lower than one mouse LD50 (5 pg) and is in th ...
... can be captured and detected using SNAPtide® in an overnight digestion at room temperature. Optimization of this assay is currently in progress. Conclusions: This highly sensitive assay captures and detects as low as 1 pg of BoNT/A which is significantly lower than one mouse LD50 (5 pg) and is in th ...
Bottromycin
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.