University of Groningen Regulation of hepatobiliary transport
... lumen, is mediated by ABC transporter proteins which couple ATP hydrolysis to transport and thereby enable uphill transport. Cholestasis refers to the condition in which the formation of bile is impaired. The causes underlying the development of cholestasis in patients can be extremely varied. It ma ...
... lumen, is mediated by ABC transporter proteins which couple ATP hydrolysis to transport and thereby enable uphill transport. Cholestasis refers to the condition in which the formation of bile is impaired. The causes underlying the development of cholestasis in patients can be extremely varied. It ma ...
Epigenetic Mechanisms of Gene Regulation
... DNA methyltransferase, which transfers a methyl group to the 5-position of cytosine within the CpG dinucleotide recognition sequence. The product of this methylation reaction, 5-methylcytosine, has drawn considerable attention because methylated DNA is believed to be associated with transcriptional ...
... DNA methyltransferase, which transfers a methyl group to the 5-position of cytosine within the CpG dinucleotide recognition sequence. The product of this methylation reaction, 5-methylcytosine, has drawn considerable attention because methylated DNA is believed to be associated with transcriptional ...
Mapping the histone code at hMLH1. - JScholarship
... result of alterations in the primary DNA sequence. It is increasingly apparent that epigenetics, heritable changes in gene expression that are not caused by changes in DNA sequence, plays an important role in tumorigenesis (Rountree et al., 2001). DNA can be methylated at the 5-carbon position of cy ...
... result of alterations in the primary DNA sequence. It is increasingly apparent that epigenetics, heritable changes in gene expression that are not caused by changes in DNA sequence, plays an important role in tumorigenesis (Rountree et al., 2001). DNA can be methylated at the 5-carbon position of cy ...
Introduction to Adipose Tissue Adipose tissue is not merely an
... enzyme PEPCK, and glycerol-3-phosphate dehydrogenase (GPD1). PPARγ also functions in macrophage lipid metabolism by inducing the expression of the macrophage scavenger receptor, CD36. The CD36 receptor is also known as fatty acid translocase (FAT) and it is one of the receptors responsible for the c ...
... enzyme PEPCK, and glycerol-3-phosphate dehydrogenase (GPD1). PPARγ also functions in macrophage lipid metabolism by inducing the expression of the macrophage scavenger receptor, CD36. The CD36 receptor is also known as fatty acid translocase (FAT) and it is one of the receptors responsible for the c ...
Gene X Environment Effects of Serotonin Transporter, Dopamine
... gene/environment correlations). Polymorphic or epigenetic variations also might lead to individual differences in the impact of environmental factors (Gene Environment [G E] interactions). As described more specifically below, certain allelic variations might potentiate the impact of risk factor ...
... gene/environment correlations). Polymorphic or epigenetic variations also might lead to individual differences in the impact of environmental factors (Gene Environment [G E] interactions). As described more specifically below, certain allelic variations might potentiate the impact of risk factor ...
Gene regulation_1130(final)
... • Insulin-regulated FAS gene transcription involves another transcription factor, USF • Sul demonstrated that E-box motif (-68 to -52 FAS promoter region) mediates the effect of insulin (in tissue culture cells) – Selective mutations in the SRE (E-box intact) had no effect on the insulin response – ...
... • Insulin-regulated FAS gene transcription involves another transcription factor, USF • Sul demonstrated that E-box motif (-68 to -52 FAS promoter region) mediates the effect of insulin (in tissue culture cells) – Selective mutations in the SRE (E-box intact) had no effect on the insulin response – ...
Calmodulin-binding protein phosphatase PP7 is involved in
... AtPP7 knockout impaired the thermotolerance of Arabidopsis seedlings while the overexpression of AtPP7 resulted in plants with increased thermotolerance. Results from realtime polymerase chain reaction (PCR) showed that the expression of AtHSP70 and AtHSP101 genes was up-regulated in AtPP7 overexpre ...
... AtPP7 knockout impaired the thermotolerance of Arabidopsis seedlings while the overexpression of AtPP7 resulted in plants with increased thermotolerance. Results from realtime polymerase chain reaction (PCR) showed that the expression of AtHSP70 and AtHSP101 genes was up-regulated in AtPP7 overexpre ...
Model for transcriptional activation
... binding to promoters and a basal level of transcription. • Gene-specific factors stimulate transcription further (or repress it) and allow fine regulatory control. ...
... binding to promoters and a basal level of transcription. • Gene-specific factors stimulate transcription further (or repress it) and allow fine regulatory control. ...
Depression and anxiety
... care homes. For more information see factsheet 445, Talking therapies (including counselling, psychotherapy and CBT). Antidepressant medication It is thought that depression is caused by low levels of certain chemicals, known as neurotransmitters, in the brain. Antidepressants are thought to boost t ...
... care homes. For more information see factsheet 445, Talking therapies (including counselling, psychotherapy and CBT). Antidepressant medication It is thought that depression is caused by low levels of certain chemicals, known as neurotransmitters, in the brain. Antidepressants are thought to boost t ...
Development and validation of a diagnostic service for epimutations
... No evidence of known microdeletions in NESP55 (sporadic). ...
... No evidence of known microdeletions in NESP55 (sporadic). ...
Characterization of PIR1, a GATA family transcription factor involved
... metabolism and the putative functional coupling between these two enzymes remains uncertain. Notably, iron is particularly important for wood-degrading fungi. This metal not only plays a key role in the central metabolism, but also serves as critical cofactor of several of the enzymes that are invol ...
... metabolism and the putative functional coupling between these two enzymes remains uncertain. Notably, iron is particularly important for wood-degrading fungi. This metal not only plays a key role in the central metabolism, but also serves as critical cofactor of several of the enzymes that are invol ...
Accounting for Non-Genetic Factors Improves the Power of eQTL
... In addition to variation due to genomic differences, human gene expression levels vary because of differing developmental stages, environmental influences and other physiological and biological factors. In principle, when collecting gene expression data sets for eQTL, non-genetic factors should be c ...
... In addition to variation due to genomic differences, human gene expression levels vary because of differing developmental stages, environmental influences and other physiological and biological factors. In principle, when collecting gene expression data sets for eQTL, non-genetic factors should be c ...
Profile of Discrete Emotions in Affective Disorders in Older Primary
... of their relationships with major and minor depression. Previous studies have not determined whether particular emotions, relative to others, are differentially correlated with these two disorders in older persons. It is unclear whether all unpleasant emotions are similarly elevated in older persons ...
... of their relationships with major and minor depression. Previous studies have not determined whether particular emotions, relative to others, are differentially correlated with these two disorders in older persons. It is unclear whether all unpleasant emotions are similarly elevated in older persons ...
overview of depression - Innovative Educational Services
... NIMH has supported considerable research magnetic resonance imaging (MRI) to examine the structure of brain tissue in various mental disorders, including bipolar disorder. The first such studies have appeared only within the past ten years, with the pace of progress accelerating steadily since that ...
... NIMH has supported considerable research magnetic resonance imaging (MRI) to examine the structure of brain tissue in various mental disorders, including bipolar disorder. The first such studies have appeared only within the past ten years, with the pace of progress accelerating steadily since that ...
(CH11) Transcription In Eukaryotes (Slides)
... Enhancers and silencers • Usually 700 to 1000 bp or more away from the start of transcription. • Increase or repress gene promoter activity either in all tissues or in a regulated manner. • Typically contain ~10 binding sites for several different transcription factors. • How can you tell an enhanc ...
... Enhancers and silencers • Usually 700 to 1000 bp or more away from the start of transcription. • Increase or repress gene promoter activity either in all tissues or in a regulated manner. • Typically contain ~10 binding sites for several different transcription factors. • How can you tell an enhanc ...
Depression - Innovative Educational Services
... NIMH has supported considerable research magnetic resonance imaging (MRI) to examine the structure of brain tissue in various mental disorders, including bipolar disorder. The first such studies have appeared only within the past ten years, with the pace of progress accelerating steadily since that ...
... NIMH has supported considerable research magnetic resonance imaging (MRI) to examine the structure of brain tissue in various mental disorders, including bipolar disorder. The first such studies have appeared only within the past ten years, with the pace of progress accelerating steadily since that ...
transcription factor
... Enhancers and silencers • Usually 700 to 1000 bp or more away from the start of transcription. • Increase or repress gene promoter activity either in all tissues or in a regulated manner. • Typically contain ~10 binding sites for several different transcription factors. • How can you tell an enhanc ...
... Enhancers and silencers • Usually 700 to 1000 bp or more away from the start of transcription. • Increase or repress gene promoter activity either in all tissues or in a regulated manner. • Typically contain ~10 binding sites for several different transcription factors. • How can you tell an enhanc ...
Chapter 17c
... • Low educational level • Poor social support • Pre-existing conduct disorder, panic disorder, GAD or depressive disorder ...
... • Low educational level • Poor social support • Pre-existing conduct disorder, panic disorder, GAD or depressive disorder ...
PDF
... Ascl1, we performed ChIP with chromatin obtained from the hindbrains of E11.5 mouse embryos. There was an approximately 20-fold enrichment of the Ascl1/Brn-containing sequence compared with the β-actin and Insm1 ORF controls, following immunoprecipitation with an anti-Ascl1 antibody (Fig. 2A). Thus, ...
... Ascl1, we performed ChIP with chromatin obtained from the hindbrains of E11.5 mouse embryos. There was an approximately 20-fold enrichment of the Ascl1/Brn-containing sequence compared with the β-actin and Insm1 ORF controls, following immunoprecipitation with an anti-Ascl1 antibody (Fig. 2A). Thus, ...
Layer 2 - CRM activity
... activity as a matrix G ={Gjk} , where j corresponds to the gene index and k to the activity class. Again, the coverage of available data for gene activity is not complete, however it is already close to 45% of all Drosophila genes, so instead of treating them as hidden variables, we simply use only ...
... activity as a matrix G ={Gjk} , where j corresponds to the gene index and k to the activity class. Again, the coverage of available data for gene activity is not complete, however it is already close to 45% of all Drosophila genes, so instead of treating them as hidden variables, we simply use only ...