Frequent and histological type-specific inactivation of 14-3
... showed unmethylated patterns. In addition to the SCLC lines, large cell lung cancer lines among NSCLC cell lines also frequently showed hypermethylation (three complete and one partial methylation in seven cell lines, 57%). In contrast, only one cell line of 17 other NSCLC cell lines showed partial ...
... showed unmethylated patterns. In addition to the SCLC lines, large cell lung cancer lines among NSCLC cell lines also frequently showed hypermethylation (three complete and one partial methylation in seven cell lines, 57%). In contrast, only one cell line of 17 other NSCLC cell lines showed partial ...
Marker-based inferences about fecundity genes contributing
... each of the F,s: 14 for F,, with the seven loci employed (i.e., 4 0 % of the associations tested) and six for F,, with the five loci (i.e., 24% of the associations tested). The number of QTLs detected for RT, NN, NF, HT, and W T were 2, 3, 2, 3, and 4, respectively, with an average of 2.8 QTLs per t ...
... each of the F,s: 14 for F,, with the seven loci employed (i.e., 4 0 % of the associations tested) and six for F,, with the five loci (i.e., 24% of the associations tested). The number of QTLs detected for RT, NN, NF, HT, and W T were 2, 3, 2, 3, and 4, respectively, with an average of 2.8 QTLs per t ...
beckwith-wiedemann syndrome
... (UPD) which occurs when both copies of chromosome 11 are derived from the same parent. Patients with BWS and paternal UPD have two paternally derived copies of 11p15.5 and no maternal contribution for this region. In these patients, there are methylation defects at both KvDMR1 and H19. ...
... (UPD) which occurs when both copies of chromosome 11 are derived from the same parent. Patients with BWS and paternal UPD have two paternally derived copies of 11p15.5 and no maternal contribution for this region. In these patients, there are methylation defects at both KvDMR1 and H19. ...
Enhancers reside in a unique epigenetic environment during early
... biology suggested that the hypo-methylated state of enhancers facilitates fast induction of gene expression upon differentiation [17, 18], implying that the low level of DNA methylation has a direct influence on enhancer functionality. Still, if and how DNA methylation directly influences enhancer a ...
... biology suggested that the hypo-methylated state of enhancers facilitates fast induction of gene expression upon differentiation [17, 18], implying that the low level of DNA methylation has a direct influence on enhancer functionality. Still, if and how DNA methylation directly influences enhancer a ...
Gene Section HDAC2 (histone deacetylase 2) Atlas of Genetics and Cytogenetics
... to be recruited by transcription factors such as YY1, SP1/SP3, the tumor suppressor genes p53 and BRCA1. HDAC2 can also be tethered to DNA as a part of the multiprotein corepressor complexes CoREST, mSin3 and NuRD. These complexes are targeted to specific genomic sequences by interactions with seque ...
... to be recruited by transcription factors such as YY1, SP1/SP3, the tumor suppressor genes p53 and BRCA1. HDAC2 can also be tethered to DNA as a part of the multiprotein corepressor complexes CoREST, mSin3 and NuRD. These complexes are targeted to specific genomic sequences by interactions with seque ...
Hammond 1 Regulation of gene expression during flocculation in
... plasmids, showing two distinct bands (one corresponding to the vector and one to the insert) were sent to sequencing for confirmation (Molecular Biology Core Facility, UTK). The plasmids for which the DNA sequence was confirmed were then digested with XhoI and EcoRI and analyzed on agarose gel elect ...
... plasmids, showing two distinct bands (one corresponding to the vector and one to the insert) were sent to sequencing for confirmation (Molecular Biology Core Facility, UTK). The plasmids for which the DNA sequence was confirmed were then digested with XhoI and EcoRI and analyzed on agarose gel elect ...
Hemolytic anemias - Hemoglobinopathies
... • There are normally four alpha chains, so there is a great variety in the severity of the disease. • At birth there are excess chains and later there are excess chains. These form stable, nonfunctional tetramers that precipitate as the RBCs age leading to decreased RBC survival. • The disease i ...
... • There are normally four alpha chains, so there is a great variety in the severity of the disease. • At birth there are excess chains and later there are excess chains. These form stable, nonfunctional tetramers that precipitate as the RBCs age leading to decreased RBC survival. • The disease i ...
FEMS Microbiology Letters
... G, similar to that in the comA null mutant (data not shown), indicating that the unphosphorylated form of ComA does not appear to have a role in the regulation of srfA. All of these results indicate that the majority of srfA expression during growth in DSM-G, in particular at late-growth phase, does ...
... G, similar to that in the comA null mutant (data not shown), indicating that the unphosphorylated form of ComA does not appear to have a role in the regulation of srfA. All of these results indicate that the majority of srfA expression during growth in DSM-G, in particular at late-growth phase, does ...
Soft inheritance: Challenging the Modern Synthesis
... that are not the result of DNA differences. It occurs during cell division in prokaryotes and mitotic cell division in the soma of eukaryotes. Sometimes it also occurs during the meiotic divisions in the germline that give rise to sperm or eggs, so offspring may inherit epigenetic variations through ...
... that are not the result of DNA differences. It occurs during cell division in prokaryotes and mitotic cell division in the soma of eukaryotes. Sometimes it also occurs during the meiotic divisions in the germline that give rise to sperm or eggs, so offspring may inherit epigenetic variations through ...
reproduction
... Although the exact ontogeny of events remains controversial (Li 2002), it is likely that when regions of active chromatin are silenced, histone deacetylases remove acetylation from the histones. If the genome is to be permanently silenced in this region (rather than just transiently, e.g. during the ...
... Although the exact ontogeny of events remains controversial (Li 2002), it is likely that when regions of active chromatin are silenced, histone deacetylases remove acetylation from the histones. If the genome is to be permanently silenced in this region (rather than just transiently, e.g. during the ...
CpG methylation analysis from targeted
... RainDance Technologies (RDT) has extended the capabilities of the RDT 1000 to target genomic regions of bisulfite converted DNA. This approach used in conjunction with highthroughput sequencing enables researchers to measure the methylation status of targeted regions of the genome with complete sequ ...
... RainDance Technologies (RDT) has extended the capabilities of the RDT 1000 to target genomic regions of bisulfite converted DNA. This approach used in conjunction with highthroughput sequencing enables researchers to measure the methylation status of targeted regions of the genome with complete sequ ...
Recent retrotransposition events have not affected
... New TEs are correlated with, but not causal to, an increase in expression divergence between human and chimpanzee. (However, TEs may still contribute substantially to within-species variation). We do not find evidence for a TE-induced increase in transcript ...
... New TEs are correlated with, but not causal to, an increase in expression divergence between human and chimpanzee. (However, TEs may still contribute substantially to within-species variation). We do not find evidence for a TE-induced increase in transcript ...
Interplay between the transcription factors acting on
... DNA-binding proteins possessing homologous GATA-type zinc fingers: two activators (Gln3 and Gat1/Nil1) and two repressors (Dal80/Uga43 and Gzf3/Deh1/Nil2). In the presence of preferred nitrogen sources, the GATA activators are sequestered in the cytoplasm by Ure2, whereas after depletion of the repr ...
... DNA-binding proteins possessing homologous GATA-type zinc fingers: two activators (Gln3 and Gat1/Nil1) and two repressors (Dal80/Uga43 and Gzf3/Deh1/Nil2). In the presence of preferred nitrogen sources, the GATA activators are sequestered in the cytoplasm by Ure2, whereas after depletion of the repr ...
Youngson and Whitelaw, 2008
... Transgenerational Epigenetic Effects Neil A. Youngson and Emma Whitelaw Department of Population Studies and Human Genetics, Queensland Institute of Medical ...
... Transgenerational Epigenetic Effects Neil A. Youngson and Emma Whitelaw Department of Population Studies and Human Genetics, Queensland Institute of Medical ...
overview of depression - Innovative Educational Services
... neural circuits – networks of interconnected nerve cells in the brain, interactions among which form the basis for normal and abnormal behaviors. Researchers hypothesize that abnormalities in the structure and/or function of certain brain circuits could underlie bipolar and other mood disorders. Bet ...
... neural circuits – networks of interconnected nerve cells in the brain, interactions among which form the basis for normal and abnormal behaviors. Researchers hypothesize that abnormalities in the structure and/or function of certain brain circuits could underlie bipolar and other mood disorders. Bet ...
