Mitotic Spindle Assembly by Two Different Pathways in Vitro
... vitro are strongly biased towards chromatin, but this does not depend on specific kinetochore-microtubule ...
... vitro are strongly biased towards chromatin, but this does not depend on specific kinetochore-microtubule ...
PDF reprint - Stanford Medicine
... Drosophila genomic DNA and obtained six DNA fragments that satisfied genetic criteria in yeast for Tin binding sites (Figure 1B). Most of the genomic DNA fragments were isolated multiple times. Sequence analysis confirmed the presence of core recognition sites for NK class homeodomains in all of the ...
... Drosophila genomic DNA and obtained six DNA fragments that satisfied genetic criteria in yeast for Tin binding sites (Figure 1B). Most of the genomic DNA fragments were isolated multiple times. Sequence analysis confirmed the presence of core recognition sites for NK class homeodomains in all of the ...
Gene Section ATF4 (activating transcription factor 4 (tax responsive enhancer element B67)) -
... Implication of ATF4 in disease comes mainly from transgenic and in vitro studies. Studies in transgenic animals have indicated that ATF4 is required for skeletal and eye development, cellular proliferation, hematopoiesis, and neurological disorders, including memory. ATF4 has also been observed in g ...
... Implication of ATF4 in disease comes mainly from transgenic and in vitro studies. Studies in transgenic animals have indicated that ATF4 is required for skeletal and eye development, cellular proliferation, hematopoiesis, and neurological disorders, including memory. ATF4 has also been observed in g ...
jing is required for wing development and to establish the
... Like most transcription factors, those that are required for PD axis formation in the Drosophila leg have additional and very distinct functions at other stages and tissues during development. For example, dac plays an important role in the development of the eye, central nervous system (CNS), and t ...
... Like most transcription factors, those that are required for PD axis formation in the Drosophila leg have additional and very distinct functions at other stages and tissues during development. For example, dac plays an important role in the development of the eye, central nervous system (CNS), and t ...
Properties of Mitotic and Meiotic Recombination in the
... in the frequency of inter-homolog recombination. They estimated that greater than 90% of the DSBs induced by X-rays in G2 were repaired by sister-chromatid exchange. A variety of other systems for the analysis of sister-chromatid mitotic recombination have been developed (Jackson and Fink, 1981; Sz ...
... in the frequency of inter-homolog recombination. They estimated that greater than 90% of the DSBs induced by X-rays in G2 were repaired by sister-chromatid exchange. A variety of other systems for the analysis of sister-chromatid mitotic recombination have been developed (Jackson and Fink, 1981; Sz ...
An analysis of taenidial fold formation via the study of Blimp-1
... Figure 10: The taenidial folds in the absence of Blimp-1 and pri//////////////////////////////////////69 Figure 11: The rescue of the taenidial folds phenotype in the Sec24CD mutant background//////////////////////////////////////////////////////////////////////////////////////////////////////// ...
... Figure 10: The taenidial folds in the absence of Blimp-1 and pri//////////////////////////////////////69 Figure 11: The rescue of the taenidial folds phenotype in the Sec24CD mutant background//////////////////////////////////////////////////////////////////////////////////////////////////////// ...
Signaling Pathways of Heme Oxygenase
... mice Poss and Tonegawa (1997) have demonstrated that these animals exhibit growth retardation, signs of a normochromic, microcytic anemia and iron overload of the kidney and liver. Moreover, HO-1 deficient mice have a proinflammatory phenotype with an exaggerated activation of mononuclear phagocytes ...
... mice Poss and Tonegawa (1997) have demonstrated that these animals exhibit growth retardation, signs of a normochromic, microcytic anemia and iron overload of the kidney and liver. Moreover, HO-1 deficient mice have a proinflammatory phenotype with an exaggerated activation of mononuclear phagocytes ...
Functional features of RUNX1 mutants in acute
... Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells that typically progresses from a relatively benign chronic phase (CP), which is characterized by massive accumulation of mature granulocytes, to an accelerated phase (AP), and ultimately into termi ...
... Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells that typically progresses from a relatively benign chronic phase (CP), which is characterized by massive accumulation of mature granulocytes, to an accelerated phase (AP), and ultimately into termi ...
The EGF-CFC Protein One-Eyed Pinhead Is Essential for
... maintained at reduced levels in MZoep mutants, establishing that some dorsal gene expression can occur in the absence of oep activity. Previous studies have shown that the dorsal yolk syncytial layer (YSL), an extraembryonic syncytium that underlies the developing embryo after the midblastula stage, ...
... maintained at reduced levels in MZoep mutants, establishing that some dorsal gene expression can occur in the absence of oep activity. Previous studies have shown that the dorsal yolk syncytial layer (YSL), an extraembryonic syncytium that underlies the developing embryo after the midblastula stage, ...
Gbx2 is required for the morphogenesis of the mouse inner ear
... homozygous mutant embryos were analyzed, and a repertoire of phenotypes was observed. We divided the specimens into four categories (I, II, III and IV), based on the severity of the phenotype (Fig. 2, Table 1). Overall, Gbx2 mutant inner ears are usually missing the endolymphatic duct (Table 1, n=18 ...
... homozygous mutant embryos were analyzed, and a repertoire of phenotypes was observed. We divided the specimens into four categories (I, II, III and IV), based on the severity of the phenotype (Fig. 2, Table 1). Overall, Gbx2 mutant inner ears are usually missing the endolymphatic duct (Table 1, n=18 ...
Altered Pax gene expression in murine notochord mutants: the
... is lost at certain stages of development, incompatible with the proper formation of vertebral components at least in the tail. Thus, they are useful tools to investigate the role of the notochord during vertebral column formation in vivo. The identification of events that lead to the premature termi ...
... is lost at certain stages of development, incompatible with the proper formation of vertebral components at least in the tail. Thus, they are useful tools to investigate the role of the notochord during vertebral column formation in vivo. The identification of events that lead to the premature termi ...
The Boron Efflux Transporter ROTTEN EAR Is
... Analogous phenotypic defects were also observed in the female reproductive organs of rte mutants. Wild-type maize ears normally produce multiple rows of spikelets, each containing florets that eventually produce the silks and female gametophytes (Figure 1F). In the Mo17 background, ears of rte-1 muta ...
... Analogous phenotypic defects were also observed in the female reproductive organs of rte mutants. Wild-type maize ears normally produce multiple rows of spikelets, each containing florets that eventually produce the silks and female gametophytes (Figure 1F). In the Mo17 background, ears of rte-1 muta ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... ATF2 is essential in the acetylation of histone H4 and H2B, and thereby may be involved in the modification of the chromatin structure. An ATF2-independent HAT activity is involved in the amino acid regulation of ASNS transcription (Bruhat et al., 2007). The histone variant macroH2A recruitement int ...
... ATF2 is essential in the acetylation of histone H4 and H2B, and thereby may be involved in the modification of the chromatin structure. An ATF2-independent HAT activity is involved in the amino acid regulation of ASNS transcription (Bruhat et al., 2007). The histone variant macroH2A recruitement int ...
Induced Adrenocortical Tumorigenesis in Mice
... adrenal glands of ovariectomized B6AF1 mice contained type A cells that expressed GATA4 antigen (Supplemental Fig. 2C) and type B cells that expressed both GATA4 (Supplemental Fig. 2C) and gremlin (Supplemental Fig. 2E). As in B6D2F1 mice, Gata4 haploinsufficiency mitigated ovariectomy-induced adren ...
... adrenal glands of ovariectomized B6AF1 mice contained type A cells that expressed GATA4 antigen (Supplemental Fig. 2C) and type B cells that expressed both GATA4 (Supplemental Fig. 2C) and gremlin (Supplemental Fig. 2E). As in B6D2F1 mice, Gata4 haploinsufficiency mitigated ovariectomy-induced adren ...
Functional Interactions of Genes Mediating Convergent Extension
... pax6 expression and retina and pigment epithelium development in the median anterior neural tube while promoting pax2 expression and optic stalk differentiation in neighboring tissue (Macdonald et al., 1995). According to this model the temporal and spatial distribution of midline signals including ...
... pax6 expression and retina and pigment epithelium development in the median anterior neural tube while promoting pax2 expression and optic stalk differentiation in neighboring tissue (Macdonald et al., 1995). According to this model the temporal and spatial distribution of midline signals including ...
Ethanol exposure affects gene expression in the embryonic
... identified numerous genes active in this embryonic structure. Among the organizer-specific genes are transcription factors, growth factors and secreted proteins. It is known that the interactions between these organizer-specific genes and others expressed around the blastopore will determine many as ...
... identified numerous genes active in this embryonic structure. Among the organizer-specific genes are transcription factors, growth factors and secreted proteins. It is known that the interactions between these organizer-specific genes and others expressed around the blastopore will determine many as ...
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... lens formation without the formation of the retina has been reported (Mencl, 1903; Spemann, 1912). How the lens develops in these species in the absence of the retina is not understood. The nature of this problem can best be demonstrated by the example of lens formation in the zebrafish retinal home ...
... lens formation without the formation of the retina has been reported (Mencl, 1903; Spemann, 1912). How the lens develops in these species in the absence of the retina is not understood. The nature of this problem can best be demonstrated by the example of lens formation in the zebrafish retinal home ...
Patterning Muscles Using Organizers: Larval Muscle
... often mediated by special cells called muscle organizers. During metamorphosis in Drosophila, a set of larval muscles function as organizers and provide scaffolding for the development of the dorsal longitudinal flight muscles. These organizers undergo defined morphological changes and dramatically ...
... often mediated by special cells called muscle organizers. During metamorphosis in Drosophila, a set of larval muscles function as organizers and provide scaffolding for the development of the dorsal longitudinal flight muscles. These organizers undergo defined morphological changes and dramatically ...
The Boron Efflux Transporter ROTTEN EAR Is
... Analogous phenotypic defects were also observed in the female reproductive organs of rte mutants. Wild-type maize ears normally produce multiple rows of spikelets, each containing florets that eventually produce the silks and female gametophytes (Figure 1F). In the Mo17 background, ears of rte-1 muta ...
... Analogous phenotypic defects were also observed in the female reproductive organs of rte mutants. Wild-type maize ears normally produce multiple rows of spikelets, each containing florets that eventually produce the silks and female gametophytes (Figure 1F). In the Mo17 background, ears of rte-1 muta ...
13 MODIFIED TRUE/FALSE 1
... 2. An extra base could be added to the sequence. 3. One base could be substituted for another within the gene. ...
... 2. An extra base could be added to the sequence. 3. One base could be substituted for another within the gene. ...
The Nodal Pathway Acts Upstream of Hedgehog
... sequences shows that nk2.1a and nk2.1b are paralogs (Figure 1) and are therefore both orthologous to mouse nkx2.1. Expression of both nk2.1a and nk2.1b is initiated toward the end of epiboly in a stripe of cells in the medial anterior neural plate (Figures 2A and 2B), a region that gives rise to the ...
... sequences shows that nk2.1a and nk2.1b are paralogs (Figure 1) and are therefore both orthologous to mouse nkx2.1. Expression of both nk2.1a and nk2.1b is initiated toward the end of epiboly in a stripe of cells in the medial anterior neural plate (Figures 2A and 2B), a region that gives rise to the ...
Could distal MSH2 upstream deletions cause HNPCC?
... of morphogenetic ligands while migrating to the villus, before being shed in the lumen. Right: a schematic description of the differentiation pathways in the gut epithelium. BMP, bone morphogeneic protein; TGFβ, transforming growth factor β. ...
... of morphogenetic ligands while migrating to the villus, before being shed in the lumen. Right: a schematic description of the differentiation pathways in the gut epithelium. BMP, bone morphogeneic protein; TGFβ, transforming growth factor β. ...
SPATULA, a bHLH carpel development gene
... develop specialised tissues that facilitate the passage of the male gametophyte from the exterior to the ovules located within. These tissues usually develop from the carpel margins and include a stigma on which pollen alights, and transmitting tissues within the style and ovary through which the po ...
... develop specialised tissues that facilitate the passage of the male gametophyte from the exterior to the ovules located within. These tissues usually develop from the carpel margins and include a stigma on which pollen alights, and transmitting tissues within the style and ovary through which the po ...
Sporulation in BhciZZus subtilis 168. Control of
... Mapping ofpho mutants. Transducing lysates of phosphatase mutants were prepared from subcultures of the original isolates using phage PBS-I as described by Karamata & Gross (1970) and adapted by Coote (rgpb). The lysates were used to transduce auxotrophic strains, essentially as described by Coote ( ...
... Mapping ofpho mutants. Transducing lysates of phosphatase mutants were prepared from subcultures of the original isolates using phage PBS-I as described by Karamata & Gross (1970) and adapted by Coote (rgpb). The lysates were used to transduce auxotrophic strains, essentially as described by Coote ( ...
