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Presentation
Presentation

... 1. Singh A, Chauhan V, Sodhi A, Bhatnagar R. Asp 187 and Phe 190 residues in lethal factor are required for the expression of anthrax lethal toxin activity. FEMS Microbiol Lett. 2002 Jul 2; 212(2):183-6. 2. Gupta P, Singh A, Chauhan V, Bhatnagar R. Involvement of residues 147VYYEIGK153 in binding of ...
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of

... PKC activation that lead to phosphorylation of the SNARE proteins and granule release. Activation of several chemoattractant receptors results in leukocyte degranulation. However, it is unclear whether chemoattractant-induced degranulation uses the same mechanisms as those triggered by Fc␧RI cross-l ...
Chapter 19
Chapter 19

... common metabolic pathway, an imaginary funnel representing what happens in the cell. ...
Fuelling the future: microbial engineering for the production
Fuelling the future: microbial engineering for the production

... To keep energy supply sustainable while mitigating the CO2 problem, the ultimate energy source must come from the sun, which radiates 120,000 TW of energy to Earth. This is much larger than the total energy demand of humans, which is 13 TW currently161. Direct harvesting of solar energy using photov ...
New insight into pathogenesis of medical diseases
New insight into pathogenesis of medical diseases

Protocol S1.
Protocol S1.

... precision levels near 90% and obtains reasonable sensitivity (Figure 2b). We also found that Relevance networks constructed using correlation (specifically correlation-squared) as a metric of dependency between two variables outperform networks constructed using mutual information (Figure S7b). This ...
Building Triketide α-Pyrone-Producing Yeast Platform Using
Building Triketide α-Pyrone-Producing Yeast Platform Using

... prolonged desiccation, and exposure to UV radiation from the harsh terrestrial environment [1-3, 17, 18]. The chemical composition of sporopollenin remains poorly characterized because it is extremely resistant to chemical and biological degradation procedures. Recent studies have shown that hydroxy ...
E ect of SB 203580 on the activity of c-Raf in vitro and in vivo
E ect of SB 203580 on the activity of c-Raf in vitro and in vivo

... members of the mitogen-activated protein (MAP) kinase family, but other members of this gene family are insensitive to SB 203580. These include SAPK3 (p38g) and SAPK4 (p38d) whose amino acid sequences are 60% identical to SAPK2a/p38 or SAPK2b/p38b2 (Goedert et al., 1997). SB 203580 also fails to inh ...
Proliferation-Independent Control of Tumor Glycolysis by PDGFR
Proliferation-Independent Control of Tumor Glycolysis by PDGFR

... had evidence of altered PDGF/PDGFR signaling did not bear mutated IDH1 (17). This dichotomy suggested to us that studying the role of an RTK, namely PDGFR, in regulating glioma glucose metabolism might be productively pursued in proneural glioma with normal IDH1 and activation of the PDGF/PDGFR grow ...
Converting Sugars to Biofuels: Ethanol and Beyond
Converting Sugars to Biofuels: Ethanol and Beyond

... to the relative technological maturity in genetically engineering these microbes. Other species have also been considered as production hosts due to advantages of their native enzymes and pathways. For instance, Zymommonas mobilis has been suggested as an alternative host to yeast due to its advanta ...
Document
Document

... This as a guide and does not replace your notes! Fig. 9.11 overview of citric acid cycle (NADH, FADH2, ATP and CO2 produced) Fig. 9.12 closer look at the Citric acid cycle 9.4 Oxidative phosphorylation, chemiosmosis couples electron transport to ATP synthesis Most of the ATP is produced in this Step ...
All Proteins Have a Basic Molecular Formula
All Proteins Have a Basic Molecular Formula

... further subdivided on the basis of similarities in enzyme reaction mechanisms, participation in biochemical pathways, functional roles, and cellular localization [3]. Although structural classifications are probably well defined on the basis of the criterion of molecular similarity, their overlap is ...
aerobic respiration
aerobic respiration

... Has membrane potential Cristae ↑ surface area of inner membrane, which ↑ capacity to generate ATP Matrix Contains 100s of enzymes which oxidize pyruvate and fatty acids, and control the Krebs cycle ...
Molecular cloning of Drosophila Rh6 rhodopsin: the
Molecular cloning of Drosophila Rh6 rhodopsin: the

... Conserved proline residues in the membrane-embedded portion of Rh6 are present in TM II (Pro102 ), TM IV (Pro181 ), TM V (Pro223 ), TM VI (Pro289 ) and TM VII (Pro324 ). Due to their ability of cis-trans isomerization, it has been suggested that these prolines serve a function in signal transduction ...
Table S6: Domains present in the primary network generated from
Table S6: Domains present in the primary network generated from

... This presumed domain is functionally uncharacterised. This uncharacterised family of proteins are principally found in cyanobacteria. This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been defined. This family of proteins are functionally uncharact ...
Protein Stability Protein Folding
Protein Stability Protein Folding

... give more stable but less active protein. • Activity can then be increased further at an unacceptable expense to stability. • Active site of enzymes and binding sites of proteins are a general source of instability, because they contain groups that are exposed to solvent in order to bind substrates ...
PURIFICATION OF TAP TAGGED YEAST PROTEINS  Annika Väntänen
PURIFICATION OF TAP TAGGED YEAST PROTEINS Annika Väntänen

... long-chain fatty acids. These mitochondrially synthesised long-chain fatty acids, for example 3-hydroxymyristoyl-ACP, are possibly used for protein acylation which is one type of lipid modifications of proteins. The best characterised physiological function of the pathway is to provide the octanoyl ...
Peroxisomes: family of versatile organelles
Peroxisomes: family of versatile organelles

... intracellular signalling molecules such as growth factors, hypolipidemic compounds, ROS or fatty acids bind to specific nuclear receptors (e.g. PPARα) leading to PPAR-dependent and potentially to PPAR-independent signalling pathways. ...
How did LUCA make a living?
How did LUCA make a living?

... using redox reactions at their plasma membrane, while the majority of heterotrophs, too, depend on oxidative phosphorylation – a process in which oxygen is just one of many possible terminal electron acceptors, like CO2 or ferric iron. Furthermore, essentially all fermenters retain some additional m ...
Transgenic Plant Cells Lacking Mitochondrial Alternative
Transgenic Plant Cells Lacking Mitochondrial Alternative

... damage to the mitochondrion or by acting as signaling molecules in the death pathway. It is unclear to what extent PCD events in plants are similar to those in animals. For example, although there is recent evidence for the release of cyt c from the mitochondrion during plant PCD (Sun et al., 1999; ...
Pharmacolecture 12 - pharmacology1lecnotes
Pharmacolecture 12 - pharmacology1lecnotes

... The actions of histamine are mediated by at least three distinct receptors: H1, H2, and H3. Of these, the H1 and H2 receptors are the best characterized and mediated welldefined response in humans that have been used as the basis for drug development. Response such as bronchoconstriction are mediat ...
Role of Bioinformatics Tools in Biological Research GPS
Role of Bioinformatics Tools in Biological Research GPS

... Drug: Kill invaders/pathogens and/or Inhibit the growth of pathogens ...
Supplementary information
Supplementary information

... To account for the bidirectional effect between the microenvironment and cellular behavior, we have developed a model of cellular metabolism that consumes nutrients from the extracellular environment and produces waste products. The conversion of extracellular nutrients into energy is a fundamental ...
Oxidative Medicine and Cellular Longevity Special Issue
Oxidative Medicine and Cellular Longevity Special Issue

... reactive electrophile products of lipid peroxidation, and maintains the thiol status of proteins. When GSH reacts with oxidants, it is oxidized to its disulfide form (GSSG), and thus the glutathione redox ratio (GSSG/GSH) is considered as an index of oxidative stress. GSH also regulates critical cel ...
Correlating mRNA and protein Abundance
Correlating mRNA and protein Abundance

... Yeast growth under two different media r = 0.45 but almost 1.0 for same loci in same pathway ...
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Biochemical cascade

A biochemical cascade (or a signaling pathway) is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.
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