FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that
... couples Fas to procaspase-8, and Daxx, which couples Fas to the Jun NH2-terminal kinase pathway, bind independently to the Fas death domain. We have identified a 130-kD kinase designated Fas-interacting serine/threonine kinase/homeodomain-interacting protein kinase (FIST/HIPK3) as a novel Fas-intera ...
... couples Fas to procaspase-8, and Daxx, which couples Fas to the Jun NH2-terminal kinase pathway, bind independently to the Fas death domain. We have identified a 130-kD kinase designated Fas-interacting serine/threonine kinase/homeodomain-interacting protein kinase (FIST/HIPK3) as a novel Fas-intera ...
Transcriptional activity and role of plasmids of
... Approximately 64% of the Pc34434568 genome was significantly DE (SDE; P-adjusted < 0.1) during growth in 35 BU hop extract, whereas only 23% of the Lb464 genome was SDE during growth in 50 BU hop extract (Table 1). Furthermore, a higher number of highly SDE genes was seen for Pc344 than for Lb464, w ...
... Approximately 64% of the Pc34434568 genome was significantly DE (SDE; P-adjusted < 0.1) during growth in 35 BU hop extract, whereas only 23% of the Lb464 genome was SDE during growth in 50 BU hop extract (Table 1). Furthermore, a higher number of highly SDE genes was seen for Pc344 than for Lb464, w ...
Adv. Bio. Ch 9 Glyco and Resp
... Glycolysis means “splitting of sugar” glucose (6C) 2 pyruvate (3C) 10 steps of glycolysis each with their own enzyme are broken down into two phases: energy ...
... Glycolysis means “splitting of sugar” glucose (6C) 2 pyruvate (3C) 10 steps of glycolysis each with their own enzyme are broken down into two phases: energy ...
Orphan nuclear receptors: therapeutic opportunities in skeletal muscle
... C203–C217, 2006; doi:10.1152/ajpcell.00476.2005.—Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that bind DNA and translate physiological signals into gene regulation. The therapeutic utility of NRs is underscored by the diversity of drugs created to manage dysfunctional ...
... C203–C217, 2006; doi:10.1152/ajpcell.00476.2005.—Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that bind DNA and translate physiological signals into gene regulation. The therapeutic utility of NRs is underscored by the diversity of drugs created to manage dysfunctional ...
The ADP-dependent sugar kinase family
... ATP-dependent kinases. As they were first identified in members of the thermococcales it was proposed that the presence of these ADP-dependent kinases is an adaptation to high temperatures. Later, homologs of these enzymes were identified in the genomes of mesophilic and thermophilic methanogenic ar ...
... ATP-dependent kinases. As they were first identified in members of the thermococcales it was proposed that the presence of these ADP-dependent kinases is an adaptation to high temperatures. Later, homologs of these enzymes were identified in the genomes of mesophilic and thermophilic methanogenic ar ...
Lecture 28 - Citrate Cycle
... isocitrate by transferring two electrons to NAD+ to form NADH, and in the process, releasing CO2, it is activated by ADP and Ca2+ and inhibited by NADH and ATP. α-ketoglutarate dehydrogenase - functionally similar to pyruvate dehydrogenase in that it is a multisubunit complex, requires the same five ...
... isocitrate by transferring two electrons to NAD+ to form NADH, and in the process, releasing CO2, it is activated by ADP and Ca2+ and inhibited by NADH and ATP. α-ketoglutarate dehydrogenase - functionally similar to pyruvate dehydrogenase in that it is a multisubunit complex, requires the same five ...
biosynthesis
... important part of eicosanoid biosynthesis - part of defense against bacteria, viruses (attack of membranes) - can hydrolyze oxidized PUFAs in PL - inhibited by glucocorticoids - PLA2 in snake venom – generated lysoPL are effective detergents erythrocyte lysis ...
... important part of eicosanoid biosynthesis - part of defense against bacteria, viruses (attack of membranes) - can hydrolyze oxidized PUFAs in PL - inhibited by glucocorticoids - PLA2 in snake venom – generated lysoPL are effective detergents erythrocyte lysis ...
A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is
... new type of GATA-binding transactivator via binding to D1CONS.15 However, GAL4-EVI1 and GAL4-MDS1/EVI1 fusion proteins showed transcription repressor activity that was dependent on GAL4 DNA-binding capability.16 Moreover, EVI1 can bind to transcriptional repressor cofactors (adenovirus E1A C-termina ...
... new type of GATA-binding transactivator via binding to D1CONS.15 However, GAL4-EVI1 and GAL4-MDS1/EVI1 fusion proteins showed transcription repressor activity that was dependent on GAL4 DNA-binding capability.16 Moreover, EVI1 can bind to transcriptional repressor cofactors (adenovirus E1A C-termina ...
Energy Metabolism Regulating Mammalian Oocyte
... oocytes progress through meiotic maturation from the GV to MII stage (Spindler et al., 2000). These same investigators also demonstrated that developmental competence postfertilization, including the ability to advance to the blastocyst embryos, directly depended on glycolytic rate. Although PPP doe ...
... oocytes progress through meiotic maturation from the GV to MII stage (Spindler et al., 2000). These same investigators also demonstrated that developmental competence postfertilization, including the ability to advance to the blastocyst embryos, directly depended on glycolytic rate. Although PPP doe ...
Transcriptome analysis reveals unique C4
... under nitrogen starvation for 27 d, its ArA content increased from 1.9% to 7.0% of dry weight (DW) biomass and 76% of the intracellular ArA accumulated in the form of neutral lipids [10]. In addition, carotenoids content increased as well under nitrogen starvation in Parietochloris incisa (synonym w ...
... under nitrogen starvation for 27 d, its ArA content increased from 1.9% to 7.0% of dry weight (DW) biomass and 76% of the intracellular ArA accumulated in the form of neutral lipids [10]. In addition, carotenoids content increased as well under nitrogen starvation in Parietochloris incisa (synonym w ...
TCA cycle cross products (also known as “nothing is simple” My
... molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes tha ...
... molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes tha ...
MOA slides - Epilepsy
... AMPA receptors mediate glutamate fast signalling • AMPA receptors are the most abundant ionotropic glutamate receptors in the mammalian brain • They are localised at excitatory synapses, post-synaptically • AMPA receptors mediate the fast response to glutamate – Generate the fast component of the e ...
... AMPA receptors mediate glutamate fast signalling • AMPA receptors are the most abundant ionotropic glutamate receptors in the mammalian brain • They are localised at excitatory synapses, post-synaptically • AMPA receptors mediate the fast response to glutamate – Generate the fast component of the e ...
EPISTASIS & METABOLISM Presented by Chintan Joshi
... - Our method can not evaluate effects of intragenic mutations which affect the protein properties. This can be fixed by partially shutting off fluxes. - Our method is not capturing the effect of mutations which might allow survivability even if the organisms growth requirements are not met exactly. ...
... - Our method can not evaluate effects of intragenic mutations which affect the protein properties. This can be fixed by partially shutting off fluxes. - Our method is not capturing the effect of mutations which might allow survivability even if the organisms growth requirements are not met exactly. ...
Identification of proteins that putatively bind the
... Stomata are microscopic epidermal pores surrounded by two specialized cells, called guard cells. These structures play two important physiological roles in plants: acquisition of CO2, a crucial raw material for photosynthesis, through diffusion; and evaporative cooling through transpiration. Stomata ...
... Stomata are microscopic epidermal pores surrounded by two specialized cells, called guard cells. These structures play two important physiological roles in plants: acquisition of CO2, a crucial raw material for photosynthesis, through diffusion; and evaporative cooling through transpiration. Stomata ...
Obesity and the regulation of fat metabolism
... spectrometry (GC/MS; Kniazeva et al., 2003; Satouchi et al., 1993; Watts and Browse, 2002). Triacylglyceride fat stores make up approximately 40–55% of total lipids depending on diet and growth stage (Ashrafi, 2006). Phospholipids pools are composed of approximately 55% ethanolamine glycerophospholi ...
... spectrometry (GC/MS; Kniazeva et al., 2003; Satouchi et al., 1993; Watts and Browse, 2002). Triacylglyceride fat stores make up approximately 40–55% of total lipids depending on diet and growth stage (Ashrafi, 2006). Phospholipids pools are composed of approximately 55% ethanolamine glycerophospholi ...
Source–Sink Relationships
... assimilate accumulation in source leaves. This causes decreased expression of genes coding for photosynthetic components and results in a lowering of photosynthetic capacity. Hence, the capacity of the sink can regulate the activity of the source. ...
... assimilate accumulation in source leaves. This causes decreased expression of genes coding for photosynthetic components and results in a lowering of photosynthetic capacity. Hence, the capacity of the sink can regulate the activity of the source. ...
BE100a - Interchim
... This cycle begins with one pyruvate molecule that, after a series of chemical reactions, is input into the cycle as oxaloacetic acid. The cycle begins and ends with oxaloacetic acid, which undergoes a series of enzyme-initiated chemical reactions during the cycle to produce energy. In the citric aci ...
... This cycle begins with one pyruvate molecule that, after a series of chemical reactions, is input into the cycle as oxaloacetic acid. The cycle begins and ends with oxaloacetic acid, which undergoes a series of enzyme-initiated chemical reactions during the cycle to produce energy. In the citric aci ...
Glycolysis
... 2. However, when oxygen is available (aerobic respiration), and cytosolic NADH can be oxidized by ETC generating ATP and pyruvate can also enter the mitochondria and be completely oxidized to CO2 via Pyruvate dehydrogenase reaction and the TCA cycle giving more ATP. The oxidation of pyruvate by PDH ...
... 2. However, when oxygen is available (aerobic respiration), and cytosolic NADH can be oxidized by ETC generating ATP and pyruvate can also enter the mitochondria and be completely oxidized to CO2 via Pyruvate dehydrogenase reaction and the TCA cycle giving more ATP. The oxidation of pyruvate by PDH ...
A point mutation in the Ch3 domain of human IgG3... secretion without affecting antigen specificity
... such vectors into mammalian cells and for harvesting of antibodies from culture supernatants are well established. However, despite the power of this technology, the production of antibodies in this way can be problematic. The recombinant antibodies are generally secreted at lower rates than traditi ...
... such vectors into mammalian cells and for harvesting of antibodies from culture supernatants are well established. However, despite the power of this technology, the production of antibodies in this way can be problematic. The recombinant antibodies are generally secreted at lower rates than traditi ...
Gas-Chromatography Mass-Spectrometry (GC
... distinctive gene and metabolic networks. In addition there is accumulating evidence of horizontal gene transfer among marine organisms especially from bacteria to algae [2,3] by means of which algae could involve new enzymes into their metabolic networks. Such an evolutional background renders algae ...
... distinctive gene and metabolic networks. In addition there is accumulating evidence of horizontal gene transfer among marine organisms especially from bacteria to algae [2,3] by means of which algae could involve new enzymes into their metabolic networks. Such an evolutional background renders algae ...
ETs08
... This pathway skips two decarboxylations, so it produces less NADH but doesn’t lose as much carbon Net reaction enables creation of oxaloacetate that can go into gluconeogenesis ...
... This pathway skips two decarboxylations, so it produces less NADH but doesn’t lose as much carbon Net reaction enables creation of oxaloacetate that can go into gluconeogenesis ...