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- Wiley Online Library
- Wiley Online Library

... fermentation in the absence of electron acceptors. Regulatory mechanisms have evolved allowing cells to shift to these metabolic capabilities in response to changes in oxygen availability. These include transcriptional activation of fnr upon oxygen limitation, a process requiring the ResD-ResE two-c ...
The acetyl-CoA pathway of autotrophic growth
The acetyl-CoA pathway of autotrophic growth

... For the most part, following this initial synthesis, the other mechanisms of CO2 fixation, the synthesis of fatty acids, carbohydrates, proteins and nucleic acids are similar to those used by organisms that require organic carbon for growth. Prior to the discovery of the acetyl-CoA pathway, there we ...
UvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository)

... Abstract: Modifying substrate uptake systems is a potentially powerful tool in metabolic engineering. This research investigates energetic and metabolic changes brought about by the genetic modification of the glucose uptake and phosphorylation system of Escherichia coli. The engineered strain PPA31 ...
review on enhancement of glucose uptake and up
review on enhancement of glucose uptake and up

... The hydroalcoholic extract of the leaves of P. americana decreased blood glucose levels and enhanced the metabolic state of the animals. PKB activation was observed in the liver and skeletal muscle of treated rats when compared with untreated diabetic rats. This result showed that the hydroalcoholic ...
Exploring Tomato Gene Functions Based on Coexpression Modules
Exploring Tomato Gene Functions Based on Coexpression Modules

... quantitative real-time polymerase chain reaction. Our findings suggest that differential coexpression may assist in the investigation of key regulatory steps in metabolic pathways. The approaches and results reported here will be useful to prioritize candidate genes for further functional genomics s ...
Preview as PDF - Pearson Higher Education
Preview as PDF - Pearson Higher Education

... Cellular respiration occurred in this baby’s cells before she was born, but the oxygen and sugar her cells required were delivered from her mother’s blood. Now this baby takes in her own oxygen—although she still can’t obtain her own food. And if Can brown fat keep a this baby is exposed to the cold ...
Muscle Metabolism - Interactive Physiology
Muscle Metabolism - Interactive Physiology

... 22. a. Creatine phosphate and anaerobic metabolism is more important when sprinting very fast for a short distance because it provides small amounts of ATP quickly, without the need for oxygen. b. When slow jogging for a long distance aerobic respiration (Krebs cycle and oxidative phosphorylation) i ...
MS Word Version - Interactive Physiology
MS Word Version - Interactive Physiology

... When slow jogging for a long distance aerobic respiration (Krebs cycle and oxidative phosphorylation) is more important since it provides a relatively slow, but long-lasting source of ATP. 23. The muscle cell has less creatine phosphate, oxygen (attached to myoglobin) and glycogen. In addition, lact ...
Probability-Based Scoring Function as a Software
Probability-Based Scoring Function as a Software

... Bangmod, Thungkru, Bangkok 10140, Thailand; 2BEC Unit, KMUTT-Bangkhuntien, 83 Moo 8, Thakham, Bangkhuntien, Bangkok 10150, Thailand; 3School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand Abstract: One of the major goals of proteomic researc ...
A multi-tissue type genome-scale metabolic network for analysis of
A multi-tissue type genome-scale metabolic network for analysis of

... metabolic network reconstruction workflow used to establish the three networks is depicted in Figure 2. First, the human genome sequence and annotation was updated in the SimPheny™ modeling platform (Genomatica, Inc.) from Build 35 to Build 36.2. Utilizing tissue-specificity information from UniProt ...
Enzymes | Principles of Biology from Nature Education
Enzymes | Principles of Biology from Nature Education

... can also be composed of RNA, in which case they are called ribozymes. Enzymes interact with specific molecules, allowing them to proceed down a specific biochemical pathway. For example, enzymes are necessary to produce a consistent and abundant supply of ATP, which provides the energy required by c ...
Bypassing the glucose/fatty acid cycle: AMP
Bypassing the glucose/fatty acid cycle: AMP

... is supported by the finding that leptin activates AMPK in H-2Kb muscle cells in culture. In contrast, a slower (6-h) response appears to be mediated via the hypothalamus and stimulation of α-adrenergic receptors. The precise molecular mechanism(s) by which leptin activates AMPK are not fully underst ...
Bio 226: Cell and Molecular Biology
Bio 226: Cell and Molecular Biology

... c) CO2 is an allosteric activator of rubisco that only binds at high pH and high [Mg2+] also: stomates open in the light ...
Full-Text PDF
Full-Text PDF

The RAVEN Toolbox and Its Use for Generating a Genome
The RAVEN Toolbox and Its Use for Generating a Genome

... well as sub-cellular localization of enzymes. Most importantly, the model must also be constructed in a way so that all reactions are balanced and well-connected [15]. This tends to become a problem if the gene-reaction relationship is automatically inferred from databases, partly due to differences ...
iRsp1095: A genome-scale reconstruction of the Rhodobacter
iRsp1095: A genome-scale reconstruction of the Rhodobacter

Problem Set 1
Problem Set 1

... The COX-2 pathway was discovered in 1991 and, because it is upregulated during inflammation, it was anticipated that this would be a more specific target than COX-1 (which produces homeostatic prostaglandins and is therefore always active). ...
DEPARTMENT OF BIOCHEMISTRY UNIVERSITY OF KERALA
DEPARTMENT OF BIOCHEMISTRY UNIVERSITY OF KERALA

... Nucleotide metabolism- de novo and salvage pathway of nucleotide synthesis, Regulation of metabolic pathways. Metabolic status and co-ordinated regulation in different physiological conditions. Associated metabolic disorders BCH 524 ...
A systems biology approach sheds new light on the regulation of
A systems biology approach sheds new light on the regulation of

... the molecular basis of acid resistance have focused on mechanisms related to proton scavenging. In my work I hypothesized that acid resistance may require the coordinate regulation of a broader spectrum of molecular pathways. I tested this hypothesis by using an Integrative Biology approach based on ...
Angiogenesis PCR Array
Angiogenesis PCR Array

... The Human Apoptosis RT² Profiler PCR Array 384HT profiles the expression of 370 key genes involved in apoptosis, or programmed cell death. The array includes the TNF ligands and their receptors; members of the bcl-2 family, BIRC (baculoviral IAP repeat) domain proteins, CARD domain (caspase recruitm ...
SPECIFIC PROTEIN SYNTHESIS IN CELLULAR
SPECIFIC PROTEIN SYNTHESIS IN CELLULAR

... of the proteinaceous eggshell (chorion) . These cells can be maintained and labeled efficiently in organ culture ; their in vitro (and cell free) protein synthetic activity reflects their activity in vivo . During differentiation the cells undergo dramatic changes in protein synthesis . For 2 days t ...
Threonine Metabolism via Two-carbon Compounds
Threonine Metabolism via Two-carbon Compounds

... oxidized an equimolar mixture of these compounds. It appeared likely that acetyl-CoA was oxidized via the TCA cycle and that glycine was metabolized by a pathway functioning anaplerotically. L-Threonine dehydrogenase formation induced by growth on threonine indicated that the initial step of threoni ...
Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae.
Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae.

... underlying pathways can show high levels of correlation [18]. This is especially true in the case of global perturbations (e.g., nutrient starvation, diurnal cycles) which affect many different branches of metabolism at once [19]. It is therefore likely that the interpretation of correlations betwee ...
PPT
PPT

... •Using perturbagen responses to map signaling pathways in normal and diseased liver: Collaboration with Vertex. ...
GABA RECEPTORS GABA RECEPTORS
GABA RECEPTORS GABA RECEPTORS

... GABA is the major inhibitory amino acid transmitter of the mammalian central nervous system and it is present in some 40% of all neurones. Most of the early studies, carried out with iontophoretic application of GABA in the CNS, indicated that it generally produced inhibitory hyperpolarizing respons ...
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Biochemical cascade

A biochemical cascade (or a signaling pathway) is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.
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