Phylogenomic Investigation of Phospholipid Synthesis in Archaea
... eukaryotic and the bacterial sequences, suggesting that these sequences could be ancestral versions that would have been lost in the rest of archaea [31]. If this is the case, a eukaryoticlike pathway (except for the IDI function, which remains ambiguous) can be proposed to have existed in the cenan ...
... eukaryotic and the bacterial sequences, suggesting that these sequences could be ancestral versions that would have been lost in the rest of archaea [31]. If this is the case, a eukaryoticlike pathway (except for the IDI function, which remains ambiguous) can be proposed to have existed in the cenan ...
Exploration of mutations in erythroid 5
... Table 1.1. Genes encoding heme biosynthesis enzymes implicated in inherited porphyrias........................................................................... 31 Table 2.1. Plasmid constructs used to express murine ALAS2 variants in mammalian cell lines. .......................................... ...
... Table 1.1. Genes encoding heme biosynthesis enzymes implicated in inherited porphyrias........................................................................... 31 Table 2.1. Plasmid constructs used to express murine ALAS2 variants in mammalian cell lines. .......................................... ...
... expression and covalent modifications of proteins. Research findings that have been generated by using molecular techniques have guided us into new territory, going way beyond classical nutrition studies such as characterization of clinical signs of nutrient deficiencies. Those nutritionists who inv ...
The Orphan Transporter Rxt1/NTT4 (SLC6A17)
... revealed an unexpected synaptic vesicle localization for Rxt1/NTT4 in glutamatergic neurons (Fischer et al., 1999; Masson et al., 1999). Based on these observations, it has been suggested that Rxt1/NTT4 might function as a vesicular transporter, or alternatively, reside in intracellular vesicles as ...
... revealed an unexpected synaptic vesicle localization for Rxt1/NTT4 in glutamatergic neurons (Fischer et al., 1999; Masson et al., 1999). Based on these observations, it has been suggested that Rxt1/NTT4 might function as a vesicular transporter, or alternatively, reside in intracellular vesicles as ...
DOC-file of additional text
... allows us not only to ignore unknown genetic interactions among non-metabolic genes, but (more importantly) it overestimates the possible sizes of deleted blocks. 3) If growth rate is nearly unaffected (in this case less than 1% effect), the deletion is assumed to be viable, and the genes are consid ...
... allows us not only to ignore unknown genetic interactions among non-metabolic genes, but (more importantly) it overestimates the possible sizes of deleted blocks. 3) If growth rate is nearly unaffected (in this case less than 1% effect), the deletion is assumed to be viable, and the genes are consid ...
Adenosine triphosphate Adenosine triphosphate Adenosine
... ATP is an unstable molecule in unbuffered water, in which it hydrolyses to ADP and phosphate. This is because the strength of the bonds between the phosphate groups in ATP are less than the strength of the hydrogen bonds (hydration bonds), between its products (ADP + phosphate), and water. Thus, if ...
... ATP is an unstable molecule in unbuffered water, in which it hydrolyses to ADP and phosphate. This is because the strength of the bonds between the phosphate groups in ATP are less than the strength of the hydrogen bonds (hydration bonds), between its products (ADP + phosphate), and water. Thus, if ...
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... axis formation. The hallmark of canonical Wnt signaling is the translocation of β-catenin into the nucleus where it activates gene transcription. However, the mechanisms regulating β-catenin nuclear localization are poorly understood. We show that Simplet/ Fam53B (Smp) is required for Wnt signaling ...
... axis formation. The hallmark of canonical Wnt signaling is the translocation of β-catenin into the nucleus where it activates gene transcription. However, the mechanisms regulating β-catenin nuclear localization are poorly understood. We show that Simplet/ Fam53B (Smp) is required for Wnt signaling ...
Glutamine and glutamate—their central role in cell metabolism and
... ATP channels, membrane depolarization, opening of voltage-dependent Ca2þ channels (VDCC), an increase in cytosolic Ca2þ concentration and promotion of insulin exocytosis.43 The mitochondria play a critical role, via oxidative phosphorylation, in increasing the ATP/ADP ratio. However, the mitochondri ...
... ATP channels, membrane depolarization, opening of voltage-dependent Ca2þ channels (VDCC), an increase in cytosolic Ca2þ concentration and promotion of insulin exocytosis.43 The mitochondria play a critical role, via oxidative phosphorylation, in increasing the ATP/ADP ratio. However, the mitochondri ...
Exploring Mouse Protein Function via Multiple Approaches
... 1% of the more than 13 million protein sequences available have been experimentally annotated with essential functions; the remaining proteins have been marked with putative, uncharacterized, hypothetical, unknown or inferred functions [1]. Although physical experimental approaches, including high-t ...
... 1% of the more than 13 million protein sequences available have been experimentally annotated with essential functions; the remaining proteins have been marked with putative, uncharacterized, hypothetical, unknown or inferred functions [1]. Although physical experimental approaches, including high-t ...
Key area 2 * Cellular respiration
... the chemical energy stored in glucose must be released by all cells through a series of enzyme-controlled reactions called respiration; the energy released from the breakdown of glucose is used to generate ATP from ADP and phosphate; the chemical energy stored in ATP can be released by breaking it d ...
... the chemical energy stored in glucose must be released by all cells through a series of enzyme-controlled reactions called respiration; the energy released from the breakdown of glucose is used to generate ATP from ADP and phosphate; the chemical energy stored in ATP can be released by breaking it d ...
Mechanistic insights into pancreatic beta
... and lipolysis. In the presence of exogenous FFA, cycle ...
... and lipolysis. In the presence of exogenous FFA, cycle ...
AD_________________ Award Number: W81XWH-07-1-0202
... The failure of the current approach to develop an anti-prostate cancer drug for prostate cancer suggests that we need essentially a new approach by defining a specific target molecule in this cancer (1). Traditional screening of anti-cancer drugs has been mostly dependent on growth inhibition assay ...
... The failure of the current approach to develop an anti-prostate cancer drug for prostate cancer suggests that we need essentially a new approach by defining a specific target molecule in this cancer (1). Traditional screening of anti-cancer drugs has been mostly dependent on growth inhibition assay ...
Eater, a Transmembrane Protein Mediating
... that corresponds to a single membrane-spanning receptor with an N-terminal signal sequence and a C-terminal membrane anchor followed by an intracellular domain of 28 amino acids containing a potential tyrosine phosphorylation motif (Figures 2C and 2D). The extracellular domain of the Eater protein i ...
... that corresponds to a single membrane-spanning receptor with an N-terminal signal sequence and a C-terminal membrane anchor followed by an intracellular domain of 28 amino acids containing a potential tyrosine phosphorylation motif (Figures 2C and 2D). The extracellular domain of the Eater protein i ...
Molecular Adaptation of Halophilic Proteins
... Christine Ebel was born on 12 July 1958 in Strasbourg, France. She is a civil service scientist of the Centre National de la Recherche Scientifique, the French national research organization, and works at the Institut de Biologie Structurale, Grenoble, France, where she heads the "Molecular Interact ...
... Christine Ebel was born on 12 July 1958 in Strasbourg, France. She is a civil service scientist of the Centre National de la Recherche Scientifique, the French national research organization, and works at the Institut de Biologie Structurale, Grenoble, France, where she heads the "Molecular Interact ...
... • AMP inhibits fructose bis phosphatase in gluconeogenesis. This is appropriate because you don’t want both pathways on at the same time.(2 pts) Choice B: • Glucagon/epinephrine are secreted to indicate glucose demand, or that the liver should make glucose. • These hormones cause enzyme phosphorylat ...
Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine
... has become a major problem. This situation is partly because today’s antibiotics are mainly based on a limited selection of chemical scaffolds, which makes it easier for bacterial pathogens to quickly develop resistance against new drug derivatives. This recurrent problem of multiple drug resistance ...
... has become a major problem. This situation is partly because today’s antibiotics are mainly based on a limited selection of chemical scaffolds, which makes it easier for bacterial pathogens to quickly develop resistance against new drug derivatives. This recurrent problem of multiple drug resistance ...
Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel
... membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is considered the default destiny of membrane receptors not being ...
... membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is considered the default destiny of membrane receptors not being ...
Energy coupling in Saccharomyces cerevisiae
... conservation of free energy (ATP) during product formation. Product pathways with a positive net ATP yield provide microorganisms with free energy for growth and maintenance processes. However, during industrial production of chemicals, excess microbial biomass constitutes an undesirable byproduct, ...
... conservation of free energy (ATP) during product formation. Product pathways with a positive net ATP yield provide microorganisms with free energy for growth and maintenance processes. However, during industrial production of chemicals, excess microbial biomass constitutes an undesirable byproduct, ...