template
... the metabolism. Proteins are made of building blocks called amino acids. There are 20 different standard amino acid types. A protein’s functions are defined related to which other protein(s) it interacts. One has to understand protein-protein interactions in order to understand all kinds of cellular ...
... the metabolism. Proteins are made of building blocks called amino acids. There are 20 different standard amino acid types. A protein’s functions are defined related to which other protein(s) it interacts. One has to understand protein-protein interactions in order to understand all kinds of cellular ...
SUPPLEMENTAL DATA FOR DUPLICATED SACCHAROMYCES
... than additive, and the role of MCK1 is the most prominent among all four paralogs in yeast [12]. Sequence comparison indicates that all residues important for kinase activity are conserved in MCK1, RIM11 and MRK1, but not in YGK3 [12]. Glycogen synthase kinase-3 is a ubiquitous serine/threonine/tyro ...
... than additive, and the role of MCK1 is the most prominent among all four paralogs in yeast [12]. Sequence comparison indicates that all residues important for kinase activity are conserved in MCK1, RIM11 and MRK1, but not in YGK3 [12]. Glycogen synthase kinase-3 is a ubiquitous serine/threonine/tyro ...
Exploring the Effects of Human Cytomegalovirus Infection on Host
... transcription of mRNA encoding immediate early proteins begins11. The immediate early proteins are all transactivators and coordinate the transcription of the early and late HCMV genes11. Early genes are expressed without viral DNA replication and generally encode proteins that modify host cell func ...
... transcription of mRNA encoding immediate early proteins begins11. The immediate early proteins are all transactivators and coordinate the transcription of the early and late HCMV genes11. Early genes are expressed without viral DNA replication and generally encode proteins that modify host cell func ...
EC->PDB
... been constructed using a combination of manual inspection and automated methods, because current automatic sequence and structure comparison tools cannot identify all structural relationships reliably. Proteins are classified in a hierarchical fashion to reflect their structural and evolutionary rel ...
... been constructed using a combination of manual inspection and automated methods, because current automatic sequence and structure comparison tools cannot identify all structural relationships reliably. Proteins are classified in a hierarchical fashion to reflect their structural and evolutionary rel ...
Molecular Cell Biology
... DNA glycosylase A DNA repair enzyme that cleaves the bond linking a purine or pyrimidine to the deoxyribose of the backbone of a DNA molecule. DNA ligase An enzyme that seals breaks in DNA strands. DNA polymerase An enzyme catalyzing the synthesis of DNA. dolichol phosphate A lipid molecule in the e ...
... DNA glycosylase A DNA repair enzyme that cleaves the bond linking a purine or pyrimidine to the deoxyribose of the backbone of a DNA molecule. DNA ligase An enzyme that seals breaks in DNA strands. DNA polymerase An enzyme catalyzing the synthesis of DNA. dolichol phosphate A lipid molecule in the e ...
Global Properties of the Metabolic Map of
... protein subunits coded by neighboring genes? Interestingly, this seems to be the case for >90% of known heteromeric enzymes (data not shown). For instance, genes for imidazole glycerol phosphate synthase subunits HisH and HisF are located at centisome positions 45.053 and 45.081, respectively. An ex ...
... protein subunits coded by neighboring genes? Interestingly, this seems to be the case for >90% of known heteromeric enzymes (data not shown). For instance, genes for imidazole glycerol phosphate synthase subunits HisH and HisF are located at centisome positions 45.053 and 45.081, respectively. An ex ...
Leptin Exhibits Pluripotent Effects on Appetite and Metabolism
... The arcuate nucleus (ARC) is a key hypothalamic area for mediating leptin’s inhibition of food intake. In the ARC are neurons that both stimulate appetite – through two hormones: neuropeptide Y (NPY) and agouti-related peptide (AgRP), and inhibit appetite – through proopiomelanocortin (POMC) neurons ...
... The arcuate nucleus (ARC) is a key hypothalamic area for mediating leptin’s inhibition of food intake. In the ARC are neurons that both stimulate appetite – through two hormones: neuropeptide Y (NPY) and agouti-related peptide (AgRP), and inhibit appetite – through proopiomelanocortin (POMC) neurons ...
Review of the reconstruction
... Aerobic, anaerobic respiration and fermentation. Aerobic respiration and the transition from aerobic to anaerobic respiration and fermentation have been extensively studied [20] (see Figures 10 and 11 in Additional file 6). The two-component system ResDE controls the transition between aerobic and a ...
... Aerobic, anaerobic respiration and fermentation. Aerobic respiration and the transition from aerobic to anaerobic respiration and fermentation have been extensively studied [20] (see Figures 10 and 11 in Additional file 6). The two-component system ResDE controls the transition between aerobic and a ...
Project One: Identification of unknown mutants in the... Overview Neurospora crassa
... Neurospora cannot synthesize—biotin. The solid VM is sterilized using the autoclave which results in greatly increased temperatures and pressures and kills even the highly resistant endospores of bacteria. After medium is prepared, you will inoculate the sterile medium with each of the strains for e ...
... Neurospora cannot synthesize—biotin. The solid VM is sterilized using the autoclave which results in greatly increased temperatures and pressures and kills even the highly resistant endospores of bacteria. After medium is prepared, you will inoculate the sterile medium with each of the strains for e ...
The Case Against a Darwinian Origin of Protein Folds
... In the face of this, either we accept that proteins are what they seem to be—long amino acid chains that need to meet stringent sequence requirements in order to work—or we suppose that they are really much simpler than they seem to be. It has to be said that the second option arouses immediate susp ...
... In the face of this, either we accept that proteins are what they seem to be—long amino acid chains that need to meet stringent sequence requirements in order to work—or we suppose that they are really much simpler than they seem to be. It has to be said that the second option arouses immediate susp ...
DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE
... Several other cytokines also participate in the regulation of mast cell proliferation and development under in vitro conditions5. The first of these cytokines to be identified as being able to drive in vitro mast cell growth and development was Interleukin-3 (IL3)10,11. IL-3 is able to independently ...
... Several other cytokines also participate in the regulation of mast cell proliferation and development under in vitro conditions5. The first of these cytokines to be identified as being able to drive in vitro mast cell growth and development was Interleukin-3 (IL3)10,11. IL-3 is able to independently ...
Protein measurement with the Folin-phenol reagent
... It is unnecessary to bring all the samples and standards to the same volume before the addition of the alkaline copper reagent, provided corThe critical volrections are made for small differences in final volume. umes are those of the alkaline copper and Folin reagents. If the protein is present in ...
... It is unnecessary to bring all the samples and standards to the same volume before the addition of the alkaline copper reagent, provided corThe critical volrections are made for small differences in final volume. umes are those of the alkaline copper and Folin reagents. If the protein is present in ...
Gene Section SPP1 (secreted phosphoprotein 1) Atlas of Genetics and Cytogenetics
... 1994 Sep;145(3):610-23 ...
... 1994 Sep;145(3):610-23 ...
Heinrichs, V., and Baker, B. S.
... understand which molecular interactions are required in splicing regulation. Both binding of SR proteins to their target pre-mRNAs and protein–protein interactions of SR proteins with both regulatory and general splicing factors are expected to be important in determining splice site choices. These ...
... understand which molecular interactions are required in splicing regulation. Both binding of SR proteins to their target pre-mRNAs and protein–protein interactions of SR proteins with both regulatory and general splicing factors are expected to be important in determining splice site choices. These ...
Chemoinformatics in Molecular Docking and Drug
... Long-term Goal of Drug Discovery • LTDD (Low Throughput Drug Design) instead of HTVS (High Throughput Virtual Screening) • Common ground: explore virtual space ...
... Long-term Goal of Drug Discovery • LTDD (Low Throughput Drug Design) instead of HTVS (High Throughput Virtual Screening) • Common ground: explore virtual space ...
Cholesterol and Heart Disease
... – If reduce drastically, you only get a 10% reduction in -/- patients • Your body is more efficient at using cholesterol • Your liver produces more when the level decreases ...
... – If reduce drastically, you only get a 10% reduction in -/- patients • Your body is more efficient at using cholesterol • Your liver produces more when the level decreases ...
I. Molecular mechanism for polyunsaturated fatty acid regulation of
... The reduction in hepatic malonyl-CoA is paralleled by a PUFA-dependent induction of genes encoding proteins involved in fatty acid oxidation and ketogenesis (3, 7, 11). These changes in gene transcription occur too quickly to be explained simply by altered hormone signaling resulting from modificati ...
... The reduction in hepatic malonyl-CoA is paralleled by a PUFA-dependent induction of genes encoding proteins involved in fatty acid oxidation and ketogenesis (3, 7, 11). These changes in gene transcription occur too quickly to be explained simply by altered hormone signaling resulting from modificati ...
Integrated search and alignment of protein structures
... individual elements of two contact strings (e.g. comparing a helix forming Arginine, RH , with a β-sheet forming asparagine, NE ). The optimal alignment that minimizes the edit distance between two SSE-enriched strings with respect to the distance matrix can be obtained using the classical dynamic p ...
... individual elements of two contact strings (e.g. comparing a helix forming Arginine, RH , with a β-sheet forming asparagine, NE ). The optimal alignment that minimizes the edit distance between two SSE-enriched strings with respect to the distance matrix can be obtained using the classical dynamic p ...
Probability-Based Scoring Function as a Software
... results, five criteria were considered consecutively, (i) probability-based score, (ii) number of matched proteins, (iii) pI, (vi) protein molecular mass and (v) % coverage. On the output interface, all results were represented in the form of tables and lists of the amino acid sequences of theoretic ...
... results, five criteria were considered consecutively, (i) probability-based score, (ii) number of matched proteins, (iii) pI, (vi) protein molecular mass and (v) % coverage. On the output interface, all results were represented in the form of tables and lists of the amino acid sequences of theoretic ...
Biochemistry, proteomics, and phosphoproteomics of plant
... more recent research has shifted toward comparative analyses to discover dynamic changes in mitochondrial protein expression. Proteomic comparisons of mitochondria from non-photosynthetic Arabidopsis suspension cells and developing photosynthetic shoots (Lee et al., 2008) as well as developing Arabi ...
... more recent research has shifted toward comparative analyses to discover dynamic changes in mitochondrial protein expression. Proteomic comparisons of mitochondria from non-photosynthetic Arabidopsis suspension cells and developing photosynthetic shoots (Lee et al., 2008) as well as developing Arabi ...
Serine/Threonine Kinase 3-Phosphoinositide
... protein kinase and protein kinase C), and control a plethora of cellular processes, downstream either to PI3K or to other pathways, such as RAS GTPase-MAPK (mitogen-activated protein kinase). Interestingly, PDK1 has been demonstrated to be crucial for the regulation of each step of cell migration, b ...
... protein kinase and protein kinase C), and control a plethora of cellular processes, downstream either to PI3K or to other pathways, such as RAS GTPase-MAPK (mitogen-activated protein kinase). Interestingly, PDK1 has been demonstrated to be crucial for the regulation of each step of cell migration, b ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.