Gene Section KLRK1 (killer cell lectin-like receptor subfamily K, member 1)
... Cosman et al., 2001; Raulet et al., 2013). These ligands are type I glycoproteins with homology to MHC class I. The KLRK1 ligands frequently are over-expressed on tumor cells, virusinfected cells, and "stressed" cells (Raulet et al., 2013). The crystal structure of KLRK1 bound to MICA has been descr ...
... Cosman et al., 2001; Raulet et al., 2013). These ligands are type I glycoproteins with homology to MHC class I. The KLRK1 ligands frequently are over-expressed on tumor cells, virusinfected cells, and "stressed" cells (Raulet et al., 2013). The crystal structure of KLRK1 bound to MICA has been descr ...
Lecture 3. Hormone action - receptors
... Characteristics of receptor binding: 1. Binding capacity of receptors 2. Receptor occupancy: low receptor occupancy may be sufficient to evoke maximal response (e.g., 2% of insulin receptor occupancy evokes maximal response in adipocytes: due to the presence of spare receptors) 3. Affinity between r ...
... Characteristics of receptor binding: 1. Binding capacity of receptors 2. Receptor occupancy: low receptor occupancy may be sufficient to evoke maximal response (e.g., 2% of insulin receptor occupancy evokes maximal response in adipocytes: due to the presence of spare receptors) 3. Affinity between r ...
Document
... (A) act through nonspecific receptors, whereas steroid hormones act through specific receptors. (B) are generally water-insoluble, whereas steroid hormones are water soluble. (C) are more stable than steroid hormones. ...
... (A) act through nonspecific receptors, whereas steroid hormones act through specific receptors. (B) are generally water-insoluble, whereas steroid hormones are water soluble. (C) are more stable than steroid hormones. ...
Symbolic Systems Biology
... propagated and interpreted appropriately in a particular cell or tissue. Signaling networks are robust and adaptive, in part because of combinatorial complex formation (several building blocks for forming the same type of complex), redundant pathways, and feedback loops. ...
... propagated and interpreted appropriately in a particular cell or tissue. Signaling networks are robust and adaptive, in part because of combinatorial complex formation (several building blocks for forming the same type of complex), redundant pathways, and feedback loops. ...
Active Transport (con`t)
... Most often, the energy used is in the form of ATP Some active transport processes involve carrier proteins. These proteins bind to specific substances on one side of cell and releases it on the other/opposite side of cell. ...
... Most often, the energy used is in the form of ATP Some active transport processes involve carrier proteins. These proteins bind to specific substances on one side of cell and releases it on the other/opposite side of cell. ...
Information flow within the cell
... involves Regulation of the activity of proteins (trancription factors) which hich bind specific DNA sequences seq ences and determine when hen they will be transcribed Regulation of chromatin structure (epigenetic control) ...
... involves Regulation of the activity of proteins (trancription factors) which hich bind specific DNA sequences seq ences and determine when hen they will be transcribed Regulation of chromatin structure (epigenetic control) ...
Protein Function
... modification is phosphorylation, where a phosphate group is attached to the –OH group in serine, threonine, or tyrosine. Many complex events in the cell are regulated by phosphorylation: for example, signaling pathways that are activated by extracellular signals and end by increasing transcription o ...
... modification is phosphorylation, where a phosphate group is attached to the –OH group in serine, threonine, or tyrosine. Many complex events in the cell are regulated by phosphorylation: for example, signaling pathways that are activated by extracellular signals and end by increasing transcription o ...
Sensory receptor organs
... Sensory Receptor Organs Detect Energy or Substances • Sensory receptor organs are organs specialized to detect a certain stimulus. • Receptor cells within the organ convert the stimulus into an electrical signal a “transduction” process. ...
... Sensory Receptor Organs Detect Energy or Substances • Sensory receptor organs are organs specialized to detect a certain stimulus. • Receptor cells within the organ convert the stimulus into an electrical signal a “transduction” process. ...
Document
... • Paracrine signaling occurs when a signal molecule released from one cell acts on a local neighboring cell. – The release of neurotransmitters into the synapse between neighboring neurons is an example of paracrine signaling. • Autocrine signaling occurs when a cell responds to its own signal molec ...
... • Paracrine signaling occurs when a signal molecule released from one cell acts on a local neighboring cell. – The release of neurotransmitters into the synapse between neighboring neurons is an example of paracrine signaling. • Autocrine signaling occurs when a cell responds to its own signal molec ...
4 - Clark College
... • Describe what substrates enter and what products exit the citric acid cycle and oxidative phosphorylation when oxygen is available to the cell. • Name the coenzymes of the citric acid cycle and their role in metabolism. • Identify where in the cell the reactions of the citric acid cycle and oxidat ...
... • Describe what substrates enter and what products exit the citric acid cycle and oxidative phosphorylation when oxygen is available to the cell. • Name the coenzymes of the citric acid cycle and their role in metabolism. • Identify where in the cell the reactions of the citric acid cycle and oxidat ...
Enzymes: Principles of Catalysis
... In cancer cells, changing roles of acetylation, methylation, phosphorylation and glycosylation have major roles In parasitic infections and bites/stings/jabs from poisonous creatures, cleaving glycosyl residues and GPI anchors helps drive the infection or accelerate death/paralysis ...
... In cancer cells, changing roles of acetylation, methylation, phosphorylation and glycosylation have major roles In parasitic infections and bites/stings/jabs from poisonous creatures, cleaving glycosyl residues and GPI anchors helps drive the infection or accelerate death/paralysis ...
Gene Section MERTK (c-mer proto-oncogene tyrosine kinase) Atlas of Genetics and Cytogenetics
... Within this tyrosine kinase domain is a signature motif, KWIAIES, which is only found in the TAM receptor tyrosine kinases (Graham et al., 1994). Following ligand binding to the extracellular domain, MERTK receptor dimerization and tyrosine autophosphorylation occurs. Three tyrosine residues (Y749, ...
... Within this tyrosine kinase domain is a signature motif, KWIAIES, which is only found in the TAM receptor tyrosine kinases (Graham et al., 1994). Following ligand binding to the extracellular domain, MERTK receptor dimerization and tyrosine autophosphorylation occurs. Three tyrosine residues (Y749, ...
Recombinant Human MEK1 (mutated K97 A) protein
... hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angula ...
... hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angula ...
Recombinant Human GM-CSF (Carrier-free) - Data Sheets
... Martinez-Moczygemba M and DP Huston 2003 J Allergy Clin Immunol 112: 653–665.Hamilton JA and GP Anderson 2005 Growth Factors 22: 225-231. ...
... Martinez-Moczygemba M and DP Huston 2003 J Allergy Clin Immunol 112: 653–665.Hamilton JA and GP Anderson 2005 Growth Factors 22: 225-231. ...
Biology for Engineers: Cellular and Systems Neurophysiology
... – G-proteins metabolize GTP to GDP. Since they use energy, these receptors are called “metabotropic” ...
... – G-proteins metabolize GTP to GDP. Since they use energy, these receptors are called “metabotropic” ...
Role of cystinosin in vesicular trafficking and membrane fusion
... structures and a diminution of the usual pattern of small discrete intracytoplasmic vesicles characteristic of lysosomes. The number of these structures was drastically decreased when cystinosin C-terminal tail, its 5th inter-TM loop, or both motifs were altered. The enlarged lysosomes are reminisce ...
... structures and a diminution of the usual pattern of small discrete intracytoplasmic vesicles characteristic of lysosomes. The number of these structures was drastically decreased when cystinosin C-terminal tail, its 5th inter-TM loop, or both motifs were altered. The enlarged lysosomes are reminisce ...
Eukaryotic transcriptional control
... •Cholesterol-derived hormones that have profound effects on gene transcription. •Examples of steroid hormones are the glucocorticoids, such as cortisol; estrogens, such as bestradiol; and androgens, such as testosterone. •Cortisol became available shortly before the 1960 presidential election and ma ...
... •Cholesterol-derived hormones that have profound effects on gene transcription. •Examples of steroid hormones are the glucocorticoids, such as cortisol; estrogens, such as bestradiol; and androgens, such as testosterone. •Cortisol became available shortly before the 1960 presidential election and ma ...
Gene Section P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7)
... Note: P2X7 receptor is overexpressed in a variety of cancers (see above). A detailed understanding of the mechanistic contribution mediated by P2RX7 has yet to be established. However, there is substantial evidence that the P2X7 receptor may mediate cell survival and growth by increasing the efficie ...
... Note: P2X7 receptor is overexpressed in a variety of cancers (see above). A detailed understanding of the mechanistic contribution mediated by P2RX7 has yet to be established. However, there is substantial evidence that the P2X7 receptor may mediate cell survival and growth by increasing the efficie ...
Cq4 INVESTIGATOR Name Elisabeth Knust Address Max
... crossreacts with Drosophila virilis, not with mouse or C. elegans. ...
... crossreacts with Drosophila virilis, not with mouse or C. elegans. ...
1998 7b – Describe the structure of mitochondria
... - The G protein is a multi-subunit protein complex which exchanges GDP for GTP in order to bring about an effect o Commonly, the heterotrimeric G-protein (αβγ) with its associate GDP is coupled to the 7 transmembrane spanning receptor - Receptor is activated by the binding of ligand on the ECF side ...
... - The G protein is a multi-subunit protein complex which exchanges GDP for GTP in order to bring about an effect o Commonly, the heterotrimeric G-protein (αβγ) with its associate GDP is coupled to the 7 transmembrane spanning receptor - Receptor is activated by the binding of ligand on the ECF side ...
book light - Journées de l`ecole Doctorale 85 de Nice
... Heterogeneous alteration of the distinct adipose tissues by HAART therapy: Molecular mechanisms, modelling and importance of their origin and function ...
... Heterogeneous alteration of the distinct adipose tissues by HAART therapy: Molecular mechanisms, modelling and importance of their origin and function ...
The Damaged Cell Surgery
... lysosomes bump into the vesicle and pour enzymes into them. • Useful amino acids and fatty acids will be returned to the cytoplasm and waste particles are removed from the cell. • The cell can make a new Mitochondria. ...
... lysosomes bump into the vesicle and pour enzymes into them. • Useful amino acids and fatty acids will be returned to the cytoplasm and waste particles are removed from the cell. • The cell can make a new Mitochondria. ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.