Gokul Das, Ph.D. - Roswell Park Cancer Institute
... through oxidative metabolism of glutamine-derived α-ketoglutarate (α-KG) (gray arrows). Subsequent metabolism around the TCA cycle generates citrate for lipid synthesis. SDH and FH deficiency interrupt this pathway, with accumulation of succinate and fumarate, respectively. FH-deficient cells redire ...
... through oxidative metabolism of glutamine-derived α-ketoglutarate (α-KG) (gray arrows). Subsequent metabolism around the TCA cycle generates citrate for lipid synthesis. SDH and FH deficiency interrupt this pathway, with accumulation of succinate and fumarate, respectively. FH-deficient cells redire ...
MolecularModelingDru..
... have we understood how aspirin works, and how it might be improved http://www.rcsb.org/pdb/molecules/pdb17_1.html ...
... have we understood how aspirin works, and how it might be improved http://www.rcsb.org/pdb/molecules/pdb17_1.html ...
Lab Stn #1 Unit 5 DNA to Protein
... Transcription occurs during interphase of the cell cycle. This is when the cell makes proteins and enzymes to catalyze metabolism and carry out their specialized task. Examples include: pancreatic cells exporting insulin to control blood sugar levels adrenal gland cells exporting adrenalin for a “fi ...
... Transcription occurs during interphase of the cell cycle. This is when the cell makes proteins and enzymes to catalyze metabolism and carry out their specialized task. Examples include: pancreatic cells exporting insulin to control blood sugar levels adrenal gland cells exporting adrenalin for a “fi ...
invited review - AJP
... form intracellular vesicles that fuse with endosomes (79, 97). Nonspecific endocytosis is a constitutive process by which substances are taken up in proportion to their concentration in the adjacent extracellular fluid (79, 97). In contrast, receptor-mediated endocytosis involves specific binding of ...
... form intracellular vesicles that fuse with endosomes (79, 97). Nonspecific endocytosis is a constitutive process by which substances are taken up in proportion to their concentration in the adjacent extracellular fluid (79, 97). In contrast, receptor-mediated endocytosis involves specific binding of ...
A General Method Applicable to the Search for Similarities in the
... differences representing amino acids with no possible corresponding bases are uncommon even in randomly selected pairs. If cells are weighted in accordance with the maximum number of coxsponding bases in codons of the represented amino acids, the maximum match will be a function of identical and non ...
... differences representing amino acids with no possible corresponding bases are uncommon even in randomly selected pairs. If cells are weighted in accordance with the maximum number of coxsponding bases in codons of the represented amino acids, the maximum match will be a function of identical and non ...
Lecture 3: Contributions to protein stability
... folding or complex formation must be compensated by interactions within the protein or within the complex, or the free energy of folding/ complex formation will have large unfavorable contributions from the lost interactions with water. For this reason, protein structures rarely contain large caviti ...
... folding or complex formation must be compensated by interactions within the protein or within the complex, or the free energy of folding/ complex formation will have large unfavorable contributions from the lost interactions with water. For this reason, protein structures rarely contain large caviti ...
Human Physiology 1-L..
... a. How does the body adapt to extreme elevations? b. Does speciation occur more quickly in tropical than temperate climates? c. Why does pollen cause allergies? d. Under what conditions are certain genes expressed? e. How can we engineer a more drought-resistant strain of corn? f. How can we improve ...
... a. How does the body adapt to extreme elevations? b. Does speciation occur more quickly in tropical than temperate climates? c. Why does pollen cause allergies? d. Under what conditions are certain genes expressed? e. How can we engineer a more drought-resistant strain of corn? f. How can we improve ...
Biophysics 101 Genomics and Computational Biology
... Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity. In vitro selection for altered divalent metal specificity in the RNase P RNA. In vitro selection of zinc fingers with altered DNA-binding specificity. In vivo select ...
... Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity. In vitro selection for altered divalent metal specificity in the RNase P RNA. In vitro selection of zinc fingers with altered DNA-binding specificity. In vivo select ...
PROTEIN ANALYSIS - Farmasi Carbon 2012
... a. The amount of color varies with different proteins. b. The color is not strictly proportional to the concentration c. Recent evidence suggests that sucrose, lipids, some buffers, monosaccharides and hexosamines react to varying degrees with the reagents in the Lowry test d. High concentrations of ...
... a. The amount of color varies with different proteins. b. The color is not strictly proportional to the concentration c. Recent evidence suggests that sucrose, lipids, some buffers, monosaccharides and hexosamines react to varying degrees with the reagents in the Lowry test d. High concentrations of ...
Molecular and Electrophysiological Evidence for a GABAC Receptor
... 15), and we have previously reported the expression of 1and 2-subunits in restricted brain domains that may contain functional GABAC receptors (16). So far, however, a clear correlation between the expression of -subunits and functional bicuculline-insensitive GABA-gated Cl⫺ channels has only bee ...
... 15), and we have previously reported the expression of 1and 2-subunits in restricted brain domains that may contain functional GABAC receptors (16). So far, however, a clear correlation between the expression of -subunits and functional bicuculline-insensitive GABA-gated Cl⫺ channels has only bee ...
Back to Table of Contents
... The sequence of amino acids in a protein defines its primary structure. The blueprint for each amino acid is laid down by sets of three letters known as base triplets that are found in the coding regions of genes. These base triplets are recognized by ribosomes, the protein building sites of the ce ...
... The sequence of amino acids in a protein defines its primary structure. The blueprint for each amino acid is laid down by sets of three letters known as base triplets that are found in the coding regions of genes. These base triplets are recognized by ribosomes, the protein building sites of the ce ...
C1qRP Is a Heavily O-Glycosylated Cell Surface Protein Involved in
... that a common motif in the collagen-like region of these molecules may be responsible for cell activation via a common cell surface receptor. The fact that mAbs R139 and R3 are able to abrogate the enhanced phagocytosis by C1q and MBL indicates that C1qRP is at least a shared, functional component o ...
... that a common motif in the collagen-like region of these molecules may be responsible for cell activation via a common cell surface receptor. The fact that mAbs R139 and R3 are able to abrogate the enhanced phagocytosis by C1q and MBL indicates that C1qRP is at least a shared, functional component o ...
3. Machinery of a factory: The cell
... to power them. And the production in one factory must be correlated with the production in other factories. If hubcaps made at one-factory lags in production, the production of the whole car will be slowed down. ATP is like the electricity that runs each factory. Electricity must be constantly suppl ...
... to power them. And the production in one factory must be correlated with the production in other factories. If hubcaps made at one-factory lags in production, the production of the whole car will be slowed down. ATP is like the electricity that runs each factory. Electricity must be constantly suppl ...
Lysinuric protein intolerance: one gene, many
... epithelial cells endowed with transporters for specific groups of amino acids. Inherited renal aminoacidurias arise as a result of mutations inactivating apical or basolateral transport systems. Although aminoacidurias are diagnosed by urine amino acid analysis, most of the disorders affect both int ...
... epithelial cells endowed with transporters for specific groups of amino acids. Inherited renal aminoacidurias arise as a result of mutations inactivating apical or basolateral transport systems. Although aminoacidurias are diagnosed by urine amino acid analysis, most of the disorders affect both int ...
Title Molecular Pathways: The Role of Primary Cilia in Cancer
... into repressor (with the exception of Gli1) and activator forms in the absence and presence of Hh, respectively. Loss of cilia mutations results in abnormal processing of both the repressor and activator forms of Gli proteins suggesting that both are dependent on cilia. In the absence of Hh, the Hh ...
... into repressor (with the exception of Gli1) and activator forms in the absence and presence of Hh, respectively. Loss of cilia mutations results in abnormal processing of both the repressor and activator forms of Gli proteins suggesting that both are dependent on cilia. In the absence of Hh, the Hh ...
training handout - Science Olympiad
... signaling pathways. o In their negative role, rafts may spatially segregate interacting components to block nonspecific pathway activation, or may directly suppress the activity of signaling proteins present in rafts. Proteins serve different functions ...
... signaling pathways. o In their negative role, rafts may spatially segregate interacting components to block nonspecific pathway activation, or may directly suppress the activity of signaling proteins present in rafts. Proteins serve different functions ...
The Logic Linking Protein Acetylation and Metabolism
... acetylation will generally be activating for glycolytic enzymes. The increase in protein acetylation in times of plenty is analogous to the increased phosphorylation of proteins by CDKs to drive the cell cycle under these conditions. More generally, phosphorylation-based signaling pathways may impin ...
... acetylation will generally be activating for glycolytic enzymes. The increase in protein acetylation in times of plenty is analogous to the increased phosphorylation of proteins by CDKs to drive the cell cycle under these conditions. More generally, phosphorylation-based signaling pathways may impin ...
Molecular cloning, expression, and bioactivity of dove B lymphocyte
... 0165-2427/$ – see front matter ß 2008 Elsevier B.V. All rights reserved. doi:10.1016/j.vetimm.2008.11.026 ...
... 0165-2427/$ – see front matter ß 2008 Elsevier B.V. All rights reserved. doi:10.1016/j.vetimm.2008.11.026 ...
B2 Protein structure and function
... (subunits). These subunits may be identical or different. The same forces which stabilize tertiary structure hold these subunits together. This level of organization called quaternary structure. ...
... (subunits). These subunits may be identical or different. The same forces which stabilize tertiary structure hold these subunits together. This level of organization called quaternary structure. ...
Pre-lab 8: Peptides and Proteins
... 4. Collect the solid protein using a funnel and filter paper. Wash the protein with two 10 mL portions of water. Weigh a watch glass. Transfer the protein to the watch glass and let the protein dry. Weigh. Calculate the mass of the milk protein. Save for part E. 5. Calculate the percentage of casein ...
... 4. Collect the solid protein using a funnel and filter paper. Wash the protein with two 10 mL portions of water. Weigh a watch glass. Transfer the protein to the watch glass and let the protein dry. Weigh. Calculate the mass of the milk protein. Save for part E. 5. Calculate the percentage of casein ...
Proteins
... 1. What is the quantity of protein or amino acids provided per serving? Many food sources of protein provide as much protein as supplements. Also megadosing will not lead to increased muscle mass, but will contribute to increased fat mass. 2. What is the supplement's cost? Many food sources provide ...
... 1. What is the quantity of protein or amino acids provided per serving? Many food sources of protein provide as much protein as supplements. Also megadosing will not lead to increased muscle mass, but will contribute to increased fat mass. 2. What is the supplement's cost? Many food sources provide ...
Going the Distance: Carboloading for Athletes Alyssa Coriell
... The three major kinds of protein supplements are casein and whey protein, both found in milk, and soy protein (1). It is very important to know what you are putting into your body. In one documented instance, a woman went to the emergency room with an anaphylactic reaction to a dietary supplement sh ...
... The three major kinds of protein supplements are casein and whey protein, both found in milk, and soy protein (1). It is very important to know what you are putting into your body. In one documented instance, a woman went to the emergency room with an anaphylactic reaction to a dietary supplement sh ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.