Protein Structure Similarity
... A ligand is a molecule that binds to another molecule to form a larger compound. For proteins, this can have the effect of inhibiting the proteins function or catalyzing its activities. Therefore, ligands are important in drug design. Given a set of ligands that are known to have the same activity ( ...
... A ligand is a molecule that binds to another molecule to form a larger compound. For proteins, this can have the effect of inhibiting the proteins function or catalyzing its activities. Therefore, ligands are important in drug design. Given a set of ligands that are known to have the same activity ( ...
Section D - Prokaryotic and Eukaryotic Chromosome Structure
... • The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
... • The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
PSIpred
... Generates reliable protein models when other widely used methods such as PSI-BLAST cannot. ...
... Generates reliable protein models when other widely used methods such as PSI-BLAST cannot. ...
E. coli
... • “the quantitative complement of all of the low molecular weight molecules present in cells in a particular physiological or developmental state” (Oliver, 1998) • “only of those native small molecules that are participants in general metabolic reactions and that are required for the maintenance, gr ...
... • “the quantitative complement of all of the low molecular weight molecules present in cells in a particular physiological or developmental state” (Oliver, 1998) • “only of those native small molecules that are participants in general metabolic reactions and that are required for the maintenance, gr ...
Proteins
... What Determines Protein Conformation? • In addition to primary structure, physical and chemical conditions can affect conformation • Alternations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel • This loss of a protein’s native conformation is c ...
... What Determines Protein Conformation? • In addition to primary structure, physical and chemical conditions can affect conformation • Alternations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel • This loss of a protein’s native conformation is c ...
A single amino acid substitution in the haemagglutinin
... The crystal structure of the HN and F proteins of NDV have been elucidated (Chen et al., 2001; Crennell et al., 2000), and a lot of information has been obtained regarding their threedimensional structure. The HN displays the six-bladed bpropeller folding typical of other known NAs (Connaris et al., ...
... The crystal structure of the HN and F proteins of NDV have been elucidated (Chen et al., 2001; Crennell et al., 2000), and a lot of information has been obtained regarding their threedimensional structure. The HN displays the six-bladed bpropeller folding typical of other known NAs (Connaris et al., ...
- Wiley Online Library
... significant loss of constriction in the IMZ, while full-length XPAPC and a control MO had no effect on constriction (Figure 1B and C). The observed failure of explants to constrict is measurable and statistically significant. For quantification, the initial length (Li), total length (Li þ IMZ), total w ...
... significant loss of constriction in the IMZ, while full-length XPAPC and a control MO had no effect on constriction (Figure 1B and C). The observed failure of explants to constrict is measurable and statistically significant. For quantification, the initial length (Li), total length (Li þ IMZ), total w ...
Purification, Cloning, and Tissue Distribution of a 23
... A typical UV chromatogram of the LEV eluate after reverse phase HPLC is presented in Fig. 1B. Nearly identical absorbance profiles were obtained when morphine (16), etorphine, and [D-Ala2,MePhe4,Gly-ol5]enkephalin (data not shown) were used as the eluting ligands. SDS-PAGE and silver staining of ind ...
... A typical UV chromatogram of the LEV eluate after reverse phase HPLC is presented in Fig. 1B. Nearly identical absorbance profiles were obtained when morphine (16), etorphine, and [D-Ala2,MePhe4,Gly-ol5]enkephalin (data not shown) were used as the eluting ligands. SDS-PAGE and silver staining of ind ...
Fructose 6
... Figure 2. Using the non-oxidative branch of the pentose pathway to produce ribose-5-phosphate for the nucleic acid pathways (Mode 1). ...
... Figure 2. Using the non-oxidative branch of the pentose pathway to produce ribose-5-phosphate for the nucleic acid pathways (Mode 1). ...
How metabolites modulate metabolic flux
... hydroxylation, with the simultaneous production of succinate and CO2 from 2OG. In addition to an oxygen dependent regulation, it has been shown that the activity of PHD2 as well as other 2OG dependent dioxygenases can be regulated by the level of succinate and 2OG, as well as by fumarate and the onc ...
... hydroxylation, with the simultaneous production of succinate and CO2 from 2OG. In addition to an oxygen dependent regulation, it has been shown that the activity of PHD2 as well as other 2OG dependent dioxygenases can be regulated by the level of succinate and 2OG, as well as by fumarate and the onc ...
Enzyme Regulatory Strategies
... • Genetic regulation of enzyme synthesis and decay determines the amount of enzyme present at any moment • Enzyme activity can be regulated allosterically (instantaneous response) • Enzyme activity can be regulated through covalent modification (interconvertable enzymes) (response times of seconds o ...
... • Genetic regulation of enzyme synthesis and decay determines the amount of enzyme present at any moment • Enzyme activity can be regulated allosterically (instantaneous response) • Enzyme activity can be regulated through covalent modification (interconvertable enzymes) (response times of seconds o ...
Cellular Localization Data - SGD-Wiki
... critical to helping you discern between possible functions you have uncovered so far and in proposing a final protein function or action based on where it is localized and what els ...
... critical to helping you discern between possible functions you have uncovered so far and in proposing a final protein function or action based on where it is localized and what els ...
BCHM 463 Supplemental Problems for Friday, April 9, 2004 1. a
... 7. Compare the relative efficiencies (in ATP’s per glucose oxidized) of glucose oxidation via glycolysis + the citric acid cycle vs. glucose oxidation via the pentose phosphate pathway + glycolysis. (Assume that NADH and NADPH are each equivalent to three ATPs and that FADH is equivalent to 2 ATPs.) ...
... 7. Compare the relative efficiencies (in ATP’s per glucose oxidized) of glucose oxidation via glycolysis + the citric acid cycle vs. glucose oxidation via the pentose phosphate pathway + glycolysis. (Assume that NADH and NADPH are each equivalent to three ATPs and that FADH is equivalent to 2 ATPs.) ...
Sec14p-like proteins regulate phosphoinositide homoeostasis and
... Sec9p t-SNARE (target membrane soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) function Stt4p and Mss4p reside in the yeast plasma membrane [22]. This raises the possibility that SFH proteins modulate exocytic and/or endocytic events at the plasma membrane. To investig ...
... Sec9p t-SNARE (target membrane soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) function Stt4p and Mss4p reside in the yeast plasma membrane [22]. This raises the possibility that SFH proteins modulate exocytic and/or endocytic events at the plasma membrane. To investig ...
Role of N-terminal protein formylation in central metabolic processes
... catabolic pathways downstream of acetyl-CoA were not affected by the lack of formylation in Δfmt. Of note, Δfmt released more of the central metabolic intermediate pyruvate to the growth medium than the wild type in the stationary phase suggesting that the metabolism of pyruvate was perturbed in the ...
... catabolic pathways downstream of acetyl-CoA were not affected by the lack of formylation in Δfmt. Of note, Δfmt released more of the central metabolic intermediate pyruvate to the growth medium than the wild type in the stationary phase suggesting that the metabolism of pyruvate was perturbed in the ...
Gene Section PDX1 (pancreatic and duodenal homeobox 1)
... by the association of their missense mutations with diabetes (Fig. 2). Several potential phosphorylation sites within PDX-1 have been identified, such as Thr 11 by DNA-PK, Ser 61 and 66 by GSK3beta, Thr 152 by PASK, Thr 231 and Ser 232 by CK2 and Ser 268 by AKT-GSK and HIPK2. ...
... by the association of their missense mutations with diabetes (Fig. 2). Several potential phosphorylation sites within PDX-1 have been identified, such as Thr 11 by DNA-PK, Ser 61 and 66 by GSK3beta, Thr 152 by PASK, Thr 231 and Ser 232 by CK2 and Ser 268 by AKT-GSK and HIPK2. ...
Full Text
... molecular weight of 76325.7 Daltons and pI of 5.23. The optimum pH of higher plant β-amylases is nearly 5.4, whereas bacterial β-amylases are about 6.7 (Hirata et al., 2004). This pH value (5.4) is so similar to our pH value as 5.23. The most abundant amino acid was found as alanin (78 residues, 11. ...
... molecular weight of 76325.7 Daltons and pI of 5.23. The optimum pH of higher plant β-amylases is nearly 5.4, whereas bacterial β-amylases are about 6.7 (Hirata et al., 2004). This pH value (5.4) is so similar to our pH value as 5.23. The most abundant amino acid was found as alanin (78 residues, 11. ...
Proteins
... size of the polymer and the composition and sequence of the amino acids in the polymer, but generally they are polar and thus soluble in water. As we will see, the amino acids have “R” groups that differ by their solubility, hence also proteins. Some proteins are not soluble; e.g., a-keratin ...
... size of the polymer and the composition and sequence of the amino acids in the polymer, but generally they are polar and thus soluble in water. As we will see, the amino acids have “R” groups that differ by their solubility, hence also proteins. Some proteins are not soluble; e.g., a-keratin ...
POP-1 and Anterior–Posterior Fate Decisions in
... Cell divisions during C. elegans embryogenesis are either anterior/posterior (a/p) or transverse (dorsal/ventral or left/right). Because of steric factors in the embryo, such as the eggshell, sister blastomeres resulting from a transverse cleavage may ultimately adopt slightly different a/p position ...
... Cell divisions during C. elegans embryogenesis are either anterior/posterior (a/p) or transverse (dorsal/ventral or left/right). Because of steric factors in the embryo, such as the eggshell, sister blastomeres resulting from a transverse cleavage may ultimately adopt slightly different a/p position ...
Class11 POGIL Translation Full Win17 KEY v1
... 2. For each different mutant cell described below, assume that ONE specific molecule or part of a molecule is mutated in that cell so that the molecule’s function has changed. Name as many molecules that could result in the description (but remember that for the mutant phenotype, you are considering ...
... 2. For each different mutant cell described below, assume that ONE specific molecule or part of a molecule is mutated in that cell so that the molecule’s function has changed. Name as many molecules that could result in the description (but remember that for the mutant phenotype, you are considering ...
Coordinated Regulation of AIB1 Transcriptional Activity by
... nucleus. In addition, AIB1 functions as a cofactor that coactivates estrogen receptor-mediated transcription in the nucleus under the treatment of E2. In light of the observation that sumoylated AIB1 was only detected in the absence of E2 stimulation, we wished to know whether the sumoylation of AIB ...
... nucleus. In addition, AIB1 functions as a cofactor that coactivates estrogen receptor-mediated transcription in the nucleus under the treatment of E2. In light of the observation that sumoylated AIB1 was only detected in the absence of E2 stimulation, we wished to know whether the sumoylation of AIB ...
Malignant Hyperthermia
... A voltage-dependent, L-type calcium channel The DHP receptors physically interact with Ryanodine (RyR-1) receptors on the sarcoplasmic reticulum which contains Ca++ Activated DHP receptors induce a conformational change in RyR-1 receptors Ca++ is released from the SR and binds to Troponin C Cross- ...
... A voltage-dependent, L-type calcium channel The DHP receptors physically interact with Ryanodine (RyR-1) receptors on the sarcoplasmic reticulum which contains Ca++ Activated DHP receptors induce a conformational change in RyR-1 receptors Ca++ is released from the SR and binds to Troponin C Cross- ...
PART IV Metabolism Introduction to Metabolism
... Experimental approaches to the study of metabolism How does one know what is written here ? Key question with regard to metabolic conversion: 1. What is the sequence of reactions ? 2. What is the mechanism ? 3. How is it controlled ? ...
... Experimental approaches to the study of metabolism How does one know what is written here ? Key question with regard to metabolic conversion: 1. What is the sequence of reactions ? 2. What is the mechanism ? 3. How is it controlled ? ...
No Slide Title
... 1. By flux of nitrogen through cycle - depends on diet lots protein in diet = carbon skeletons used for fuel, lots of urea starvation = breakdown muscle protein for energy, lots of urea All enzymes (CPS-I and 4 in cycle) synthesized at higher rates in starving animals and animals on high protein die ...
... 1. By flux of nitrogen through cycle - depends on diet lots protein in diet = carbon skeletons used for fuel, lots of urea starvation = breakdown muscle protein for energy, lots of urea All enzymes (CPS-I and 4 in cycle) synthesized at higher rates in starving animals and animals on high protein die ...
Protein kinases - Institut de recherches cliniques de Montréal
... How many phosphorylation sites are there? If there are ~10,000 proteins per cell with an average length of 400 aa (~ 17% of which are Ser, Thr or Tyr), then there are ~700,000 potential phosphorylation sites for any given kinase (including hidden residues). Although protein kinases have relatively ...
... How many phosphorylation sites are there? If there are ~10,000 proteins per cell with an average length of 400 aa (~ 17% of which are Ser, Thr or Tyr), then there are ~700,000 potential phosphorylation sites for any given kinase (including hidden residues). Although protein kinases have relatively ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.