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... we provide evidence for the existence and quantification two primary splice variants that are generated from zebrafish and mice. In addition, we also identified a minor 27-nucleotide (NT) splice variant of zebrafish PCLO that is also present in mouse and has been shown to be functionally significant ...
... we provide evidence for the existence and quantification two primary splice variants that are generated from zebrafish and mice. In addition, we also identified a minor 27-nucleotide (NT) splice variant of zebrafish PCLO that is also present in mouse and has been shown to be functionally significant ...
Progeria
... This protein is what holds the cells nucleus together When this protein is defected it makes the nucleus unstable This is the process that leads to premature aging ...
... This protein is what holds the cells nucleus together When this protein is defected it makes the nucleus unstable This is the process that leads to premature aging ...
Animal and Plant viruses
... - VP4 protein subunits coat the interior and help package the (+) strand RNA genome. Figure 11.11B ...
... - VP4 protein subunits coat the interior and help package the (+) strand RNA genome. Figure 11.11B ...
PowerPoint 0.8MB - The Biomolecular Modeling & Computational
... 3. QM with solvation (enzyme reactions) ...
... 3. QM with solvation (enzyme reactions) ...
8.5
... KEY CONCEPT Translation converts an mRNA message into a polypeptide, or protein. Translation is the process that converts an mRNA message into a polypeptide, or protein. An mRNA message is made up of combinations of four nucleotides, whereas proteins are made up of twenty types of amino acids. The m ...
... KEY CONCEPT Translation converts an mRNA message into a polypeptide, or protein. Translation is the process that converts an mRNA message into a polypeptide, or protein. An mRNA message is made up of combinations of four nucleotides, whereas proteins are made up of twenty types of amino acids. The m ...
Quantitative profiling of differentiation
... proteins in the naïve and PMA-treated cells are shown, respectively, in Figure 3A and B. The two peptides differed in their chromatographic retention time by 4 s, and their parent proteins were identified by sequence database searching as the transmembrane tyrosine phosphatase CD45 and the calcium p ...
... proteins in the naïve and PMA-treated cells are shown, respectively, in Figure 3A and B. The two peptides differed in their chromatographic retention time by 4 s, and their parent proteins were identified by sequence database searching as the transmembrane tyrosine phosphatase CD45 and the calcium p ...
Interactions of Visinin-like Proteins with Phospho-inositides
... The family of neuronal calcium sensor (NCS) proteins comprises five subfamilies, namely recoverins, frequenins, Visinin-like Proteins (VILIPs), GCAPs and KChlPs, which are involved in various signalling cascades in neuronal cells [1-3]. All members of the NCS protein family are EFhand proteins and s ...
... The family of neuronal calcium sensor (NCS) proteins comprises five subfamilies, namely recoverins, frequenins, Visinin-like Proteins (VILIPs), GCAPs and KChlPs, which are involved in various signalling cascades in neuronal cells [1-3]. All members of the NCS protein family are EFhand proteins and s ...
Sports and Protein Metabolism
... of bodyweight. In a 70kg (154lb) individual this equates to just 58 grams of protein per day or about two chicken breasts worth ...
... of bodyweight. In a 70kg (154lb) individual this equates to just 58 grams of protein per day or about two chicken breasts worth ...
Protein structure
... FIGURE 9.8. The helix. In B and C the carbon atoms of the backbone are black, with carbons so marked. Peptide bond nitrogens are deep blue and their attached hydrogens are white. Peptide bond oxygens are red. Green spheres represent the amino acid side chains. D shows only the backbone with all ...
... FIGURE 9.8. The helix. In B and C the carbon atoms of the backbone are black, with carbons so marked. Peptide bond nitrogens are deep blue and their attached hydrogens are white. Peptide bond oxygens are red. Green spheres represent the amino acid side chains. D shows only the backbone with all ...
Biochemistry-Review of the Basics
... In chemical reactions the energy is usually provided in the form of heat Exothermic reactions result in products with less potential energy than the reactants ...
... In chemical reactions the energy is usually provided in the form of heat Exothermic reactions result in products with less potential energy than the reactants ...
Accelerating Protein ID for Deep Proteome Profiling
... extremely high requiring that extensive fractionation is done to deeply interrogate the proteome. The key goal is to spread the peptides out across fractions such that when each is analyzed by LC-MS/MS, the mass spectrometer has time to collect high quality MS/MS spectra on as many peptides as possi ...
... extremely high requiring that extensive fractionation is done to deeply interrogate the proteome. The key goal is to spread the peptides out across fractions such that when each is analyzed by LC-MS/MS, the mass spectrometer has time to collect high quality MS/MS spectra on as many peptides as possi ...
Proteomic Survey of Camel Urine Reveals High Levels of
... estimation of the false discovery rate (FDR). These decoy searches use random sequences (one for every ‘real’ sequence, of matching length) having the same average amino acid composition as the ‘real’ sequence database. The average FDR for peptide matches above the identity threshold was 2.6%. The F ...
... estimation of the false discovery rate (FDR). These decoy searches use random sequences (one for every ‘real’ sequence, of matching length) having the same average amino acid composition as the ‘real’ sequence database. The average FDR for peptide matches above the identity threshold was 2.6%. The F ...
View PDF - e-Science Central
... PEGs are hydrophilic, non-toxic, non-immunogenic, and relatively chemically inert polymers consisting of repetitive units of ethylene oxide. It has been approved by the FDA as “generally recognized as safe” [3]. A large number of potential PEG molecules are available in linear or branched configurat ...
... PEGs are hydrophilic, non-toxic, non-immunogenic, and relatively chemically inert polymers consisting of repetitive units of ethylene oxide. It has been approved by the FDA as “generally recognized as safe” [3]. A large number of potential PEG molecules are available in linear or branched configurat ...
Experimental Approaches to Protein–Protein Interactions
... proteins in the cell) of the yeast Saccharomyces cerevisiae has been described by two independent groups, in both cases using TAP tagging [8,9]. The results are broadly consistent, in that they show that approx. 70% of proteins in the cell have at least one interacting partner: in other words, inter ...
... proteins in the cell) of the yeast Saccharomyces cerevisiae has been described by two independent groups, in both cases using TAP tagging [8,9]. The results are broadly consistent, in that they show that approx. 70% of proteins in the cell have at least one interacting partner: in other words, inter ...
High School Chemistry Essential Questions
... 2. What observations about chemical systems and chemical interactions lead us to form the physical, graphical, and mathematical models that we use to represent, analyze, and communicate structure and relationships in chemical systems and chemical interactions? 3. How do we use the physical models, s ...
... 2. What observations about chemical systems and chemical interactions lead us to form the physical, graphical, and mathematical models that we use to represent, analyze, and communicate structure and relationships in chemical systems and chemical interactions? 3. How do we use the physical models, s ...
Biophysics II Key points to be covered
... Biological functions of biological molecules are not only determined by the primary structure, but also to a large extent by the secondary, tertiary, quaternary structures ...
... Biological functions of biological molecules are not only determined by the primary structure, but also to a large extent by the secondary, tertiary, quaternary structures ...
Proteolysis in Mixed Organic-Aqueous Solvent
... The resulting peptides are analyzed with matrix-assisted laser desorption ionization (MALDI) mass spectrometry, and this information is interrogated by searching the protein and nucleic acid databases. Although this procedure has become routine, it is inefficient regarding the time required to prepa ...
... The resulting peptides are analyzed with matrix-assisted laser desorption ionization (MALDI) mass spectrometry, and this information is interrogated by searching the protein and nucleic acid databases. Although this procedure has become routine, it is inefficient regarding the time required to prepa ...
Using PEPscreen to Study Protein Phosphorylation - Sigma
... between specific PKs and particular sites is crucial to elucidate related biological pathways. On a more technical level, highthroughput assays are needed to establish these valid kinase-client interactions. Past methods have used low-throughput methods such as radiolabeling or 2D-gel electrophoresi ...
... between specific PKs and particular sites is crucial to elucidate related biological pathways. On a more technical level, highthroughput assays are needed to establish these valid kinase-client interactions. Past methods have used low-throughput methods such as radiolabeling or 2D-gel electrophoresi ...
Poster
... critical role in the ubiquitination process. Ubch5b is one of many E2s that is involved in tagging unwanted proteins with ubiquitin. Researchers are studying the relationship between the yeast Ubch5b and a specific form of misfolded protein called prions. Prions are unique because when one protein t ...
... critical role in the ubiquitination process. Ubch5b is one of many E2s that is involved in tagging unwanted proteins with ubiquitin. Researchers are studying the relationship between the yeast Ubch5b and a specific form of misfolded protein called prions. Prions are unique because when one protein t ...
Study Questions
... (b) telling her that she needs to go to a nursing home. (c) suggesting some diet modifications so that she may continue to enjoy life. (d) telling her neighbors to not worry about her. Answer: c Rationale: If competent, she must be allowed to make her own decisions, even if they are not the ideal on ...
... (b) telling her that she needs to go to a nursing home. (c) suggesting some diet modifications so that she may continue to enjoy life. (d) telling her neighbors to not worry about her. Answer: c Rationale: If competent, she must be allowed to make her own decisions, even if they are not the ideal on ...
Additional file 1
... Assumptions, Abstractions, and Simplifications As described here, assumptions, abstractions, and simplifications have been made in the example cell-cycle model. Some of these assumptions, abstractions, and simplifications have been made for brevity; some have been made out of necessity. Except for t ...
... Assumptions, Abstractions, and Simplifications As described here, assumptions, abstractions, and simplifications have been made in the example cell-cycle model. Some of these assumptions, abstractions, and simplifications have been made for brevity; some have been made out of necessity. Except for t ...
Protein Family Classification using Sparse Markov Transducers
... is a model that predicts the next symbol in a sequence based on the previous symbols. This approach is based on the presence of common short sequences (motifs) through the protein family. One drawback of PSTs is that they rely on exact matches to the conditional sequences (e.g., 3-hydroxyacyl-Co ...
... is a model that predicts the next symbol in a sequence based on the previous symbols. This approach is based on the presence of common short sequences (motifs) through the protein family. One drawback of PSTs is that they rely on exact matches to the conditional sequences (e.g., 3-hydroxyacyl-Co ...
a more thorough description of current interests.
... with novel structure and spectroscopy. However, designing new and useful Fig. 2. Functional metallopeptides: (Path A) Proximity-driven catalytic reactivity and catalytic function remains protein modification; (Path B) Cooperative inhibition of protein– a daunting challenge. We have focused protein i ...
... with novel structure and spectroscopy. However, designing new and useful Fig. 2. Functional metallopeptides: (Path A) Proximity-driven catalytic reactivity and catalytic function remains protein modification; (Path B) Cooperative inhibition of protein– a daunting challenge. We have focused protein i ...
Cyclol
![](https://commons.wikimedia.org/wiki/Special:FilePath/Cyclol_reaction.png?width=300)
The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.