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Division of Clinical Pharmacology Department of Medicine and Health Sciences Linköping University
Division of Clinical Pharmacology Department of Medicine and Health Sciences Linköping University

... indicators to form triage algorithms. Three algorithms (one completely data driven, one semi-automated and one based on clinical knowledge) based on pharmacological and reported clinical information and the relative reporting rate of an ADR with a drug combination were developed. The algorithms were ...
Ephedrine and Other Stimulants As Ergogenic Aids
Ephedrine and Other Stimulants As Ergogenic Aids

... through crushing tablets for sublingual mucosal absorption, usually for recreational purposes, and this use could lead to detection during drug testing by regulatory agencies such as the NCAA. Amphetamine was synthesized in 1920 and used to reduce fatigue and increase alertness during World War II. ...
A self-organizing model of disparity maps in the primary visual cortex
A self-organizing model of disparity maps in the primary visual cortex

... light and bright light respectively. Rods are more numerous than cones but are conspicuously absent at the centre of the retina. This region is known as the fovea and represents the centre of fixation. It contains a high concentration of cones, thereby making it well-suited for fine-detailed vision. ...
B N ULLETI I N F O R M A T I O...
B N ULLETI I N F O R M A T I O...

... cartridge cleaner,” and “nail enamel remover” for approximately $100 per bottle—much more expensive than comparable products. Law enforcement’s efforts to identify the abuse of GHB analogs are hampered by the fact that routine toxicological screens do not detect the presence of these analogs. In add ...
Mechanisms of potential novel antimalarials and Plasmodium falciparum  Denise Steyn
Mechanisms of potential novel antimalarials and Plasmodium falciparum Denise Steyn

... artemisinin-derivative combination therapies are readily available in Africa there are numerous reports of poor quality products which may lead to the development of drug resistance in Plasmodium parasites. Other aspects such as counterfeit medicines with sub-therapeutic levels of active ingredients ...
Memantine is a clinically well tolerated N-methyl-D
Memantine is a clinically well tolerated N-methyl-D

... N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, ALS) to symptomatic treatment (e.g. epi ...
Introducing a New Product
Introducing a New Product

...  Somatic motor division carries information to the somatic effectors (skeletal muscles) ...
Fentanyl - CannAmm
Fentanyl - CannAmm

... Similar to heroin, morphine, and other opioid drugs, fentanyl acts on the body by binding to the opioid receptors in the areas of the brain responsible for the experience of pain and emotions. When opioid drugs bind to the receptors they increase dopamine levels in the brain’s reward areas, resultin ...
Neural networks underlying parietal lobe seizures: A
Neural networks underlying parietal lobe seizures: A

... and/or metabolic neuroimaging largely contribute to the diagnosis of PLS (Kim et al., 2004). However, in many cases and particularly when MRI is non-contributive or show large lesional areas, studies using depth electrodes are often required. These investigations offer the unique opportunity to prec ...
Soghomonian J.J., Sethares C., and Peters, A
Soghomonian J.J., Sethares C., and Peters, A

... monkeys, axon terminals forming axosomatic synapses are significantly larger and contain more mitochondria than those forming axodendritic synapses and both axodendritic and axosomatic terminals become larger with age. However, while mitochondria in axodendritic terminals do not change in either siz ...
A SURVEY BASED STUDY IN CURRENT SCENARIO OF GENERIC AND... Research Article
A SURVEY BASED STUDY IN CURRENT SCENARIO OF GENERIC AND... Research Article

... Objectives: Cost of the medicines is a concern for the patients. Within India cost of medicines varies, the basic reason behind this is the brand price quoted by the pharmaceutical industries. Survey was undertaken to review and analyse various facts about branded and generic medicines of the same d ...
Potential Effects of Introducing Behind the Counter Drugs
Potential Effects of Introducing Behind the Counter Drugs

... prescription versions. The effect on overall utilization, however, is more ambiguous, and depends to some degree on the structure of private and public health insurance and on whether the BTC/OTC versions are covered by insurers. In addition, there is a general consensus that BTC/OTC drugs reduce sp ...
Full-Text  - Academic Journals
Full-Text - Academic Journals

... biliverdin into bilirubin, which is further converted into a water-soluble conjugate and excreted through urine. Malaria parasite does not use this pathway for heme metabolism. In the food vacuole, heme is changed into hemozoin, a malaria pigment, which is a dimer of heme units linked through an iro ...
Motivational views of reinforcement: implications - Research
Motivational views of reinforcement: implications - Research

... either in general or specifically, and to control their vigor and efficiency. The other is to guide behavior to specific ends, i.e. to give direction to behavior’. Although there are a number of distinct views of the critical characteristics of reinforcing stimuli, there is a common pattern that run ...


... VII. REFERENCE LIST ......................................................................................................... 129 VIII. APPENDIX...................................................................................................................... 153 ...
Organization of the Honey Bee Mushroom Body
Organization of the Honey Bee Mushroom Body

... calyces, defined by their afferent inputs and the dendritic domains of class I Kenyon cells, are each represented in the lobes by immunoreactive layers that subdivide the lobes into three parallel divisions (Strausfeld and Li, 1999a,b). These divisions lie behind an anterior component that is suppli ...
Document
Document

... Possible new hypothesis to test: • Long term effects of caffeine in combination with supplements found in energy drinks • Increasing risk of caffeine overdoses due to the trends of rising concentrations and availability of caffeinated ...
Pharmacy Therapeutics Policies and Procedures
Pharmacy Therapeutics Policies and Procedures

... on these guiding principles.  These principles reflect the 6 AIMS (safe, timely, effective, equitable,  efficient and patient centered).  These principles are prioritized in descending order (i.e. effectiveness is  weighted most heavily, followed by safety issues, and then by cost).  Formulary decis ...
MS_349Formated - University of Alberta
MS_349Formated - University of Alberta

... together. Gels that do not have this capability because they are held together by covalent bonds are termed permanent gels. Pluronic F-127 (Poloxamer 407, PF-127) is a thermoreversible gel (3-6). This characteristic has allowed PF-127 to be used as a carrier for most routes of administration includi ...
Comparison of uterotonic effects of three low dose oxytocin
Comparison of uterotonic effects of three low dose oxytocin

... We compared three low dose regimens of oxytocin; bolus followed by continuous infusion (group A), bolus alone (group B) and continuous infusion alone (group C). The higher prevalence of adequate uterine tone (uterine tone score ≥ 3) at 2 minutes in group A and B in comparison to group C reflects an ...
Increased risk of atherothrombotic events associated with
Increased risk of atherothrombotic events associated with

... Review Board, and the study was conducted at the SNUH cardiovascular centre. All subjects provided written informed consent before enrolment. We enrolled consecutive patients at the Seoul National University Cardiovascular Center who had undergone successful coronary angioplasty with implantation of ...
The Effects of Antibiotics and Cancer
The Effects of Antibiotics and Cancer

... L1210 leukemia cells in vitro. Table 2 shows the doseresponse of this effect. At 10 3M(418 /ig/ml) inhibition was 46.5% of control uptake at 40 min of incubation. At 10~5M (4.18 /ig/ml) little if any effect on MTX transport was seen. Of the "drugs" evaluated, hydrocortisone was the most effective in ...
PDF - Journal of Applied Pharmaceutical Science
PDF - Journal of Applied Pharmaceutical Science

... Healthy adult rats Wistar, 250-300 g were used in this study. They were maintained under standard laboratory conditions with free access to food and water. Trachea ring were used to study the possible bronchoactive effects of extracts. The rats were anesthetized, the trachea were excised, placed in ...
150-505-1-SP - Baqiyatallah University of Medical Sciences
150-505-1-SP - Baqiyatallah University of Medical Sciences

... factor. Although the expression of VEGF type-1 receptor (fatal hepatic kinase receptor, FIK1) significantly decreased in animals treated with EPO for three days after the ischemia, Li and his colleagues suggested that regardless of the increased level of endothelial vascular growth factor, EPO maint ...
THALAMUS
THALAMUS

... the thalamus, separating it into medial and lateral nuclear masses. The medial mass consists of the medial nuclear group; the lateral mass contains the lateral nuclear group and the ventral nuclear group. In the rostral part of the thalamus the internal medullary lamina splits to form a partial caps ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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