Neuroscience of psychoactive substance use and dependence
... attributable to substance use and dependence is the result of a wide variety of health and social problems, including HIV/AIDS, which is driven in many countries by injecting drug use. This neuroscience report is the first attempt by WHO to provide a comprehensive overview of the biological factors ...
... attributable to substance use and dependence is the result of a wide variety of health and social problems, including HIV/AIDS, which is driven in many countries by injecting drug use. This neuroscience report is the first attempt by WHO to provide a comprehensive overview of the biological factors ...
A zebrafish model of CLN2 disease is deficient in
... Amongst the vertebrates, one mouse model (Sleat et al., 2004) and one canine model (Awano et al., 2006) exist for CLN2 disease. Both models reflect the clinical phenotype of CLN2 disease and provide valuable insights into CLN2 disease pathogenesis. However, both model systems are relatively slow to ...
... Amongst the vertebrates, one mouse model (Sleat et al., 2004) and one canine model (Awano et al., 2006) exist for CLN2 disease. Both models reflect the clinical phenotype of CLN2 disease and provide valuable insights into CLN2 disease pathogenesis. However, both model systems are relatively slow to ...
Research Paper Synthesis and Evaluation of Clozapine
... largest disease in the world in the age group of 15-30 and posing it as one of the major medical challenges. The medical management of schizophrenia often requires a combination of antipsychotic, antidepressant, and antianxiety drugs (Helio Elkis., 2007). Disruption of the dopamine system has been s ...
... largest disease in the world in the age group of 15-30 and posing it as one of the major medical challenges. The medical management of schizophrenia often requires a combination of antipsychotic, antidepressant, and antianxiety drugs (Helio Elkis., 2007). Disruption of the dopamine system has been s ...
Acute and Chronic Effects of Inhalants in Intracranial Self
... there is a great deal of ongoing research involved in isolating their binding site(s). (Borghese et al, 2006; Lecker et al, 2013; Werner et al, 2011). In mutant models of GABAA receptors, it has been demonstrated that point mutations of key proteins can dramatically reduce the overall pharmacologica ...
... there is a great deal of ongoing research involved in isolating their binding site(s). (Borghese et al, 2006; Lecker et al, 2013; Werner et al, 2011). In mutant models of GABAA receptors, it has been demonstrated that point mutations of key proteins can dramatically reduce the overall pharmacologica ...
synaptic connections made by axons
... changes in arborizations and synapses, may continue to be made long after birth. In the embryo, some of these events may be facilitated by the short distance that usually separates most neurones from their targets and the time differences in the genesis, migration and neurite outgrowth normally exhi ...
... changes in arborizations and synapses, may continue to be made long after birth. In the embryo, some of these events may be facilitated by the short distance that usually separates most neurones from their targets and the time differences in the genesis, migration and neurite outgrowth normally exhi ...
connect_review_20150316 - Royal Holloway, University of London
... A current challenge for visual neuroscience is to explain how perception of complex and meaningful objects is achieved. High-level vision is associated with anatomically-focal, functionally-defined brain areas in human occipitotemporal cortex, usually localized using functional magnetic resonance im ...
... A current challenge for visual neuroscience is to explain how perception of complex and meaningful objects is achieved. High-level vision is associated with anatomically-focal, functionally-defined brain areas in human occipitotemporal cortex, usually localized using functional magnetic resonance im ...
A Comprehensive Protocol for Manual Segmentation of the Medial
... , the present protocol presents a comprehensive set of guidelines that address inconsistencies in the extant literature. Complemented by the accompanying visual materials, this work is expected to promote clearer understanding of the MTL structures, and stir up interest of future research in adoptin ...
... , the present protocol presents a comprehensive set of guidelines that address inconsistencies in the extant literature. Complemented by the accompanying visual materials, this work is expected to promote clearer understanding of the MTL structures, and stir up interest of future research in adoptin ...
Marine Origin Polysaccharides in Drug Delivery Systems
... bioactivity. Recently, a growing interest in many scientific areas that study the diverse applications of marine compounds has been found, justified by their large biodiversity and simplicity of the extraction and purification processes [1,2]. Marine biomaterials have wide applicability in biomedici ...
... bioactivity. Recently, a growing interest in many scientific areas that study the diverse applications of marine compounds has been found, justified by their large biodiversity and simplicity of the extraction and purification processes [1,2]. Marine biomaterials have wide applicability in biomedici ...
The next wave of scientific innovation
... 2010, and one of the first jobs that I had to do was go through and review the portfolio to rank and prioritise projects. AZD9291 was in discovery at the time and I think it’s helpful to go back to the origins of thinking ‘why would we want a drug like this?’ because at the time it wasn't as obvious ...
... 2010, and one of the first jobs that I had to do was go through and review the portfolio to rank and prioritise projects. AZD9291 was in discovery at the time and I think it’s helpful to go back to the origins of thinking ‘why would we want a drug like this?’ because at the time it wasn't as obvious ...
Neurobiology of Pain - Lewis Mehl
... Brain regions involved in modulating pain perception seem identified best with studies involving neurotransmitter and neuroreceptor changes, although psychological modulation of pain is also being examined with fMRI, PET, and EEG/MEG studies. There seems to be good evidence for somatotopic organiza ...
... Brain regions involved in modulating pain perception seem identified best with studies involving neurotransmitter and neuroreceptor changes, although psychological modulation of pain is also being examined with fMRI, PET, and EEG/MEG studies. There seems to be good evidence for somatotopic organiza ...
The Neuronal Endomembrane System
... fast axonal transport pass through the Golgi apparatus (GA) (Hammerschlag et al., 1982). Collectively, these findings indicate that each of these systems may play distinct roles in the fast transport of new neuronal products. Uncertainty remains, however, concerning the intimate anatomical interrela ...
... fast axonal transport pass through the Golgi apparatus (GA) (Hammerschlag et al., 1982). Collectively, these findings indicate that each of these systems may play distinct roles in the fast transport of new neuronal products. Uncertainty remains, however, concerning the intimate anatomical interrela ...
Dietary Supplements: Kava
... grated, (chewed) Traditionally used in ceremonies valued for its tranquilizing and relaxant effects weddings, births, funerals, official ceremonies ...
... grated, (chewed) Traditionally used in ceremonies valued for its tranquilizing and relaxant effects weddings, births, funerals, official ceremonies ...
Hippocampal CA1 atrophy and synaptic loss during
... white matter (WM) demyelinating disease, characterized by focal WM lesions consisting of T lymphocyte and macrophage infiltrates, demyelination and axonal transection.2–4 However, WM pathology does not occur exclusively. Gray matter atrophy has been shown to occur in cortical and deep sub-cortical b ...
... white matter (WM) demyelinating disease, characterized by focal WM lesions consisting of T lymphocyte and macrophage infiltrates, demyelination and axonal transection.2–4 However, WM pathology does not occur exclusively. Gray matter atrophy has been shown to occur in cortical and deep sub-cortical b ...
Pharmacokinetics and pharmacodynamics of the - e
... The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, ...
... The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, ...
Drug treatments for Parkinson`s
... drugs are not used to treat the symptoms of Parkinson’s that are not related to movement. These types of non-motor symptoms will be treated separately depending on the problems you experience. Constipation and depression, for example, may be treated with drugs designed to treat those symptoms. There ...
... drugs are not used to treat the symptoms of Parkinson’s that are not related to movement. These types of non-motor symptoms will be treated separately depending on the problems you experience. Constipation and depression, for example, may be treated with drugs designed to treat those symptoms. There ...
Projections of the amygdala to the thalamus in the cynomolgus
... The subjects were 15 cynomolgus monkeys (Macacafascicularis) weighing 2.5-7.5 kg at the time of surgery. The animals were tranquilized with ketamine hydrochloride (10 mgkg), anesthetized with Nembutal (35 mgkg), and placed in a stereotaxic apparatus. Five monkeys received injections of horseradish p ...
... The subjects were 15 cynomolgus monkeys (Macacafascicularis) weighing 2.5-7.5 kg at the time of surgery. The animals were tranquilized with ketamine hydrochloride (10 mgkg), anesthetized with Nembutal (35 mgkg), and placed in a stereotaxic apparatus. Five monkeys received injections of horseradish p ...
field and action potential recordings in heart slices
... Langendorff hearts, papillary muscle or Purkinje fibers provide evidence of drug action under conditions more or less close to in vivo physiology, but are time-consuming and expensive, because only a limited number of drugs or drug concentrations can be tested in the heart of one animal. Heart slice ...
... Langendorff hearts, papillary muscle or Purkinje fibers provide evidence of drug action under conditions more or less close to in vivo physiology, but are time-consuming and expensive, because only a limited number of drugs or drug concentrations can be tested in the heart of one animal. Heart slice ...
Hepatic but Not CNS-Expressed Human C
... was sufficient to influence the outcome of MOG peptideinduced EAE. As we reported previously [16, 18], we found that EAE onset was significantly delayed and EAE severity was significantly reduced in CRPtg compared to wildtype, but neuronal expression of CRP had no such impact (Figure 5 and Table 1). ...
... was sufficient to influence the outcome of MOG peptideinduced EAE. As we reported previously [16, 18], we found that EAE onset was significantly delayed and EAE severity was significantly reduced in CRPtg compared to wildtype, but neuronal expression of CRP had no such impact (Figure 5 and Table 1). ...
- ISpatula
... tissues, where it is bound by specialized receptors that are found on the membranes of most tissues. • The biologic responses promoted by these insulin-receptor complexes have been identified in the primary target tissues, ie, liver, muscle, and adipose tissue. The receptors bind insulin with high s ...
... tissues, where it is bound by specialized receptors that are found on the membranes of most tissues. • The biologic responses promoted by these insulin-receptor complexes have been identified in the primary target tissues, ie, liver, muscle, and adipose tissue. The receptors bind insulin with high s ...
"Marijuana - Not Just Blowing Smoke"
... chemicals with a similar makeup. The areas of the brain controlling pleasure, thinking, memory, the ability to focus, sensory and time perception, and coordinated movement have high concentrations of these receptors. Consequently, these functions are affected the most by marijuana. Marijuana exposes ...
... chemicals with a similar makeup. The areas of the brain controlling pleasure, thinking, memory, the ability to focus, sensory and time perception, and coordinated movement have high concentrations of these receptors. Consequently, these functions are affected the most by marijuana. Marijuana exposes ...
The Distribution of Tyrosine Hydroxylase
... Comparison of these distribution patterns with those produced by an antiserum directed against dopamine-&hydroxylase (DBH), a specific marker of neocortical noradrenergic axons, revealed marked differences. DBH-immunoreactive fibers were observed in some cortical locations where few or no TH-labeled ...
... Comparison of these distribution patterns with those produced by an antiserum directed against dopamine-&hydroxylase (DBH), a specific marker of neocortical noradrenergic axons, revealed marked differences. DBH-immunoreactive fibers were observed in some cortical locations where few or no TH-labeled ...
Neuromechanical coupling in the regulation of muscle tone and joint
... Neuromechanical coupling and stiffness regulation reflex and heightened muscle tone. This may serve to maximize muscular responsiveness and protect the individual under stressful conditions (Davis et al., 2011). However, if muscle tone is increased excessively, such as when an individual becomes st ...
... Neuromechanical coupling and stiffness regulation reflex and heightened muscle tone. This may serve to maximize muscular responsiveness and protect the individual under stressful conditions (Davis et al., 2011). However, if muscle tone is increased excessively, such as when an individual becomes st ...
Combinations of antifungal agents in therapy–what value are they?
... albicans,28,29 and synergistic against clinical isolates of Candida lusitaniae.30 Concurrent therapy with amphotericin B and flucytosine is considered the standard treatment for cryptococcal meningitis and thus there are several studies of their interaction in vitro against Cryptococcus neoformans. ...
... albicans,28,29 and synergistic against clinical isolates of Candida lusitaniae.30 Concurrent therapy with amphotericin B and flucytosine is considered the standard treatment for cryptococcal meningitis and thus there are several studies of their interaction in vitro against Cryptococcus neoformans. ...
MRI INTERVENTIONS, INC.
... Forward Looking Statements Certain statements in this presentation may constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements often can be identified by words such as “a ...
... Forward Looking Statements Certain statements in this presentation may constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements often can be identified by words such as “a ...
10-Sensation of Taste lecture
... Primary modalities of taste: – Sour – Salt – Sweet – Bitter – umami (deliciousness), a taste associated with glutamate & other nucleotides has receptors located at the back of the pharynx. ...
... Primary modalities of taste: – Sour – Salt – Sweet – Bitter – umami (deliciousness), a taste associated with glutamate & other nucleotides has receptors located at the back of the pharynx. ...