Toxicologic Pathology Induced Oxidative Liver Damage -Carotene on Methotrexate
... lipid peroxidation, significantly increased ( p ¼ .008), while SOD ( p ¼ .03), CAT ( p ¼ .004), and GP-x ( p ¼ .004) activities significantly decreased compared with the livers of rats in the control group. When rats were given b-carotene þ MTX, their biochemical parameters were statistically differ ...
... lipid peroxidation, significantly increased ( p ¼ .008), while SOD ( p ¼ .03), CAT ( p ¼ .004), and GP-x ( p ¼ .004) activities significantly decreased compared with the livers of rats in the control group. When rats were given b-carotene þ MTX, their biochemical parameters were statistically differ ...
BoNT_A Presentation UMass Dartmouth 081029
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
ANAMIRTA COCCULUS LINN Research Article V. SATYA*
... trend towards the usage of herbal medicines which may be probably due to the side effects and enormous cost involved in modern medicines. At present people are turning towards the herbal wound healers so as to prevent allergy and other complications that are often encountered due to the application ...
... trend towards the usage of herbal medicines which may be probably due to the side effects and enormous cost involved in modern medicines. At present people are turning towards the herbal wound healers so as to prevent allergy and other complications that are often encountered due to the application ...
Efficacy of Lidocaine Iontophoresis Using Either Alternating or Direct
... electrodes at t, and T is the period of the square wave. However, there have been fewer studies in which the efficacy of AC-IOP is compared with that of DCIOP, which is widely used. Yan et al. reported the good correlations between phenylalanine and mannitol transport across human epidermal membra ...
... electrodes at t, and T is the period of the square wave. However, there have been fewer studies in which the efficacy of AC-IOP is compared with that of DCIOP, which is widely used. Yan et al. reported the good correlations between phenylalanine and mannitol transport across human epidermal membra ...
Aalborg Universitet
... than 30 years using various administration formulations such as intravenous, sublingual and spinal-epidural [42]. However, after the introduction of TDS of the drug, there has been a renaissance of interest in its analgesic profile. The analgesic effect of transdermal buprenorphine has previously be ...
... than 30 years using various administration formulations such as intravenous, sublingual and spinal-epidural [42]. However, after the introduction of TDS of the drug, there has been a renaissance of interest in its analgesic profile. The analgesic effect of transdermal buprenorphine has previously be ...
Session 230 IOP Measurement and characterization I
... the orbital wall, and IOP was transmitted to the transducer via an aqueous-filled silicone tube inserted into the anterior chamber. The implant was large, and the battery required intraperitoneal placement. We have developed an updated bilateral IOP and ocular perfusion pressure (OPP) telemetry syst ...
... the orbital wall, and IOP was transmitted to the transducer via an aqueous-filled silicone tube inserted into the anterior chamber. The implant was large, and the battery required intraperitoneal placement. We have developed an updated bilateral IOP and ocular perfusion pressure (OPP) telemetry syst ...
Antiangiogenic Activity of N-substituted and
... microvessel outgrowth in the rat aorta as well as HUVEC proliferation and tube formation at 12.5 M. In contrast, CPS48 did not show activity in the rat aortic ring and HUVEC proliferation assays. Gütschow et al. (24) previously tested these three analogues for their ability to block lipopolysaccha ...
... microvessel outgrowth in the rat aorta as well as HUVEC proliferation and tube formation at 12.5 M. In contrast, CPS48 did not show activity in the rat aortic ring and HUVEC proliferation assays. Gütschow et al. (24) previously tested these three analogues for their ability to block lipopolysaccha ...
Oleo-gum-resin of Ferula asafoetida: A traditional culinary spice with
... known to exert antioxidant activity by reducing vascular disorders in humans by strengthening the membranes It is well recognized that antioxidants play an significant role in preventing gastric mucosal damage by strong cell defence mechanisms, likely to stimulate the endogenous synthesis of prostag ...
... known to exert antioxidant activity by reducing vascular disorders in humans by strengthening the membranes It is well recognized that antioxidants play an significant role in preventing gastric mucosal damage by strong cell defence mechanisms, likely to stimulate the endogenous synthesis of prostag ...
ABCB1 haplotypes do not influence transport Linköping University Post Print
... as well as imatinib plasma concentration have previously been correlated with the outcome of CML therapy. 13–15 These findings indicate that analysis of drug-transport activity, or markers thereof, might be useful predictors of response to imatinib, and perhaps to the second-generation TKIs as well. ...
... as well as imatinib plasma concentration have previously been correlated with the outcome of CML therapy. 13–15 These findings indicate that analysis of drug-transport activity, or markers thereof, might be useful predictors of response to imatinib, and perhaps to the second-generation TKIs as well. ...
... the kidney, the concentrations of Cd, Cr, Ti, V, Cu, Se, and Zn were found to be at a lower level than in the noncancerous parts. Ligands having electron donor atoms like N, O, S, and P etc. may form coordination bond with metal ion. Chelation causes drastic changes in biological properties of ligan ...
The effect of caffeine on oxidative stress in liver and heart tissues of
... caused oxidative stress. In their in vivo research, Karas et al. (23) found that the oral administration of caffeine (150 mg/kg) increased MDA levels in the livers of rats that had been treated with allyl alcohol to reduce the hepatotoxicity of the high dose of caffeine. Mukhopadhyay et al. (24) sta ...
... caused oxidative stress. In their in vivo research, Karas et al. (23) found that the oral administration of caffeine (150 mg/kg) increased MDA levels in the livers of rats that had been treated with allyl alcohol to reduce the hepatotoxicity of the high dose of caffeine. Mukhopadhyay et al. (24) sta ...
DMSO inhibits human platelet activation through cyclooxygenase
... a rare but serious complication observed following DES deployment [30,31]. Furthermore, platelet activation is also a relevant contributing factor in the regulation of tissue factor (TF) expression [7] – the key regulator of the coagulation cascade. In fact, platelets were shown to not only lead to ...
... a rare but serious complication observed following DES deployment [30,31]. Furthermore, platelet activation is also a relevant contributing factor in the regulation of tissue factor (TF) expression [7] – the key regulator of the coagulation cascade. In fact, platelets were shown to not only lead to ...
Biowaiver extension potential to BCS Class III high solubility
... studies be extended to Class III drugs (Blume and Schug, 1999; Yu et al., 2002). However, what kind of in vitro dissolution requirements should be set to ensure that the drug release has no significant impact on in vivo bioavailability is still unknown, and data available for supporting biowaivers o ...
... studies be extended to Class III drugs (Blume and Schug, 1999; Yu et al., 2002). However, what kind of in vitro dissolution requirements should be set to ensure that the drug release has no significant impact on in vivo bioavailability is still unknown, and data available for supporting biowaivers o ...
Bischoff_Thesis_notes
... Miyachi et al. (1997) – inactivation of anterior caudate and putamen disrupted learning a new sequence, injections into middle-posterior putamen disrupted execution of well-learned sequences Jenkins et al. (1994) – human PET – putamen equally active during learning sequence and executed overlear ...
... Miyachi et al. (1997) – inactivation of anterior caudate and putamen disrupted learning a new sequence, injections into middle-posterior putamen disrupted execution of well-learned sequences Jenkins et al. (1994) – human PET – putamen equally active during learning sequence and executed overlear ...
chemistry-15
... Aims This module covers material dealing with fundamental medicinal chemistry. It encompasses Module Content/ CH3041, CH3042 and CH3043 Description* CH3041 - Introduction to Medicinal Chemistry - 15 Lectures - M. Southern Principles of drug action; drug properties; drug targets and modes of action. ...
... Aims This module covers material dealing with fundamental medicinal chemistry. It encompasses Module Content/ CH3041, CH3042 and CH3043 Description* CH3041 - Introduction to Medicinal Chemistry - 15 Lectures - M. Southern Principles of drug action; drug properties; drug targets and modes of action. ...
Subicular and CA1 hippocampal projections to the accessory
... yielded retrograde-labeled cells in the ventral CA1 (de Olmos et al., 1978), although authors were unsure of this projection due to the large sizes of their injections. The reason could be methodological and/or due to species differences. Sensitive retrograde tracers such as FG gave rise to retrogra ...
... yielded retrograde-labeled cells in the ventral CA1 (de Olmos et al., 1978), although authors were unsure of this projection due to the large sizes of their injections. The reason could be methodological and/or due to species differences. Sensitive retrograde tracers such as FG gave rise to retrogra ...
Somatosensory processes subserving perception and action
... targets on the insensate arm (Aglioti et al. 1996; Rossetti et al. 1995b), others showed that movements with the impaired arm were still possible despite the absence of proprioceptive feedback (Brochier et al. 1994; Pause et al. 1989; Volpe et al. 1979). Regarding the neural substrate of these uncon ...
... targets on the insensate arm (Aglioti et al. 1996; Rossetti et al. 1995b), others showed that movements with the impaired arm were still possible despite the absence of proprioceptive feedback (Brochier et al. 1994; Pause et al. 1989; Volpe et al. 1979). Regarding the neural substrate of these uncon ...
Development of a facile antibody–drug conjugate
... the reduced antibody. However, since it is known that Pt(II) can also bind to various amino acids such as histidine, methionine, cysteine etc.,24,25 we conrmed that our Pt–PEG–CPT molecule binds only to the reduced antibody upon exposure of cysteine thiols i.e., Pt–PEG–CPT showed negligible associa ...
... the reduced antibody. However, since it is known that Pt(II) can also bind to various amino acids such as histidine, methionine, cysteine etc.,24,25 we conrmed that our Pt–PEG–CPT molecule binds only to the reduced antibody upon exposure of cysteine thiols i.e., Pt–PEG–CPT showed negligible associa ...
Cerebral amyloidosis, amyloid angiopathy, and their relationship to
... Mutations in the amyloid precursor protein (AβPP) on chromosome 21 or presenilins (PS) 1 (chromosome 14) and 2 (chromosome 1) genes have been linked to autosomal dominant forms of familial AD (FAD) (reviewed in [48]). As indicated in Fig. 1, multiple mutation sites either within or immediately outsi ...
... Mutations in the amyloid precursor protein (AβPP) on chromosome 21 or presenilins (PS) 1 (chromosome 14) and 2 (chromosome 1) genes have been linked to autosomal dominant forms of familial AD (FAD) (reviewed in [48]). As indicated in Fig. 1, multiple mutation sites either within or immediately outsi ...
The practice of digoxin therapeutic drug monitoring - BN6Team-10
... how high the concentration is, and the half-life of digoxin in that patient. In a patient with normal renal function (half-life approximately 30 h) and a concentration of 3.0 nmol/l, the digoxin should be withheld for 1–2 days before restarting at the appropriately altered dose, as this will allow t ...
... how high the concentration is, and the half-life of digoxin in that patient. In a patient with normal renal function (half-life approximately 30 h) and a concentration of 3.0 nmol/l, the digoxin should be withheld for 1–2 days before restarting at the appropriately altered dose, as this will allow t ...
renamed_ce891 - Spiral
... Adverse event and pharmacogenetics All vasopressors can lead to serious adverse events (SAEs), primarily due to the intense vasoconstriction they induce. The prevalence of these SAEs is reported as ranging from 10-72% [14], presumably reflecting the heterogeneity of patient populations, treatment re ...
... Adverse event and pharmacogenetics All vasopressors can lead to serious adverse events (SAEs), primarily due to the intense vasoconstriction they induce. The prevalence of these SAEs is reported as ranging from 10-72% [14], presumably reflecting the heterogeneity of patient populations, treatment re ...
Advances in and applications of proteasome inhibitors
... same anticancer properties as salinosporamide A. Further proteasome inhibitors of the b-lactone family include belactosines A and C (Figure 2) from Streptomyces sp. UCK14 that selectively inhibit the b5-subunit of the proteasome, with the modified homobelactosin C derivative (Figure 2) having an IC5 ...
... same anticancer properties as salinosporamide A. Further proteasome inhibitors of the b-lactone family include belactosines A and C (Figure 2) from Streptomyces sp. UCK14 that selectively inhibit the b5-subunit of the proteasome, with the modified homobelactosin C derivative (Figure 2) having an IC5 ...
Disorders of the Cerebellum and Its Connections
... movement, as well as in the movements of posture and equilibrium. The cerebellum is vulnerable to most of the nonspecific disease processes that affect other areas of the central nervous system, as well as to certain diseases unique to the cerebellum (Table 19-1). When the cerebellum or its direct c ...
... movement, as well as in the movements of posture and equilibrium. The cerebellum is vulnerable to most of the nonspecific disease processes that affect other areas of the central nervous system, as well as to certain diseases unique to the cerebellum (Table 19-1). When the cerebellum or its direct c ...
Insulin-like actions of vanadium: Potential as a
... insulin is mediated by both enhancing glucose uptake and stimulation of glycogen synthesis [55]. Among insulin sensitive tissues, skeletal muscle because of its mass, is the major target tissue for insulin-stimulated glucose disposal. The metabolic effects of insulin are initiated by activation of i ...
... insulin is mediated by both enhancing glucose uptake and stimulation of glycogen synthesis [55]. Among insulin sensitive tissues, skeletal muscle because of its mass, is the major target tissue for insulin-stimulated glucose disposal. The metabolic effects of insulin are initiated by activation of i ...
Copy Right- Hongqi ZHANG-Department of Anatomy
... ZHANG-Department of Anatomy-Fudan University and Copy septi,Rightas well as the course taken by entering and departing axons. ...
... ZHANG-Department of Anatomy-Fudan University and Copy septi,Rightas well as the course taken by entering and departing axons. ...