Cathepsin B is a New Drug Target for Traumatic Brain Injury
... risks for many age-related neurological diseases, including amyotrophic lateral sclerosis (ALS) (20), Parkinson’s disease (PD) (21), Alzheimer’s disease (AD) (22), epilepsy (23), and possibly multiple sclerosis (MS) (24). As such, TBI can also be viewed as a model of neurodegenerative diseases gener ...
... risks for many age-related neurological diseases, including amyotrophic lateral sclerosis (ALS) (20), Parkinson’s disease (PD) (21), Alzheimer’s disease (AD) (22), epilepsy (23), and possibly multiple sclerosis (MS) (24). As such, TBI can also be viewed as a model of neurodegenerative diseases gener ...
results - Pakistan Journal of Pharmaceutical Sciences
... et al., 2006. Almost all NSAIDs are reported to cause elevated levels of aminotransferases that is not clinically relevant and returns to normal upon cessation of therapy (Zimmerman 1990, Brass 1993, Manoukian and Carson 1996). In contrast double dose caused a significant increase (P<0.01) in ALT le ...
... et al., 2006. Almost all NSAIDs are reported to cause elevated levels of aminotransferases that is not clinically relevant and returns to normal upon cessation of therapy (Zimmerman 1990, Brass 1993, Manoukian and Carson 1996). In contrast double dose caused a significant increase (P<0.01) in ALT le ...
Cyclophosphamide Modulates Rat Hepatic Cytochrome P450 2C11
... The feminization of the gender-dependent hepatic cytochrome P450 enzymes and steroid 5a-reductase by cyclophosphamide treatment of adult male rats is associated with depletion of serum testosterone (9). Therefore, serum testosterone concentrations were compared in ifos phamide- and cyclophosphamide- ...
... The feminization of the gender-dependent hepatic cytochrome P450 enzymes and steroid 5a-reductase by cyclophosphamide treatment of adult male rats is associated with depletion of serum testosterone (9). Therefore, serum testosterone concentrations were compared in ifos phamide- and cyclophosphamide- ...
Distinct Neuropathologic Phenotypes After Disrupting the
... effective therapies for these autosomal recessive disorders, their relentless disease course invariably ends in premature death (12, 13). Disease-causing mutations have been identified in at least 8 genes (13, 14), but there are still variant and adultonset NCL cases with no characterized molecular b ...
... effective therapies for these autosomal recessive disorders, their relentless disease course invariably ends in premature death (12, 13). Disease-causing mutations have been identified in at least 8 genes (13, 14), but there are still variant and adultonset NCL cases with no characterized molecular b ...
Unraveling the Genetics of Distal Hereditary Motor Neuronopathies
... In a branch of a large Bulgarian family mild pyramidal tract signs and rarely Babinski signs were present. No sensory symptoms, except for slightly reduced vibration sense in the feet, were observed in 30% of the patients. Neurophysiological studies confirmed chronic denervation in distal muscles wi ...
... In a branch of a large Bulgarian family mild pyramidal tract signs and rarely Babinski signs were present. No sensory symptoms, except for slightly reduced vibration sense in the feet, were observed in 30% of the patients. Neurophysiological studies confirmed chronic denervation in distal muscles wi ...
Product Monograph
... aggression and depersonalization. In some cases, the events occurred within several weeks of starting treatment. ...
... aggression and depersonalization. In some cases, the events occurred within several weeks of starting treatment. ...
Comparison of the effects of cimetidine and hyoscine-n
... Cimetidine can also cause direct relaxation of GIT smooth muscle which can in turn reduce the rate of gastric emptying & consequently cause a decrease in absorption rate of co-administered drugs. This effect was found to occur when there was a change in the study protocol where rather than administe ...
... Cimetidine can also cause direct relaxation of GIT smooth muscle which can in turn reduce the rate of gastric emptying & consequently cause a decrease in absorption rate of co-administered drugs. This effect was found to occur when there was a change in the study protocol where rather than administe ...
Sequence of information processing for emotions based on the
... The amygdala and the prefrontal cortex have synergistic roles in regulating purposive behavior (Schoenbaum et al., 2000; Izquierdo and Murray, 2005; reviewed in Barbas, 2000; Bechara et al., 2000). The amygdala appears to extract the affective significance of stimuli, and the prefrontal cortex guide ...
... The amygdala and the prefrontal cortex have synergistic roles in regulating purposive behavior (Schoenbaum et al., 2000; Izquierdo and Murray, 2005; reviewed in Barbas, 2000; Bechara et al., 2000). The amygdala appears to extract the affective significance of stimuli, and the prefrontal cortex guide ...
Chapter 1 Key Terms
... 30. The study of drugs and their actions in living response; a receptor blocker. organisms. Medication that enhances the effect of another medication. Pertaining to being applied to a surface. ...
... 30. The study of drugs and their actions in living response; a receptor blocker. organisms. Medication that enhances the effect of another medication. Pertaining to being applied to a surface. ...
International Journal of Ayurveda and Pharma Research
... passages (haritaki pathyanam). Haritaki enjoys wide patronage in Tibetan medicine also which is known as A-ru-ra and praised with the adjective Sman-mchog-rgyal-pa (the king of best medicines). Haritaki in day to day life by judicious combinations of different adjuvants will be a boon for the person ...
... passages (haritaki pathyanam). Haritaki enjoys wide patronage in Tibetan medicine also which is known as A-ru-ra and praised with the adjective Sman-mchog-rgyal-pa (the king of best medicines). Haritaki in day to day life by judicious combinations of different adjuvants will be a boon for the person ...
INVESTIGATING THE SOPHISTICATION OF LONG-LATENCY UPPER LIMB
... voluntary motor behaviour involves the sophisticated manipulation of sensory feedback. Although this theory can explain how people move in the world, it does not specifically describe how this control process is implemented by the nervous system. In this thesis, we propose and explore one physiologi ...
... voluntary motor behaviour involves the sophisticated manipulation of sensory feedback. Although this theory can explain how people move in the world, it does not specifically describe how this control process is implemented by the nervous system. In this thesis, we propose and explore one physiologi ...
uniformity (a required drug dose). This led to the develop-
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
Report of the International Narcotics Control Board for 2015
... However, INCB is convinced that these challenges can be met by fully implementing the conventions and the principles of the political declarations. The drug control system is a balanced system, driving towards improving public health and welfare, based on the underlying principles of proportionalit ...
... However, INCB is convinced that these challenges can be met by fully implementing the conventions and the principles of the political declarations. The drug control system is a balanced system, driving towards improving public health and welfare, based on the underlying principles of proportionalit ...
Antiepileptic drugs for neuropathic pain and fibromyalgia
... neuropathy, postherpetic neuralgia, and central neuropathic pain) and fibromyalgia. Only a minority of people achieved acceptably good pain relief with either drug, but it is known that quality of life and function improved markedly with the outcome of at least 50% pain intensity reduction. For othe ...
... neuropathy, postherpetic neuralgia, and central neuropathic pain) and fibromyalgia. Only a minority of people achieved acceptably good pain relief with either drug, but it is known that quality of life and function improved markedly with the outcome of at least 50% pain intensity reduction. For othe ...
Jennifer McFarland - University of Evansville Faculty Web sites
... popular controversy that both intrigues me, and may be useful for my graduate school pursuits. If there are any further questions about this review, I can be reached at [email protected]. ...
... popular controversy that both intrigues me, and may be useful for my graduate school pursuits. If there are any further questions about this review, I can be reached at [email protected]. ...
Routine analysis of amphetamine class drugs as their
... Analysis of these amphetamines in urine is difficult due to the lack of specificity and / or sensitivity of the commonly used analytical methods. Preliminary testing of these drugs in urine is usually by immunoassay techniques which have adequate sensitivity but suffer from interference from chemica ...
... Analysis of these amphetamines in urine is difficult due to the lack of specificity and / or sensitivity of the commonly used analytical methods. Preliminary testing of these drugs in urine is usually by immunoassay techniques which have adequate sensitivity but suffer from interference from chemica ...
Product Monograph Template - Standard
... In subjects with hepatic impairment, Celexa clearance was significantly decreased and plasma concentrations, as well as elimination half-life significantly increased (see ACTION AND CLINICAL PHARMACOLOGY, Pharmacokinetics, Special Populations, Hepatic Impairment). Consequently, the use of Celexa in ...
... In subjects with hepatic impairment, Celexa clearance was significantly decreased and plasma concentrations, as well as elimination half-life significantly increased (see ACTION AND CLINICAL PHARMACOLOGY, Pharmacokinetics, Special Populations, Hepatic Impairment). Consequently, the use of Celexa in ...
In vitro metabolism and drug-drug interaction potential of irosustat, a
... developed with these sites of metabolism blocked, thereby slowing metabolic clearance. A second possible consequence of drug metabolism is the formation of active metabolites (those having the desired activity to an extent similar to/or greater than the parent drug). In some of these cases, the drug ...
... developed with these sites of metabolism blocked, thereby slowing metabolic clearance. A second possible consequence of drug metabolism is the formation of active metabolites (those having the desired activity to an extent similar to/or greater than the parent drug). In some of these cases, the drug ...
Statins Transport, side effects and cytoxicity_Rev2
... lactone statins are also metabolized by the CYP enzymes, except pravastatin and rosuvastatin, with the lactones having a higher metabolic rate. [17,18] While it has been found that rosuvastatin is not significantly metabolized by the CYP enzymes, and is largely excreted unchanged, this situation is ...
... lactone statins are also metabolized by the CYP enzymes, except pravastatin and rosuvastatin, with the lactones having a higher metabolic rate. [17,18] While it has been found that rosuvastatin is not significantly metabolized by the CYP enzymes, and is largely excreted unchanged, this situation is ...
TRAMADOL – A Drug to be used cautiously
... of the racemate. As one of the least potent opioid painkillers many people believe tramadol is not addictive. This false sense of security can lead some people to develop an addiction without even realizing it. Tramadol was originally considered to have a much better safety profile than other opioid ...
... of the racemate. As one of the least potent opioid painkillers many people believe tramadol is not addictive. This false sense of security can lead some people to develop an addiction without even realizing it. Tramadol was originally considered to have a much better safety profile than other opioid ...
Download CV
... Tsai G, *Stauch B, Vornov JJ, Coyle JT. “Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo.” Brain Research, 1990, 518:313-316 Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. “Rat brain N-acetylated alpha-linked acidic dipeptidase activity: pur ...
... Tsai G, *Stauch B, Vornov JJ, Coyle JT. “Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo.” Brain Research, 1990, 518:313-316 Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. “Rat brain N-acetylated alpha-linked acidic dipeptidase activity: pur ...
DHA Effects in Brain Development and Function
... mature breastmilk have shown that the concentration of AA is influenced to a larger extent than that of DHA [41,47,48]. Findings in plasma from both mothers and neonates have shown strong inverse associations between the minor allele for two FADS SNPs and the concentrations of DHA and eicosapentaeno ...
... mature breastmilk have shown that the concentration of AA is influenced to a larger extent than that of DHA [41,47,48]. Findings in plasma from both mothers and neonates have shown strong inverse associations between the minor allele for two FADS SNPs and the concentrations of DHA and eicosapentaeno ...
GINKGO BILOBA: A Cognitive Enhancer?
... The ginkgo tree is indigenous to Korea, China, and Japan. It is popular for lining streets and for parks, although its seeds are reported to give off a foul odor when ripe. The tree may grow to 40 m in height and may live for more than 1,000 years. It flowers for the first time when it is about 25 y ...
... The ginkgo tree is indigenous to Korea, China, and Japan. It is popular for lining streets and for parks, although its seeds are reported to give off a foul odor when ripe. The tree may grow to 40 m in height and may live for more than 1,000 years. It flowers for the first time when it is about 25 y ...
American College of Radiology ACR Appropriateness Criteria
... Gold standard test. Usually performed after initial noninvasive imaging with MR or CT. Parenchymal imaging and CT or MR vascular brain imaging should be considered. MRI is superior to CT for parenchymal evaluation due to greater range of soft-tissue contrast and improved anatomic detail. It is helpf ...
... Gold standard test. Usually performed after initial noninvasive imaging with MR or CT. Parenchymal imaging and CT or MR vascular brain imaging should be considered. MRI is superior to CT for parenchymal evaluation due to greater range of soft-tissue contrast and improved anatomic detail. It is helpf ...
CELEXA PM MKT Control 149419 10Jan2012 En
... In subjects with hepatic impairment, Celexa clearance was significantly decreased and plasma concentrations, as well as elimination half-life significantly increased (see ACTION AND CLINICAL PHARMACOLOGY, Pharmacokinetics, Special Populations, Hepatic Impairment). Consequently, the use of Celexa in ...
... In subjects with hepatic impairment, Celexa clearance was significantly decreased and plasma concentrations, as well as elimination half-life significantly increased (see ACTION AND CLINICAL PHARMACOLOGY, Pharmacokinetics, Special Populations, Hepatic Impairment). Consequently, the use of Celexa in ...