ABC Clinical Guide 2003 - American Botanical Council
... Sedative-hypnotic. In mice, intraperitoneal injections of valerenic acid, valerenal, and whole herb extracts produced significant sedation, ataxia, and anti-convulsant effects (Hendriks et al., 1981; Veith et al., 1986). Intraperitoneal injections of 100 mg/kg had sedative effects as strong as barbi ...
... Sedative-hypnotic. In mice, intraperitoneal injections of valerenic acid, valerenal, and whole herb extracts produced significant sedation, ataxia, and anti-convulsant effects (Hendriks et al., 1981; Veith et al., 1986). Intraperitoneal injections of 100 mg/kg had sedative effects as strong as barbi ...
ALDACTAZIDE
... thiazide therapy (e.g. hyperbilirubinemia, thrombocytopenia, altered carbohydrate metabolism) can occur in the newborn since thiazides have been demonstrated to appear in breast milk. Monitoring and Laboratory Tests General: ALDACTAZIDE therapy may result in a transient elevation of BUN, especially ...
... thiazide therapy (e.g. hyperbilirubinemia, thrombocytopenia, altered carbohydrate metabolism) can occur in the newborn since thiazides have been demonstrated to appear in breast milk. Monitoring and Laboratory Tests General: ALDACTAZIDE therapy may result in a transient elevation of BUN, especially ...
“All flesh is coupled by the wave of circular rotational similarity” 1
... During the preparation of this manuscript, the author should become familiar with previously unknown areas of knowledge. It was necessary for him to learn the notions and terminology that exist in each field of science. Medical science consists of several special directions. A fruitful professional ...
... During the preparation of this manuscript, the author should become familiar with previously unknown areas of knowledge. It was necessary for him to learn the notions and terminology that exist in each field of science. Medical science consists of several special directions. A fruitful professional ...
Allergan to Acquire Naurex - McCormick School of Engineering
... decade, according to NeuroPerspective, a newsletter. This year so far, $4.3 billion has already been put into such firms, not including this deal. Among the beneficiaries have been neuroscience-based companies like Sage Therapeutics and Intracellular therapies. Discussions for the deal began late la ...
... decade, according to NeuroPerspective, a newsletter. This year so far, $4.3 billion has already been put into such firms, not including this deal. Among the beneficiaries have been neuroscience-based companies like Sage Therapeutics and Intracellular therapies. Discussions for the deal began late la ...
HISTORY OF ANESIATHIA - International Society for the History
... Young Simpson, who, in a wide-ranging study of organic compounds, found chloroform's efficacy on 4 November 1847. Its use spread quickly and gained royal approval in 1853 when John Snow gave it to Queen Victoria during the birth of Prince Leopold. Unfortunately, chloroform is not as safe an agent as ...
... Young Simpson, who, in a wide-ranging study of organic compounds, found chloroform's efficacy on 4 November 1847. Its use spread quickly and gained royal approval in 1853 when John Snow gave it to Queen Victoria during the birth of Prince Leopold. Unfortunately, chloroform is not as safe an agent as ...
Effects of Nonsteroidal Antiinflammatory Drugs on Platelet Function
... that blocks platelet aggregation by a variety of stimuli.32 Chronic aspirin therapy at the lowest dose causing near-complete blockade of thromboxane synthase (40 mg/day) is associated with the same degree of platelet function inhibition as seen with a higher dose (325 mg/day). 59 After a single dose ...
... that blocks platelet aggregation by a variety of stimuli.32 Chronic aspirin therapy at the lowest dose causing near-complete blockade of thromboxane synthase (40 mg/day) is associated with the same degree of platelet function inhibition as seen with a higher dose (325 mg/day). 59 After a single dose ...
Chronic Use and Cognitive Functioning and Mental Health
... who reported greater lifetime exposure to cannabis and an earlier onset of use. These differences in brain activity were diminished among individuals who reported longer periods of abstinence from cannabis (Chang, Yakupov, Cloak, & Ernst, 2006). Another brain imaging study of 28 adolescents found mo ...
... who reported greater lifetime exposure to cannabis and an earlier onset of use. These differences in brain activity were diminished among individuals who reported longer periods of abstinence from cannabis (Chang, Yakupov, Cloak, & Ernst, 2006). Another brain imaging study of 28 adolescents found mo ...
this PDF file
... By 1950 it was established that aspirin in high doses caused bleeding by prolonging the prothrombin time13,14. However, even low doses of aspirin which did not affect the prothrombin time prevented coronary thrombosis12. Because aspirin in high doses was associated with bleeding, many physicians in ...
... By 1950 it was established that aspirin in high doses caused bleeding by prolonging the prothrombin time13,14. However, even low doses of aspirin which did not affect the prothrombin time prevented coronary thrombosis12. Because aspirin in high doses was associated with bleeding, many physicians in ...
Neuronal Cell Death and Degeneration through Increased
... HIV-infected people are unclear. Therefore, this study was aimed to investigate the mechanisms of increased neurodegeneration in 5-month old male HIV-1 Transgenic (Tg) rats compared to the age- and gender-matched wild-type (WT) by evaluating histological changes and biochemical parameters of the key ...
... HIV-infected people are unclear. Therefore, this study was aimed to investigate the mechanisms of increased neurodegeneration in 5-month old male HIV-1 Transgenic (Tg) rats compared to the age- and gender-matched wild-type (WT) by evaluating histological changes and biochemical parameters of the key ...
Simulation Based Assessment of Limited Sampling Strategies
... the individual’s drug concentrations and, consequently, the AUC [14]. One advantage of B-LSS over R-LSS is its flexibility in terms of sampling time deviations which are implicitly included in the framework of the Pop-PK modeling and the estimation of individual PK parameters. Nevertheless, the use ...
... the individual’s drug concentrations and, consequently, the AUC [14]. One advantage of B-LSS over R-LSS is its flexibility in terms of sampling time deviations which are implicitly included in the framework of the Pop-PK modeling and the estimation of individual PK parameters. Nevertheless, the use ...
Pain White Paper by Joseph Vaughan, M.D.
... There is general consensus today that both peripheral and central nervous system processes play a role in appreciating neuropathic pain. The CNS changes, however, are driven largely by changes in the PNS. Thus, controlling pathophysiological change in the periphery is likely to have greater therapeu ...
... There is general consensus today that both peripheral and central nervous system processes play a role in appreciating neuropathic pain. The CNS changes, however, are driven largely by changes in the PNS. Thus, controlling pathophysiological change in the periphery is likely to have greater therapeu ...
Limbic systems for emotion and for memory, but no
... many steps ahead, and for example deferring short-term rewards in order to execute a long-term plan. This system may use syntactic processing to perform the planning, and is therefore part of a linguistic system which performs explicit (conscious) processing, as described more fully elsewhere (Rolls ...
... many steps ahead, and for example deferring short-term rewards in order to execute a long-term plan. This system may use syntactic processing to perform the planning, and is therefore part of a linguistic system which performs explicit (conscious) processing, as described more fully elsewhere (Rolls ...
Ear manipulations help model neuroplasticity limitations
... to the hindbrain or hair cells, respectively, is not well understood at the molecular level beyond a small set of experimental data (Simmons et al., 2011, Yang et al., 2011). It has been suggested that efferents to the ear are rerouted facial branchial motor neurons that ...
... to the hindbrain or hair cells, respectively, is not well understood at the molecular level beyond a small set of experimental data (Simmons et al., 2011, Yang et al., 2011). It has been suggested that efferents to the ear are rerouted facial branchial motor neurons that ...
Ouabain - the insulin of the heart - Herzinfarkt
... in vivo studies. Ouabain significantly increases the endurance perforrnance of rats. Hyperttophy of the heart is reduced by adrninisttation of ouabain (44). Orally adrninistered ouabain improves physical endurance in guinea pigs (45) as well as in healthy volunteers (41). Digoxin, however, does not ...
... in vivo studies. Ouabain significantly increases the endurance perforrnance of rats. Hyperttophy of the heart is reduced by adrninisttation of ouabain (44). Orally adrninistered ouabain improves physical endurance in guinea pigs (45) as well as in healthy volunteers (41). Digoxin, however, does not ...
Aminoglycosides
... 4. The most important mechanism of bacterial resistance to an Aminoglycoside antibiotic is : (a) Plasmid mediated acquisition of aminoglycoside conjugating enzyme (b) Mutational acquisition of aminoglycoside hydrolyzing enzyme (c) Mutation reducing affinity of ribosomal protein for the antibiotic (d ...
... 4. The most important mechanism of bacterial resistance to an Aminoglycoside antibiotic is : (a) Plasmid mediated acquisition of aminoglycoside conjugating enzyme (b) Mutational acquisition of aminoglycoside hydrolyzing enzyme (c) Mutation reducing affinity of ribosomal protein for the antibiotic (d ...
The Relationship between Drug-Induced Neurogenesis and Pain Behavior in Mice.
... other senses by rendering the sufferer unable to focus on anything else. Pain is also arguably more adaptive than the other senses because it serves as a warning and helps to direct behavior to avoid painful stimuli. Those individuals who are born with one of a handful of rare conditions in which th ...
... other senses by rendering the sufferer unable to focus on anything else. Pain is also arguably more adaptive than the other senses because it serves as a warning and helps to direct behavior to avoid painful stimuli. Those individuals who are born with one of a handful of rare conditions in which th ...
PDF Full-text
... observed after two days of incubation. The MIC (minimum inhibitory concentration) was expressed as the lowest concentration of the drug that inhibited Mtb-growth or prevented change in color of the resazurin from blue to pink based on a REMA. 2.6. Evaluation of Drug Susceptibility of M. tuberculosis ...
... observed after two days of incubation. The MIC (minimum inhibitory concentration) was expressed as the lowest concentration of the drug that inhibited Mtb-growth or prevented change in color of the resazurin from blue to pink based on a REMA. 2.6. Evaluation of Drug Susceptibility of M. tuberculosis ...
A decade of the anaphase-promoting complex in the nervous system
... After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http:// creativecommons.org/licenses/by-nc/4.0/. ...
... After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http:// creativecommons.org/licenses/by-nc/4.0/. ...
Macrocycles in new drug discovery
... being focused on the wider use of macrocyclic scaffolds in medicinal chemistry in the search for new drugs for increasingly challenging targets. With the increasing awareness of concepts of drug-likeness and the dangers of ‘molecular obesity’, functionalized macrocyclic scaffolds could provide a way ...
... being focused on the wider use of macrocyclic scaffolds in medicinal chemistry in the search for new drugs for increasingly challenging targets. With the increasing awareness of concepts of drug-likeness and the dangers of ‘molecular obesity’, functionalized macrocyclic scaffolds could provide a way ...
THERAPEUTIC MDMA (ECSTASY): THE FEDERAL GOVERNMENT
... severely hindered the chance of any further research into the drug’s therapeutic potential.34 30 See Beck and Rosenbaum, supra note 24, at 21 (citing to Ricuarte, G. et.al, “Hallucinogenic Amphetamine Selectivity Destroys Brain Serotonin Nerve Terminals,” Science 229:986988 (1985). 31 In the Matter ...
... severely hindered the chance of any further research into the drug’s therapeutic potential.34 30 See Beck and Rosenbaum, supra note 24, at 21 (citing to Ricuarte, G. et.al, “Hallucinogenic Amphetamine Selectivity Destroys Brain Serotonin Nerve Terminals,” Science 229:986988 (1985). 31 In the Matter ...
Document
... placing thirty million synapses in their proper three-dimensional position. In March 2008, Blue Brain project was progressing faster than expected: "Consciousness is just a massive amount of information being exchanged by trillions of brain cells." Some proponents of strong AI speculate that compute ...
... placing thirty million synapses in their proper three-dimensional position. In March 2008, Blue Brain project was progressing faster than expected: "Consciousness is just a massive amount of information being exchanged by trillions of brain cells." Some proponents of strong AI speculate that compute ...
Document
... Hyoscyamus niger (Solanaceae), or henbane, is a European native with a long history as a medicinal plant. Its inclusion in mediaeval concoctions and its power to induce hallucinations with visions of flight may well have contributed to our imaginary view of witches on broomsticks. The plant has both ...
... Hyoscyamus niger (Solanaceae), or henbane, is a European native with a long history as a medicinal plant. Its inclusion in mediaeval concoctions and its power to induce hallucinations with visions of flight may well have contributed to our imaginary view of witches on broomsticks. The plant has both ...
Selective stimulation of the subthalamic nucleus in Parkinson`s
... of Forel. The rat STN is considered to be an open nucleus, which means that the dendrites of the STN neurons reach outside the boundaries of the STN, while in humans the nucleus is closed (except for the medial border). The STN distinguishes itself from all other, inhibitory, basal ganglia nuclei si ...
... of Forel. The rat STN is considered to be an open nucleus, which means that the dendrites of the STN neurons reach outside the boundaries of the STN, while in humans the nucleus is closed (except for the medial border). The STN distinguishes itself from all other, inhibitory, basal ganglia nuclei si ...
Neural Correlates of Knowledge: Stable Representation of Stimulus
... information that can enable correct performance. However, because the neuronal signals in these earlier studies were evaluated only on correct trials, for which knowledge and behavior are correlated, it is unclear whether these neurons represent memory of the learned association or the impending beh ...
... information that can enable correct performance. However, because the neuronal signals in these earlier studies were evaluated only on correct trials, for which knowledge and behavior are correlated, it is unclear whether these neurons represent memory of the learned association or the impending beh ...