THE AMYGDALA AND REWARD
... cortex reflect both the probability and quantity of expected reward for a visuomotor response. There is similar evidence for the orbital frontal cortex30–34. In the more purely sensory domain, Jagadeesh et al.35 showed that responses of neurons of the inferotemporal cortex to objects were modulated ...
... cortex reflect both the probability and quantity of expected reward for a visuomotor response. There is similar evidence for the orbital frontal cortex30–34. In the more purely sensory domain, Jagadeesh et al.35 showed that responses of neurons of the inferotemporal cortex to objects were modulated ...
... The purpose of this study was to confirm earlier indications [23, 24] that the orally active and selective receptor antagonist of cysteinyl-leukotrienes, ICI-204,219 (Accolate) [28, 29], could inhibit allergen-induced airway obstruction in atopic asthmatics. We focused on the early airway reaction ( ...
Studies on Variability in Olanzapine Disposition
... Schizophrenia and schizoaffective disorders are chronic conditions with a significant impact on many functions. Positive, negative, cognitive and motor symptoms appear in different degrees and constellations. Antipsychotics are of fundamental importance to reduce symptoms. However, insufficient clin ...
... Schizophrenia and schizoaffective disorders are chronic conditions with a significant impact on many functions. Positive, negative, cognitive and motor symptoms appear in different degrees and constellations. Antipsychotics are of fundamental importance to reduce symptoms. However, insufficient clin ...
METOPROLOL ACTAVIS
... can be made. Other metabolic effects: Beta-adrenoceptors are involved in the regulation of lipid as well as carbohydrate metabolism. Some drugs affect the lipid profile adversely although the long-term clinical significance of this change is unknown and the effect appears to be less for drugs with i ...
... can be made. Other metabolic effects: Beta-adrenoceptors are involved in the regulation of lipid as well as carbohydrate metabolism. Some drugs affect the lipid profile adversely although the long-term clinical significance of this change is unknown and the effect appears to be less for drugs with i ...
The Acceleration of Articular Cartilage Degeneration in
... Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world for the treatment of osteoarthritis (OA) symptoms, and are taken by 20-30% of elderly people in developed countries. Because of the potential for significant side effects of these medications on the liv ...
... Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world for the treatment of osteoarthritis (OA) symptoms, and are taken by 20-30% of elderly people in developed countries. Because of the potential for significant side effects of these medications on the liv ...
PHYTOCHEMICAL, BIOLOGICAL AND TOXICOLOGICAL STUDIES
... immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. Hymore, for their encouragement and support throughout the duration of the research. My deep appreciation also goes to the Dean and Sub-Dean, School of Postgraduate Studies, ...
... immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. Hymore, for their encouragement and support throughout the duration of the research. My deep appreciation also goes to the Dean and Sub-Dean, School of Postgraduate Studies, ...
anti-inflammatory, analgesic and antipyretic activities of the aqueous
... Pakistan (8). The present study was carried out to evaluate the analgesic, anti-inflammatory and antipyretic activity of Berberis calliobotrys to validate ...
... Pakistan (8). The present study was carried out to evaluate the analgesic, anti-inflammatory and antipyretic activity of Berberis calliobotrys to validate ...
Spasticity after stroke: Physiology, assessment and treatment
... of the H reflex—a muscle reflex appearing after electrical stimulation of sensory fibres—on the spastic side of the quadriceps, when compared to the unaffected side and to a healthy control population. An improvement of the transmission in the inter-neuronal pathway co-activated by the two groups, I ...
... of the H reflex—a muscle reflex appearing after electrical stimulation of sensory fibres—on the spastic side of the quadriceps, when compared to the unaffected side and to a healthy control population. An improvement of the transmission in the inter-neuronal pathway co-activated by the two groups, I ...
The Impact of Pre-onset Cannabis Use on Age at Onset of
... of which are briefly described here, may demonstrate the biologic plausibility of pre-onset cannabis use impacting not only vulnerability for developing schizophrenia, but also the age at onset among those who do develop the disorder. First, exogenous cannabinoids (eg, marijuana) are extremely lipid ...
... of which are briefly described here, may demonstrate the biologic plausibility of pre-onset cannabis use impacting not only vulnerability for developing schizophrenia, but also the age at onset among those who do develop the disorder. First, exogenous cannabinoids (eg, marijuana) are extremely lipid ...
Effect of grapefruit juice on bioavailability of montelukast
... this enzyme results in increases in AUC and Cmax levels of drugs that are metabolized by CYP3A4.1,9,10 Therefore, bioavailability of those drugs is improved after consuming grapefruit juice.2 Montelukast is one of the drugs that is metabolized by the cytochrome P450 enzyme system, and CYP3A4 and CYP ...
... this enzyme results in increases in AUC and Cmax levels of drugs that are metabolized by CYP3A4.1,9,10 Therefore, bioavailability of those drugs is improved after consuming grapefruit juice.2 Montelukast is one of the drugs that is metabolized by the cytochrome P450 enzyme system, and CYP3A4 and CYP ...
“left or right” Decision-making beyond
... neuroscientists try to gain insights into the actual brain processes during decision-making and to answer how mathematical and psychological concepts are eventually implemented in the brain. With this thesis, we aim to contribute to elucidating this latter problem from a computational point of view: ...
... neuroscientists try to gain insights into the actual brain processes during decision-making and to answer how mathematical and psychological concepts are eventually implemented in the brain. With this thesis, we aim to contribute to elucidating this latter problem from a computational point of view: ...
Spike-based Winner-Take-All Computation in a Multi
... capability of biological systems with the real world. Taking inspiration from key principles of biological information processing systems to improve our artificial systems is a logical step. Many differences between biological and artificial computational architectures have been pointed out, such as ...
... capability of biological systems with the real world. Taking inspiration from key principles of biological information processing systems to improve our artificial systems is a logical step. Many differences between biological and artificial computational architectures have been pointed out, such as ...
The Impact of Probiotics on the Gastrointestinal
... The influence of microorganisms on intestinal motility was reported for the first time by Abraham and Bishop. These researchers observed that both small and large intestinal transit time and gastric emptying decreased in germ-free animals (Abraham & Bishop, 1967). Husebye et al. (1994) detected that ...
... The influence of microorganisms on intestinal motility was reported for the first time by Abraham and Bishop. These researchers observed that both small and large intestinal transit time and gastric emptying decreased in germ-free animals (Abraham & Bishop, 1967). Husebye et al. (1994) detected that ...
Neuropsychiatric effects of caffeine
... There is also evidence that people with schizophrenia have higher than average intakes of caffeine, although the literature is inconsistent. There are a number of case reports of high caffeine intake among in-patients with schizophrenia (Benson & David, 1986; Zaslove et al, 1991). Studies published ...
... There is also evidence that people with schizophrenia have higher than average intakes of caffeine, although the literature is inconsistent. There are a number of case reports of high caffeine intake among in-patients with schizophrenia (Benson & David, 1986; Zaslove et al, 1991). Studies published ...
Marijuana - The Children`s Aid Society
... sociation between chronic marijuana use and mental illness. High doses of mariju-‐ ana can produce a temporary psychotic reaction (involving hallucinations and paranoia) in some users, and using mari-‐ juana can ...
... sociation between chronic marijuana use and mental illness. High doses of mariju-‐ ana can produce a temporary psychotic reaction (involving hallucinations and paranoia) in some users, and using mari-‐ juana can ...
Interactions between the cytochrome P450 system and
... Chang and colleagues41 noted that fluvoxamine caused 48.5% inhibition of clozapine metabolism; 42.0% inhibition was observed with the chemical CYP1A2 furafyline. Similarly, Olesen and Linnet42 noted significant inhibition of clozapine demethylation in vitro after incubation with fluvoxamine, a react ...
... Chang and colleagues41 noted that fluvoxamine caused 48.5% inhibition of clozapine metabolism; 42.0% inhibition was observed with the chemical CYP1A2 furafyline. Similarly, Olesen and Linnet42 noted significant inhibition of clozapine demethylation in vitro after incubation with fluvoxamine, a react ...
Linear visuomotor transformations in midbrain superior colliculus
... Nearly every neural model of the saccadic system assumes that the main sequence properties result from nonlinear local feedback circuits in the brainstem, in which socalled medium lead burst cells in the paramedian pontine reticular formation (PPRF, for horizontal saccades; [20, 24, 43]) and in the ...
... Nearly every neural model of the saccadic system assumes that the main sequence properties result from nonlinear local feedback circuits in the brainstem, in which socalled medium lead burst cells in the paramedian pontine reticular formation (PPRF, for horizontal saccades; [20, 24, 43]) and in the ...
Clenbuterol and the Horse
... agent, there has been great concern about clenbuterol’s ability to enhance performance. The amount of bronchodilation that occurs in normal horses is very small. In healthy human athletes, a measurable dilation of the airways induced by a 2-agonist is not associated with an improvement in oxygen co ...
... agent, there has been great concern about clenbuterol’s ability to enhance performance. The amount of bronchodilation that occurs in normal horses is very small. In healthy human athletes, a measurable dilation of the airways induced by a 2-agonist is not associated with an improvement in oxygen co ...
Chapter Pharmaceutical Compounding – Nonsterile
... the course of professional practice. Compounding includes the following: • Preparation of drug dosage forms for both human and animal patients • Preparation of drugs or devices in anticipation of prescription drug orders based on routine, regularly observed prescribing patterns • Reconstitution or m ...
... the course of professional practice. Compounding includes the following: • Preparation of drug dosage forms for both human and animal patients • Preparation of drugs or devices in anticipation of prescription drug orders based on routine, regularly observed prescribing patterns • Reconstitution or m ...
Specificity and Plasticity of Thalamocortical Connections in Sema6A
... Semaphorin-6A to test this model. In these mutants, Semaphorin6A axons from the visual part of the thalamus are subcortically misrouted and fail to innervate the presumptive visual cortex, which is instead invaded by somatosensory thalamic axons. Despite this major disruption in initial connectivity ...
... Semaphorin-6A to test this model. In these mutants, Semaphorin6A axons from the visual part of the thalamus are subcortically misrouted and fail to innervate the presumptive visual cortex, which is instead invaded by somatosensory thalamic axons. Despite this major disruption in initial connectivity ...
Express Scripts 2015 Drug Trend Report
... recent years. Compared to 2014, brand prices in 2015 were 16% higher. Brand medications have increased in price by 164% between 2008 and 2015. Consider the case of Gleevec: In 2015, Novartis, the exclusive manufacturer, engaged in the prevalent practice of increasing the price of a medication in the ...
... recent years. Compared to 2014, brand prices in 2015 were 16% higher. Brand medications have increased in price by 164% between 2008 and 2015. Consider the case of Gleevec: In 2015, Novartis, the exclusive manufacturer, engaged in the prevalent practice of increasing the price of a medication in the ...
Naloxone: Frequently Asked Questions
... depression that would otherwise lead to death from overdose. ...
... depression that would otherwise lead to death from overdose. ...
Stability indicating RP-HPLC method development and validation for
... Stability indicating methods have become an important aspect of analytical method validation and a part of US FDA requirements [1]. The stability of a drug product or a drug substance is a critical parameter which may affect purity, potency and safety. Changes in drug stability can risk patient safe ...
... Stability indicating methods have become an important aspect of analytical method validation and a part of US FDA requirements [1]. The stability of a drug product or a drug substance is a critical parameter which may affect purity, potency and safety. Changes in drug stability can risk patient safe ...