Stability indicating RP-HPLC method development and validation for
... Stability indicating methods have become an important aspect of analytical method validation and a part of US FDA requirements [1]. The stability of a drug product or a drug substance is a critical parameter which may affect purity, potency and safety. Changes in drug stability can risk patient safe ...
... Stability indicating methods have become an important aspect of analytical method validation and a part of US FDA requirements [1]. The stability of a drug product or a drug substance is a critical parameter which may affect purity, potency and safety. Changes in drug stability can risk patient safe ...
BIOLOGICAL EVALUATION OF OPIOIDS, STIMULANTS, AND
... approximately 25,000 times the potency of morphine in mice. One interesting aspect of this class of compounds is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and ...
... approximately 25,000 times the potency of morphine in mice. One interesting aspect of this class of compounds is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and ...
Analgesic and Anti-inflammatory Activities of Ethanolic Root Extract
... activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the acetic acid-induced writhing test and the radiant heat tail-flick method. In rat paw edema model induced by carrageenan, the ...
... activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the acetic acid-induced writhing test and the radiant heat tail-flick method. In rat paw edema model induced by carrageenan, the ...
show - FACETS Project
... 5.1 Sensitivity of the spike patterns with respect to the cutoff value . . . . . . . . . . . . . . . . . . . 122 A.1 Cauchy Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124 ...
... 5.1 Sensitivity of the spike patterns with respect to the cutoff value . . . . . . . . . . . . . . . . . . . 122 A.1 Cauchy Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124 ...
NIH Public Access - The Scripps Research Institute
... The MAP-rFAAH structure remained as the only crystal structure of FAAH for many years. However, the high levels of expression of the h/rFAAH protein offered a new opportunity to solve structures of the enzyme that would be of great relevance to structure-based drug design. Indeed, as noted above, h/ ...
... The MAP-rFAAH structure remained as the only crystal structure of FAAH for many years. However, the high levels of expression of the h/rFAAH protein offered a new opportunity to solve structures of the enzyme that would be of great relevance to structure-based drug design. Indeed, as noted above, h/ ...
Taste, olfactory, and food reward value processing
... eating, and it is therefore important to understand the brain mechanisms involved in food reward, in order to understand the control of appetite and food intake. When the behavior is goaldirected, brain regions such as the cingulate cortex are likely to be engaged (see Fig. 1). However, it is a usef ...
... eating, and it is therefore important to understand the brain mechanisms involved in food reward, in order to understand the control of appetite and food intake. When the behavior is goaldirected, brain regions such as the cingulate cortex are likely to be engaged (see Fig. 1). However, it is a usef ...
Codeine Therapy in the Context of Cytochrome P450 2D6
... Currently, there are no diseases or conditions known to be linked to variations in the CYP2D6 gene independent of drug metabolism and response. Although there are some isolated reports of CYP2D6 genetic effects on phenotypes other than in relation to drug response,4,5 these findings have not been co ...
... Currently, there are no diseases or conditions known to be linked to variations in the CYP2D6 gene independent of drug metabolism and response. Although there are some isolated reports of CYP2D6 genetic effects on phenotypes other than in relation to drug response,4,5 these findings have not been co ...
Ferrario A, Kanavos P, Managed entry agreements for pharmaceuticals: the European experience. EMiNet, Brussels, Belgium
... drugs and increasing patient expectations, mean that manufacturers seeking inclusion in reimbursement lists need to demonstrate that their drugs can provide additional benefit in relation to current therapies and value-for-money in order to obtain coverage. Data and the overall evidence base availab ...
... drugs and increasing patient expectations, mean that manufacturers seeking inclusion in reimbursement lists need to demonstrate that their drugs can provide additional benefit in relation to current therapies and value-for-money in order to obtain coverage. Data and the overall evidence base availab ...
insight into production, drug loading, targeting, and
... Extracellular vesicles (EVs) are secreted from any types of cells and shuttle between ...
... Extracellular vesicles (EVs) are secreted from any types of cells and shuttle between ...
Pilocarpine-Induced Convulsive Activity Is Limited by Multidrug
... generalized tonic-clonic seizures). Convulsive activity characteristics and SE-associated EEG patterns were comparable in mouse genotypes. In 40% of EEG-monitored mice, SE was selflimiting before diazepam administration. In animals with selflimiting SE, EEG analysis revealed that SE duration was sho ...
... generalized tonic-clonic seizures). Convulsive activity characteristics and SE-associated EEG patterns were comparable in mouse genotypes. In 40% of EEG-monitored mice, SE was selflimiting before diazepam administration. In animals with selflimiting SE, EEG analysis revealed that SE duration was sho ...
A role for subplate neurons in the patterning of
... cortical targets. The selection of an appropriate target is first evident even before thalamic axons grow into the cortical plate: initially axons accumulate and wait below their cortical target area in a zone called the subplate. This zone also contains the first postmitotic neurons of the cerebral ...
... cortical targets. The selection of an appropriate target is first evident even before thalamic axons grow into the cortical plate: initially axons accumulate and wait below their cortical target area in a zone called the subplate. This zone also contains the first postmitotic neurons of the cerebral ...
How to Protect Yourself Against Malaria
... microscopic crystals, made surfaces lethal to mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, ma ...
... microscopic crystals, made surfaces lethal to mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, ma ...
Inborn errors affecting vitamin B metabolism
... epilepsy has no encephalopathy and no brain structural abnormalities. Seizures may commence at any time up to 3 years of age [26]. Often, these are seizures occurring in the context of a febrile illness, which may develop into status epilepticus. There is usually an initial response to conventional ...
... epilepsy has no encephalopathy and no brain structural abnormalities. Seizures may commence at any time up to 3 years of age [26]. Often, these are seizures occurring in the context of a febrile illness, which may develop into status epilepticus. There is usually an initial response to conventional ...
Review Cannabis and Ecstasy/MDMA
... emphasized that there is no empirical data on the effectiveness of this apparent strategy (Parrott, 2001; Schifano, 2000). Many Ecstasy users also report taking cannabis during the initial acute stimulatory phase. Boys et al. (2001) noted that 36% of cannabis users reported taking it together with M ...
... emphasized that there is no empirical data on the effectiveness of this apparent strategy (Parrott, 2001; Schifano, 2000). Many Ecstasy users also report taking cannabis during the initial acute stimulatory phase. Boys et al. (2001) noted that 36% of cannabis users reported taking it together with M ...
audition - Neuroanatomy
... The sensitivity of hearing Think of the adjacent graph as a map of hearing space. It shows how acute our hearing is for different sounds. The pitch (frequency) of pure tone sounds of varied frequency is plotted along the bottom on the X axis, progressing from low pitch to high pitch pure tones from ...
... The sensitivity of hearing Think of the adjacent graph as a map of hearing space. It shows how acute our hearing is for different sounds. The pitch (frequency) of pure tone sounds of varied frequency is plotted along the bottom on the X axis, progressing from low pitch to high pitch pure tones from ...
Applications of NMR in Drug Discovery
... proteins can be screened when TROSY is used. TROSY is based on a pulse sequence that increases transverse relaxation time (Figure 4). Line broadening and low sensitivity are two main limiting factors for obtaining structural information at high molecular weights, but TROSY improves both by reducing ...
... proteins can be screened when TROSY is used. TROSY is based on a pulse sequence that increases transverse relaxation time (Figure 4). Line broadening and low sensitivity are two main limiting factors for obtaining structural information at high molecular weights, but TROSY improves both by reducing ...
View PDF - CiteSeerX
... Single subject. There are important limitations that arise from the use of single brain to develop a cerebellar atlas. A number of variables are by definition excluded from consideration. It is not possible, for example, to evaluate consistency of hemispheric asymmetry and the individual variation o ...
... Single subject. There are important limitations that arise from the use of single brain to develop a cerebellar atlas. A number of variables are by definition excluded from consideration. It is not possible, for example, to evaluate consistency of hemispheric asymmetry and the individual variation o ...
PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT Research Article
... An extensive review of the published medical literature and the manufacturer's clinical trial and post marketing database identified six reports of priapism following the use of sildenafil in an estimated 1.2 billion users.11‐14 The earlier reports of priapism following the use of si ...
... An extensive review of the published medical literature and the manufacturer's clinical trial and post marketing database identified six reports of priapism following the use of sildenafil in an estimated 1.2 billion users.11‐14 The earlier reports of priapism following the use of si ...
WARNING: DEATH RELATED TO ULTRA
... • Decreased mental alertness with impaired mental and/or physical abilities [see Warnings and Precautions (5.5)] • Paralytic ileus [see Warnings and Precautions (5.7)] Use of chlorpheniramine, an antihistamine, may result in: • Decreased mental alertness with impaired mental and/or physical abili ...
... • Decreased mental alertness with impaired mental and/or physical abilities [see Warnings and Precautions (5.5)] • Paralytic ileus [see Warnings and Precautions (5.7)] Use of chlorpheniramine, an antihistamine, may result in: • Decreased mental alertness with impaired mental and/or physical abili ...
Biophysics of Extracellular Action Potentials
... large neurons in the deep layers. If the detection and clustering algorithm is sensitive enough to include low-amplitude spikes then bias is moderate. If only high amplitude units (> 200 µV) are picked up, then recording will be significantly biased towards the deep layers. The majority of spikes in ...
... large neurons in the deep layers. If the detection and clustering algorithm is sensitive enough to include low-amplitude spikes then bias is moderate. If only high amplitude units (> 200 µV) are picked up, then recording will be significantly biased towards the deep layers. The majority of spikes in ...
Prescribing Information
... mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. Advise patients to avoid engaging in hazardous tasks requiring mental alertness and motor coordination after ingestion of TUZISTRA XR. Concurrent use of TUZISTRA ...
... mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. Advise patients to avoid engaging in hazardous tasks requiring mental alertness and motor coordination after ingestion of TUZISTRA XR. Concurrent use of TUZISTRA ...
Functions of the nucleus of the optic tract (NOT).
... 1990). In particular, the macaque middle temporal area (MT) contains cells whose responses are related to image motion (Dubner and Zeki 1971; Van Essen et al. 1981; Albright 1984; Movshon et al. 1985). Using a step-ramp paradigm, Newsome et al. (1985) demonstrated that small electrolytic lesions in ...
... 1990). In particular, the macaque middle temporal area (MT) contains cells whose responses are related to image motion (Dubner and Zeki 1971; Van Essen et al. 1981; Albright 1984; Movshon et al. 1985). Using a step-ramp paradigm, Newsome et al. (1985) demonstrated that small electrolytic lesions in ...
Antipsychotic Medication
... Initial nursing treatment plan should address target symptoms; selection of drug, dose, response, observed side effects and their treatment; patient safety, education, reassurance Nurse-patient relationship forms basis for ongoing therapeutic alliance Nonpharmacological treatment of residual symptom ...
... Initial nursing treatment plan should address target symptoms; selection of drug, dose, response, observed side effects and their treatment; patient safety, education, reassurance Nurse-patient relationship forms basis for ongoing therapeutic alliance Nonpharmacological treatment of residual symptom ...
Evidence of sympathetic ®bers in the male rat pelvic nerve
... nerve labeled about 100 neurons in the paravertebral sympathetic chain mainly at the L5-L6 levels.31 In the present study LSC neurons which send axons in the pelvic nerve are more numerous and more widely distributed. It may be partly explained by the fact that the pelvic nerve contains neurons dest ...
... nerve labeled about 100 neurons in the paravertebral sympathetic chain mainly at the L5-L6 levels.31 In the present study LSC neurons which send axons in the pelvic nerve are more numerous and more widely distributed. It may be partly explained by the fact that the pelvic nerve contains neurons dest ...
Pharmacokinetics, toxicity, and cytochrome P450
... and tissue distribution of radiolabeled plumbagin (99mTechnetium-plumbagin complex) was investigated in healthy and P. berghei-infected mice [8]. The labeled complex distributed to all organs of both healthy and infected mice but with high intensity in liver, followed by lung, stomach, large intesti ...
... and tissue distribution of radiolabeled plumbagin (99mTechnetium-plumbagin complex) was investigated in healthy and P. berghei-infected mice [8]. The labeled complex distributed to all organs of both healthy and infected mice but with high intensity in liver, followed by lung, stomach, large intesti ...