Sorting and convergence of primary olfactory axons are
... Where are these cues for convergence and targeting localised? Recent analyses of mice with a reduced complement of mitral cells have suggested that these postsynaptic neurons are not involved in the sorting and convergence of primary olfactory axons to their topographic targets (Bulfone et al., 1998 ...
... Where are these cues for convergence and targeting localised? Recent analyses of mice with a reduced complement of mitral cells have suggested that these postsynaptic neurons are not involved in the sorting and convergence of primary olfactory axons to their topographic targets (Bulfone et al., 1998 ...
View eBook - Absorption Systems
... Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enzymes and some transporters. Therefore, reliance on probe substrates and inhibitors can potentially lead to false negatives. In recognition of this, the n ...
... Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enzymes and some transporters. Therefore, reliance on probe substrates and inhibitors can potentially lead to false negatives. In recognition of this, the n ...
Fein A (2012) Nociceptors and the Perception of Pain.
... synaptic membrane potential. Therefore, by recording the variation of the membrane potential at the synapse, the nociceptor output could be indirectly surmised. Unfortunately, in most cases, it is technically difficult, if not impossible to record intracellularly from a synaptic terminal. The vast m ...
... synaptic membrane potential. Therefore, by recording the variation of the membrane potential at the synapse, the nociceptor output could be indirectly surmised. Unfortunately, in most cases, it is technically difficult, if not impossible to record intracellularly from a synaptic terminal. The vast m ...
Product Monograph - Ask Novartis Pharma
... Sensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma. The possibility of exacerbation or activation of systemic lupus erythematosus has been reported in patients treated with hydrochlorothiazide. Special Populations Pregnant Wome ...
... Sensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma. The possibility of exacerbation or activation of systemic lupus erythematosus has been reported in patients treated with hydrochlorothiazide. Special Populations Pregnant Wome ...
... Background.—Updated guidelines for the preventive treatment of episodic migraine have been issued by the American Headache Society (AHS) and the American Academy of Neurology (AAN). We summarize key 2012 guideline recommendations and changes from previous guidelines. We review the characteristics, m ...
lactuca sativa linn. - Journal of Pharmaceutical and Scientific
... Plant origin drugs have played a vital role in the prevention and treatment of diseases in Unani medicine and it becomes popular day by day due to its low cost and less adverse effect. One such drug is Tukhme kahu (Seeds) belong to the family Asteraceae is an important herbal drugs which have hypogl ...
... Plant origin drugs have played a vital role in the prevention and treatment of diseases in Unani medicine and it becomes popular day by day due to its low cost and less adverse effect. One such drug is Tukhme kahu (Seeds) belong to the family Asteraceae is an important herbal drugs which have hypogl ...
The effects of normal aging on myelinated nerve fibers in monkey
... is that they are not subject to Alzheimer’s disease, and overall, do not lose significant numbers of neurons from their cerebral cortex with age (see Merrill et al., 2000; Morrison and Hof, 1997; Peters et al., 1998), However, Smith et al. (2004) have recently claimed that there may be a focal loss ...
... is that they are not subject to Alzheimer’s disease, and overall, do not lose significant numbers of neurons from their cerebral cortex with age (see Merrill et al., 2000; Morrison and Hof, 1997; Peters et al., 1998), However, Smith et al. (2004) have recently claimed that there may be a focal loss ...
Inhibitors of Factor VIIa/Tissue Factor
... The success of several small protein- and antibody-based inhibitors of the FVIIa/TF pathway in preclinical models and clinical trials1,2 has led to substantial interest in the development of orally active small molecule inhibitors of the enzyme active site that could be used for the long-term preven ...
... The success of several small protein- and antibody-based inhibitors of the FVIIa/TF pathway in preclinical models and clinical trials1,2 has led to substantial interest in the development of orally active small molecule inhibitors of the enzyme active site that could be used for the long-term preven ...
How do you feel -- now? The anterior insula and
... bilaterally (with no ACC activation). They suggested that the AIC/IFG focus must be “of central importance” in time perception. Attention. Activation of the AIC (and the ACC) is reported by most studies of goal-directed attention, but these studies often lack comments regarding the role of this acti ...
... bilaterally (with no ACC activation). They suggested that the AIC/IFG focus must be “of central importance” in time perception. Attention. Activation of the AIC (and the ACC) is reported by most studies of goal-directed attention, but these studies often lack comments regarding the role of this acti ...
Advances in phage display technology for drug discovery
... billions of components with a fast screening or selection procedure [3-8]. One of the most widely used library methods is based on the use of filamentous phages, which seems to play an increasingly important role in the future of drug discovery [1,2,9,10]. Phage display was first described more than ...
... billions of components with a fast screening or selection procedure [3-8]. One of the most widely used library methods is based on the use of filamentous phages, which seems to play an increasingly important role in the future of drug discovery [1,2,9,10]. Phage display was first described more than ...
MRI OF THE FETAL CNS Introduction Review
... performed on 3T scanners, as they provide better anatomical detail. In the guidelines prepared in 2014 by Patenaude et al. on the use of MRI in obstetric patients it is stated that “Fetal magnetic resonance imaging is safe at 3.0 tesla or less, during the second and third trimesters”(8). Due to the ...
... performed on 3T scanners, as they provide better anatomical detail. In the guidelines prepared in 2014 by Patenaude et al. on the use of MRI in obstetric patients it is stated that “Fetal magnetic resonance imaging is safe at 3.0 tesla or less, during the second and third trimesters”(8). Due to the ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... weights were reduced at 45 mg/kg/day. Delays in sexual maturation were noted in male and female rats at doses ≥ 30 mg/kg/day. Memantine induced neuronal lesions in several areas of the brain on PND 15 and 17 at doses ≥ 30 mg/kg/day. Behavioral toxicity (decrease percent of auditory startle habituati ...
... weights were reduced at 45 mg/kg/day. Delays in sexual maturation were noted in male and female rats at doses ≥ 30 mg/kg/day. Memantine induced neuronal lesions in several areas of the brain on PND 15 and 17 at doses ≥ 30 mg/kg/day. Behavioral toxicity (decrease percent of auditory startle habituati ...
Mechanisms of Contour Perception in Monkey Visual Cortex. I. Lines
... would have to conclude that these signalsrepresenta stageof processingthat is preliminary, or completely unrelated, to the elaboration of contours. Our resultsindicate that signalsin area Vl of the monkey still represent a preliminary stage,whereas truly contour-related signals,by our definition, ar ...
... would have to conclude that these signalsrepresenta stageof processingthat is preliminary, or completely unrelated, to the elaboration of contours. Our resultsindicate that signalsin area Vl of the monkey still represent a preliminary stage,whereas truly contour-related signals,by our definition, ar ...
Full-Text PDF
... The skin, being the largest organ in the human body, has various functions, including protecting the body from its external environment, from excessive water loss, friction and impact wounds, and from external stimuli that could potentially harm the body, whilst also providing sensory abilities [1]. ...
... The skin, being the largest organ in the human body, has various functions, including protecting the body from its external environment, from excessive water loss, friction and impact wounds, and from external stimuli that could potentially harm the body, whilst also providing sensory abilities [1]. ...
Food Poisoning
... These Substances Assist the Treatment of Recreational Drug Addiction Smart Drugs Diapid alleviates the delayed long term after-effects of Recreational Drug abuse [scientific observation - physician treated "burn-out" victim of 60s drug culture who suffered memory loss, anxiety and confusion with Dia ...
... These Substances Assist the Treatment of Recreational Drug Addiction Smart Drugs Diapid alleviates the delayed long term after-effects of Recreational Drug abuse [scientific observation - physician treated "burn-out" victim of 60s drug culture who suffered memory loss, anxiety and confusion with Dia ...
effect of five alive juice on the dissolution and
... It is common place for patients to take drugs with drinks other than water for various reasons, one of which is to mask the unpleasant taste already associated with some drugs and secondly, fruit juice is often part of the menu for breakfast in some homes when medications are taken. Moreover it’s al ...
... It is common place for patients to take drugs with drinks other than water for various reasons, one of which is to mask the unpleasant taste already associated with some drugs and secondly, fruit juice is often part of the menu for breakfast in some homes when medications are taken. Moreover it’s al ...
Role of azathioprine in preventing recurrences in a patient of
... with release of tissue damaging enzymes.2 – 4 An imbalance of immunoregulatory T-cell subsets has also been demonstrated in ENL.5 Tumour necrosis factor-a (TNF-a), a proinflammatory cytokine, plays an important role in the pathogenesis of ENL. There is activation of T-cells and macrophages, inducing ...
... with release of tissue damaging enzymes.2 – 4 An imbalance of immunoregulatory T-cell subsets has also been demonstrated in ENL.5 Tumour necrosis factor-a (TNF-a), a proinflammatory cytokine, plays an important role in the pathogenesis of ENL. There is activation of T-cells and macrophages, inducing ...
Eszopiclone
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
View/Open - DukeSpace
... corresponds roughly to a zone (F7) delineated by Matelli, Luppino, and Rizzolatti using cytoarchitectonics, ...
... corresponds roughly to a zone (F7) delineated by Matelli, Luppino, and Rizzolatti using cytoarchitectonics, ...
Human and Rodent Homologies in Action Control - Research
... Although the influence of overtraining on contingency sensitivity has not been assessed in human subjects, there is considerable evidence that rat actions and human causal judgments exhibit a comparable sensitivity to the degradation of the action–outcome contingency produced by the delivery of unpa ...
... Although the influence of overtraining on contingency sensitivity has not been assessed in human subjects, there is considerable evidence that rat actions and human causal judgments exhibit a comparable sensitivity to the degradation of the action–outcome contingency produced by the delivery of unpa ...
10117sgp02
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
Pathways for emotions and memory prefrontal cortices in the rhesus monkey
... The anterior thalamic nuclei occupy a central position in pathways associated with emotions and memory [AMA Arch. Neurol. Psychiatry 38 (1937) 725]. The goal of this study was to determine the anatomic interaction of the anterior nuclei with distinct prefrontal cortices that have been implicated in ...
... The anterior thalamic nuclei occupy a central position in pathways associated with emotions and memory [AMA Arch. Neurol. Psychiatry 38 (1937) 725]. The goal of this study was to determine the anatomic interaction of the anterior nuclei with distinct prefrontal cortices that have been implicated in ...
How fast and how often: The pharmacokinetics of drug use are
... This assumption is dangerous. Variation in the pharmacokinetic profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at ...
... This assumption is dangerous. Variation in the pharmacokinetic profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at ...
Addiction neurobiology: Ethical and social implications
... of the developments occurring in this field. Neuroscience provides us with a better understanding of how people become addicted to drugs and why they find it so difficult to stop, even when experiencing severe negative consequences. It also holds out the prospect of providing us with some novel appr ...
... of the developments occurring in this field. Neuroscience provides us with a better understanding of how people become addicted to drugs and why they find it so difficult to stop, even when experiencing severe negative consequences. It also holds out the prospect of providing us with some novel appr ...
Modification of morphine analgesia by venlafaxine in diabetic
... interleukin-1b, and accumulation of morphine-3glucuronide were reported in diabetic rats [9]. Repeated (21 days) administration of venlafaxine (10 mg/kg, po) was reported to suppress mechanical hyperalgesia in STZ-induced diabetic rats, whereas a single administration of the drug reduced it only sli ...
... interleukin-1b, and accumulation of morphine-3glucuronide were reported in diabetic rats [9]. Repeated (21 days) administration of venlafaxine (10 mg/kg, po) was reported to suppress mechanical hyperalgesia in STZ-induced diabetic rats, whereas a single administration of the drug reduced it only sli ...