Bipolar Disorder
... with bipolar disorder (Rajkowska et al., 2001). These observations may account for cell loss observed in brain imaging and post-mortem studies of bipolar patients (Brown et al., 2003). These deficits differ from reported observations of increased neuronal density noted in patients with schizophrenia ...
... with bipolar disorder (Rajkowska et al., 2001). These observations may account for cell loss observed in brain imaging and post-mortem studies of bipolar patients (Brown et al., 2003). These deficits differ from reported observations of increased neuronal density noted in patients with schizophrenia ...
How fast and how often: The pharmacokinetics of drug use are
... This assumption is dangerous. Variation in the pharmacokinetic profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at ...
... This assumption is dangerous. Variation in the pharmacokinetic profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at ...
effects of dust formulations of three entomophatogenic fungal
... toxicity in laboratory animals and in man. It is possible that one substance may alter the bioavailability of another substance by inducing the phase I and phase II hepatic enzymes system, and subsequently affect drug therapeutic effect or even generate toxicity when two or more substances are given ...
... toxicity in laboratory animals and in man. It is possible that one substance may alter the bioavailability of another substance by inducing the phase I and phase II hepatic enzymes system, and subsequently affect drug therapeutic effect or even generate toxicity when two or more substances are given ...
Eyeblink Conditioning During an Interstimulus Interval Switch in
... The role of the cerebellar cortex in eyeblink classical conditioning remains unclear. Experimental manipulations that disrupt the normal function impair learning to various degrees, and task parameters may be important factors in determining the severity of impairment. This study examined the role o ...
... The role of the cerebellar cortex in eyeblink classical conditioning remains unclear. Experimental manipulations that disrupt the normal function impair learning to various degrees, and task parameters may be important factors in determining the severity of impairment. This study examined the role o ...
Disease Modeling Using Embryonic Stem Cells
... wild-type and ESCs lacking MeCP2 generated neuronal cultures of high purity, with more than 90% of the cells expressing neuronal markers after a few days in culture. These neurons were previously characterized as glutamatergic using antibodies to a glutamate vesicular transporter and to form functio ...
... wild-type and ESCs lacking MeCP2 generated neuronal cultures of high purity, with more than 90% of the cells expressing neuronal markers after a few days in culture. These neurons were previously characterized as glutamatergic using antibodies to a glutamate vesicular transporter and to form functio ...
Drugs and Human Performance Fact Sheets
... lower, more delayed peak THC levels. Bioavailability is reduced following oral ingestion due to extensive first pass metabolism. Smoking marijuana results in rapid absorption with peak THC plasma concentrations occurring prior to the end of smoking. Concentrations vary depending on the potency of ma ...
... lower, more delayed peak THC levels. Bioavailability is reduced following oral ingestion due to extensive first pass metabolism. Smoking marijuana results in rapid absorption with peak THC plasma concentrations occurring prior to the end of smoking. Concentrations vary depending on the potency of ma ...
A Split-LexA-based Concatenate Expression System for
... leucine zippers (zip) from the Split Gal4 system (supplementary Figure S1). We then tested the efficacy of the resulting "zipLexADBD" and "VP16ADzip" constructs in Drosophila S2 cells. When co-expressed, the two complementary domains drove strong expression of a LexAop-GFP reporter (supplementary Fi ...
... leucine zippers (zip) from the Split Gal4 system (supplementary Figure S1). We then tested the efficacy of the resulting "zipLexADBD" and "VP16ADzip" constructs in Drosophila S2 cells. When co-expressed, the two complementary domains drove strong expression of a LexAop-GFP reporter (supplementary Fi ...
Intravitreal Amphotericin B
... • The drug should be given slowly in the central vitreous space, as a bolus of even very small doses near the retina may result in retinal necrosis. • The drug has been found to reach the retinal surface in a few hours. ...
... • The drug should be given slowly in the central vitreous space, as a bolus of even very small doses near the retina may result in retinal necrosis. • The drug has been found to reach the retinal surface in a few hours. ...
Drugs and Human Performance Fact Sheets
... lower, more delayed peak THC levels. Bioavailability is reduced following oral ingestion due to extensive first pass metabolism. Smoking marijuana results in rapid absorption with peak THC plasma concentrations occurring prior to the end of smoking. Concentrations vary depending on the potency of ma ...
... lower, more delayed peak THC levels. Bioavailability is reduced following oral ingestion due to extensive first pass metabolism. Smoking marijuana results in rapid absorption with peak THC plasma concentrations occurring prior to the end of smoking. Concentrations vary depending on the potency of ma ...
World of Children 1st ed
... This multimedia product and its content are protected under copyright law. The following are prohibited by law: ...
... This multimedia product and its content are protected under copyright law. The following are prohibited by law: ...
Appetite Suppressor Induced Psychosis
... weeks of discontinuing amphetamine analogues and starting low doses of antipsychotics. This said, a few cases have progressed to chronic psychotic disorder, although the causal relationship with amphetamine analogues is unclear.17) Importantly, most cases did not show associative loosening or social ...
... weeks of discontinuing amphetamine analogues and starting low doses of antipsychotics. This said, a few cases have progressed to chronic psychotic disorder, although the causal relationship with amphetamine analogues is unclear.17) Importantly, most cases did not show associative loosening or social ...
The fight against fake drugs by NAFDAC in Nigeria
... country of manufacture to the recipient countries. Hence, national measures for combating of fake drugs in country might be insufficient because of the advanced sophistications of those who manufactures and sells them (bates, 2008). Nigeria is not an exception in the problems of fake drugs till date ...
... country of manufacture to the recipient countries. Hence, national measures for combating of fake drugs in country might be insufficient because of the advanced sophistications of those who manufactures and sells them (bates, 2008). Nigeria is not an exception in the problems of fake drugs till date ...
National Conference on “Recent Advances in Herbal Drug Technology”
... heptapeptide unit Boc-L-ser-L-leu-L-pro-L-pro-L-ile-L-phe-gly-OMe which was in turn, prepared via carbodiimide coupling of tripeptide unit Boc-L-ser-L-leu-L-pro-OMe and tetrapeptide unit Boc-L-pro-L-ile-L-phe-gly-OMe after suitable deprotection at carboxyl and amino terminals using LiOH and TFA resp ...
... heptapeptide unit Boc-L-ser-L-leu-L-pro-L-pro-L-ile-L-phe-gly-OMe which was in turn, prepared via carbodiimide coupling of tripeptide unit Boc-L-ser-L-leu-L-pro-OMe and tetrapeptide unit Boc-L-pro-L-ile-L-phe-gly-OMe after suitable deprotection at carboxyl and amino terminals using LiOH and TFA resp ...
Lab 10 – Nervous Tissue Nervous Tissue
... pia mater is a delicate layer consisting of flattened, impermeable cells and CT fibers; it rests upon a limiting layer of astrocyte foot processes known as the glial limitans (not seen in routine slide preparations) which acts as a barrier between the CNS neural tissue and surrounding non-neural tis ...
... pia mater is a delicate layer consisting of flattened, impermeable cells and CT fibers; it rests upon a limiting layer of astrocyte foot processes known as the glial limitans (not seen in routine slide preparations) which acts as a barrier between the CNS neural tissue and surrounding non-neural tis ...
Week 3 – Day 1
... The swordfish has a heat-generating organ that warms its brain and eyes up to 14°C above the surrounding water temperature. What structures are likely to be found in relatively high concentrations in the cells of this organ? A) Chromosomes B) Mitochondria C) Nuclei D) Ribosomes ...
... The swordfish has a heat-generating organ that warms its brain and eyes up to 14°C above the surrounding water temperature. What structures are likely to be found in relatively high concentrations in the cells of this organ? A) Chromosomes B) Mitochondria C) Nuclei D) Ribosomes ...
Psilocybin – Summary of knowledge and new perspectives
... attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals w ...
... attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals w ...
Drug Elimination and Clearance
... 1. Glomerular filtration is a unidirectional process that occurs for most small molecules (MW < 500), including undissociated (nonionized) and dissociated (ionized) drugs. Protein-bound drugs behave as large molecules and do not get filtered at the glomerulus. The major driving force for glomerular ...
... 1. Glomerular filtration is a unidirectional process that occurs for most small molecules (MW < 500), including undissociated (nonionized) and dissociated (ionized) drugs. Protein-bound drugs behave as large molecules and do not get filtered at the glomerulus. The major driving force for glomerular ...
PDF
... hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or ‘pioneer’ neuron, blocks the ...
... hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or ‘pioneer’ neuron, blocks the ...
fMRI sample and movement - Open Research Exeter
... lifelong illness and disability [1,2]. Although effective treatments for adolescent depression exist [3], it is sobering that nearly 50% of adolescents relapse in the two years following effective treatment [4]. No current psychosocial treatment effectively protects adolescents against depressive re ...
... lifelong illness and disability [1,2]. Although effective treatments for adolescent depression exist [3], it is sobering that nearly 50% of adolescents relapse in the two years following effective treatment [4]. No current psychosocial treatment effectively protects adolescents against depressive re ...
Do Apparent Overlaps between Schizophrenia and Autistic
... disorders (ASD) group and a typically developing individuals group (TYP).41 Each of the three clinical groups showed deficits in social function and atypical development of language. Notably, the ASD (i.e., HFA/AS subjects) subjects showed greater grammatical and pragmatic language symptoms (e.g., d ...
... disorders (ASD) group and a typically developing individuals group (TYP).41 Each of the three clinical groups showed deficits in social function and atypical development of language. Notably, the ASD (i.e., HFA/AS subjects) subjects showed greater grammatical and pragmatic language symptoms (e.g., d ...
Glucagon Receptor Agonists and Antagonists
... mRNA levels in the retina increase with plus lens wear.6 Conversely, the absence of immediate early gene production during form deprivation or negative lens wear implies minimal release of peptides from glucagon amacrine cells and suggests that the lack of glucagon is responsible for the development ...
... mRNA levels in the retina increase with plus lens wear.6 Conversely, the absence of immediate early gene production during form deprivation or negative lens wear implies minimal release of peptides from glucagon amacrine cells and suggests that the lack of glucagon is responsible for the development ...
Isolation and characterization of antibacterial compounds from Garcinia livingstonei
... Although pharmaceutical industries have produced a number of new antibiotics in the last three decades, resistance to these drugs by infectious microorganisms has increased. For a long period of time, plants have been a valuable source of natural products for maintaining human and animal health. The ...
... Although pharmaceutical industries have produced a number of new antibiotics in the last three decades, resistance to these drugs by infectious microorganisms has increased. For a long period of time, plants have been a valuable source of natural products for maintaining human and animal health. The ...
Drug therapy in autism: a present and future perspective
... before 3 years of age [23]. Autism is a behaviorally defined syndrome diagnosed on the basis of clinical history of the patient [4] as there is no specific biomarker for this disorder. While there are no definitive medical tests to indicate the presence of any form of ASD, diagnosis can be made by t ...
... before 3 years of age [23]. Autism is a behaviorally defined syndrome diagnosed on the basis of clinical history of the patient [4] as there is no specific biomarker for this disorder. While there are no definitive medical tests to indicate the presence of any form of ASD, diagnosis can be made by t ...