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9. Wakil, S. J., Green, DE, Mii, S., and Mahler, HR (1954) Studies on
9. Wakil, S. J., Green, DE, Mii, S., and Mahler, HR (1954) Studies on

... reactions, has been accepted and applied to all major pathways involving the metabolism of carbohydrates, lipids, proteins, and nucleic acids. Many of Dr. Wakil’s contributions have been landmarks in the field. He demonstrated carbon dioxide’s stimulatory effect on fatty acid synthesis and that long ...
Li_uta_2502D_12817
Li_uta_2502D_12817

Bettendorff L, Wins P. Biological functions of thiamine
Bettendorff L, Wins P. Biological functions of thiamine

... Thiamine in stress, diabetes and neurodegenerative diseases In many instances, beneficial and probiotic effects of thiamine (and/or pharmaceutical preparations of thiamine precursors with higher bioavailability) have been demonstrated. In these cases, we are most likely dealing with pharmacological ...
insulin therapy for children and adolescents with type 1 diabetes
insulin therapy for children and adolescents with type 1 diabetes

...  Easier use for the patient → a reduction of mistakes.  Separated use: more logical, effective and less expensive. ...
Lectins, as non-self-recognition factors, in crustaceans
Lectins, as non-self-recognition factors, in crustaceans

... and Lis, 1989.. Their specificity is always determined by the type of carbohydrate to which they bind. Hemagglutination inhibition assays in which the agglutinin is incubated with various carbohydrates or glycoconjugates before the addition of the target red blood cell are the mean to establish this ...
Propionic Acid Degradation by Syntrophic Bacteria During
Propionic Acid Degradation by Syntrophic Bacteria During

... This dissertation discusses results upon propionic acid degradation under anaerobic conditions in different habitats. Some results published in manuscripts listed below are included in this thesis: I Felchner-Zwirello M, Winter J, Gallert C (2012) Interspecies distances between propionic acid degrade ...
The Unusual Binding Properties of the Third Distinct Teleost
The Unusual Binding Properties of the Third Distinct Teleost

Rousselot® Gelatine
Rousselot® Gelatine

... different amino acids, including 8 out of the 9 essential amino acids, the exception being tryptophan. It is particularly rich in glycine, proline and hydroxyproline, which together represent almost 50% of the composition of the molecule and give gelatine its unique properties. Hydroxyproline is an ...
npr review - Olivamine
npr review - Olivamine

... indirect molecular targets. These targets modulated by curcumin can be upregulated or downregulated depending upon the target. Included among these molecular targets are transcription factors, enzymes, inflammatory mediators, protein kinases, drug resistance proteins, cell-cycle regulatory proteins, ...
novel aspects of carnitine function and metabolism
novel aspects of carnitine function and metabolism

... Normal functioning of fatty acid oxidation and energy metabolism depends on carnitine. Although this compound has been extensively studied over the years, some aspects of carnitine metabolism and function remain unclear. This thesis aimed to: 1) elucidate the reverse action of the carnitine shuttle ...
Platelet isolation and incubation with LDL - HAL
Platelet isolation and incubation with LDL - HAL

... malondialdehyde but normal alpha-tocopherol concentrations. By contrast, LDL from sexand age-matched healthy volunteers had no activating effects on platelets. Conclusions: Our results indicate that LDL modified by glycoxidation may play an important contributing role in platelet hyperactivation obs ...
Patterns, motifs, PSI-BLAST
Patterns, motifs, PSI-BLAST

... • One possible trick is to add a small number to all observed frequencies. These small non-observed frequencies are referred to as pseudo-counts. • From the previous example with a pseudo-counts of 1: ...
Osmo- and thermo-adaptation in hyperthermophilic Archaea
Osmo- and thermo-adaptation in hyperthermophilic Archaea

Molecular and biochemical characterization of cytosolic
Molecular and biochemical characterization of cytosolic

... ADP-glucose (ADPG) can be synthesized in the cytosol and taken up directly by the amyloplast as well as being synthesized within the organelle. The possession of a cytosolic AGPase could bypass the need for the G1P produced by the plastidial PGM reaction, since ADPG synthesis could be directly linke ...
The role of homocysteine in endothelial dysfunction
The role of homocysteine in endothelial dysfunction

... expression of pro-inflammatory cytokines, such as monocyte chemoattractant protein 1 (MCP1), which regulates migration and activation of monocytes/macrophages, and interleukin 8 (IL8), which is an important chemoattractant for neutrophils and T-lymphocytes [13]. Homocysteine has been shown to initia ...
principles of metabolic regulation: glucose and glycogen
principles of metabolic regulation: glucose and glycogen

Glutamine and the bowel
Glutamine and the bowel

... the systemic flux of glutamine. → intestinal glutamine metabolism: 1. Contribute a nutritionally important portion of intestinal energy generation. 2. As precursor:synthesis of ornithine, cotrulline, proline and arginine. ...
13-Alanine as an Ethylene Precursor
13-Alanine as an Ethylene Precursor

... obtained when the cofactors and substrate necessary for the conversion of /8-alanine to ethylene (26) were added to a suspension of 0.5 g lyophilized particulate fraction (crude enzyme system). From both experiments, it can be seen that the added compounds caused a significant increase in ethylene p ...
Document
Document

... • Fatty acids are activated to acyl CoA by thiokinases or acyl CoA synthetases • The reaction occurs in two steps and requires ATP, coenzyme A and Mg2+ • Fatty acid reacts with ATP to form acyladenylate which then combines with coenzyme A to produce acyl CoA. • Two high energy phosphates are utiliz ...
Physiological Strategies During Animal Diapause: Lessons from
Physiological Strategies During Animal Diapause: Lessons from

... During the summer months, females of the brine shrimp Artemia franciscana reproduce ovoviviparously by releasing free-swimming nauplius larvae directly from the brood pouch into the water column (Fig. 1). With the onset of shorter days in the autumn, ovigerous females begin reproducing oviparously. ...
Vanillin formation from ferulic acid in Vanilla planifolia is catalysed
Vanillin formation from ferulic acid in Vanilla planifolia is catalysed

... because the pathway has remained unknown. Vanillin has been produced by microbial bioconversion of substrates structurally related to vanillin5 as well as from glucose6. Previous studies have shown the conversion of a variety of compounds into vanillin glucoside after administration to V. planifolia ...
The Protein Cevalently Linked  to  the  5'... of  Poliovirus RNA by Victor Robert  Ambros
The Protein Cevalently Linked to the 5'... of Poliovirus RNA by Victor Robert Ambros

... 5' terminus can be demonstrated on nascent RNA, and the yield of VPg is consistent with one molecule of the protein on each nascent chain. ...
View/Open
View/Open

... protein unavailable to the animal. Therefore, bright, golden colored DDGS that has a sweet and fermented smell should be used to achieve the best feeding value and growth performance for beef cattle. Marketers of DDGS often discount the price of dark and heat damaged DDGS to account for the reductio ...
Differential effects of nipecotic acid and w x 4,5,6,7
Differential effects of nipecotic acid and w x 4,5,6,7

... tiagabine ŽNielsen et al., 1991. as well as Ž4,5,6,7-tetrahydroisoxazolow4,5-c xpyridin-3-ol. ŽTHPO. and its related GABA analogues ŽSchousboe et al., 1991., all of which have structural analogy to nipecotic acid, one of the first recognized potent and specific inhibitors of high affinity GABA uptak ...
Ch23-Oxidation of Fatty Acids and Ketone Bodies
Ch23-Oxidation of Fatty Acids and Ketone Bodies

... acyl group is transferred back to CoA by a second enzyme, carnitine:palmitoyltransferase II (CPTII or CATII). The carnitine released in this reaction returns to the cytosolic side of the mitochondrial membrane by the same translocase that brings fatty acylcarnitine to the matrix side. Long-chain fat ...
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Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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