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Summer 2010 - Wake Forest University
Summer 2010 - Wake Forest University

lecture 5
lecture 5

... - the cytoplasm has a reducing environment where disulfide bonds do not occur • disulfide-bonded proteins occur in the endoplasmic reticulum in eukaryotes; secreted proteins • periplasmic space in prokaryotes ...
2. Structure and bonding of carbohydrates, proteins and lipids
2. Structure and bonding of carbohydrates, proteins and lipids

... of covalent bonds). The conformation of proteins is also subject to intricate folding processes connected to different types of bonds such as hydrogen bonds and disulfide bonds. The primary structure of proteins, though, determines their ability to form a secondary and tertiary structure, which is r ...
LS1a Fall 09
LS1a Fall 09

... embedded in a membrane or not. Proteins that are either secreted or inserted into a membrane via a transmembrane domain must have an ER signal sequence. Unless there is an additional “secondary retention signal,” a protein that enters secretory pathway will either be secreted or end up embedded in t ...
Presentación de PowerPoint
Presentación de PowerPoint

... less highly ordered than the native protein, shown in (B). Note that the molten globule contains most of the secondary structure of the native form, although the ends of the alpha helices are frayed and one of these helices is only partly formed. ...
Initiation
Initiation

Protein purification: the basics
Protein purification: the basics

L 06 _code
L 06 _code

... AUG is the start codon. It encodes methionine, so all translation begins with met (which is often removed from the polypeptide after synthesis). AUG can also occur within a translated sequence, so met can also occur within a polypeptide. There are 64 codons, but only 20 amino acids – most amino acid ...


... are the building blocks for protein synthesis, allowing for the production of muscle fibers. Growth enhancers, such as beta agonists and steroidal implants, increase protein synthesis and promote lean muscle growth. One of the side effects of beta agonists is an increase in overall toughness of the ...
Biochemistry of Cells
Biochemistry of Cells

... • Proteins are polymers made of monomers called amino acids All proteins are made of 20 different amino acids linked in different orders Proteins are used to build cells, act as hormones & enzymes, and do much of the work in a cell ...
Protein Kinases Structural Features
Protein Kinases Structural Features

Review Problems #2 (Enzyme Review, Phosphatases
Review Problems #2 (Enzyme Review, Phosphatases

... 2) The branchpoint for aromatic amino acid biosynthesis is chorismate. What is the structure of chorismate? What are the three immediate products derived from chorismate that constitute the first unique steps in the synthesis of the three aromatic amino acids? 3) From where are the two carbons of th ...
103 topic summary
103 topic summary

... Transport across cell membranes: simple, facilitated and active transport ...
Amino Acids, Peptides and Proteins Convener : Dr
Amino Acids, Peptides and Proteins Convener : Dr

... The range of compounds that an enzyme excepts varies from a particular functional group to a specific compound Emil Fischer formulated the lock-and-key mechanism for enzymes All reactions which occur in living cells are mediated by enzymes and are catalysed by 106-108 Some enzymes may require the pr ...
Protein Degradation at Lysosome
Protein Degradation at Lysosome

Structure of Nucleic Acids
Structure of Nucleic Acids

... Chemistry of Life Bio A ...
Transcription - Simone Damiano Ph.D.
Transcription - Simone Damiano Ph.D.

... A three-nucleotides codon (i.e. AUC) in a sequence specifies a single amino acid. With few exceptions, the genetic code is universal for all living organisms ...
4 slides pdf
4 slides pdf

... Unique sequence of amino acids in protein is determined by order of nucleotide bases in gene. Protein’s 3-D structure is critical to its function: • shape and function of protein is determined by amino acid sequence (primary structure) • 3-D results from interactions between amino acid side chains ...
Fatty Acid Spiral
Fatty Acid Spiral

... Our diets must contain a reasonable ratio of the essential amino acids in order for our bodies to maintain health. – Meat, eggs, soy and milk contain the essential amino acids in a similar ratio to that needed by humans. – Fruits, vegetables, nuts, seeds, and grains tend to be high in some and low i ...
slide - KOCSEA
slide - KOCSEA

Document
Document

... Our diets must contain a reasonable ratio of the essential amino acids in order for our bodies to maintain health. – Meat, eggs, soy and milk contain the essential amino acids in a similar ratio to that needed by humans. – Fruits, vegetables, nuts, seeds, and grains tend to be high in some and low i ...
Porting Biological Application in GRID. An Experience within the
Porting Biological Application in GRID. An Experience within the

... The resulting structures are subjected to a energy minimization procedure using a semi-empirical force field. The principal non-local interactions considered are hydrophobic interactions, electrostatic interactions, main chain hydrogen bonds and excluded volume. The compatible structures both with l ...
Document
Document

... 4. What kind of RNA brings (carries) the amino acids to the ribosomes? tRNA 5. What does rRNA (ribosomal RNA) do? Makes up the ribosome ...
WP2: Diets with varying amount and amino acid composition
WP2: Diets with varying amount and amino acid composition

... implications for the treatment of obesity and metabolic diseases [14]. Compared to white fat, BAT is more metabolically active and burns off energy to heat and it has been suggested that dietary increased brown fat metabolism may induce weight loss – where high leucine may be one dietary factor acti ...
Mihaela_Leonida_Abstract
Mihaela_Leonida_Abstract

... with increasing protein concentration in particles and nisin presenting a somewhat reversed pattern. LC increased with increasing protein concentration in the preparative mixtures. Particles with low protein concentration have demonstrated initial burst release followed by a slower and constant rele ...
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Protein structure prediction



Protein structure prediction is the prediction of the three-dimensional structure of a protein from its amino acid sequence — that is, the prediction of its folding and its secondary, tertiary, and quaternary structure from its primary structure. Structure prediction is fundamentally different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by bioinformatics and theoretical chemistry; it is highly important in medicine (for example, in drug design) and biotechnology (for example, in the design of novel enzymes). Every two years, the performance of current methods is assessed in the CASP experiment (Critical Assessment of Techniques for Protein Structure Prediction). A continuous evaluation of protein structure prediction web servers is performed by the community project CAMEO3D.
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