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Bacterial Genetics
Bacterial Genetics

... Lactose Operon 1. E Coli can use either Glucose or other sugars (ex: lactose) as the source of carbon & energy. 2. In Glu-medium, the activity of the enzymes need to metabolize Lactose is very low. 3. Switching to the Lac-medium, the Lac-metabolizing enzymes become increased for this change . 4. Th ...
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... the formation of proteins.  How could 4 different base pairs code for 20 different amino acids?  1:1 obviously didn’t work; a 2 letter code didn’t work either; but a 3 letter code would ...
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... Eukaryotic mRNA can last hours or even weeks Length of time before degraded by cellular enzymes is related to quantity of protein synthesis they can direct Translation of mRNA can be delayed until control signal initiates it Initiation factors may be required for translation Polypeptides are extensi ...
Powerpoint notes for chapter 17
Powerpoint notes for chapter 17

... the first tRNA molecule is “bumped” out of the ribosome. With each new tRNA a new amino acid is added to the polypeptide chain. The cycle of amino acids linking together is repeated until a “stop” codon (UAA, UAG or UGA) is reached. Once this tRNA is read, the amino acid is released from the ribosom ...
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RNA Detection and quantitation
RNA Detection and quantitation

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... 1944: Oswald Avery, Colin MacLeod and Maclyn McCarty show that DNA can transform bacteria, demonstrating that DNA is the hereditary material. 1953: James Watson and Francis Crick determine the structure of the DNA molecule, which leads directly to knowledge of how it replicates 1966: Marshall Nirenb ...
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Bio Sem I review
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...  DNA is arranged in a double helix – has 2 strands and twists like a ladder  Replication – process in which DNA makes a copy of itself – it unzips and free bases attach following the base pair rule.  DNA holds the code for the making of proteins needed for life. Three bases in a row is a codon th ...
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... Sometimes a mutation may have no effect at all, other times it may be of benefit to the individual, but this is rare Interestingly, the Human Genome Project reveled we all have mutations in our DNA sequence which do not affect the phenotype!! Occurs at a very low rate: about 1 in 1mil bases. UV radi ...
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Chapter 20 DNA Metabolism Gene: A segment of DNA or RNA that

... Replisome: A complex of proteins involved in DNA replication. It consists of: Helicases: Use ATP to dissociate DNA strands. Topoisomerases: Relieve topological stress due to strand separation. ...
Agilent 101: An Introduction to Microarrays and Genomics
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... tell the ribosome to start or stop making a protein. Amino acids are the building blocks of proteins and are assembled by the ribosome according to the instruction specified by the messenger RNA. The code to specify a human being is a spiral staircase of DNA with about 3 billion steps, less than a g ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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