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A GRAPHICAL MODEL FORMULATION OF THE DNA BASE
A GRAPHICAL MODEL FORMULATION OF THE DNA BASE

... from this general model. We will follow this exposition, to first account for the available possibilities, and, then identify the one that we think has more merit and will be pursued further. For example; if we reduce the ancestral subset to just the last event (Z M(i) = {zi−1 }), we get a first-ord ...
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... alogy of Tn1721 [2,20] and the near identity of the tet determinants of RP1 and Tn1721. In subsequent discussions results pertaining to the tet genes of RP1 and Tn1721 will be taken to be equally applicable to either determinant. Open reading frames Bennett and Shales [21] used insertional inactivat ...
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... not been a GMO strawberry commercialized anywhere in the world. All commercial strawberry varieties have been developed by conventional breeding methods. While foods derived from genetically engineered crops have shown no evidence of health risks, there are still major social barriers to the accepta ...
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... frequency of at least several hundred lesions per human cell per day by reaction of intracellularly produced reactive oxygen species with DNA (1); this rate is further increased under oxidative stress conditions (2,3). Failure of repair mechanisms to properly deal with such a damage load has several ...
A new drug inactivates the helicase enzyme by binding to its active
A new drug inactivates the helicase enzyme by binding to its active

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... one of four possible nitrogenous bases (“bases” for short) on the other. The phosphate group is acidic and thus negatively charged. This is why DNA has a net negative charge. Because all nucleotides in DNA contain deoxyribose they are called deoxyribonucleotides, though for simplicity we will just c ...
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... dynamics associated with hybridization, about which little is known. In particular, there is insufficient understanding of the mechanism underlying the fundamental event in this process, the binding兾unbinding of an individual base pair. In this work we use atomistic simulations to examine the free e ...
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... Further  poten?al  for  confusion  comes  from  new  uses  of  the  term  ‘genome’  recently  spawned  by   genome  sequencers.  These  concern  the  counter-­‐intui?ve  meaning  of  a  ‘wholly’,  ‘completely’  or   ‘en?rely’  sequenced  geno ...
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... Each National Reference Centre (NRC) must meet both the general and the specific terms of reference. In the specific terms of reference, the NRC tasks dedicated to each selected pathogen or group of pathogens are described. It aims to guarantee the knowledge, the know-how and the epidemiological sur ...
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...  Amino acids with nonpolar side chains.  Aromatic R Groups.  Amino acids with uncharged polar side chains.  Positively Charged (Basic) R Groups.  Amino acids with acidic side chains. ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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