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Biochemical Defects Associated with Cancer
Biochemical Defects Associated with Cancer

... Evolutionarily conserved process Mechanism involves several protein dimers necessary for successful repair MutLα is composed of two separate proteins, MLH1 and PMS2 ...
WYSE – “Academic Challenge” - Worldwide Youth in Science and
WYSE – “Academic Challenge” - Worldwide Youth in Science and

... © 2006 Worldwide Youth in Science and Engineering “WYSE”, “Worldwide Youth in Science and Engineering” and the “WYSE Design” are service marks of and this work is Copyright © 2006 Board of Trustees of the University of Illinois at Urbana - Champaign. ...
Programmed Cell Death during Leaf Senescence in Eucommia
Programmed Cell Death during Leaf Senescence in Eucommia

... no degradation (Fig.1, lane1 and lane2). However, as we proceed from green2 to yellow leaves, bands of DNA degradation can be observed clearer (Fig.1, lane3 and lane4). The size of the DNA bands corresponds to multiples of around 200bp, suggesting that they are produced by internucleosomal degradati ...
dna tech 2014 - Valhalla High School
dna tech 2014 - Valhalla High School

Dissecting the Molecular Origins of Specific Protein
Dissecting the Molecular Origins of Specific Protein

... © 2002 by the Biophysical Society ...
rational selection of pcr-based platforms for pharmacogenomic testing
rational selection of pcr-based platforms for pharmacogenomic testing

dna tech 2014 - Valhalla High School
dna tech 2014 - Valhalla High School

... The Tools of Molecular Biology How do scientists make changes to DNA? ...
Cunningham Cunningham An Exploration of Bacterial
Cunningham Cunningham An Exploration of Bacterial

... The increased temperature caused the DNA to split into two different complementary strands, which primers and nucleotides are added to by taq polymerase to form new DNA fragments. Eventually, millions of new, identical DNA molecules are formed since every round produces two more fragments than in th ...
The application of Microarray in Medicine
The application of Microarray in Medicine

... via different microbiological tools. According to aforementioned part, traditional diagnostic techniques are not suitable methods for detecting pathogenic microorganisms. The traditional diagnostics are even weaker for detecting and identifying multidrug-resistant pathogenic microbial agents. For th ...
Chapter 21: Genomics I: Analysis of DNA and Transposable Elements
Chapter 21: Genomics I: Analysis of DNA and Transposable Elements

... elements (TEs), also called transposons, have sometimes been referred to as “jumping genes” because they are inherently mobile. They were discovered by Barbara McClintock in the 1950s through her classic studies with corn. Since then, geneticists have discovered many different types of TEs in organi ...
L-Arginine A Versatile, Conditionally Essential Amino Acid
L-Arginine A Versatile, Conditionally Essential Amino Acid

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... describe homology between proteins and establish relationships between well-known and new protein sequences. More specifically, discrete motifs identify amino acids sharing important properties conserved in evolution. Further, they are often able to identify structurally or functionally important re ...
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... Viruses equipped with an outer envelope use the envelope to enter the host cell. ○ Glycoproteins on the envelope bind to specific receptors on the host’s membrane. ○ The envelope fuses with the host’s membrane, transporting the capsid and the viral genome inside. ○ In the reproductive cycle of an en ...
Spring 1997 - University of Idaho
Spring 1997 - University of Idaho

...  DNA Strand is an efficient chelator of iron and copper ions. Binding Constant 1012 Primarily through phosphate residues  DNA-FeII ,- CuI complexes participates in Fenton type chemistries.  DNA degradation by .OH (or other oxidizing products) leads to attack on deoxyribose residues which releases ...
Small-Subunit Ribosomal RNA Sequence from
Small-Subunit Ribosomal RNA Sequence from

... universally conserved positions. The early branch point may explain this result, since a similar observation was made when the Euglena and Trypanosoma sequences were determined (Sogin et al. 1986). It must also be remembered that only a single, cloned copy of the approximately 4,000 genes per cell w ...
CHAPTER 17 FROM GENE TO PROTEIN Section C: The Synthesis
CHAPTER 17 FROM GENE TO PROTEIN Section C: The Synthesis

... pair of complimentary nucleotides with another nucleotide pair is called a base-pair substitution. • Some base-pair substitutions have little or no impact on protein function. • In silent mutations, alterations of nucleotides still indicate the same amino acids because of redundancy in the genetic c ...
17C-SynthesisOfProtein
17C-SynthesisOfProtein

... pair of complimentary nucleotides with another nucleotide pair is called a base-pair substitution. • Some base-pair substitutions have little or no impact on protein function. • In silent mutations, alterations of nucleotides still indicate the same amino acids because of redundancy in the genetic c ...
17C-SynthesisOfProtein
17C-SynthesisOfProtein

... pair of complimentary nucleotides with another nucleotide pair is called a base-pair substitution. • Some base-pair substitutions have little or no impact on protein function. • In silent mutations, alterations of nucleotides still indicate the same amino acids because of redundancy in the genetic c ...
Penn rDNA Registration Forms
Penn rDNA Registration Forms

the molecules of life - Betavak-NLT
the molecules of life - Betavak-NLT

... pancreas. The cause of these problems seems to lie with the mucus-producing cells. These cells, which can be found in the lungs, intestines and pancreas, do not function properly. They produce inadequate amounts of mucus as well as sticky, thick mucus. To understand precisely where the problem lies, ...
The Urea Cycle - LSU School of Medicine
The Urea Cycle - LSU School of Medicine

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The ocean as regional enabler A Pacific Northwest success

... present in the samples. • Second, low-cost biosensors to assay the selected analytes in time series across chemical and physical gradients in different habitats. Like planes and helicopters: both are used to fly, but have very different applications. ...
Mammalian Systematics
Mammalian Systematics

Bacteria Transformation
Bacteria Transformation

... New Words: Insulin, recombinant DNA, plasmid, gene splicing The first successful insulin preparations came from cows (and later pigs). In the 1980's technology had advanced to the point where we could make human insulin. The technology which made this approach possible was the development of recombi ...
PATTERNS IN THE PERIODIC TABLE
PATTERNS IN THE PERIODIC TABLE

... are trapped in the cell. However, during cooking the cell walls can be broken by moisture within the cell evaporating and rupturing the walls. Also chemicals can damage the walls which are made of a structural carbohydrate called cellulose. Volatile flavour molecules can then leave the food and ente ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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