EXTEMPORANEOUS PREPARATION OF PAEDIATRIC ORAL
... uniformity of content, selection of safe excipients and stability issues are part of the main challenges faced in the preparation of extemporaneous drug products. The present study examined the chemical stabilities and content uniformities of extemporaneously prepared nifedipine oral dosage forms to ...
... uniformity of content, selection of safe excipients and stability issues are part of the main challenges faced in the preparation of extemporaneous drug products. The present study examined the chemical stabilities and content uniformities of extemporaneously prepared nifedipine oral dosage forms to ...
The Effects of Caffeine on the Human Metabolism
... An experiment was designed to measure the effects that caffeine has on the time it takes to complete an exercise over a specific distance (Kovacs 710). An experiment was performed in which participants were given varying amounts of caffeine, placebo and a carbohydrateelectrolyte solution (Kovacs 712 ...
... An experiment was designed to measure the effects that caffeine has on the time it takes to complete an exercise over a specific distance (Kovacs 710). An experiment was performed in which participants were given varying amounts of caffeine, placebo and a carbohydrateelectrolyte solution (Kovacs 712 ...
How to Protect Yourself Against Malaria
... Sunset — the hunt for human blood begins. From dusk to dawn the female Anopheles, the malaria-carrying mosquito searches for a host to supply her with blood. Blood is an absolute necessity for her because it provides the protein needed for the development of her eggs which she later deposits in her ...
... Sunset — the hunt for human blood begins. From dusk to dawn the female Anopheles, the malaria-carrying mosquito searches for a host to supply her with blood. Blood is an absolute necessity for her because it provides the protein needed for the development of her eggs which she later deposits in her ...
Didanosine - WHO archives - World Health Organization
... were given triple combination antiretroviral therapy (2 nucleoside analogues + 1 protease inhibitor). After 18 months of treatment, participants gained a median of 180 CD4+ cells and showed a median drop in plasma viral load of 2.8 log10 copies/ml. During the study period, there were 7 clinical AIDS ...
... were given triple combination antiretroviral therapy (2 nucleoside analogues + 1 protease inhibitor). After 18 months of treatment, participants gained a median of 180 CD4+ cells and showed a median drop in plasma viral load of 2.8 log10 copies/ml. During the study period, there were 7 clinical AIDS ...
View PDF - Open Access Journals
... which no standard therapy was available were recruited. Patients received docetaxel 75 mg/m2 and ramucirumab 10 mg/kg on day 1 of a 3-week cycle. In cycle 1, docetaxel was administered alone; in cycle 2 and subsequent cycles, ramucirumab was administered followed by docetaxel. Blood was drawn immedi ...
... which no standard therapy was available were recruited. Patients received docetaxel 75 mg/m2 and ramucirumab 10 mg/kg on day 1 of a 3-week cycle. In cycle 1, docetaxel was administered alone; in cycle 2 and subsequent cycles, ramucirumab was administered followed by docetaxel. Blood was drawn immedi ...
The Strange Case of Strontium Ecklonia Cava Extract
... conditions. Peroxynitrite plays a main role in Dr. Pall’s mechanism, along with NF-kappaB and other inflamma- ...
... conditions. Peroxynitrite plays a main role in Dr. Pall’s mechanism, along with NF-kappaB and other inflamma- ...
MHRA PUBLIC ASSESSMENT REPORT
... placebo in reducing cough symptoms[3,4]. One of these studies tested codeine in a twophase study (laboratory and home) at a dose of 30 mg four times daily for four days (n=81)[3]. Codeine was no more effective than placebo either as a single dose or as a total daily dose of 120 mg (p > 0.2). In the ...
... placebo in reducing cough symptoms[3,4]. One of these studies tested codeine in a twophase study (laboratory and home) at a dose of 30 mg four times daily for four days (n=81)[3]. Codeine was no more effective than placebo either as a single dose or as a total daily dose of 120 mg (p > 0.2). In the ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... (GABA) receptor agonists. However, a "gold standard" drug has not been defined. Among the drugs, opiates are most potent; however, the opiates are associated wide-ranging and unpredictable side effects. In various studies it has been shown that when Clonidine used as a neuraxial adjunct, prolongs th ...
... (GABA) receptor agonists. However, a "gold standard" drug has not been defined. Among the drugs, opiates are most potent; however, the opiates are associated wide-ranging and unpredictable side effects. In various studies it has been shown that when Clonidine used as a neuraxial adjunct, prolongs th ...
... formulations are expected to be approved over the next few years. These formulations will undoubtedly be the subject extensive sales,marketing and physician sampling efforts, particularly in view of the void created by the recent withdrawal of Vioxx@ and Bextra@,and the genericization of Ultram@,Ult ...
oral cyclosporine use in dogs
... tracts within perianal tissues.9 Oral cyclosporine has been shown in multiple studies to be effective for treatment of anal furunculosis in most dogs at a typical starting dosage of 4 to 8 mg/kg PO Q 12 H or Q 24 H.9 Measurement of blood cyclosporine concentrations is not typically recommended durin ...
... tracts within perianal tissues.9 Oral cyclosporine has been shown in multiple studies to be effective for treatment of anal furunculosis in most dogs at a typical starting dosage of 4 to 8 mg/kg PO Q 12 H or Q 24 H.9 Measurement of blood cyclosporine concentrations is not typically recommended durin ...
AusPAR: Vernakalant - Therapeutic Goods Administration
... the sponsor states that there is a clinical need for better pharmacological approaches to convert AF to sinus rhythm. The sponsor claims that rapid pharmacological cardioversion by vernakalant injection, suitable for a broad-based AF population with typical cardiovascular co-morbidities, provides a ...
... the sponsor states that there is a clinical need for better pharmacological approaches to convert AF to sinus rhythm. The sponsor claims that rapid pharmacological cardioversion by vernakalant injection, suitable for a broad-based AF population with typical cardiovascular co-morbidities, provides a ...
MedSafe Paperapplication/msword
... the condition (i.e. self limiting) it should be considered whether any risk is acceptable in the patient population involved. General Cough cold remedies have been widely available in the over the counter arena for many years now, and there is wide acceptance of use of these products in the paediatr ...
... the condition (i.e. self limiting) it should be considered whether any risk is acceptable in the patient population involved. General Cough cold remedies have been widely available in the over the counter arena for many years now, and there is wide acceptance of use of these products in the paediatr ...
HIGHLIGHTS OF PRESCRIBING INFORMATION •
... Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism ...
... Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism ...
Acipimox-Mediated Plasma Free Fatty Acid Depression per se
... After their increasein plasma and despite the buffering effect of serum albumin, the amphiphilic FFA molecules rapidly partition into the cell plasma membrane, influencing the physicochemical state of lipid domains (29). After incorporation into the membrane, FFA perturb the bilayer structure of the ...
... After their increasein plasma and despite the buffering effect of serum albumin, the amphiphilic FFA molecules rapidly partition into the cell plasma membrane, influencing the physicochemical state of lipid domains (29). After incorporation into the membrane, FFA perturb the bilayer structure of the ...
curriculum vitae - West Texas Retina
... Primary Investigator: S. Young Lee, M.D. Sub-Investigator: Sunil S. Patel, M.D., Ph.D. Ophthotech OPH3000, “A phase I ascending dose and parallel group trial to establish the safety, tolerability and pharmacokenetics profile of multiple intravitreous injections of Volociximab (α5β1 integrin antagoni ...
... Primary Investigator: S. Young Lee, M.D. Sub-Investigator: Sunil S. Patel, M.D., Ph.D. Ophthotech OPH3000, “A phase I ascending dose and parallel group trial to establish the safety, tolerability and pharmacokenetics profile of multiple intravitreous injections of Volociximab (α5β1 integrin antagoni ...
PDF - Circulation
... inotropic drug infusion, cardiac outputs and pressures were measured at 5 and 10 min. After 10 min the first drug dosage was changed to the next higher increment of the same drug unless systolic arterial pressure was greater than 140 torr, in which case the initial dosage was halved. After an additi ...
... inotropic drug infusion, cardiac outputs and pressures were measured at 5 and 10 min. After 10 min the first drug dosage was changed to the next higher increment of the same drug unless systolic arterial pressure was greater than 140 torr, in which case the initial dosage was halved. After an additi ...
Organ Specific Guide
... monitored more closely for this possible effect. Synopsis of research: (Please the online Tropical Plant Database for all cited research.) • A double-blind, randomized, placebo-controlled study was published in 2000 on artichoke leaf extract. For six weeks, 143 patients with high cholesterol were gi ...
... monitored more closely for this possible effect. Synopsis of research: (Please the online Tropical Plant Database for all cited research.) • A double-blind, randomized, placebo-controlled study was published in 2000 on artichoke leaf extract. For six weeks, 143 patients with high cholesterol were gi ...
WELLBUTRIN® (bupropion hydrochloride) Tablets
... Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and ...
... Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and ...
ICH E10
... They might facilitate heart rate correction approaches based on individual subject data. ...
... They might facilitate heart rate correction approaches based on individual subject data. ...
Direct and quantitative evaluation of the human CYP3A4
... heterologous oligomers, etc.) (Parmentier et al., 2007). Other in vitro techniques, like human liver microsomes (HLM), require the use of inhibitors, which suffer from a lack of specificity (e.g. antibody anti-CYP450) or have too specific in vitro conditions of use (e.g. chemical competitive CYP450 ...
... heterologous oligomers, etc.) (Parmentier et al., 2007). Other in vitro techniques, like human liver microsomes (HLM), require the use of inhibitors, which suffer from a lack of specificity (e.g. antibody anti-CYP450) or have too specific in vitro conditions of use (e.g. chemical competitive CYP450 ...
Protease inhibitor plasma concentrations in HIV antiretroviral therapy
... neurological adverse events had at least a 3-fold higher concentration than 2100 ng/ml (IC90). The study conclusion included a proposal to use drug monitoring to guide drug downward titration in these patients. In studies with HIV-infected patients receiving indinavir at a dose of 800 mg three-times ...
... neurological adverse events had at least a 3-fold higher concentration than 2100 ng/ml (IC90). The study conclusion included a proposal to use drug monitoring to guide drug downward titration in these patients. In studies with HIV-infected patients receiving indinavir at a dose of 800 mg three-times ...
Fentanyl Data Sheet Oct 13
... Some tests on female rats showed reduced fertility as well as embryo mortality. These findings were related to maternal toxicity and not a direct effect of the drug on the developing embryo. There was no evidence of teratogenic effects. Administration during childbirth (including caesarean section) ...
... Some tests on female rats showed reduced fertility as well as embryo mortality. These findings were related to maternal toxicity and not a direct effect of the drug on the developing embryo. There was no evidence of teratogenic effects. Administration during childbirth (including caesarean section) ...
Novel pharmacotherapeutic treatments for cocaine addiction R E V I E W
... with modafinil at two oral dosages (200 mg and 400 mg, respectively) demonstrated an ability to significantly attenuate euphoria from intravenously administered cocaine in one subjective measure (P = 0.02). Importantly, this early study suggested safety as well as the possibility of a cocaine-blunti ...
... with modafinil at two oral dosages (200 mg and 400 mg, respectively) demonstrated an ability to significantly attenuate euphoria from intravenously administered cocaine in one subjective measure (P = 0.02). Importantly, this early study suggested safety as well as the possibility of a cocaine-blunti ...
Eryped 200 (erythromycin ethylsuccinate) Suspension
... immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ery-Ped or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometime after startin ...
... immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ery-Ped or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometime after startin ...
prescribing information
... epinephrine administration. Patients with Parkinson’s disease may notice a temporary worsening of symptoms. In case of accidental injection, the patient should be advised to immediately go to the emergency room for treatment. Since the epinephrine in the EpiPen Auto-Injector is a strong vasoconstric ...
... epinephrine administration. Patients with Parkinson’s disease may notice a temporary worsening of symptoms. In case of accidental injection, the patient should be advised to immediately go to the emergency room for treatment. Since the epinephrine in the EpiPen Auto-Injector is a strong vasoconstric ...