Version 7
... buspirone (Cmax increased 13-fold and AUC 19-fold). If buspirone and itraconazole are to be used in combination, a low dose of buspirone (e.g., 2.5 mg once daily) is recommended. Subsequent dose adjustments of either drug should be based on clinical response. Association with precautions of use: Dil ...
... buspirone (Cmax increased 13-fold and AUC 19-fold). If buspirone and itraconazole are to be used in combination, a low dose of buspirone (e.g., 2.5 mg once daily) is recommended. Subsequent dose adjustments of either drug should be based on clinical response. Association with precautions of use: Dil ...
New horizons in pulmonary arterial hypertension therapies
... translate into an improved safety profile, particularly with regards to gastrointestinal effects as, unlike iloprost and beraprost, selexipag and its metabolite do not stimulate gastric smooth muscle via the prostaglandin E (EP) receptors EP3 and EP1 [30]. In a phase II proof-of-concept study in 43 ...
... translate into an improved safety profile, particularly with regards to gastrointestinal effects as, unlike iloprost and beraprost, selexipag and its metabolite do not stimulate gastric smooth muscle via the prostaglandin E (EP) receptors EP3 and EP1 [30]. In a phase II proof-of-concept study in 43 ...
Breastfeeding guidelines for substance using mothers
... Much confusion surrounds the issue of whether a woman should breast feed her baby whilst continuing to take drugs. Many women and their partners are concerned about breastfeeding whilst taking drugs or drinking alcohol and will ask for advice. Parents should be informed that for most drugs the benef ...
... Much confusion surrounds the issue of whether a woman should breast feed her baby whilst continuing to take drugs. Many women and their partners are concerned about breastfeeding whilst taking drugs or drinking alcohol and will ask for advice. Parents should be informed that for most drugs the benef ...
SW QA 174_4 Acitretin in RI or RRT
... The toxic dose of acitretin is close to the therapeutic dose and most patients experience some sideeffects during the initial period whilst dosage is being adjusted1. There is no dose of etretinate at which therapeutic, but not adverse effects, are likely to appear 4. Therefore it is difficult to es ...
... The toxic dose of acitretin is close to the therapeutic dose and most patients experience some sideeffects during the initial period whilst dosage is being adjusted1. There is no dose of etretinate at which therapeutic, but not adverse effects, are likely to appear 4. Therefore it is difficult to es ...
QA84_3_Folic_acid_methotrexate
... methotrexate treatment may increase them further (21, 22. Folic acid supplementation lowers the prevalence of chronic hyperhomocysteinemia (20, 21, 23). Two trials (HOPE 2 and NORVIT) investigated the effect on homocysteine and cardiovascular disease in patients taking folic acid supplements and nei ...
... methotrexate treatment may increase them further (21, 22. Folic acid supplementation lowers the prevalence of chronic hyperhomocysteinemia (20, 21, 23). Two trials (HOPE 2 and NORVIT) investigated the effect on homocysteine and cardiovascular disease in patients taking folic acid supplements and nei ...
Module 2: The Science of Addiction
... • Clinical experience has suggest that induction procedures with patients receiving long-acting opioids (e.g. methadone-maintenance patients) are basically the same as those used with patients taking shortacting opioids, except: – The time interval between the last dose of medication and the first d ...
... • Clinical experience has suggest that induction procedures with patients receiving long-acting opioids (e.g. methadone-maintenance patients) are basically the same as those used with patients taking shortacting opioids, except: – The time interval between the last dose of medication and the first d ...
Discriminative Stimulus Effects of Zolpidem in Pentobarbital
... contrast, both chlordiazepoxide and triazolam occasioned full chlordiazepoxide-appropriate responding (i.e., greater than 80% drug-appropriate responding) in all rats tested (Depoortere et al., 1986; Sanger et al., 1987). Conversely, when zolpidem (2.0 mg/kg) was trained as a discriminative stimulus ...
... contrast, both chlordiazepoxide and triazolam occasioned full chlordiazepoxide-appropriate responding (i.e., greater than 80% drug-appropriate responding) in all rats tested (Depoortere et al., 1986; Sanger et al., 1987). Conversely, when zolpidem (2.0 mg/kg) was trained as a discriminative stimulus ...
Reyataz ® (atazanavir) - Bristol
... Due to inhibition of CYP3A4 by REYATAZ, co-administration of REYATAZ with quetiapine may result in increased quetiapine concentrations. Serious and/or life-threatening quetiapinerelated adverse reactions, including severe sedation and coma, have been reported for concomitant use of HIV protease inh ...
... Due to inhibition of CYP3A4 by REYATAZ, co-administration of REYATAZ with quetiapine may result in increased quetiapine concentrations. Serious and/or life-threatening quetiapinerelated adverse reactions, including severe sedation and coma, have been reported for concomitant use of HIV protease inh ...
Guidelines on Common Technical Document (CTD)
... This guideline applies to import / manufacture and marketing approval of new drugs including New chemical entity, new indication, new dosage forms, modified release form, new route of administration etc. under the definition of new drug under Rule 122E of Drugs & Cosmetics rules as a finished phar ...
... This guideline applies to import / manufacture and marketing approval of new drugs including New chemical entity, new indication, new dosage forms, modified release form, new route of administration etc. under the definition of new drug under Rule 122E of Drugs & Cosmetics rules as a finished phar ...
WHAT ARE THE POSSIBLE SIDE EFFECTS OF DICLOFENAC
... function, ALT (SGPT) is recommended for the monitoring of liver injury. In clinical trials, meaningful elevations (i.e., more than 3 times the ULN) of AST (GOT) (ALT was not measured in all studies) occurred in about 2% of approximately 5,700 patients at some time during diclofenac treatment. In a l ...
... function, ALT (SGPT) is recommended for the monitoring of liver injury. In clinical trials, meaningful elevations (i.e., more than 3 times the ULN) of AST (GOT) (ALT was not measured in all studies) occurred in about 2% of approximately 5,700 patients at some time during diclofenac treatment. In a l ...
Australian public assessment for Thyroxine Sodium
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
HIGHLIGHTS OF PRESCRIBING INFORMATION --------------------------WARNINGS AND PRECAUTIONS---------------------------
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety data in this section is b ...
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety data in this section is b ...
Medicines Management Programme Preferred Drugs Calcium
... Table 8: Meta-analyses and reviews of CCBs in stable angina.......................................................................... 21 Table 9: Review of clinical guidelines for stable angina .................................................................................... 23 Table 10: Dosing r ...
... Table 8: Meta-analyses and reviews of CCBs in stable angina.......................................................................... 21 Table 9: Review of clinical guidelines for stable angina .................................................................................... 23 Table 10: Dosing r ...
CELEBREX Cardiovascular Risk celecoxib capsules
... anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, CELEBREX does not inhibit ...
... anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, CELEBREX does not inhibit ...
ABSTRACT Title of Document:
... Currently, the most effective method for treating serious ocular disorders is to inject drug solutions directly into the vitreous. However, injecting in this manner carries a high risk of severe side effects. As a safer alternative, researchers in recent years have been investigating transscleral dr ...
... Currently, the most effective method for treating serious ocular disorders is to inject drug solutions directly into the vitreous. However, injecting in this manner carries a high risk of severe side effects. As a safer alternative, researchers in recent years have been investigating transscleral dr ...
T he cardiovascular effects of erythropoietin *
... Several studies have documented a decrease in the bleeding time of dialysis patients after initiation of rHuEpo therapy [54,60]. Although this response could be due to changes in the vessel wall or circulating proteins, several lines of evidence suggest that at least part of the response is from dir ...
... Several studies have documented a decrease in the bleeding time of dialysis patients after initiation of rHuEpo therapy [54,60]. Although this response could be due to changes in the vessel wall or circulating proteins, several lines of evidence suggest that at least part of the response is from dir ...
RISPERDAL
... additional benefit was observed above 3 mg per day, and higher doses were associated with more adverse events. Doses higher than 6 mg per day have not been studied. Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily. Maintenance Therapy While ...
... additional benefit was observed above 3 mg per day, and higher doses were associated with more adverse events. Doses higher than 6 mg per day have not been studied. Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily. Maintenance Therapy While ...
Wellbutrin - GSK Source
... Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and ...
... Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and ...
Anticancer Potential of Turmeric
... Contact dermatitis has been reported with occupational exposure and a small number of patients using turmeric topically reported pruritis at the site. (17,18) Anecdotal reports of mild giddiness have been published. Turmeric can cause gastrointestinal irritation, especially in high doses or after pr ...
... Contact dermatitis has been reported with occupational exposure and a small number of patients using turmeric topically reported pruritis at the site. (17,18) Anecdotal reports of mild giddiness have been published. Turmeric can cause gastrointestinal irritation, especially in high doses or after pr ...
Jemds.com
... disorder after longer duration of treatment may also be seen.[4] TD is more common in patients with schizophrenia, schizoaffective disorders, bipolar disorders who have been treated with antipsychotics for a long time. People with organic disorder like foetal alcohol syndrome and other developmental ...
... disorder after longer duration of treatment may also be seen.[4] TD is more common in patients with schizophrenia, schizoaffective disorders, bipolar disorders who have been treated with antipsychotics for a long time. People with organic disorder like foetal alcohol syndrome and other developmental ...
efficacy of topiramate in migraine prophylaxis
... More recently, gabapentin has been investigated in migraine prophylaxis although it is not yet formally approved for this use. Studies have shown it to be effective, with an improved side-effect profile compared with valproate, but these studies are limited.2,3 Topiramate is one of the newer antiepi ...
... More recently, gabapentin has been investigated in migraine prophylaxis although it is not yet formally approved for this use. Studies have shown it to be effective, with an improved side-effect profile compared with valproate, but these studies are limited.2,3 Topiramate is one of the newer antiepi ...
1. PACKAGE INSERT OXYCONTIN® (OXYCODONE HCl
... analgesic action with OxyContin occurred within 1 hour in most patients following oral administration. CLINICAL TRIALS A double-blind placebo-controlled, fixed-dose, parallel group, two-week study was conducted in 133 patients with chronic, moderate to severe pain, who were judged as having inadequa ...
... analgesic action with OxyContin occurred within 1 hour in most patients following oral administration. CLINICAL TRIALS A double-blind placebo-controlled, fixed-dose, parallel group, two-week study was conducted in 133 patients with chronic, moderate to severe pain, who were judged as having inadequa ...
Bioequivalence - Physiologie et Thérapeutique
... Is it a good veterinary practice to encourage the use of old antibiotics rather new ones? • Traditionally, from a public health perspective, veterinarians are encouraged not to employ new drugs, but rather to use the older antibiotics. • The recommendation whether to choose older rather than new an ...
... Is it a good veterinary practice to encourage the use of old antibiotics rather new ones? • Traditionally, from a public health perspective, veterinarians are encouraged not to employ new drugs, but rather to use the older antibiotics. • The recommendation whether to choose older rather than new an ...
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50
... thoughts or behaviour beyond 24 weeks could not be assessed. Patients who were treated for epilepsy, psychiatric disorders, and other conditions were all at increased risk for suicidality when compared to placebo, and there did not appear to be a specific demographic subgroup of patients to which th ...
... thoughts or behaviour beyond 24 weeks could not be assessed. Patients who were treated for epilepsy, psychiatric disorders, and other conditions were all at increased risk for suicidality when compared to placebo, and there did not appear to be a specific demographic subgroup of patients to which th ...