Sterile Vancomycin Hydrochloride, USP
... to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. If CDAD is susp ...
... to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. If CDAD is susp ...
EU Core Safety Profile
... CNS medicinal products/alcohol: Given the primary effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting medicinal products and alcohol. ADDITIONAL TEXT FOR Intramuscular ONLY Effect of ziprasidone on other medicinal products: All interaction studi ...
... CNS medicinal products/alcohol: Given the primary effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting medicinal products and alcohol. ADDITIONAL TEXT FOR Intramuscular ONLY Effect of ziprasidone on other medicinal products: All interaction studi ...
MSc Dissertation The toxicity and therapeutic index of a methotrexate polymeric
... MTX-polyglutamates inhibits the enzymatic conversion of 5-aminoimidazole-4carboxamide-ribonucleotide (AICAR) to formyl-AICAR by the enzyme AICARtransformylase. This leads to the intracellular accumulation of AICAR (Figure 1.3). This then in turn leads to the inhibition of adenosine production that i ...
... MTX-polyglutamates inhibits the enzymatic conversion of 5-aminoimidazole-4carboxamide-ribonucleotide (AICAR) to formyl-AICAR by the enzyme AICARtransformylase. This leads to the intracellular accumulation of AICAR (Figure 1.3). This then in turn leads to the inhibition of adenosine production that i ...
DEXDOMITOR Dosing Chart - Canine
... Do not use DEXDOMITOR in dogs or cats, and ANTISEDAN in dogs, with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. DEXDOMITOR should not be administered in the presence of preexis ...
... Do not use DEXDOMITOR in dogs or cats, and ANTISEDAN in dogs, with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. DEXDOMITOR should not be administered in the presence of preexis ...
Effect of cranberry dietary supplements with
... cranberry supplement from nine manufacturers. The content of a cranberry product, equivalent to one capsule, was extracted with methanol. Aliquots of the extract were tested for their ability to inhibit the metabolism of the human CYP3A4 substrate quinine, using an in vitro liver microsomal techniqu ...
... cranberry supplement from nine manufacturers. The content of a cranberry product, equivalent to one capsule, was extracted with methanol. Aliquots of the extract were tested for their ability to inhibit the metabolism of the human CYP3A4 substrate quinine, using an in vitro liver microsomal techniqu ...
March 2017 PBAC Meeting Agenda (Word 67KB)
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
How to Protect Yourself Against Malaria
... Sunset — the hunt for human blood begins. From dusk to dawn the female Anopheles, the malaria-carrying mosquito searches for a host to supply her with blood. Blood is an absolute necessity for her because it provides the protein needed for the development of her eggs which she later deposits in her ...
... Sunset — the hunt for human blood begins. From dusk to dawn the female Anopheles, the malaria-carrying mosquito searches for a host to supply her with blood. Blood is an absolute necessity for her because it provides the protein needed for the development of her eggs which she later deposits in her ...
Risperdal Label
... than 5 years of age have not been established. The dosage of RISPERDAL® should be individualized according to the response and tolerability of the patient. The total daily dose of RISPERDAL® can be administered once daily, or half the total daily dose can be administered twice daily. Dosing should b ...
... than 5 years of age have not been established. The dosage of RISPERDAL® should be individualized according to the response and tolerability of the patient. The total daily dose of RISPERDAL® can be administered once daily, or half the total daily dose can be administered twice daily. Dosing should b ...
... Accelerated approval clinical benefit studies. In December 1992, FDA published new regulations [21 CFR 314, subpart H and 601 subpart E] to establish a process for FDA to grant marketing approval under an accelerated review process for products that treat serious and life-threatening illnesses and t ...
PAXIL CR™ PRODUCT MONOGRAPH
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
ENCLOSURE 1
... Three clinical safety studies in 845 children aged 6 months to 5 years with allergic rhinitis comparing 15 mg twice daily (n=85) and 30 mg twice daily (n°330) of an experimental formulation of fexofenadine to placebo (n--430) have been conducted. In general, fexofenadine hydrochloride was well toler ...
... Three clinical safety studies in 845 children aged 6 months to 5 years with allergic rhinitis comparing 15 mg twice daily (n=85) and 30 mg twice daily (n°330) of an experimental formulation of fexofenadine to placebo (n--430) have been conducted. In general, fexofenadine hydrochloride was well toler ...
Use of Codeine in Children
... There have been growing safety concerns of codeine toxicity in ultra-rapid metabolizers o Ultra-rapid metabolizers convert codeine to morphine more rapidly and completely than the general population. They have plasma levels of morphine 50% higher than normal, leading to dose-related opioid adverse ...
... There have been growing safety concerns of codeine toxicity in ultra-rapid metabolizers o Ultra-rapid metabolizers convert codeine to morphine more rapidly and completely than the general population. They have plasma levels of morphine 50% higher than normal, leading to dose-related opioid adverse ...
Mykofenolatmofetil Actavis capsule, hard ENG SmPC
... recommended dose in renal transplant patients is 1 g administered twice daily (2 g daily dose). Paediatric population aged 2 to 18 years The recommended dose of mycophenolate mofetil is 600 mg/m2 administered orally twice daily (up to a maximum of 2 g daily). Mykofenolatmofetil Actavis capsules shou ...
... recommended dose in renal transplant patients is 1 g administered twice daily (2 g daily dose). Paediatric population aged 2 to 18 years The recommended dose of mycophenolate mofetil is 600 mg/m2 administered orally twice daily (up to a maximum of 2 g daily). Mykofenolatmofetil Actavis capsules shou ...
the prophylactic effect of nigella sativa against cyclophosphamide in
... MATERIALS AND METHODS Forty eight ICR mature adult female mice, aged 18 weeks were divided into three main experimental groups (n=6/group, Figure 1): group (i) = vehicle-treated control, group (ii) = CPA alone and group (iii) = NSO six hours prior to CPA treatment. In group i, control mice were inje ...
... MATERIALS AND METHODS Forty eight ICR mature adult female mice, aged 18 weeks were divided into three main experimental groups (n=6/group, Figure 1): group (i) = vehicle-treated control, group (ii) = CPA alone and group (iii) = NSO six hours prior to CPA treatment. In group i, control mice were inje ...
PRESCRIBING INFORMATION AND CONSUMER
... Drug-Herb Interactions Interactions with herbs have not been established. Drug-Laboratory Interactions Interactions with laboratory tests have not been established. DOSAGE AND ADMINISTRATION Dosing Considerations Individual response to hyoscine butylbromide may vary and doses should be adjusted acc ...
... Drug-Herb Interactions Interactions with herbs have not been established. Drug-Laboratory Interactions Interactions with laboratory tests have not been established. DOSAGE AND ADMINISTRATION Dosing Considerations Individual response to hyoscine butylbromide may vary and doses should be adjusted acc ...
Paracetamol - A Review of Three Routes of Administration - e
... blinded study of analgesia following gynaecological surgery, 200 women were randomised to receive either 2 intravenous doses of propacetamol 2g, or ketorolac 30mg, alongside morphine via a patientcontrolled analgesia (PCA) system.20 Patients were monitored for 12 hours and propacetamol was found to ...
... blinded study of analgesia following gynaecological surgery, 200 women were randomised to receive either 2 intravenous doses of propacetamol 2g, or ketorolac 30mg, alongside morphine via a patientcontrolled analgesia (PCA) system.20 Patients were monitored for 12 hours and propacetamol was found to ...
Product Monograph
... 50 mg/day: 26%; 100 mg/day: 41%). Pediatric patients under two years of age who were treated with adjunctive topiramate for partial onset epilepsy, also experienced hyperammonemia (placebo: 8%; 5 mg/kg/day: 10%; 15 mg/kg/day: 0%; 25 mg/kg/day: 9%). TOPAMAX® is not indicated for migraine prophylaxis ...
... 50 mg/day: 26%; 100 mg/day: 41%). Pediatric patients under two years of age who were treated with adjunctive topiramate for partial onset epilepsy, also experienced hyperammonemia (placebo: 8%; 5 mg/kg/day: 10%; 15 mg/kg/day: 0%; 25 mg/kg/day: 9%). TOPAMAX® is not indicated for migraine prophylaxis ...
prescribing information - Purdue Pharma (Canada)
... with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioid ...
... with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioid ...
(PSD) July 2016 PBAC Meeting
... weeks. The maximum dose of omalizumab (750 mg) and a proportion of the 450 mg and 600 mg doses are required to be split into two equal doses to be administered every 2 weeks. This results in additional administration costs with omalizumab. 6.20 Using the DUSC utilisation data, it was calculated that ...
... weeks. The maximum dose of omalizumab (750 mg) and a proportion of the 450 mg and 600 mg doses are required to be split into two equal doses to be administered every 2 weeks. This results in additional administration costs with omalizumab. 6.20 Using the DUSC utilisation data, it was calculated that ...
The Haunting of Medical Journals: How Ghostwriting Sold ``HRT``
... Prempro for preventing Alzheimer’s disease, Parkinson’s disease, age-related macular degeneration, and wrinkles. The scope of these articles is summarized in ...
... Prempro for preventing Alzheimer’s disease, Parkinson’s disease, age-related macular degeneration, and wrinkles. The scope of these articles is summarized in ...
TAZORAC® Cream Prescribing Information
... cream at 2 mg/cm2 over a 35% body surface area in a controlled pharmacokinetic study, and 4 and 44 times the maximum systemic exposure in acne patients treated with tazarotene cream, 0.1% at 2 mg/cm2 over a 15% body surface area. When tazarotene was given orally to experimental animals, developmenta ...
... cream at 2 mg/cm2 over a 35% body surface area in a controlled pharmacokinetic study, and 4 and 44 times the maximum systemic exposure in acne patients treated with tazarotene cream, 0.1% at 2 mg/cm2 over a 15% body surface area. When tazarotene was given orally to experimental animals, developmenta ...
THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED
... findings are supported by earlier studies, which have reported a coinduction of CYP3A11 and OATP2 in PXR⫹/⫹ mice, but not in the PXR⫺/⫺ model, after treatment with the known PXR activators RU486 and pregnenolone 16␣-carbonitrile (Staudinger et al., 2001; Teng and Piquette-Miller, 2004). Interestingl ...
... findings are supported by earlier studies, which have reported a coinduction of CYP3A11 and OATP2 in PXR⫹/⫹ mice, but not in the PXR⫺/⫺ model, after treatment with the known PXR activators RU486 and pregnenolone 16␣-carbonitrile (Staudinger et al., 2001; Teng and Piquette-Miller, 2004). Interestingl ...
Core-Shell Type Lipid-Polymer Hybrid Nanoparticles as
... hydrophilic compounds on the bilayer surface and insertion of hydrophobic molecules into the hydrophobic lamellar region. 51–54 This feature allows CSLPHNs to entrap and deliver multiple hydrophilic and hydrophobic therapeutic agents simultaneously. 29,55 • Optimization of the core and shell can res ...
... hydrophilic compounds on the bilayer surface and insertion of hydrophobic molecules into the hydrophobic lamellar region. 51–54 This feature allows CSLPHNs to entrap and deliver multiple hydrophilic and hydrophobic therapeutic agents simultaneously. 29,55 • Optimization of the core and shell can res ...
Aldehyde Oxidase Activity in Donor
... BioreclamationIVT (Baltimore, MD). All other reagents and chemicals were of the highest purity available. Hepatocyte Isolation Procedure. Human livers from 10 donors that were not suitable for transplantation for various reasons (demographic constraints; lifestyle history; anatomic concerns such as ...
... BioreclamationIVT (Baltimore, MD). All other reagents and chemicals were of the highest purity available. Hepatocyte Isolation Procedure. Human livers from 10 donors that were not suitable for transplantation for various reasons (demographic constraints; lifestyle history; anatomic concerns such as ...
HIV Drug Therapy - Immunodeficiency Clinic
... interactions, medication adherence, and cost need to be carefully considered when designing a particular treatment regimen for an individual patient. A new section on pharmacology of directly acting antivirals (DAAs) for hepatitis C infection has also been added. Costs of various treatment protocols ...
... interactions, medication adherence, and cost need to be carefully considered when designing a particular treatment regimen for an individual patient. A new section on pharmacology of directly acting antivirals (DAAs) for hepatitis C infection has also been added. Costs of various treatment protocols ...