Studies on Variability in Olanzapine Disposition
... than men. However, the higher C/D ratio for OLA in women was statistically significant only in the non-smoking group. Non-smokers had significantly higher C/D ratio for OLA than smokers. Smokers received significantly higher daily doses of OLA than non-smokers. In the group with reported ADRs, the s ...
... than men. However, the higher C/D ratio for OLA in women was statistically significant only in the non-smoking group. Non-smokers had significantly higher C/D ratio for OLA than smokers. Smokers received significantly higher daily doses of OLA than non-smokers. In the group with reported ADRs, the s ...
METHOTREXAT “EBEWE” 10 mg/ml and 100 mg/ml
... serum creatinine, methotrexate levels and calcium folinate rescue performed till the methotrexate levels decrease below 10-7 mol/l. During the conventional dose of methotrexate a dose reduction of 50% is recommended if the serum creatinine values are 1.2–2 mg/dl and cessation of therapy is recommend ...
... serum creatinine, methotrexate levels and calcium folinate rescue performed till the methotrexate levels decrease below 10-7 mol/l. During the conventional dose of methotrexate a dose reduction of 50% is recommended if the serum creatinine values are 1.2–2 mg/dl and cessation of therapy is recommend ...
University of Groningen Human and rat organ slices de
... Species differences in metabolism are widely recognized, however, only a few studies compared metabolism of a single substrate in whole cell systems from different species, as rat, dog and man [22,84]. This type of study is most common using microsomal preparations [123]. Certain species differences ...
... Species differences in metabolism are widely recognized, however, only a few studies compared metabolism of a single substrate in whole cell systems from different species, as rat, dog and man [22,84]. This type of study is most common using microsomal preparations [123]. Certain species differences ...
AERIUS® AERIUS KIDS®
... In separate single dose studies, at the recommended doses, pediatric patients had comparable AUC and Cmax values of desloratadine to those in adults who received a 5 mg dose of desloratadine syrup or tablets. Distribution: No information available. Metabolism: Desloratadine is extensively metabolize ...
... In separate single dose studies, at the recommended doses, pediatric patients had comparable AUC and Cmax values of desloratadine to those in adults who received a 5 mg dose of desloratadine syrup or tablets. Distribution: No information available. Metabolism: Desloratadine is extensively metabolize ...
- Obstetrics & Gynecology Clinics of North America
... birth is sufficient to recognize the symptoms of withdrawal, although with long-acting opioids in particular, such as methadone, the withdrawal period can be longer.7 Several scoring tools are available for measuring signs and symptoms of withdrawal and to determine when to start therapy, based prim ...
... birth is sufficient to recognize the symptoms of withdrawal, although with long-acting opioids in particular, such as methadone, the withdrawal period can be longer.7 Several scoring tools are available for measuring signs and symptoms of withdrawal and to determine when to start therapy, based prim ...
Protocol - The EMMES Corporation
... 70, who have symptomatic MM requiring treatment, who have received at least two cycles of systemic therapy and who are within 2-12 months of initiation of the initial therapy. Patients must have available an autograft 4 x 106 CD34+ cells/kg patient weight. ...
... 70, who have symptomatic MM requiring treatment, who have received at least two cycles of systemic therapy and who are within 2-12 months of initiation of the initial therapy. Patients must have available an autograft 4 x 106 CD34+ cells/kg patient weight. ...
Prescribing Information
... other CNS depressants (including alcohol), has been associated with significant respiratory depression and death. Many, but not all, post-marketing reports regarding coma and death associated with the concomitant use of buprenorphine and benzodiazepines involved misuse by self-injection. Deaths have ...
... other CNS depressants (including alcohol), has been associated with significant respiratory depression and death. Many, but not all, post-marketing reports regarding coma and death associated with the concomitant use of buprenorphine and benzodiazepines involved misuse by self-injection. Deaths have ...
Adverse Reactions to Radiopharmaceuticals
... of drugs, they are also associated with the use of radiopharmaceuticals, and instead of the term “side effect”, which is generally used in common drugs, “adverse reaction”, a term with broader sense is used to refer them. Another definition of adverse drug reaction includes any side effects, damage, ...
... of drugs, they are also associated with the use of radiopharmaceuticals, and instead of the term “side effect”, which is generally used in common drugs, “adverse reaction”, a term with broader sense is used to refer them. Another definition of adverse drug reaction includes any side effects, damage, ...
methylene blue
... (possible signs in parentheses where appropriate)— not necessarily inclusive: Those indicating need for medical attention Incidence unknown Cats Heinz body production{R-11; 13} Note: The development of hemolytic anemia in response to methylene blue administration is a dose-dependent effect that may ...
... (possible signs in parentheses where appropriate)— not necessarily inclusive: Those indicating need for medical attention Incidence unknown Cats Heinz body production{R-11; 13} Note: The development of hemolytic anemia in response to methylene blue administration is a dose-dependent effect that may ...
- Nottingham ePrints
... Twelve clear Perspex chambers (39.5 cm long × 23.5 cm wide × 24.5 cm deep) with metal grid lids were used (Photobeam Activity System, San Diego Instruments, USA). The chambers were surrounded by frames containing two levels of photobeams as described previously (Jones, Brown, Auer, & Fone, 2011; Pez ...
... Twelve clear Perspex chambers (39.5 cm long × 23.5 cm wide × 24.5 cm deep) with metal grid lids were used (Photobeam Activity System, San Diego Instruments, USA). The chambers were surrounded by frames containing two levels of photobeams as described previously (Jones, Brown, Auer, & Fone, 2011; Pez ...
Medroxyprogesterone at High Altitude. The Effects on Blood Gases
... acute mountain sickness (AMS). Design.—Two placebo-controlled trials during rapid ascent to high altitude. Participants.—In the first trial, 20 participants, and in the second trial, 24 participants. Setting.—During rapid ascent to 4680 m and on rapid ascent to 5200 m. Intervention.—In the first tri ...
... acute mountain sickness (AMS). Design.—Two placebo-controlled trials during rapid ascent to high altitude. Participants.—In the first trial, 20 participants, and in the second trial, 24 participants. Setting.—During rapid ascent to 4680 m and on rapid ascent to 5200 m. Intervention.—In the first tri ...
overview of comments received on community - EMA
... and for further generations furthermore the current wide variability of herbal medicinal products in the EU memberstates. In general, it has to be remarked with respect to the well-established use, that clinical The mentioned issues will be discussed at the relevant data support the use in the treat ...
... and for further generations furthermore the current wide variability of herbal medicinal products in the EU memberstates. In general, it has to be remarked with respect to the well-established use, that clinical The mentioned issues will be discussed at the relevant data support the use in the treat ...
Study 33: Analysing a cross-over study. Statistical work and
... background for the study planning, but are usually (with very few exceptions for extremely rare indications) not considered as studies providing conclusive evidence for a submission. In addition this is a globally rapidly evolving field of gaining knowledge of actual effects in every day practice ...
... background for the study planning, but are usually (with very few exceptions for extremely rare indications) not considered as studies providing conclusive evidence for a submission. In addition this is a globally rapidly evolving field of gaining knowledge of actual effects in every day practice ...
PrCOPAXONE - Teva Canada Innovation
... Reproduction and Teratology). Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. During pre-marketing clinical trials with COPAXONE (20 mg/mL once per day), seven women conceived while being treated with ...
... Reproduction and Teratology). Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. During pre-marketing clinical trials with COPAXONE (20 mg/mL once per day), seven women conceived while being treated with ...
... of CARLSEN et al. [30], suggesting that children may benefit and obtain adequate clinical protection even from only 25 µg of inhaled salmeterol. Tachyphylaxis to the functional antagonism of salmeterol against EIA is an emerging problem. Recent studies have shown that 2–4 weeks regular treatment wit ...
Safety and Efficacy of Oxcarbazepine - Deep Blue
... Comparative Monotherapy Trials The safety and efficacy of oxcarbazepine monotherapy was evaluated in four international trials in patients with newly diagnosed partial seizures or generalized tonic-clonic seizures (Table 1).9–12 All four trials were multicenter, double-blind, parallel-group design t ...
... Comparative Monotherapy Trials The safety and efficacy of oxcarbazepine monotherapy was evaluated in four international trials in patients with newly diagnosed partial seizures or generalized tonic-clonic seizures (Table 1).9–12 All four trials were multicenter, double-blind, parallel-group design t ...
Survey study of challenging experiences after ingesting psilocybin
... Descriptive statistics (percentages, mean, median, range, and standard error of the mean) were used to characterize the responses to questions and the subscale scores of the questionnaires. Pearson correlations were used to analyze the associations among participant ratings of the degree of difficul ...
... Descriptive statistics (percentages, mean, median, range, and standard error of the mean) were used to characterize the responses to questions and the subscale scores of the questionnaires. Pearson correlations were used to analyze the associations among participant ratings of the degree of difficul ...
Carisoprodol: an underrecognized drug of abuse in north India
... to our previous study [12] the most common initiator to carisoprodol intake was co-addicts (vs. local chemist), and the most common reason for initiating carisoprodol was for better “kick” (vs. to combat aches). Dose-dependent effect (general wellbeing→ hypomania→confusional state) and craving, tole ...
... to our previous study [12] the most common initiator to carisoprodol intake was co-addicts (vs. local chemist), and the most common reason for initiating carisoprodol was for better “kick” (vs. to combat aches). Dose-dependent effect (general wellbeing→ hypomania→confusional state) and craving, tole ...
ACTELION`S NEW DUAL OREXIN RECEPTOR ANTAGONIST
... The following information contains certain “forward-looking statements”, relating to the company’s business, which can be identified by the use of forward-looking terminology such as “estimates”, “believes”, “expects”, “may”, “are expected to”, “will”, “will continue”, “should”, “would be”, “seeks” ...
... The following information contains certain “forward-looking statements”, relating to the company’s business, which can be identified by the use of forward-looking terminology such as “estimates”, “believes”, “expects”, “may”, “are expected to”, “will”, “will continue”, “should”, “would be”, “seeks” ...
RM-0106.02
... Clinical studies of vancomycin HCl for oral use did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients ...
... Clinical studies of vancomycin HCl for oral use did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients ...
DOXYCYCLINE HYCLATE TABLETS, USP Rev. 06/11
... growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every 6 hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic ef ...
... growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every 6 hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic ef ...
2048998_Open_OCTREOTIDE ACETATE INJECTION SAG US.cdr
... deficiency, epistaxis; Miscellaneous: otitis, allergic reaction, increased CK, weight loss. Evaluation of 20 patients treated for at least 6 months has failed to demonstrate titers of antibodies exceeding background levels. However, antibody titers to octreotide acetate were subsequently reported in ...
... deficiency, epistaxis; Miscellaneous: otitis, allergic reaction, increased CK, weight loss. Evaluation of 20 patients treated for at least 6 months has failed to demonstrate titers of antibodies exceeding background levels. However, antibody titers to octreotide acetate were subsequently reported in ...
Inhaled clemastine, an H
... challenge except that progressively more dilute saline solutions were placed in the nebulizer according to the sequence 0.9% saline (isotonic solution), 0.45%, 0.23%, 0.11 %, 0.06% and 0.03%. The challenge ended once the FEV1 had fallen greater than 20% compared to the pre-challenge FEV1 , or the 0. ...
... challenge except that progressively more dilute saline solutions were placed in the nebulizer according to the sequence 0.9% saline (isotonic solution), 0.45%, 0.23%, 0.11 %, 0.06% and 0.03%. The challenge ended once the FEV1 had fallen greater than 20% compared to the pre-challenge FEV1 , or the 0. ...
Anticoagulation-Warfarin - National Medical Research Council
... Warfarin (irrespective of INR) is not fully effective in the first several days of therapy because of a delayed decrease in several circulating clotting factors. Loading doses can increase a patient’s risk of supra-therapeutic INR and make it more difficult to determine a steady-state dose. 5.1.2 Th ...
... Warfarin (irrespective of INR) is not fully effective in the first several days of therapy because of a delayed decrease in several circulating clotting factors. Loading doses can increase a patient’s risk of supra-therapeutic INR and make it more difficult to determine a steady-state dose. 5.1.2 Th ...
Bleomycin
... The microscopic tissue changes due to bleomycin toxicity include bronchiolar squamous metaplasia, reactive macrophages, atypical alveolar epithelial cells, fibrinous edema, and interstitial fibrosis. The acute stage may involve capillary changes and subsequent fibrinous exudation into alveoli produc ...
... The microscopic tissue changes due to bleomycin toxicity include bronchiolar squamous metaplasia, reactive macrophages, atypical alveolar epithelial cells, fibrinous edema, and interstitial fibrosis. The acute stage may involve capillary changes and subsequent fibrinous exudation into alveoli produc ...